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The map label for this gene is purR [H]

Identifier: 21244989

GI number: 21244989

Start: 5042064

End: 5043116

Strand: Direct

Name: purR [H]

Synonym: XAC4272

Alternate gene names: 21244989

Gene position: 5042064-5043116 (Clockwise)

Preceding gene: 21244985

Following gene: 21244990

Centisome position: 97.42

GC content: 69.42

Gene sequence:

>1053_bases
ATGAGTCGGCCACGGTCCGAAGGCGGCAGCGTCACCATCAAGGACGTTGCGCGCGAAGCGCAGGTGTCGGTGGCGACGGT
CTCGCGCACCATGAACGGGCATCAGCACGTGGCCGAGTCGGTGCGCGAGCGTGTCTTGCGGGTGGCGCGTGCGCTCAATT
ACATCCCGCACCACGCCGCGCGCAGCCTCAGCAGCCGGCGCACCCACACCATCGGGGTGGTGCTGCCGGACCTGCATGGC
GAATTCTTTTCCGAATTGATCCGCGGCATCGATCAGGTGGCGCGCGACCAGGGCTACCATCTGCTGGTGTCCAGCTCGCA
CGGCGACCCGCAGGCGCAGCGCCGGGCACTGGAGCGCCTGCCCGGGCGCGTGGACGGGGTGGTGGTGATGTCGCCGTCGC
TGGGCGATTCGGGCGTGCATGAAGACGCGCTGCCCGGCGGCCTGCCGGCGGTGCTGCTCAATTGCGCGGGTAGCGCGAGC
CAGCGCCCGGTGCTCAATGTGGACAACTACGGCGGCGCGCGGGTCATGACCCGGCATCTGCGCGACAGTGGCCACCGCCG
CATCGCCTTCATCGCCGGGCCGGACGACAACTTCGATGCGCATGAGCGCATGCGCGGGTATCGCGACGAACTGGCGCTGG
ACCCGGCCGTGCAGCCGTGGGTCTTGCCCGGCAACTTCGACGAAGAATCCGGTTACCGCGCCGGCCAGGCGTTGGCCCGG
GACACGCGGCCCGACGCGGTGTTCGCCGCCAACGACATGATGGCCTTGGGCTGCCTGTTCGCGCTCGGCCATGCCGGGCT
CAAGGTGCCGCAGGACATTGCGCTGGCCGGATTCGACGACGTGCCGATGGCGCGCTACGTGCTGCCTGCGCTGACCACGA
TGCGGGTGGATATCGCCGGCCTGGGCGCGCGTGCGTTGCAGTTGTTGCTGGGCCAGCAGTTGGTCGATGCGCCTGCACCG
CCTGCCGAAGCCGCACCGCCAGCATTTTCGCAGATGGTTCCGGAACTGATCGTGCGTGCCTCCAGCGCCGCCCGTGGCAC
ACCCGGACGTTGA

Upstream 100 bases:

>100_bases
CATGCATGTGCCTGTCCGACACGGGCGCTCGGTGCCAGCAGGCCGTGCGCCCTACCCCGGCGCGCGGCGCCACGTGCGTT
GACCTGGAGAACGCCACAGC

Downstream 100 bases:

>100_bases
CAACGATGCGCCGCATCGCATCTTCACGAATTATTTACGCTTTCTTATGTTTTTTATAACTCTATCGTTGCCGCTACCGC
TGCTCGTTCGTCCTTGAAAT

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MSRPRSEGGSVTIKDVAREAQVSVATVSRTMNGHQHVAESVRERVLRVARALNYIPHHAARSLSSRRTHTIGVVLPDLHG
EFFSELIRGIDQVARDQGYHLLVSSSHGDPQAQRRALERLPGRVDGVVVMSPSLGDSGVHEDALPGGLPAVLLNCAGSAS
QRPVLNVDNYGGARVMTRHLRDSGHRRIAFIAGPDDNFDAHERMRGYRDELALDPAVQPWVLPGNFDEESGYRAGQALAR
DTRPDAVFAANDMMALGCLFALGHAGLKVPQDIALAGFDDVPMARYVLPALTTMRVDIAGLGARALQLLLGQQLVDAPAP
PAEAAPPAFSQMVPELIVRASSAARGTPGR

Sequences:

