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The map label for this gene is czcD [H]

Identifier: 21244777

GI number: 21244777

Start: 4755525

End: 4756547

Strand: Direct

Name: czcD [H]

Synonym: XAC4060

Alternate gene names: 21244777

Gene position: 4755525-4756547 (Clockwise)

Preceding gene: 21244775

Following gene: 21244781

Centisome position: 91.88

GC content: 64.42

Gene sequence:

>1023_bases
ATGTCGATCACGCACGCCGCGCCGCATTGCACCCAGTCGCACACCTTTGCCAGCGCCAACCCGCTCGCCGAGCGCAGCAC
CCGCAAGGCGGTGATCCTGACCGTGCTCATGATGATGGTGGAGATCGTGGGCGGTTGGACGCTCAACTCCATGGCCCTGC
TCGCCGACGGCTGGCATATGAGTTCGCATGCGCTGGCGCTGGGACTGGCGCTGTTCGCCTATCGCTTCGCGCGGCAGCAT
GCCGGCGATGTGCGCTTCACCTTCGGCACCTGGAAGGTGGAGGTGCTGGGCGGTTACACCAGCGCGATCCTGTTGCTGGG
CGTGGCCGGGCTGATGGCATTCCAGTCTGTGGAACGCTTGTTCACGCCCAAGCCCATCCAGTATCAGGAAGCCACCTTCA
TCGCAGTGATCGGCCTGCTGGTGAACCTGATTTGCGCGTGGTGGCTGCGCGATTCGCATGGACATGGCCACGCGCACGGG
CATCACCATGGTCACACACACGACAGTCATGGTCATGGTCATGGTCATGGTCATGGTCATGGTCATGGTCATGGTCATGG
TCATCACCACGATACGCACAGCGATCTGAATCTGCGCGCGGCATATCTGCATGTGGTGGCCGATGCCGCGACCTCGGTGC
TCGCCATCGTGGCGCTGGTGGCCGGCATGCACTGGGGCGTGACCTGGCTGGACCCGCTCATGGGCATCGTCGGCGCGGTG
CTGGTCACCGTCTGGGCCTGGGGATTGCTGCGCAGCACCGGCAGCGTGTTGCTGGATGCGGAAATGGACGCGCCGGTGGT
GGCGGAAGTGAAGCAGGTCATCGCCGCGCTTGGGCATGCGATCGACATCGACGACCTGCATGTCTGGCGCGTCGGCAGCG
AGCGTTATGCCTGCGTCGTCAGCCTGGTCACTGCAGCCGACATCGATGCGGACCTGGTGCGCGAAGCACTGCAGATCCAC
GAAGAACTGGTGCATGTCACGGTCGAGCTGCAGCGCCCGCCGGCGCTCCCTGCTGCGGCCTAG

Upstream 100 bases:

>100_bases
AGCAGTCTGGATTTGTCCTGATTGAGATGTGCCATCGCCGTATACCCCCCAGGGGTATTTAGGATACCCTGTGGGGGTAC
CTTAGCCAGAGCCACCGCCG

Downstream 100 bases:

>100_bases
CAACTCGGCAGCGCAGTGCCATCGCGCGCTGGTTGGCGGGCGATTTTCAGTTGATCGCTGACACAGCAGACATCATGAAG
TCACCGCCGGCCTGATCTTG

Product: heavy metal transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSITHAAPHCTQSHTFASANPLAERSTRKAVILTVLMMMVEIVGGWTLNSMALLADGWHMSSHALALGLALFAYRFARQH
AGDVRFTFGTWKVEVLGGYTSAILLLGVAGLMAFQSVERLFTPKPIQYQEATFIAVIGLLVNLICAWWLRDSHGHGHAHG
HHHGHTHDSHGHGHGHGHGHGHGHGHGHHHDTHSDLNLRAAYLHVVADAATSVLAIVALVAGMHWGVTWLDPLMGIVGAV
LVTVWAWGLLRSTGSVLLDAEMDAPVVAEVKQVIAALGHAIDIDDLHVWRVGSERYACVVSLVTAADIDADLVREALQIH
EELVHVTVELQRPPALPAAA

Sequences:

