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The map label for this gene is tmk

Identifier: 21244732

GI number: 21244732

Start: 4705176

End: 4705859

Strand: Direct

Name: tmk

Synonym: XAC4014

Alternate gene names: 21244732

Gene position: 4705176-4705859 (Clockwise)

Preceding gene: 21244731

Following gene: 21244736

Centisome position: 90.91

GC content: 69.74

Gene sequence:

>684_bases
ATGACAATCGAACTGAAGCCCGGCGGCTTGCTGATCGCCATCGAAGGCATCGACGGCGCTGGCAAGACCACCCTCGCCCG
CCGCCTGGCCGCCACCCTGGACGCCGCCGGCGCGCGCGTCGTGCTGAGCAAGGAGCCCACCAACGGCCCATGGGGCACCC
AATTGCGCCAGTCCGCCGCCACCGGCCGCCTGAGTGCAGAGGAAGAAGCCGAACTGCTCATCCGCGACCGCCACGAACAC
GTGGACACGTTGATCGCGCCCGCGCTGGCACGCGGCGACATCGTCATCCTGGACCGCTATTTCCCGTCGATGGTGGCCTA
TCAGGGCGCGGCCGGTCTGCCGCTGGACGAACTCCTGGAGCGCAACGCCTTCGCGCCGCGCCCGGACGTCCTGCTGCTGC
TCGACCTGCCCCCGCCCACCGGCCTGGCCCGTATCCGCGCCCGCGGCGATGCGCCCAACCACTTCGAAACCCAGGACAAC
CTGGAACGCTGCCGCACGATTTTTGCCGCGCTGGAATTGCCCGGCAAACACGTGGTGGACGCCAGCGCCGATGCCGACAG
CGTGCTGCGCCAGGCCCACGCCATCATCGTGGCCGCATTGGCCGACCGACTGAGCGGCGATGCAGCACATACAGACACCG
GCAAGGCCGCGCTGGAACTGCTCTCGGCCGGCCGCCCGGCCTGA

Upstream 100 bases:

>100_bases
CCTGCGGCTGATTTTCGCCAGCACGGGTGTCGCGAAGACTGCATGCTCGCCATTGCTGCTGGCGGTAGGGTCCATCGCCA
CGATCAGATAAAGTAGCGCG

Downstream 100 bases:

>100_bases
TGCTGCACCTCGCATCGCGCGATCAACATCGCGCGATGTACGTGACATGGTGCGAGCCACTTTAAGCGGCTACCAAAACG
ATGCGAGCAGCCTTCAGGCG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MTIELKPGGLLIAIEGIDGAGKTTLARRLAATLDAAGARVVLSKEPTNGPWGTQLRQSAATGRLSAEEEAELLIRDRHEH
VDTLIAPALARGDIVILDRYFPSMVAYQGAAGLPLDELLERNAFAPRPDVLLLLDLPPPTGLARIRARGDAPNHFETQDN
LERCRTIFAALELPGKHVVDASADADSVLRQAHAIIVAALADRLSGDAAHTDTGKAALELLSAGRPA

Sequences:

>Translated_227_residues
MTIELKPGGLLIAIEGIDGAGKTTLARRLAATLDAAGARVVLSKEPTNGPWGTQLRQSAATGRLSAEEEAELLIRDRHEH
VDTLIAPALARGDIVILDRYFPSMVAYQGAAGLPLDELLERNAFAPRPDVLLLLDLPPPTGLARIRARGDAPNHFETQDN
LERCRTIFAALELPGKHVVDASADADSVLRQAHAIIVAALADRLSGDAAHTDTGKAALELLSAGRPA
>Mature_226_residues
TIELKPGGLLIAIEGIDGAGKTTLARRLAATLDAAGARVVLSKEPTNGPWGTQLRQSAATGRLSAEEEAELLIRDRHEHV
DTLIAPALARGDIVILDRYFPSMVAYQGAAGLPLDELLERNAFAPRPDVLLLLDLPPPTGLARIRARGDAPNHFETQDNL
ERCRTIFAALELPGKHVVDASADADSVLRQAHAIIVAALADRLSGDAAHTDTGKAALELLSAGRPA

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=193, Percent_Identity=34.7150259067358, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_XANAC (Q8PFG7)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_644314.1
- ProteinModelPortal:   Q8PFG7
- SMR:   Q8PFG7
- GeneID:   1158085
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC4014
- NMPDR:   fig|190486.1.peg.3958
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   PRK00698
- BioCyc:   XAXO190486:XAC4014-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 24031; Mature: 23899

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIELKPGGLLIAIEGIDGAGKTTLARRLAATLDAAGARVVLSKEPTNGPWGTQLRQSAA
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH
TGRLSAEEEAELLIRDRHEHVDTLIAPALARGDIVILDRYFPSMVAYQGAAGLPLDELLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCCHHHHHH
RNAFAPRPDVLLLLDLPPPTGLARIRARGDAPNHFETQDNLERCRTIFAALELPGKHVVD
CCCCCCCCCEEEEEECCCCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
ASADADSVLRQAHAIIVAALADRLSGDAAHTDTGKAALELLSAGRPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TIELKPGGLLIAIEGIDGAGKTTLARRLAATLDAAGARVVLSKEPTNGPWGTQLRQSAA
EEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHH
TGRLSAEEEAELLIRDRHEHVDTLIAPALARGDIVILDRYFPSMVAYQGAAGLPLDELLE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCCHHHHHH
RNAFAPRPDVLLLLDLPPPTGLARIRARGDAPNHFETQDNLERCRTIFAALELPGKHVVD
CCCCCCCCCEEEEEECCCCCCHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEE
ASADADSVLRQAHAIIVAALADRLSGDAAHTDTGKAALELLSAGRPA
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217