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The map label for this gene is lrp [H]

Identifier: 21244414

GI number: 21244414

Start: 4366586

End: 4367065

Strand: Direct

Name: lrp [H]

Synonym: XAC3689

Alternate gene names: 21244414

Gene position: 4366586-4367065 (Clockwise)

Preceding gene: 21244411

Following gene: 21244416

Centisome position: 84.37

GC content: 62.5

Gene sequence:

>480_bases
ATGAGCATCCGCGCCCGCGAGCTGGACAAGATCGACCGCAAGATCCTGCGCATCCTGCAGCAGGAGGGGCGGATTTCGTT
TACCGAACTGGGCGAGCGGGTCGGCCTATCGACCACGCCGTGCACCGAGCGCGTGCGACGGCTGGAGCGCGACGGCGCCA
TCACCGGCTATTACGCGCGGCTGGACCCGCACTACCTCAAGGCCAGCCTGCTGGTATTCGTGGAGATCAGCCTGGCCTAC
AAATCCGGCGATATCTTCGAAGAATTCCGCCGCGCCGCGCTAAAGCTGCCCAACGTGCTGGAGTGCCACCTGGTCTCCGG
CGACTTCGACTATCTGCTCAAGGCGCGCATCAGCGAGATGGCGTCCTACCGCAAGTTGCTCGGCAGCACCTTGCTGACCA
TGCCGCATGTGCGTGAATCCAAGAGCTACATCGTGATGGAAGAGGTCAAGGAGACGCTAGCGTTGCCGATCGCCGATTGA

Upstream 100 bases:

>100_bases
ACAGTTAGACGCAGTATATTGCGAGCCAGGCAGTGCCATTTCTGGAATCAGCACGGCTTTGCAGTGAAACTTCCTGCCAA
ACCTTGCCGAGACAAACCCC

Downstream 100 bases:

>100_bases
GCCGGGATTCGGGATTCGGGATTCGGGATTCGGGATTGGCGGTTGGCGGTTGGCGGTTGGCGGTTGGCGGTTGGCACCAG
CAGATTGCGCCGCTGCTGTC

Product: leucine responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MSIRARELDKIDRKILRILQQEGRISFTELGERVGLSTTPCTERVRRLERDGAITGYYARLDPHYLKASLLVFVEISLAY
KSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEMASYRKLLGSTLLTMPHVRESKSYIVMEEVKETLALPIAD

Sequences:

>Translated_159_residues
MSIRARELDKIDRKILRILQQEGRISFTELGERVGLSTTPCTERVRRLERDGAITGYYARLDPHYLKASLLVFVEISLAY
KSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEMASYRKLLGSTLLTMPHVRESKSYIVMEEVKETLALPIAD
>Mature_158_residues
SIRARELDKIDRKILRILQQEGRISFTELGERVGLSTTPCTERVRRLERDGAITGYYARLDPHYLKASLLVFVEISLAYK
SGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEMASYRKLLGSTLLTMPHVRESKSYIVMEEVKETLALPIAD

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=61.437908496732, Blast_Score=194, Evalue=2e-51,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=36.6666666666667, Blast_Score=110, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18237; Mature: 18105

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIRARELDKIDRKILRILQQEGRISFTELGERVGLSTTPCTERVRRLERDGAITGYYAR
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEHH
LDPHYLKASLLVFVEISLAYKSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEM
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
ASYRKLLGSTLLTMPHVRESKSYIVMEEVKETLALPIAD
HHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SIRARELDKIDRKILRILQQEGRISFTELGERVGLSTTPCTERVRRLERDGAITGYYAR
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEHH
LDPHYLKASLLVFVEISLAYKSGDIFEEFRRAALKLPNVLECHLVSGDFDYLLKARISEM
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHH
ASYRKLLGSTLLTMPHVRESKSYIVMEEVKETLALPIAD
HHHHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]