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The map label for this gene is copA [H]

Identifier: 21244355

GI number: 21244355

Start: 4304624

End: 4306405

Strand: Direct

Name: copA [H]

Synonym: XAC3630

Alternate gene names: 21244355

Gene position: 4304624-4306405 (Clockwise)

Preceding gene: 77748734

Following gene: 21244356

Centisome position: 83.17

GC content: 66.39

Gene sequence:

>1782_bases
ATGTCTTTCGATCCCCCGTTTTCCCACGGCTCAACCGCCAGCGGCCTGAGCCGGCGCCGCTTCGTCCAGGGCCTGGCCCT
GGGCGGCATCGCCGCCAGCGGCCTGTGGCGCAACGATGCGCGCGCCGCGGCCCAGGCGAACACGCCCGTGCTGCGCGGAA
GCAGCCAGTCGCTGCAGATCGGCCGCCTGCCGGTCAACTTCACCGGGCGCCCCCGCTCCGCAATCACCGTCAACCAGAGC
CTGCCGGCACCCACCTTGCGCTGGCGCGAGGGCGACACGGTGAGCGTGCGCGTGCGCAACGCGCTGACCGACCAACCCAC
CTCGGTGCATTGGCATGGCCTGTTGCTGCCGGCCAACATGGACGGGGTGCCGGGCATGAGTTTCGACGGCATCGCGCCGG
GCCAGGAGTATCACTACCGCTTTGCGCTGCGCCAGTCCGGCACCTACTGGTACCACAGCCATTCGATGTTTCAGGAGCAG
TCAGGGCTGTATGGCGCCATCGTCATCGACCCGCTGGTGCCGCCGCCGTACCGGCACGATCGCGAACATGTGGTGCTGCT
CTCGGACTGGACCGATCTGGACCCGGCCGCCCTGTTCCGTCGTTTGAAACAGATGCCGAGCCACGACAACTACGCGCAGC
GCACCGTCGGCGATTTTCTACGCGATGCGCGCGACGACGGCCTGCGCGCCACGCTGGCCGACCGCGGCATGTGGGGGCGC
ATGCGCATGACGCCCACCGACCTGTCCGACGTCAACGCCAACACCTACACCTACCTGCTCAACGGCGTGGCACCGGCCGG
CAATTGGACCGGCTTGTTCAAACCCGGCGAGAAGGTGCTGCTGCGTTTCATCAATGGCTCGTCGATGACCTACTTCGACA
TCCGTATCCCCGGCCTGCGCATGACCGTGGTGGCCGCCGACGGGCAATACGTGCATCCGGTCAGCGTGGACGAACTGCGC
ATCGCCGCGGCCGAAACCTTCGACGTGATTGTCGAACCGCTCGGCCAGGATGCGTTTACGTTATTCGCGCAGGACATGGG
CCGCACCGGCTTCGCCTGCGGCACGCTGGCAGTGCAGCACGGCTTGCAGGCGCCGATTCCTGCGCTGGATCCGCGCGCCA
TCCTGACCATGCAGGACATGGGGCATGGCGATGGCATGGATCACGCGCTGCCCGCAATGCACGGCGCGCCCGGGATGCTG
GCGGCGCATGGGATGCACACCATGCACTCGCATGACGATGCCAAGGCACACGACAAGGCGCCGCATCATTCCGCCAGCGA
AACCGGCAACCCGCTGATCGACATGCGCAGCAATGCCACTGCACCGCGCCTGGACGACCCCGGCGTGGGCCTGCGCGACA
ACGGCCGCCGCGTGCTGTGCTACGCCGATCTGCATAGCGTGTTCGACGACCCGGATGGGCGCGAACCGGGCCGTGACATC
GAGCTGCATCTGACCGGGCATATGGAAAAATTCGCATGGTCCTTCGATGGCATCGCGTTCGCTTCCGCGCAACCCTTGCA
GCTGCAATACGGCGAGCGCCTGCGCATCGTGCTGGTCAACGACACCATGATGCAGCACCCCATCCATCTACATGGCATGT
GGAGCGACCTGGAAGATGCGCACGGCAACTTCCAGGTACGCAAGCACACCATCGACATGCCGCCCGGCACCCGCCGCACC
TACCGCGTGCGTGCCGATGCGCTCGGCCGCTGGGCGTATCACTGCCATCTGCTGTACCACATGGAAGCGGGCATGATGCG
CGAAGTGCGGGTGGAAGCATGA

Upstream 100 bases:

>100_bases
GGCCCTGCCTTGGCCGTCCTCGGCCCCGCGCGTGCTTGCGCGGGTTCCCTCAGTTGTGCGCTGCGCCCATCTCTTGCCGA
TGGAGCGCGCAGGAGATGTC

Downstream 100 bases:

