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The map label for this gene is fixL [C]

Identifier: 21243288

GI number: 21243288

Start: 3014193

End: 3015815

Strand: Reverse

Name: fixL [C]

Synonym: XAC2555

Alternate gene names: 21243288

Gene position: 3015815-3014193 (Counterclockwise)

Preceding gene: 21243289

Following gene: 21243283

Centisome position: 58.27

GC content: 62.42

Gene sequence:

>1623_bases
TTGAACGATCCCGGTCACGGAGAGCTGCGAGCGCCTCACATCAGCGAATCTCGCAGCCTGCCTGTCGAGAAGCACCGCTC
GGACATCTTCTTTGCCGCAGTGGAAACCACGCGCATGCCGATGACGGTGACCGACCCCCATCTTCCGGATAATCCCATCG
TGTTCGCCAACCGCGCGTTCCTGGAGATGACCGGCTATGCCGCCGATGAAGTCATCGGCAACAACTGCCGCTTCCTGCAG
GGGCCGGAGACCGATCCGGCCAGCATCAGCGATGTGCGCGAATCGATCGAAAGCCGTCGCGAATTTGCCACCGAGGTGCT
GAATTACCGCAAGGACGGCTCCTCGTTCTGGAATGCGCTCTTCATCTCGCCGGTGTTCGACGACAAGGGCAACCTGGTGT
ATTTCTTCGGCTCGCAGCTGGATGTGAGCCGGCGCCGCGATGCCGAAGATGCGCTGCGCCAGGCGCAGAAGATGGAAGCG
CTGGGCCAGCTGACCGGCGGCATCGCGCACGATTTCAACAATCTGCTGCAGGTGATGTCTGGCCATCTGGAAGTGATCCA
GACGATGGCCAGCGCCGGCGGCAGTAGTGCCGAGCGCATTGCCTTCAGTGCCGAACACGCGGCGGCAGCGGCTGCCAAGG
CGGCCACCTTGACCCAGCAACTGCTGGCGTTTTCGCGCAAGCAGAAACTGCGCGGGCGGGTAGTGAACCTCAACGGATTG
GTGGCCGGCATGACCAACATGGCCGAGCGCGCGCTGGGAGGCGGAGTCACTCTGCGCCAGTCGCTGGAAGAAGGGCTGTG
GAACTGCCAGATCGACACCACCCAGGCAGAGGTGGCGCTGTTGAACGTGTTGATCAATGCGCGCGACGCGATGGCCCAGG
CCGAACGCAAGGAAGTGACGGTGCAGACCCAGAACGTGGAGATCACCGGCCACGATCTGGCGATGTACCACCAGCTGGCA
CCGGGCCGCTACGTCAGCATTGCCGTGACCGACACCGGCTCGGGCATGCCGCCGGAGGTGGTCAGCCGGGTGATGGAACC
GTTCTTCACCACCAAGGAGGAAGGCCAGGGCACCGGCCTGGGCCTGTCGATGGTGTATGGATTCGTCAAGCAGTCCGGCG
GCACCGTACGCATCTACAGCGAGGTGGGCGAGGGCAGCACGGTGCGGCTGTATTTCCCCGCCTCCAGCGAATTCGAAAAC
GATTTGCAGATAGCCAAGAGTCGCGCCATCGACAAGGGTGGCAACGAAACCATCCTGGTGGTGGAAGACAAGCAGGATGT
GGCGGTGGTGGCGCGGATGTTTCTGGAAAATGCCGGTTACCGCATCCTGTCTGCGTCCAGCGGACGCGAGGCGATGGAGA
TCCTGGAGAAGAACCCGGAAGTGGATGCGCTATTCACCGACCTGATCATGCCCGGCGGTATGAACGGGGTGATGCTCGCC
CGTGAGGCGCGCCGCATGTTGCCGAAGATCAAGATCCTGCTCACCACCGGCTACGCCGATGCCAGCATCCAGCGTACCGA
TGTGGGCGGCGCCGAGTTCGATGTGGTGAACAAGCCCTATACGCAGAAGGAATTGCTCAAGCGCATCCGCATGTTGCTGG
ATGGGCCGACCGGGGTTGGTTGA

