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The map label for this gene is trxA

Identifier: 21672829

GI number: 21672829

Start: 628212

End: 628538

Strand: Reverse

Name: trxA

Synonym: BUsg573

Alternate gene names: 21672829

Gene position: 628538-628212 (Counterclockwise)

Preceding gene: 21672830

Following gene: 21672828

Centisome position: 97.99

GC content: 25.69

Gene sequence:

>327_bases
ATGAATAAAATAATCGAACTTACTGATCAAAATTTTGAAAAAGAAGTATTAGAACATAAAAGTTTTGTATTAGTTGATTT
CTGGGCTGAATGGTGTAATCCATGTAAAATATTAGCTCCTATTTTAGAAGAAATAGCACAAGAATATTTTAATAAAATTA
AAGTTGGTAAATTAAATATCGAAAAAAATCCAAATACTGCTCCTATTTACTCTATTCGAGGAATTCCAGCATTACTATTA
TTTCATGGAAGAGAAGTTCTTGCTACTAAAGTTGGAGCAATTTCTAAATTACAACTCAAAGATTTTTTAGATGAGAATAT
TAAATAA

Upstream 100 bases:

>100_bases
AAAATTATTTAATTTTAGTTTAAATCAATTCCCAAAAATGATATTATAATAGAATTAATTAAGAAAATTTTTTATTATTA
AATATAGAGTATCATAAAAA

Downstream 100 bases:

>100_bases
ATATTTATATATAGTTAATTAACTTTAACTCAAAAAATTAAATTCAATTTTATGAAAAATTTATTAATGACAATAAAAAA
ATTTATAATTGATATCACAG

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 108; Mature: 108

Protein sequence:

>108_residues
MNKIIELTDQNFEKEVLEHKSFVLVDFWAEWCNPCKILAPILEEIAQEYFNKIKVGKLNIEKNPNTAPIYSIRGIPALLL
FHGREVLATKVGAISKLQLKDFLDENIK

Sequences:

>Translated_108_residues
MNKIIELTDQNFEKEVLEHKSFVLVDFWAEWCNPCKILAPILEEIAQEYFNKIKVGKLNIEKNPNTAPIYSIRGIPALLL
FHGREVLATKVGAISKLQLKDFLDENIK
>Mature_108_residues
MNKIIELTDQNFEKEVLEHKSFVLVDFWAEWCNPCKILAPILEEIAQEYFNKIKVGKLNIEKNPNTAPIYSIRGIPALLL
FHGREVLATKVGAISKLQLKDFLDENIK

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=7e-12,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=64.1509433962264, Blast_Score=147, Evalue=2e-37,
Organism=Escherichia coli, GI1788936, Length=106, Percent_Identity=33.0188679245283, Blast_Score=75, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17549970, Length=80, Percent_Identity=40, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=96, Percent_Identity=31.25, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=37.5, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=40, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664269, Length=72, Percent_Identity=36.1111111111111, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=30, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_BUCAP (O51890)

Other databases:

- EMBL:   AF008210
- EMBL:   AE013218
- RefSeq:   NP_660896.1
- ProteinModelPortal:   O51890
- SMR:   O51890
- EnsemblBacteria:   EBBUCT00000000286
- GeneID:   1005580
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg573
- GeneTree:   EBGT00050000008037
- HOGENOM:   HBG493509
- OMA:   NPGIAST
- ProtClustDB:   CLSK873791
- BioCyc:   BAPH198804:BUSG573-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 12440; Mature: 12440

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIIELTDQNFEKEVLEHKSFVLVDFWAEWCNPCKILAPILEEIAQEYFNKIKVGKLNI
CCCEEECCCCCHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
EKNPNTAPIYSIRGIPALLLFHGREVLATKVGAISKLQLKDFLDENIK
CCCCCCCCEEEECCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKIIELTDQNFEKEVLEHKSFVLVDFWAEWCNPCKILAPILEEIAQEYFNKIKVGKLNI
CCCEEECCCCCHHHHHHHCCCEEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEE
EKNPNTAPIYSIRGIPALLLFHGREVLATKVGAISKLQLKDFLDENIK
CCCCCCCCEEEECCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9516544; 12089438