>Translated_340_residues
MSITHAAPHCTQSHTFASANPLAERSTRKAVILTVLMMMVEIVGGWTLNSMALLADGWHMSSHALALGLALFAYRFARQH
AGDVRFTFGTWKVEVLGGYTSAILLLGVAGLMAFQSVERLFTPKPIQYQEATFIAVIGLLVNLICAWWLRDSHGHGHAHG
HHHGHTHDSHGHGHGHGHGHGHGHGHGHHHDTHSDLNLRAAYLHVVADAATSVLAIVALVAGMHWGVTWLDPLMGIVGAV
LVTVWAWGLLRSTGSVLLDAEMDAPVVAEVKQVIAALGHAIDIDDLHVWRVGSERYACVVSLVTAADIDADLVREALQIH
EELVHVTVELQRPPALPAAA
>Mature_339_residues
SITHAAPHCTQSHTFASANPLAERSTRKAVILTVLMMMVEIVGGWTLNSMALLADGWHMSSHALALGLALFAYRFARQHA
GDVRFTFGTWKVEVLGGYTSAILLLGVAGLMAFQSVERLFTPKPIQYQEATFIAVIGLLVNLICAWWLRDSHGHGHAHGH
HHGHTHDSHGHGHGHGHGHGHGHGHGHHHDTHSDLNLRAAYLHVVADAATSVLAIVALVAGMHWGVTWLDPLMGIVGAVL
VTVWAWGLLRSTGSVLLDAEMDAPVVAEVKQVIAALGHAIDIDDLHVWRVGSERYACVVSLVTAADIDADLVREALQIHE
ELVHVTVELQRPPALPAAA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=323, Percent_Identity=25.6965944272446, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI40255009, Length=323, Percent_Identity=25.6965944272446, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI20070323, Length=326, Percent_Identity=29.1411042944785, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI21359890, Length=297, Percent_Identity=25.2525252525253, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI52352805, Length=294, Percent_Identity=22.7891156462585, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI52351208, Length=127, Percent_Identity=33.0708661417323, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=315, Percent_Identity=29.8412698412698, Blast_Score=96, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI32564488, Length=278, Percent_Identity=31.6546762589928, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17555794, Length=271, Percent_Identity=25.0922509225092, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17555796, Length=271, Percent_Identity=25.0922509225092, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17550440, Length=172, Percent_Identity=30.2325581395349, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17550442, Length=172, Percent_Identity=30.2325581395349, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193210990, Length=348, Percent_Identity=22.7011494252874, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323899, Length=349, Percent_Identity=22.0630372492837, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324892, Length=360, Percent_Identity=20.2777777777778, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24656728, Length=318, Percent_Identity=25.4716981132075, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656724, Length=318, Percent_Identity=25.4716981132075, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656720, Length=318, Percent_Identity=25.4716981132075, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24656715, Length=318, Percent_Identity=25.4716981132075, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357035, Length=318, Percent_Identity=25.4716981132075, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24645863, Length=298, Percent_Identity=25.1677852348993, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24585900, Length=343, Percent_Identity=21.865889212828, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585898, Length=343, Percent_Identity=21.865889212828, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24585896, Length=343, Percent_Identity=21.865889212828, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921672, Length=343, Percent_Identity=21.865889212828, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583858, Length=292, Percent_Identity=25, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36638; Mature: 36506

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITHAAPHCTQSHTFASANPLAERSTRKAVILTVLMMMVEIVGGWTLNSMALLADGWHM
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCC
SSHALALGLALFAYRFARQHAGDVRFTFGTWKVEVLGGYTSAILLLGVAGLMAFQSVERL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
FTPKPIQYQEATFIAVIGLLVNLICAWWLRDSHGHGHAHGHHHGHTHDSHGHGHGHGHGH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GHGHGHGHHHDTHSDLNLRAAYLHVVADAATSVLAIVALVAGMHWGVTWLDPLMGIVGAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVTVWAWGLLRSTGSVLLDAEMDAPVVAEVKQVIAALGHAIDIDDLHVWRVGSERYACVV
HHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHH
SLVTAADIDADLVREALQIHEELVHVTVELQRPPALPAAA
HHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCC
>Mature Secondary Structure 
SITHAAPHCTQSHTFASANPLAERSTRKAVILTVLMMMVEIVGGWTLNSMALLADGWHM
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCC
SSHALALGLALFAYRFARQHAGDVRFTFGTWKVEVLGGYTSAILLLGVAGLMAFQSVERL
HHHHHHHHHHHHHHHHHHHCCCCEEEEECEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
FTPKPIQYQEATFIAVIGLLVNLICAWWLRDSHGHGHAHGHHHGHTHDSHGHGHGHGHGH
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GHGHGHGHHHDTHSDLNLRAAYLHVVADAATSVLAIVALVAGMHWGVTWLDPLMGIVGAV
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LVTVWAWGLLRSTGSVLLDAEMDAPVVAEVKQVIAALGHAIDIDDLHVWRVGSERYACVV
HHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHH
SLVTAADIDADLVREALQIHEELVHVTVELQRPPALPAAA
HHHHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]