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The map label for this gene is atpA

Identifier: 21672300

GI number: 21672300

Start: 4287

End: 5819

Strand: Direct

Name: atpA

Synonym: BUsg006

Alternate gene names: 21672300

Gene position: 4287-5819 (Clockwise)

Preceding gene: 21672299

Following gene: 21672301

Centisome position: 0.67

GC content: 30.66

Gene sequence:

>1533_bases
ATGCAATTAAATTCTACAGAAATTAGTCAATTGATTAAAGAAAGAATTGCTCAATTTGAAGTATTTAATCAATCTTATAA
TGAAGGTACTATTATTTCTGTTAATGATGGTATCATAAAAATTTATGGTCTTTCTGATGTTATGTTAGGAGAAATGATTT
TATTACCTGACAATGAATATGCAATTGCATTAAATATAGAAAGAGATACAATTGGTGCTGTAGTGATGGGACCTTATATT
CATATTACTGAAGGTACTAAGGTTCGATGTACAGGAAAAATCCTAGAAGTTCCAGTTGGTGTTGCACTTTTAGGAAGGAT
AGTGAATGCATTAGGTTTTCCTATTGATGGCAAAGGTTCTATAGAACATGATATTTATTTACCAGTAGAGGCGGATGCAC
CTGGTGTTATTGAACGCGAATCTATTAATGAACCGATACAAACTGGTTATAAAGCTATTGATGCTATGGTTCCTATCGGT
CGTGGACAACGTGAATTAATTATTGGAGATAGACAAACGGGAAAAACAGCACTTGCAATAGATACTATTATTAATCAAAA
AAAAATTAATCTTCCATGTGTTTACGTTGCTATCGGTCAAAAACTTTCAACTATTATAAACGTTGTAAAAAAATTAGATG
AGCATGATGCTTTATTAAATACTATTGTTGTTGTTGCTTCAGCTTCAGAAGCAGCTTCTTTGCAATATTTAGCACCTTAT
TCCGGTTGTGCAATGGGTGAATATTTTCGCGATCGAGGAAAAGATGCTTTAATTGTTTATGATGATCTTTCAAAACATGC
GGTAGCGTATCGTCAAATTTCTTTATTATTACGTAGACCACCTGGAAGAGAAGCATTTCCGGGAGATGTATTTTATCTTC
ATTCACGTTTATTAGAAAGAGCATCTCGTGTTTCTAAAGAACATGTGAAAAATGTTACTAAAGGTAAAATCACTGGAAAA
ACTGGTTCTCTTACAGCTTTACCTATTATTGAAACGCAATCTGGTGACGTTTCTGCATTTGTTCCTACAAATGTAATTTC
CATCACTGATGGACAAATATTTTTAGAATCTAATTTATTTAATTCAGGTATTCGTCCTGCAGTGAATGCAGGTATATCTG
TATCTCGTGTTGGCAGTGCTGCTCAAACTAAAATTATTAAAAAATTATCTTCTGGAATTCGTACTGCATTAGCTCAATAT
CACGAACTTGCAGCATTTTCGCAATTTGCATCTGATTTAGATCAAACAACTAGAAAACAATTAATATACGGTCAAAAAAT
TACTGAGTTATTGAAACAAAAACAATATAGACCTATGTCTATATCAGAACAAGGATTAATGTTTTTTATCGCTGAAAATA
ATTTTCTTGACGATATCTCTGTAGAAAATATTATTCAATTTGAAAAAGAAATTTTGACATATGCTTATAATTATCATTTA
GATTTAATGGAAGAAATAAACAAAGATGGAAATTTCAATGATATAATAAAGAAAAAATTTATAGAATTAATTAATAATTT
TAAGAATTCTTAA

Upstream 100 bases:

>100_bases
GGCATAATTATAAAAAAAGCTGATACAGTTTTTGATTTTTCTGTTCGTAGTTATCTTAAACAATTATCTGACGTTTTAAA
TTTTTAAGTGAGCATTGTAT

Downstream 100 bases:

>100_bases
TTGTAAAATTTTTATTTTCTTATTTTTATTTTTTGATAATGCAAAAAAATTCATTGAGAAAACATAGTGGCAAGTAAAAA
AGAAATAAAAGATCAAATAA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MQLNSTEISQLIKERIAQFEVFNQSYNEGTIISVNDGIIKIYGLSDVMLGEMILLPDNEYAIALNIERDTIGAVVMGPYI
HITEGTKVRCTGKILEVPVGVALLGRIVNALGFPIDGKGSIEHDIYLPVEADAPGVIERESINEPIQTGYKAIDAMVPIG
RGQRELIIGDRQTGKTALAIDTIINQKKINLPCVYVAIGQKLSTIINVVKKLDEHDALLNTIVVVASASEAASLQYLAPY
SGCAMGEYFRDRGKDALIVYDDLSKHAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERASRVSKEHVKNVTKGKITGK
TGSLTALPIIETQSGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNAGISVSRVGSAAQTKIIKKLSSGIRTALAQY
HELAAFSQFASDLDQTTRKQLIYGQKITELLKQKQYRPMSISEQGLMFFIAENNFLDDISVENIIQFEKEILTYAYNYHL
DLMEEINKDGNFNDIIKKKFIELINNFKNS

Sequences:

>Translated_510_residues
MQLNSTEISQLIKERIAQFEVFNQSYNEGTIISVNDGIIKIYGLSDVMLGEMILLPDNEYAIALNIERDTIGAVVMGPYI
HITEGTKVRCTGKILEVPVGVALLGRIVNALGFPIDGKGSIEHDIYLPVEADAPGVIERESINEPIQTGYKAIDAMVPIG
RGQRELIIGDRQTGKTALAIDTIINQKKINLPCVYVAIGQKLSTIINVVKKLDEHDALLNTIVVVASASEAASLQYLAPY
SGCAMGEYFRDRGKDALIVYDDLSKHAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERASRVSKEHVKNVTKGKITGK
TGSLTALPIIETQSGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNAGISVSRVGSAAQTKIIKKLSSGIRTALAQY
HELAAFSQFASDLDQTTRKQLIYGQKITELLKQKQYRPMSISEQGLMFFIAENNFLDDISVENIIQFEKEILTYAYNYHL
DLMEEINKDGNFNDIIKKKFIELINNFKNS
>Mature_510_residues
MQLNSTEISQLIKERIAQFEVFNQSYNEGTIISVNDGIIKIYGLSDVMLGEMILLPDNEYAIALNIERDTIGAVVMGPYI
HITEGTKVRCTGKILEVPVGVALLGRIVNALGFPIDGKGSIEHDIYLPVEADAPGVIERESINEPIQTGYKAIDAMVPIG
RGQRELIIGDRQTGKTALAIDTIINQKKINLPCVYVAIGQKLSTIINVVKKLDEHDALLNTIVVVASASEAASLQYLAPY
SGCAMGEYFRDRGKDALIVYDDLSKHAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLERASRVSKEHVKNVTKGKITGK
TGSLTALPIIETQSGDVSAFVPTNVISITDGQIFLESNLFNSGIRPAVNAGISVSRVGSAAQTKIIKKLSSGIRTALAQY
HELAAFSQFASDLDQTTRKQLIYGQKITELLKQKQYRPMSISEQGLMFFIAENNFLDDISVENIIQFEKEILTYAYNYHL
DLMEEINKDGNFNDIIKKKFIELINNFKNS

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=512, Percent_Identity=53.90625, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI4757810, Length=512, Percent_Identity=53.90625, Blast_Score=542, Evalue=1e-154,
Organism=Homo sapiens, GI19913428, Length=324, Percent_Identity=27.4691358024691, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI19913426, Length=376, Percent_Identity=25.7978723404255, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI32189394, Length=324, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI19913424, Length=269, Percent_Identity=27.1375464684015, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790172, Length=510, Percent_Identity=72.5490196078431, Blast_Score=781, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=380, Percent_Identity=24.7368421052632, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788251, Length=345, Percent_Identity=24.0579710144928, Blast_Score=99, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71988063, Length=512, Percent_Identity=53.515625, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71988080, Length=512, Percent_Identity=53.515625, Blast_Score=536, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71988074, Length=512, Percent_Identity=50, Blast_Score=490, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17510931, Length=373, Percent_Identity=27.0777479892761, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17570191, Length=372, Percent_Identity=26.8817204301075, Blast_Score=113, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI25144756, Length=433, Percent_Identity=23.3256351039261, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17509265, Length=47, Percent_Identity=70.2127659574468, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=268, Percent_Identity=26.4925373134328, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=496, Percent_Identity=52.8225806451613, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6319603, Length=310, Percent_Identity=28.7096774193548, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6322581, Length=327, Percent_Identity=26.2996941896024, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24658560, Length=515, Percent_Identity=53.9805825242718, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI281361666, Length=310, Percent_Identity=28.0645161290323, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24646341, Length=310, Percent_Identity=28.0645161290323, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136796, Length=310, Percent_Identity=28.0645161290323, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24638766, Length=324, Percent_Identity=25.6172839506173, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574560, Length=313, Percent_Identity=26.1980830670927, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24583992, Length=340, Percent_Identity=25.2941176470588, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583988, Length=269, Percent_Identity=27.1375464684015, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583986, Length=269, Percent_Identity=27.1375464684015, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24583984, Length=269, Percent_Identity=27.1375464684015, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_BUCAP (O51874)

