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The map label for this gene is nodT [H]

Identifier: 21245018

GI number: 21245018

Start: 5090617

End: 5092077

Strand: Direct

Name: nodT [H]

Synonym: XAC4306

Alternate gene names: 21245018

Gene position: 5090617-5092077 (Clockwise)

Preceding gene: 21245017

Following gene: 21245019

Centisome position: 98.36

GC content: 69.95

Gene sequence:

>1461_bases
ATGAACCGCACGATCTTGCGTCCGCTGGGAGTGGCCGCACTGCTGAGCATGCTCACTGCCTGCAGCACGGTCGGCCCGAA
CTACGCCGTGCCGGCCGAGTCGGCCTACCGGCGGCCGGCCGCCAATGCCGCCTTTCTGGACACTGGCAACGCGCAGGTGC
AACCCGGTGCCGCGCTGCCGGCGCGCTGGTGGGCGCTGTATCAGGACCCGATGCTGGATGGCCTGATCGAGCAGGCGCTG
CGCGACAACATCGAGCTGAAGGTGGCCGGTGCCAATCTGCGCCGCGCCGCTGCGGTCTACGAACAGGCCATGGATGCCGG
CGGTTTCGATTACGAAGTGGAAGCCGGCGTCAGCCGCGCGCAGGTGTCGGCCGAGGCGTTTTTGCAGGAAGAAAAATTGC
CGGTGTTCAACCTGGCCGATGGCAAGTTCGGCGTGTCGTACCAGTTCGATCTGTTCGGCAAGCTGCAACGCGGTGCCGAA
GCCGCGCACGCCGACACCCAGGTGGCGCAGGCGGCGATCGATCTGGCGCGCGTCAGCGTGGCCGCGCAGGTGGCCGGCAG
TTATGTGGAGATTTGCCACGCCAACCATGAGTTGCAGGTGGCCGAGCATTCGCTGCAGTTGCAGCAACACAGCCGCCAGA
TCACCCAACGCCTGATCGCGGCCGGTCGCGGCACGCCGCCCGATCTGGCGCGCGCCACCGCACAGGTGGCGATGCTGGAA
GCGTCGCTGCCGCCGCTACGCGCGCGCCGCCAGGCCGCCGGTTACCAATTGGCCGCGCTGCTCGGCAAGACCCCCGGCGA
GGTGCCGGCCGGCGTGGACAGCTGCGCGCACGCGCCTGCATTGCAGCAGCCGATCCCGATCGGCGATGGGCGCGCGCTGC
TGGCGCGCCGCCCGGATGTGCGCCAGGCCGAGCGCCGGCTCGCCGCCGCCACCGCACGCATCGGCGTGGCCACCGCCGAG
TTGTACCCGGACATCCGCCTGGGTGGTTCGATCGGCGCCACCGGCCTGCTGGCGGATTTCGGCGAGCCGGCCACGCACGC
GTGGTCGTTCGGCCCGCTGATTTCCTGGACGCTGCCCTCCAGCGGCGCACGTGCGCGGGTGCGCGCCACCGAAGCCGGCG
CCGACGCTGCGCTGGCGCAGTTCGACAACACCGTGCTGCAGGCCTTGCGCGAAGTGCAGACCACCTTGTCGCGCTATGCG
CAGGATCTGGACCGCCTGCATCTGCTGGAACAGGCGCAACAGCAGGCCGAGCTGGCGTCGGCGCAAAACCGGCGCCTGTA
TCAGGGTGGGCGCACGCCGTACCTGTCCAGCCTGGACGCCGAGCGCACCCTGGCCACCGCCGACATGACCCTGGCCACTG
CACAAGCGCAGGTGTCGCAGGACCAGATCCAGCTGTTTCTGGCGCTGGGCGGCGGTTGGGATGCCGACGCCGGGCGCAAC
CACACCAAGGCTGCGCGATGA

Upstream 100 bases:

>100_bases
CAGGGCGCACTGCCACGGTGAGCATTCTGCCCGACACGGCCAATACGGCTCCGGCAACCCCGGCCGTCGCGCCTGCCCGT
GTGCAGGCCAAGGCGGCGCC

Downstream 100 bases:

>100_bases
TTCCGTTGCTGCGCGATCGCCAGGCCTGGCTGTTTTCGGCCAAGACCTTTGCCGCCTCGATCGCGGCGCTGTATGTCGCG
CTGGCCGGCAATCTGTCGCG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MNRTILRPLGVAALLSMLTACSTVGPNYAVPAESAYRRPAANAAFLDTGNAQVQPGAALPARWWALYQDPMLDGLIEQAL
RDNIELKVAGANLRRAAAVYEQAMDAGGFDYEVEAGVSRAQVSAEAFLQEEKLPVFNLADGKFGVSYQFDLFGKLQRGAE
AAHADTQVAQAAIDLARVSVAAQVAGSYVEICHANHELQVAEHSLQLQQHSRQITQRLIAAGRGTPPDLARATAQVAMLE
ASLPPLRARRQAAGYQLAALLGKTPGEVPAGVDSCAHAPALQQPIPIGDGRALLARRPDVRQAERRLAAATARIGVATAE
LYPDIRLGGSIGATGLLADFGEPATHAWSFGPLISWTLPSSGARARVRATEAGADAALAQFDNTVLQALREVQTTLSRYA
QDLDRLHLLEQAQQQAELASAQNRRLYQGGRTPYLSSLDAERTLATADMTLATAQAQVSQDQIQLFLALGGGWDADAGRN
HTKAAR

Sequences:

>Translated_486_residues
MNRTILRPLGVAALLSMLTACSTVGPNYAVPAESAYRRPAANAAFLDTGNAQVQPGAALPARWWALYQDPMLDGLIEQAL
RDNIELKVAGANLRRAAAVYEQAMDAGGFDYEVEAGVSRAQVSAEAFLQEEKLPVFNLADGKFGVSYQFDLFGKLQRGAE
AAHADTQVAQAAIDLARVSVAAQVAGSYVEICHANHELQVAEHSLQLQQHSRQITQRLIAAGRGTPPDLARATAQVAMLE
ASLPPLRARRQAAGYQLAALLGKTPGEVPAGVDSCAHAPALQQPIPIGDGRALLARRPDVRQAERRLAAATARIGVATAE
LYPDIRLGGSIGATGLLADFGEPATHAWSFGPLISWTLPSSGARARVRATEAGADAALAQFDNTVLQALREVQTTLSRYA
QDLDRLHLLEQAQQQAELASAQNRRLYQGGRTPYLSSLDAERTLATADMTLATAQAQVSQDQIQLFLALGGGWDADAGRN
HTKAAR
>Mature_486_residues
MNRTILRPLGVAALLSMLTACSTVGPNYAVPAESAYRRPAANAAFLDTGNAQVQPGAALPARWWALYQDPMLDGLIEQAL
RDNIELKVAGANLRRAAAVYEQAMDAGGFDYEVEAGVSRAQVSAEAFLQEEKLPVFNLADGKFGVSYQFDLFGKLQRGAE
AAHADTQVAQAAIDLARVSVAAQVAGSYVEICHANHELQVAEHSLQLQQHSRQITQRLIAAGRGTPPDLARATAQVAMLE
ASLPPLRARRQAAGYQLAALLGKTPGEVPAGVDSCAHAPALQQPIPIGDGRALLARRPDVRQAERRLAAATARIGVATAE
LYPDIRLGGSIGATGLLADFGEPATHAWSFGPLISWTLPSSGARARVRATEAGADAALAQFDNTVLQALREVQTTLSRYA
QDLDRLHLLEQAQQQAELASAQNRRLYQGGRTPYLSSLDAERTLATADMTLATAQAQVSQDQIQLFLALGGGWDADAGRN
HTKAAR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=483, Percent_Identity=27.536231884058, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI2367348, Length=480, Percent_Identity=23.125, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51712; Mature: 51712

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTILRPLGVAALLSMLTACSTVGPNYAVPAESAYRRPAANAAFLDTGNAQVQPGAALP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCC
ARWWALYQDPMLDGLIEQALRDNIELKVAGANLRRAAAVYEQAMDAGGFDYEVEAGVSRA
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCHHH
QVSAEAFLQEEKLPVFNLADGKFGVSYQFDLFGKLQRGAEAAHADTQVAQAAIDLARVSV
HHHHHHHHHHCCCCEEEECCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AAQVAGSYVEICHANHELQVAEHSLQLQQHSRQITQRLIAAGRGTPPDLARATAQVAMLE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ASLPPLRARRQAAGYQLAALLGKTPGEVPAGVDSCAHAPALQQPIPIGDGRALLARRPDV
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEECCCCCH
RQAERRLAAATARIGVATAELYPDIRLGGSIGATGLLADFGEPATHAWSFGPLISWTLPS
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCC
SGARARVRATEAGADAALAQFDNTVLQALREVQTTLSRYAQDLDRLHLLEQAQQQAELAS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQNRRLYQGGRTPYLSSLDAERTLATADMTLATAQAQVSQDQIQLFLALGGGWDADAGRN
HHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEEEEEECCCCCCCCCCC
HTKAAR
CCCCCC
>Mature Secondary Structure
MNRTILRPLGVAALLSMLTACSTVGPNYAVPAESAYRRPAANAAFLDTGNAQVQPGAALP
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCC
ARWWALYQDPMLDGLIEQALRDNIELKVAGANLRRAAAVYEQAMDAGGFDYEVEAGVSRA
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCHHH
QVSAEAFLQEEKLPVFNLADGKFGVSYQFDLFGKLQRGAEAAHADTQVAQAAIDLARVSV
HHHHHHHHHHCCCCEEEECCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
AAQVAGSYVEICHANHELQVAEHSLQLQQHSRQITQRLIAAGRGTPPDLARATAQVAMLE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ASLPPLRARRQAAGYQLAALLGKTPGEVPAGVDSCAHAPALQQPIPIGDGRALLARRPDV
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEECCCCCH
RQAERRLAAATARIGVATAELYPDIRLGGSIGATGLLADFGEPATHAWSFGPLISWTLPS
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCC
SGARARVRATEAGADAALAQFDNTVLQALREVQTTLSRYAQDLDRLHLLEQAQQQAELAS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQNRRLYQGGRTPYLSSLDAERTLATADMTLATAQAQVSQDQIQLFLALGGGWDADAGRN
HHCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHEEEEEEECCCCCCCCCCC
HTKAAR
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]