Upstream 100 bases:

>100_bases
GCAGGCGCGGCCGTACGGGAAATGCTCATGGATGTGACGAATCGCCTCACCGGACCCAACTAGACTGTGGCCACGGGAAT
GGCCCCGCGGAGAACATCAC

Downstream 100 bases:

>100_bases
GTCCGACAGATCGCCACTGCGATGCCGCTGCGGCATCGCACTGCAATCGCCGTTGAGCTTCAAGATTGCGGCAGTCCGCT
AGCGCAGCGCCCGGAGCAGC

Product: histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MNDPGHGELRAPHISESRSLPVEKHRSDIFFAAVETTRMPMTVTDPHLPDNPIVFANRAFLEMTGYAADEVIGNNCRFLQ
GPETDPASISDVRESIESRREFATEVLNYRKDGSSFWNALFISPVFDDKGNLVYFFGSQLDVSRRRDAEDALRQAQKMEA
LGQLTGGIAHDFNNLLQVMSGHLEVIQTMASAGGSSAERIAFSAEHAAAAAAKAATLTQQLLAFSRKQKLRGRVVNLNGL
VAGMTNMAERALGGGVTLRQSLEEGLWNCQIDTTQAEVALLNVLINARDAMAQAERKEVTVQTQNVEITGHDLAMYHQLA
PGRYVSIAVTDTGSGMPPEVVSRVMEPFFTTKEEGQGTGLGLSMVYGFVKQSGGTVRIYSEVGEGSTVRLYFPASSEFEN
DLQIAKSRAIDKGGNETILVVEDKQDVAVVARMFLENAGYRILSASSGREAMEILEKNPEVDALFTDLIMPGGMNGVMLA
REARRMLPKIKILLTTGYADASIQRTDVGGAEFDVVNKPYTQKELLKRIRMLLDGPTGVG

Sequences:

>Translated_540_residues
MNDPGHGELRAPHISESRSLPVEKHRSDIFFAAVETTRMPMTVTDPHLPDNPIVFANRAFLEMTGYAADEVIGNNCRFLQ
GPETDPASISDVRESIESRREFATEVLNYRKDGSSFWNALFISPVFDDKGNLVYFFGSQLDVSRRRDAEDALRQAQKMEA
LGQLTGGIAHDFNNLLQVMSGHLEVIQTMASAGGSSAERIAFSAEHAAAAAAKAATLTQQLLAFSRKQKLRGRVVNLNGL
VAGMTNMAERALGGGVTLRQSLEEGLWNCQIDTTQAEVALLNVLINARDAMAQAERKEVTVQTQNVEITGHDLAMYHQLA
PGRYVSIAVTDTGSGMPPEVVSRVMEPFFTTKEEGQGTGLGLSMVYGFVKQSGGTVRIYSEVGEGSTVRLYFPASSEFEN
DLQIAKSRAIDKGGNETILVVEDKQDVAVVARMFLENAGYRILSASSGREAMEILEKNPEVDALFTDLIMPGGMNGVMLA
REARRMLPKIKILLTTGYADASIQRTDVGGAEFDVVNKPYTQKELLKRIRMLLDGPTGVG
>Mature_540_residues
MNDPGHGELRAPHISESRSLPVEKHRSDIFFAAVETTRMPMTVTDPHLPDNPIVFANRAFLEMTGYAADEVIGNNCRFLQ
GPETDPASISDVRESIESRREFATEVLNYRKDGSSFWNALFISPVFDDKGNLVYFFGSQLDVSRRRDAEDALRQAQKMEA
LGQLTGGIAHDFNNLLQVMSGHLEVIQTMASAGGSSAERIAFSAEHAAAAAAKAATLTQQLLAFSRKQKLRGRVVNLNGL
VAGMTNMAERALGGGVTLRQSLEEGLWNCQIDTTQAEVALLNVLINARDAMAQAERKEVTVQTQNVEITGHDLAMYHQLA
PGRYVSIAVTDTGSGMPPEVVSRVMEPFFTTKEEGQGTGLGLSMVYGFVKQSGGTVRIYSEVGEGSTVRLYFPASSEFEN
DLQIAKSRAIDKGGNETILVVEDKQDVAVVARMFLENAGYRILSASSGREAMEILEKNPEVDALFTDLIMPGGMNGVMLA
REARRMLPKIKILLTTGYADASIQRTDVGGAEFDVVNKPYTQKELLKRIRMLLDGPTGVG