Other databases:

- EMBL:   AF008210
- EMBL:   AE013218
- RefSeq:   NP_660367.1
- ProteinModelPortal:   O51874
- SMR:   O51874
- EnsemblBacteria:   EBBUCT00000000455
- GeneID:   1005804
- GenomeReviews:   AE013218_GR
- KEGG:   bas:BUsg006
- GeneTree:   EBGT00050000007862
- HOGENOM:   HBG565875
- OMA:   TKQTLNR
- ProtClustDB:   PRK09281
- BioCyc:   BAPH198804:BUSG006-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 56392; Mature: 56392

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNSTEISQLIKERIAQFEVFNQSYNEGTIISVNDGIIKIYGLSDVMLGEMILLPDNEY
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECCHHHHCCEEEECCCCE
AIALNIERDTIGAVVMGPYIHITEGTKVRCTGKILEVPVGVALLGRIVNALGFPIDGKGS
EEEEEECCCCCCEEEECCEEEEECCCEEEEECEEEECCHHHHHHHHHHHHHCCCCCCCCC
IEHDIYLPVEADAPGVIERESINEPIQTGYKAIDAMVPIGRGQRELIIGDRQTGKTALAI
CCCEEEEEEECCCCCCEEHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
DTIINQKKINLPCVYVAIGQKLSTIINVVKKLDEHDALLNTIVVVASASEAASLQYLAPY
HHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCC
SGCAMGEYFRDRGKDALIVYDDLSKHAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLER
CCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASRVSKEHVKNVTKGKITGKTGSLTALPIIETQSGDVSAFVPTNVISITDGQIFLESNLF
HHHHHHHHHCCCCCCEEECCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEECCCC
NSGIRPAVNAGISVSRVGSAAQTKIIKKLSSGIRTALAQYHELAAFSQFASDLDQTTRKQ
CCCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIYGQKITELLKQKQYRPMSISEQGLMFFIAENNFLDDISVENIIQFEKEILTYAYNYHL
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DLMEEINKDGNFNDIIKKKFIELINNFKNS
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MQLNSTEISQLIKERIAQFEVFNQSYNEGTIISVNDGIIKIYGLSDVMLGEMILLPDNEY
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECCHHHHCCEEEECCCCE
AIALNIERDTIGAVVMGPYIHITEGTKVRCTGKILEVPVGVALLGRIVNALGFPIDGKGS
EEEEEECCCCCCEEEECCEEEEECCCEEEEECEEEECCHHHHHHHHHHHHHCCCCCCCCC
IEHDIYLPVEADAPGVIERESINEPIQTGYKAIDAMVPIGRGQRELIIGDRQTGKTALAI
CCCEEEEEEECCCCCCEEHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEE
DTIINQKKINLPCVYVAIGQKLSTIINVVKKLDEHDALLNTIVVVASASEAASLQYLAPY
HHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCC
SGCAMGEYFRDRGKDALIVYDDLSKHAVAYRQISLLLRRPPGREAFPGDVFYLHSRLLER
CCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
ASRVSKEHVKNVTKGKITGKTGSLTALPIIETQSGDVSAFVPTNVISITDGQIFLESNLF
HHHHHHHHHCCCCCCEEECCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEECCCC
NSGIRPAVNAGISVSRVGSAAQTKIIKKLSSGIRTALAQYHELAAFSQFASDLDQTTRKQ
CCCCCHHHHCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIYGQKITELLKQKQYRPMSISEQGLMFFIAENNFLDDISVENIIQFEKEILTYAYNYHL
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
DLMEEINKDGNFNDIIKKKFIELINNFKNS
HHHHHCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9216881; 9516544; 12089438