>100_bases
GCCGCTTTCGCATGCAGGCCTGGTTCGCGGCTGCGTTCTTGGCGAGCGCATCTGCGGTTGCGCAGGAGCATCAGCACGAT
GCGATGGAGGAGGCACCGCA

Product: copper resistance protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSFDPPFSHGSTASGLSRRRFVQGLALGGIAASGLWRNDARAAAQANTPVLRGSSQSLQIGRLPVNFTGRPRSAITVNQS
LPAPTLRWREGDTVSVRVRNALTDQPTSVHWHGLLLPANMDGVPGMSFDGIAPGQEYHYRFALRQSGTYWYHSHSMFQEQ
SGLYGAIVIDPLVPPPYRHDREHVVLLSDWTDLDPAALFRRLKQMPSHDNYAQRTVGDFLRDARDDGLRATLADRGMWGR
MRMTPTDLSDVNANTYTYLLNGVAPAGNWTGLFKPGEKVLLRFINGSSMTYFDIRIPGLRMTVVAADGQYVHPVSVDELR
IAAAETFDVIVEPLGQDAFTLFAQDMGRTGFACGTLAVQHGLQAPIPALDPRAILTMQDMGHGDGMDHALPAMHGAPGML
AAHGMHTMHSHDDAKAHDKAPHHSASETGNPLIDMRSNATAPRLDDPGVGLRDNGRRVLCYADLHSVFDDPDGREPGRDI
ELHLTGHMEKFAWSFDGIAFASAQPLQLQYGERLRIVLVNDTMMQHPIHLHGMWSDLEDAHGNFQVRKHTIDMPPGTRRT
YRVRADALGRWAYHCHLLYHMEAGMMREVRVEA

Sequences:

>Translated_593_residues
MSFDPPFSHGSTASGLSRRRFVQGLALGGIAASGLWRNDARAAAQANTPVLRGSSQSLQIGRLPVNFTGRPRSAITVNQS
LPAPTLRWREGDTVSVRVRNALTDQPTSVHWHGLLLPANMDGVPGMSFDGIAPGQEYHYRFALRQSGTYWYHSHSMFQEQ
SGLYGAIVIDPLVPPPYRHDREHVVLLSDWTDLDPAALFRRLKQMPSHDNYAQRTVGDFLRDARDDGLRATLADRGMWGR
MRMTPTDLSDVNANTYTYLLNGVAPAGNWTGLFKPGEKVLLRFINGSSMTYFDIRIPGLRMTVVAADGQYVHPVSVDELR
IAAAETFDVIVEPLGQDAFTLFAQDMGRTGFACGTLAVQHGLQAPIPALDPRAILTMQDMGHGDGMDHALPAMHGAPGML
AAHGMHTMHSHDDAKAHDKAPHHSASETGNPLIDMRSNATAPRLDDPGVGLRDNGRRVLCYADLHSVFDDPDGREPGRDI
ELHLTGHMEKFAWSFDGIAFASAQPLQLQYGERLRIVLVNDTMMQHPIHLHGMWSDLEDAHGNFQVRKHTIDMPPGTRRT
YRVRADALGRWAYHCHLLYHMEAGMMREVRVEA
>Mature_592_residues
SFDPPFSHGSTASGLSRRRFVQGLALGGIAASGLWRNDARAAAQANTPVLRGSSQSLQIGRLPVNFTGRPRSAITVNQSL
PAPTLRWREGDTVSVRVRNALTDQPTSVHWHGLLLPANMDGVPGMSFDGIAPGQEYHYRFALRQSGTYWYHSHSMFQEQS
GLYGAIVIDPLVPPPYRHDREHVVLLSDWTDLDPAALFRRLKQMPSHDNYAQRTVGDFLRDARDDGLRATLADRGMWGRM
RMTPTDLSDVNANTYTYLLNGVAPAGNWTGLFKPGEKVLLRFINGSSMTYFDIRIPGLRMTVVAADGQYVHPVSVDELRI
AAAETFDVIVEPLGQDAFTLFAQDMGRTGFACGTLAVQHGLQAPIPALDPRAILTMQDMGHGDGMDHALPAMHGAPGMLA
AHGMHTMHSHDDAKAHDKAPHHSASETGNPLIDMRSNATAPRLDDPGVGLRDNGRRVLCYADLHSVFDDPDGREPGRDIE
LHLTGHMEKFAWSFDGIAFASAQPLQLQYGERLRIVLVNDTMMQHPIHLHGMWSDLEDAHGNFQVRKHTIDMPPGTRRTY
RVRADALGRWAYHCHLLYHMEAGMMREVRVEA

Specific function: Could be involved in copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321067, Length=270, Percent_Identity=29.2592592592593, Blast_Score=90, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323703, Length=126, Percent_Identity=38.0952380952381, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320714, Length=321, Percent_Identity=23.3644859813084, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281360167, Length=303, Percent_Identity=25.0825082508251, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24585842, Length=303, Percent_Identity=25.0825082508251, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI221330000, Length=303, Percent_Identity=25.0825082508251, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221329998, Length=303, Percent_Identity=25.0825082508251, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574104, Length=139, Percent_Identity=37.410071942446, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859919, Length=271, Percent_Identity=26.1992619926199, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24650186, Length=566, Percent_Identity=22.0848056537102, Blast_Score=83, Evalue=6e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 65708; Mature: 65577

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDPPFSHGSTASGLSRRRFVQGLALGGIAASGLWRNDARAAAQANTPVLRGSSQSLQI
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHCCCCCEEECCCCCEEE
GRLPVNFTGRPRSAITVNQSLPAPTLRWREGDTVSVRVRNALTDQPTSVHWHGLLLPANM
ECEEEEECCCCCCEEEECCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEEEEEEEECCC
DGVPGMSFDGIAPGQEYHYRFALRQSGTYWYHSHSMFQEQSGLYGAIVIDPLVPPPYRHD
CCCCCCCCCCCCCCCCEEEEEEEECCCCEEEECCHHHHHHCCCEEEEEEECCCCCCCCCC
REHVVLLSDWTDLDPAALFRRLKQMPSHDNYAQRTVGDFLRDARDDGLRATLADRGMWGR
CCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCE
MRMTPTDLSDVNANTYTYLLNGVAPAGNWTGLFKPGEKVLLRFINGSSMTYFDIRIPGLR
EECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHEEEEEECCCCEEEEEEEECCEE
MTVVAADGQYVHPVSVDELRIAAAETFDVIVEPLGQDAFTLFAQDMGRTGFACGTLAVQH
EEEEECCCCEECCCCHHHEEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHC
GLQAPIPALDPRAILTMQDMGHGDGMDHALPAMHGAPGMLAAHGMHTMHSHDDAKAHDKA
CCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCHHHHCCCHHHCCCCCCCCCCCC
PHHSASETGNPLIDMRSNATAPRLDDPGVGLRDNGRRVLCYADLHSVFDDPDGREPGRDI
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCEE
ELHLTGHMEKFAWSFDGIAFASAQPLQLQYGERLRIVLVNDTMMQHPIHLHGMWSDLEDA
EEEEECCCHHHEECCCCEEECCCCCEEEECCCEEEEEEECCHHHHCCEEEEECCCCHHHC
HGNFQVRKHTIDMPPGTRRTYRVRADALGRWAYHCHLLYHMEAGMMREVRVEA
CCCEEEEEEEECCCCCCCEEEEEEHHHHCCEEEEEEEEEEECCCCEEEEEECC
>Mature Secondary Structure 
SFDPPFSHGSTASGLSRRRFVQGLALGGIAASGLWRNDARAAAQANTPVLRGSSQSLQI
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCCHHHHCCCCCEEECCCCCEEE
GRLPVNFTGRPRSAITVNQSLPAPTLRWREGDTVSVRVRNALTDQPTSVHWHGLLLPANM
ECEEEEECCCCCCEEEECCCCCCCCEEECCCCEEEEEEECCCCCCCCEEEEEEEEEECCC
DGVPGMSFDGIAPGQEYHYRFALRQSGTYWYHSHSMFQEQSGLYGAIVIDPLVPPPYRHD
CCCCCCCCCCCCCCCCEEEEEEEECCCCEEEECCHHHHHHCCCEEEEEEECCCCCCCCCC
REHVVLLSDWTDLDPAALFRRLKQMPSHDNYAQRTVGDFLRDARDDGLRATLADRGMWGR
CCEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCE
MRMTPTDLSDVNANTYTYLLNGVAPAGNWTGLFKPGEKVLLRFINGSSMTYFDIRIPGLR
EECCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHEEEEEECCCCEEEEEEEECCEE
MTVVAADGQYVHPVSVDELRIAAAETFDVIVEPLGQDAFTLFAQDMGRTGFACGTLAVQH
EEEEECCCCEECCCCHHHEEEEHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHC
GLQAPIPALDPRAILTMQDMGHGDGMDHALPAMHGAPGMLAAHGMHTMHSHDDAKAHDKA
CCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHCCCCCHHHHCCCHHHCCCCCCCCCCCC
PHHSASETGNPLIDMRSNATAPRLDDPGVGLRDNGRRVLCYADLHSVFDDPDGREPGRDI
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCEE
ELHLTGHMEKFAWSFDGIAFASAQPLQLQYGERLRIVLVNDTMMQHPIHLHGMWSDLEDA
EEEEECCCHHHEECCCCEEECCCCCEEEECCCEEEEEEECCHHHHCCEEEEECCCCHHHC
HGNFQVRKHTIDMPPGTRRTYRVRADALGRWAYHCHLLYHMEAGMMREVRVEA
CCCEEEEEEEECCCCCCCEEEEEEHHHHCCEEEEEEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]