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI6912446, Length=95, Percent_Identity=37.8947368421053, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI27886667, Length=94, Percent_Identity=37.2340425531915, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI38569493, Length=142, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=267, Percent_Identity=28.8389513108614, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1788549, Length=339, Percent_Identity=23.3038348082596, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI48994928, Length=457, Percent_Identity=23.1947483588621, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17136946, Length=98, Percent_Identity=31.6326530612245, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58919; Mature: 58919

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDPGHGELRAPHISESRSLPVEKHRSDIFFAAVETTRMPMTVTDPHLPDNPIVFANRAF
CCCCCCCCEECCCCCCCCCCCHHHCCCCEEEEEEECCCCCEEECCCCCCCCCEEEECCEE
LEMTGYAADEVIGNNCRFLQGPETDPASISDVRESIESRREFATEVLNYRKDGSSFWNAL
EEECCCCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEE
FISPVFDDKGNLVYFFGSQLDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMS
EEEEEECCCCCEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
GHLEVIQTMASAGGSSAERIAFSAEHAAAAAAKAATLTQQLLAFSRKQKLRGRVVNLNGL
HHHHHHHHHHHCCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHH
VAGMTNMAERALGGGVTLRQSLEEGLWNCQIDTTQAEVALLNVLINARDAMAQAERKEVT
HHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEEE
VQTQNVEITGHDLAMYHQLAPGRYVSIAVTDTGSGMPPEVVSRVMEPFFTTKEEGQGTGL
EEEEEEEEECCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLSMVYGFVKQSGGTVRIYSEVGEGSTVRLYFPASSEFENDLQIAKSRAIDKGGNETILV
HHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEE
VEDKQDVAVVARMFLENAGYRILSASSGREAMEILEKNPEVDALFTDLIMPGGMNGVMLA
EECCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHH
REARRMLPKIKILLTTGYADASIQRTDVGGAEFDVVNKPYTQKELLKRIRMLLDGPTGVG
HHHHHCCCEEEEEEEECCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNDPGHGELRAPHISESRSLPVEKHRSDIFFAAVETTRMPMTVTDPHLPDNPIVFANRAF
CCCCCCCCEECCCCCCCCCCCHHHCCCCEEEEEEECCCCCEEECCCCCCCCCEEEECCEE
LEMTGYAADEVIGNNCRFLQGPETDPASISDVRESIESRREFATEVLNYRKDGSSFWNAL
EEECCCCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHEE
FISPVFDDKGNLVYFFGSQLDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMS
EEEEEECCCCCEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHH
GHLEVIQTMASAGGSSAERIAFSAEHAAAAAAKAATLTQQLLAFSRKQKLRGRVVNLNGL
HHHHHHHHHHHCCCCCHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECHH
VAGMTNMAERALGGGVTLRQSLEEGLWNCQIDTTQAEVALLNVLINARDAMAQAERKEVT
HHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEEE
VQTQNVEITGHDLAMYHQLAPGRYVSIAVTDTGSGMPPEVVSRVMEPFFTTKEEGQGTGL
EEEEEEEEECCHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCC
GLSMVYGFVKQSGGTVRIYSEVGEGSTVRLYFPASSEFENDLQIAKSRAIDKGGNETILV
HHHHHHHHHHCCCCEEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEE
VEDKQDVAVVARMFLENAGYRILSASSGREAMEILEKNPEVDALFTDLIMPGGMNGVMLA
EECCCHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHH
REARRMLPKIKILLTTGYADASIQRTDVGGAEFDVVNKPYTQKELLKRIRMLLDGPTGVG
HHHHHCCCEEEEEEEECCCCCCEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA