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The map label for this gene is hemL [H]

Identifier: 21244959

GI number: 21244959

Start: 5007448

End: 5007858

Strand: Reverse

Name: hemL [H]

Synonym: XAC4242

Alternate gene names: 21244959

Gene position: 5007858-5007448 (Counterclockwise)

Preceding gene: 21244960

Following gene: 21244958

Centisome position: 96.76

GC content: 67.88

Gene sequence:

>411_bases
ATGCGCTACTTCGAGCAGCGCTGCCAAGGCTCCAAGCAGTTGGGCGACGCCGCGCAGCGGGTGATTCCCGGCGGCGTGCA
GCACAACCTGGCCTTCAACTACCCGTTCTCGCTGGCGATGCGCAGCGCCGAGGGCGCTTACCTGACCGACGTCGACGACA
ACCGCTACATCGATTTCCTGCAGGCCGGCGGCCCGACCTTGCTCGGCTCCAACCCACCGGCGTTGCGCGCACGCGTCAAC
GAGGTGCTGGACCAGTGCGGACCGGTGACCGGACTGCTGCACGAATACGAGGTCAAACTGGCCGAGCTGGTCTGCGCCAG
CATGCCGGCGGTGGAGATGGTGCGCCTGCTCGGTTCGGGAACCGAGGCGGTGATGGGCGCGGTGCGCCTGGCACGCGCGT
ATACCCGCTAG

Upstream 100 bases:

>100_bases
GATTTCGCAATGGCCCGATGTGGACCAGCTGTATCGCCGCTTCGATGCGTTGGTCAAACAGCCGATGCGGCCGATCCGGC
GCGATGGCATGGACAAGGTG

Downstream 100 bases:

>100_bases
TGCTGGATCATCAAGATCGGCGGTGCGTATCACGGCTGGAGCGACCAGTTGGTGTACGGCCTGCGCCTGCCCGGCACCGG
CCGCATGGAAGCGATCGGCA

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALRARVN
EVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSGTEAVMGAVRLARAYTR

Sequences:

>Translated_136_residues
MRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALRARVN
EVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSGTEAVMGAVRLARAYTR
>Mature_136_residues
MRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFLQAGGPTLLGSNPPALRARVN
EVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSGTEAVMGAVRLARAYTR

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786349, Length=128, Percent_Identity=45.3125, Blast_Score=94, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 14804; Mature: 14804

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFL
CCHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHCCCCCEEECCCCCCHHHHH
QAGGPTLLGSNPPALRARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSG
HCCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
TEAVMGAVRLARAYTR
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRYFEQRCQGSKQLGDAAQRVIPGGVQHNLAFNYPFSLAMRSAEGAYLTDVDDNRYIDFL
CCHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHCCCCCEEECCCCCCHHHHH
QAGGPTLLGSNPPALRARVNEVLDQCGPVTGLLHEYEVKLAELVCASMPAVEMVRLLGSG
HCCCCEEECCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
TEAVMGAVRLARAYTR
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA