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The map label for this gene is lpxC/fabZ

Identifier: 21674480

GI number: 21674480

Start: 1570691

End: 1572094

Strand: Direct

Name: lpxC/fabZ

Synonym: CT1662

Alternate gene names: 21674480

Gene position: 1570691-1572094 (Clockwise)

Preceding gene: 21674479

Following gene: 21674484

Centisome position: 72.89

GC content: 59.23

Gene sequence:

>1404_bases
ATGCTCATTCATCAACGCACCCTCCAGAACGAAATTTCGCTCACGGGGATCGGCCTCCACACCGGCCACGAATGCACCAT
CACGTTCAAGCCCGCACCGGTCAACACCGGCTATATTTTCGTCAGAACCGACATCAATGACTGCCCGGAGATTCCGGCGC
TGATCGATCACGTCGTCGATGTGCTCCGCGGCACCACCATTGGCATCGGCGATGTCAAGGTGCACACCACCGAGCACGTG
CTTGCCGCCCTGTACGGATTGCAGATCGACAACTGCCGCATCGAGCTGAGCGGCCCCGAGCCGCCGGTGCTCGACGGCAG
CTCAAATCCGTTCGCCGAAGCGCTGCTTTCGGCAGGCATCGCCGAGCAGGACGAACCGAAAAACTATCTCGTGATCGACG
AGACCATCGAGTTTCACAATCCGGAAAAGAGCGTGGACATCGTGGCCCTGCCGCTTGACGGCTTCCGCATGACGGTGATG
GTCGATTACAAAAACCCGGCGCTCGGCTCGCAGCACTCCGGCCTGTTCGACCTCGACAAGGAGTTCCTGCGCGAGTTCTC
GCCGTGCCGAACCTTCTGCTTCCTTTCGGAGGTCGAAGCGATGGCCAACCAGGGCATCATCAAGGGTGCGGATATTGACA
ACGCCATCGTGATCGTTGACAAGCAGCTCGATGAAACCGAGGTGCAGACGCTCGCCGACAAGGTTGGCGTGGACGCTTCG
CACCTGGTGCTCGGCCAGAACGGCATTCTGAACAACCGCGAACTGCGCTTCTCCAACGAACCGGCCCGCCACAAACTGCT
CGACCTGCTCGGCGATCTGGCACTGCTCGGCATGCCGGTCAAGGCGCAGATCCTCGCCGMCCGTCCCGGCCACGCCTCGA
ACGTCGAATTCGTCAAGCAGCTCAAGAAGTACGCCGACCGCAACAAGCTTGCCCGCCAGTACCAGCACGAGAAAAAAGCT
GGCGTCATTTTCGACATCAACGCCATCCAGAACATCCTGCCGCATCGCTACCCGTTCCTTCTGATCGACAAGATCGTCGA
ATTCAAGCTCGACGAAAAGATCGTCTCGATCAAGAACGTCACGATGAACGAACCCTTCTTCCAGGGTCACTTCCCTGGCA
ACCCGATCATGCCCGGCGTGCTCATCATCGAGGCGATGGCCCAGACCGGCGGCATCATGATGCTCAACGGCAAGGAGAAC
ATCAAGGAATCGGTGGTCTTCTTCATGGGCATCGACAAGGCACGGTTCAGGAAGCCGGTGCTGCCCGGCGATACGCTGGT
CATCGAAGCGGTCATGACCAACATGCGGCGCACGGTCTGCCAGTTTGACGCCAAGGCCTACGTGCGAGGCGAGCTGGTCT
GCGAAGCTTCGCTGATGGCTACCGTGATGGAGAAAAAGAACTGA

Upstream 100 bases:

>100_bases
CGGCGGCATTTCGGGGCCTGACCCGCGTCAAGCAGCCAATTTGAAGAGTTGGCGCCGCTTTCGTATCTTTGATATTTTTC
ATCGCAAGCTCCAGCCATCC

Downstream 100 bases:

>100_bases
AACACTGTCAGAAAATACGTCATCATGAAAAAACCCCGGAGTTCCGGGGTTTTTTCATGATTTCCACACTCTTCCACACC
TGACCAACAGGCTTGCCAAC

Product: bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase

Products: NA

Alternate protein names: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; UDP-3-O-acyl-GlcNAc deacetylase; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; (3R)-hydroxymyristoyl ACP dehydrase

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MLIHQRTLQNEISLTGIGLHTGHECTITFKPAPVNTGYIFVRTDINDCPEIPALIDHVVDVLRGTTIGIGDVKVHTTEHV
LAALYGLQIDNCRIELSGPEPPVLDGSSNPFAEALLSAGIAEQDEPKNYLVIDETIEFHNPEKSVDIVALPLDGFRMTVM
VDYKNPALGSQHSGLFDLDKEFLREFSPCRTFCFLSEVEAMANQGIIKGADIDNAIVIVDKQLDETEVQTLADKVGVDAS
HLVLGQNGILNNRELRFSNEPARHKLLDLLGDLALLGMPVKAQILAXRPGHASNVEFVKQLKKYADRNKLARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEPFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGKEN
IKESVVFFMGIDKARFRKPVLPGDTLVIEAVMTNMRRTVCQFDAKAYVRGELVCEASLMATVMEKKN

Sequences:

>Translated_467_residues
MLIHQRTLQNEISLTGIGLHTGHECTITFKPAPVNTGYIFVRTDINDCPEIPALIDHVVDVLRGTTIGIGDVKVHTTEHV
LAALYGLQIDNCRIELSGPEPPVLDGSSNPFAEALLSAGIAEQDEPKNYLVIDETIEFHNPEKSVDIVALPLDGFRMTVM
VDYKNPALGSQHSGLFDLDKEFLREFSPCRTFCFLSEVEAMANQGIIKGADIDNAIVIVDKQLDETEVQTLADKVGVDAS
HLVLGQNGILNNRELRFSNEPARHKLLDLLGDLALLGMPVKAQILAXRPGHASNVEFVKQLKKYADRNKLARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEPFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGKEN
IKESVVFFMGIDKARFRKPVLPGDTLVIEAVMTNMRRTVCQFDAKAYVRGELVCEASLMATVMEKKN
>Mature_467_residues
MLIHQRTLQNEISLTGIGLHTGHECTITFKPAPVNTGYIFVRTDINDCPEIPALIDHVVDVLRGTTIGIGDVKVHTTEHV
LAALYGLQIDNCRIELSGPEPPVLDGSSNPFAEALLSAGIAEQDEPKNYLVIDETIEFHNPEKSVDIVALPLDGFRMTVM
VDYKNPALGSQHSGLFDLDKEFLREFSPCRTFCFLSEVEAMANQGIIKGADIDNAIVIVDKQLDETEVQTLADKVGVDAS
HLVLGQNGILNNRELRFSNEPARHKLLDLLGDLALLGMPVKAQILAXRPGHASNVEFVKQLKKYADRNKLARQYQHEKKA
GVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNVTMNEPFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGKEN
IKESVVFFMGIDKARFRKPVLPGDTLVIEAVMTNMRRTVCQFDAKAYVRGELVCEASLMATVMEKKN

Specific function: Involved in saturated fatty acids biosynthesis

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thioester dehydratase family

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=35.5263157894737, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786377, Length=138, Percent_Identity=46.3768115942029, Blast_Score=145, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXZ_CHLTE (Q8KBX0)

Other databases:

- EMBL:   AE006470
- RefSeq:   NP_662545.1
- ProteinModelPortal:   Q8KBX0
- SMR:   Q8KBX0
- GeneID:   1006145
- GenomeReviews:   AE006470_GR
- KEGG:   cte:CT1662
- NMPDR:   fig|194439.1.peg.1639
- TIGR:   CT1662
- HOGENOM:   HBG302394
- OMA:   PGHASNV
- ProtClustDB:   PRK13188
- BioCyc:   CTEP194439:CT_1662-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00388
- HAMAP:   MF_00406
- InterPro:   IPR013114
- InterPro:   IPR010084
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR01750
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF07977 FabA; PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-; 4.2.1.-

Molecular weight: Translated: 51791; Mature: 51791

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: ACT_SITE 370-370

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIHQRTLQNEISLTGIGLHTGHECTITFKPAPVNTGYIFVRTDINDCPEIPALIDHVVD
CCCCCHHHHCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VLRGTTIGIGDVKVHTTEHVLAALYGLQIDNCRIELSGPEPPVLDGSSNPFAEALLSAGI
HHCCCEECCCCEEEEHHHHHHHHHHCCEEECEEEECCCCCCCCCCCCCCHHHHHHHHCCC
AEQDEPKNYLVIDETIEFHNPEKSVDIVALPLDGFRMTVMVDYKNPALGSQHSGLFDLDK
CCCCCCCCEEEEECEEECCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHH
EFLREFSPCRTFCFLSEVEAMANQGIIKGADIDNAIVIVDKQLDETEVQTLADKVGVDAS
HHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCC
HLVLGQNGILNNRELRFSNEPARHKLLDLLGDLALLGMPVKAQILAXRPGHASNVEFVKQ
EEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
LKKYADRNKLARQYQHEKKAGVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNV
HHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
TMNEPFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGKENIKESVVFFMGIDKARFRKPV
CCCCCCEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHEEEEEECCHHHHCCCC
LPGDTLVIEAVMTNMRRTVCQFDAKAYVRGELVCEASLMATVMEKKN
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MLIHQRTLQNEISLTGIGLHTGHECTITFKPAPVNTGYIFVRTDINDCPEIPALIDHVVD
CCCCCHHHHCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VLRGTTIGIGDVKVHTTEHVLAALYGLQIDNCRIELSGPEPPVLDGSSNPFAEALLSAGI
HHCCCEECCCCEEEEHHHHHHHHHHCCEEECEEEECCCCCCCCCCCCCCHHHHHHHHCCC
AEQDEPKNYLVIDETIEFHNPEKSVDIVALPLDGFRMTVMVDYKNPALGSQHSGLFDLDK
CCCCCCCCEEEEECEEECCCCCCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCHHHHH
EFLREFSPCRTFCFLSEVEAMANQGIIKGADIDNAIVIVDKQLDETEVQTLADKVGVDAS
HHHHHCCHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCCC
HLVLGQNGILNNRELRFSNEPARHKLLDLLGDLALLGMPVKAQILAXRPGHASNVEFVKQ
EEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHH
LKKYADRNKLARQYQHEKKAGVIFDINAIQNILPHRYPFLLIDKIVEFKLDEKIVSIKNV
HHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
TMNEPFFQGHFPGNPIMPGVLIIEAMAQTGGIMMLNGKENIKESVVFFMGIDKARFRKPV
CCCCCCEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHHEEEEEECCHHHHCCCC
LPGDTLVIEAVMTNMRRTVCQFDAKAYVRGELVCEASLMATVMEKKN
CCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901