>Translated_350_residues
MSRPRSEGGSVTIKDVAREAQVSVATVSRTMNGHQHVAESVRERVLRVARALNYIPHHAARSLSSRRTHTIGVVLPDLHG
EFFSELIRGIDQVARDQGYHLLVSSSHGDPQAQRRALERLPGRVDGVVVMSPSLGDSGVHEDALPGGLPAVLLNCAGSAS
QRPVLNVDNYGGARVMTRHLRDSGHRRIAFIAGPDDNFDAHERMRGYRDELALDPAVQPWVLPGNFDEESGYRAGQALAR
DTRPDAVFAANDMMALGCLFALGHAGLKVPQDIALAGFDDVPMARYVLPALTTMRVDIAGLGARALQLLLGQQLVDAPAP
PAEAAPPAFSQMVPELIVRASSAARGTPGR
>Mature_349_residues
SRPRSEGGSVTIKDVAREAQVSVATVSRTMNGHQHVAESVRERVLRVARALNYIPHHAARSLSSRRTHTIGVVLPDLHGE
FFSELIRGIDQVARDQGYHLLVSSSHGDPQAQRRALERLPGRVDGVVVMSPSLGDSGVHEDALPGGLPAVLLNCAGSASQ
RPVLNVDNYGGARVMTRHLRDSGHRRIAFIAGPDDNFDAHERMRGYRDELALDPAVQPWVLPGNFDEESGYRAGQALARD
TRPDAVFAANDMMALGCLFALGHAGLKVPQDIALAGFDDVPMARYVLPALTTMRVDIAGLGARALQLLLGQQLVDAPAPP
AEAAPPAFSQMVPELIVRASSAARGTPGR

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=303, Percent_Identity=35.973597359736, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1788474, Length=341, Percent_Identity=34.6041055718475, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1787948, Length=304, Percent_Identity=34.8684210526316, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1790369, Length=319, Percent_Identity=33.2288401253918, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1789202, Length=299, Percent_Identity=36.1204013377926, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789068, Length=297, Percent_Identity=28.956228956229, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786540, Length=312, Percent_Identity=32.3717948717949, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787580, Length=308, Percent_Identity=27.5974025974026, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI48994940, Length=304, Percent_Identity=29.2763157894737, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1790715, Length=310, Percent_Identity=26.4516129032258, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1787906, Length=302, Percent_Identity=29.1390728476821, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1789456, Length=313, Percent_Identity=28.1150159744409, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786268, Length=316, Percent_Identity=23.1012658227848, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790689, Length=328, Percent_Identity=25.9146341463415, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790192, Length=245, Percent_Identity=26.530612244898, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37513; Mature: 37382

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPRSEGGSVTIKDVAREAQVSVATVSRTMNGHQHVAESVRERVLRVARALNYIPHHAA
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLSSRRTHTIGVVLPDLHGEFFSELIRGIDQVARDQGYHLLVSSSHGDPQAQRRALERL
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHC
PGRVDGVVVMSPSLGDSGVHEDALPGGLPAVLLNCAGSASQRPVLNVDNYGGARVMTRHL
CCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHH
RDSGHRRIAFIAGPDDNFDAHERMRGYRDELALDPAVQPWVLPGNFDEESGYRAGQALAR
HCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHH
DTRPDAVFAANDMMALGCLFALGHAGLKVPQDIALAGFDDVPMARYVLPALTTMRVDIAG
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHH
LGARALQLLLGQQLVDAPAPPAEAAPPAFSQMVPELIVRASSAARGTPGR
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SRPRSEGGSVTIKDVAREAQVSVATVSRTMNGHQHVAESVRERVLRVARALNYIPHHAA
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RSLSSRRTHTIGVVLPDLHGEFFSELIRGIDQVARDQGYHLLVSSSHGDPQAQRRALERL
HHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHC
PGRVDGVVVMSPSLGDSGVHEDALPGGLPAVLLNCAGSASQRPVLNVDNYGGARVMTRHL
CCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEECCCCCCHHHHHHHH
RDSGHRRIAFIAGPDDNFDAHERMRGYRDELALDPAVQPWVLPGNFDEESGYRAGQALAR
HCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCHHHHHHHH
DTRPDAVFAANDMMALGCLFALGHAGLKVPQDIALAGFDDVPMARYVLPALTTMRVDIAG
CCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHH
LGARALQLLLGQQLVDAPAPPAEAAPPAFSQMVPELIVRASSAARGTPGR
CCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA