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The map label for this gene is hutU

Identifier: 21242385

GI number: 21242385

Start: 1885653

End: 1887320

Strand: Reverse

Name: hutU

Synonym: XAC1635

Alternate gene names: 21242385

Gene position: 1887320-1885653 (Counterclockwise)

Preceding gene: 21242386

Following gene: 77748597

Centisome position: 36.47

GC content: 66.97

Gene sequence:

>1668_bases
ATGACCCGTCACGATGCAACCCGCGTCATCCGCGCCGCCACCGGCACCACGCTCACCGCCAAGAGCTGGCTCACCGAAGC
GCCGCTGCGCATGTTGATGAACAACCTGGACCCGGACGTGGCCGAGCGCCCGCAGGAACTGGTGGTCTACGGCGGTATCG
GCCGCGCCGCGCGCGACTGGGAATCCTTCGACGCGATCGTTGCTGCGCTCACGCGTCTGGACGAGGACCACACCTTGCTG
GTGCAGTCCGGCAAACCGGTGGGCGTGTTCCGCACCCATGCCGATGCGCCGCGCGTGCTGATCGCCAATTCCAACCTGGT
GCCGCGCTGGGCCAACTGGGACCACTTCAACGAACTCGATCAAAAGGGCCTGGCCATGTACGGCCAGATGACCGCCGGCA
GCTGGATCTACATCGGCGCGCAAGGCATCGTGCAGGGCACCTACGAAACCTTCGTGGAAATGGGCCGCCAGCACTATGAC
GGCAACCTGGCCGGCAAGTGGCTGTTCACCGGCGGTCTCGGCGGCATGGGCGGCGCGCAACCGCTTGCGGCGGTGATGGC
CGGCGCCTCGTGCCTGGCGGTGGAGTGCCGCCGCTCCAGCATCGACATGCGCCTGCGCACCGGGTATCTCGATACCTGGA
CCGATTCGCTGGATGAAGCGCTGCGCCTGATCGAAGAGTCGTGCACCGCGAGGAAGCCACTGTCGGTCGGCCTGCTCGGC
AATGTCGCCGACGTGCTGGACGAACTGCTGCTGCGCGGGATCAGGCCGGATCTGTTGACCGACCAGACCTCTGCACACGA
CCCGGTCAACGGCTACCTGCCGCAGGGCTGGAGCGTGGAAGAGTGGGACGCAAAGCGCGTGAGCGCGCCCAAAGAAGTGG
AAGCGGCGGCGCGCGATTCGATGGCCAACCACATCCGCGCCATGCTCACCTTCCACGCACTGGGCGTGCCTACCGTGGAT
TACGGCAACAACCTGCGCCAGATGGCGCTGGAGGCCGGCGTCGACAACGCGTTCGATTTCCCCGGCTTCGTGCCTGCCTA
CATCCGCCCGCTGTTTTGTCGCGGTATTGGCCCGTTCCGCTGGGTCGCGCTCAGCGGCGACCCGGACGACATCGCCAAGA
CCGACGCCAAGGTCAAGGAACTCATTCCCGACGATGCGCATCTGCATCGCTGGCTCGACATGGCGGCCGACAAGATCGCC
TTCCAGGGCCTGCCCGCGCGCATTTGCTGGGTCGGCCTGGGCGACCGCCACCGGCTGGGCCTGGCCTTCAACGCAATGGT
GCGCAGCGGCGAGCTGAAGGCACCGGTGGTGATCGGCCGCGACCATCTGGATTCGGGCAGCGTGGCCTCGCCCAATCGCG
AAACCGAAGCGATGGCCGACGGCTCGGACGCGGTCTCCGACTGGCCGCTGCTCAACGCCCTGCTCAATACCGCCAGCGGC
GCCACCTGGGTATCGCTGCACCACGGCGGCGGCGTCGGCATGGGCTTCTCGCAACATGCTGGCATGGTGATCGTCTGCGA
CGGCAGCGAGGCCGCCGACAAGCGCCTGGAACGCGTGCTCTGGAACGACCCGGCCACCGGCGTGATGCGCCACGCCGATG
CCGGTTACGCCATTGCAACCGATTGCGCGAAGGCAAAAGGGCTGGATTTGCCGGGCATTCTGCGCTGA

Upstream 100 bases:

>100_bases
GTACTGCGCCACGTGCTGCAGGCCTGCCTGCACTTCGCCAACGCGCCCTCTTCCGACACCGCGCCGCCTGCGGCCAACCG
CTGATTGCAAGGAACCCGGC

Downstream 100 bases:

>100_bases
CCCAGCCGAACAGCGCGCTTGGGGGCACCGCTGCATCGTCCGGGCCGCTCCCGCGCGCAGCCCCCTCTTCGTGCATTCCC
TTACCCCGCAGTGGCGCGCT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAERPQELVVYGGIGRAARDWESFDAIVAALTRLDEDHTLL
VQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYD
GNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTARKPLSVGLLG
NVADVLDELLLRGIRPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVD
YGNNLRQMALEAGVDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAADKIA
FQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKAKGLDLPGILR

Sequences:

>Translated_555_residues
MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAERPQELVVYGGIGRAARDWESFDAIVAALTRLDEDHTLL
VQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYD
GNLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTARKPLSVGLLG
NVADVLDELLLRGIRPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVD
YGNNLRQMALEAGVDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAADKIA
FQGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKAKGLDLPGILR
>Mature_554_residues
TRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAERPQELVVYGGIGRAARDWESFDAIVAALTRLDEDHTLLV
QSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFNELDQKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYDG
NLAGKWLFTGGLGGMGGAQPLAAVMAGASCLAVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTARKPLSVGLLGN
VADVLDELLLRGIRPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSAPKEVEAAARDSMANHIRAMLTFHALGVPTVDY
GNNLRQMALEAGVDNAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAADKIAF
QGLPARICWVGLGDRHRLGLAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASGA
TWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIATDCAKAKGLDLPGILR

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=554, Percent_Identity=35.7400722021661, Blast_Score=315, Evalue=8e-86,
Organism=Homo sapiens, GI260306182, Length=614, Percent_Identity=33.2247557003257, Blast_Score=285, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71997891, Length=545, Percent_Identity=35.4128440366973, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_XANAC (P58987)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_641967.1
- ProteinModelPortal:   P58987
- SMR:   P58987
- GeneID:   1155706
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC1635
- NMPDR:   fig|190486.1.peg.1611
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   XAXO190486:XAC1635-MONOMER
- BRENDA:   4.2.1.49
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60121; Mature: 59990

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 409-409

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAERPQELVVYGGIGRAARDW
CCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCHHHHH
ESFDAIVAALTRLDEDHTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHH
QKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYDGNLAGKWLFTGGLGGMGGAQ
HHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
PLAAVMAGASCLAVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTARKPLSVGLLG
HHHHHHCCCHHEEEEHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEECHHH
NVADVLDELLLRGIRPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSAPKEVEAAARDS
HHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHH
MANHIRAMLTFHALGVPTVDYGNNLRQMALEAGVDNAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAADKIAFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
LAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
CEEEHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIAT
CEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEH
DCAKAKGLDLPGILR
HHHHHCCCCCCCCCC
>Mature Secondary Structure 
TRHDATRVIRAATGTTLTAKSWLTEAPLRMLMNNLDPDVAERPQELVVYGGIGRAARDW
CCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCCCHHHCCCCEEEEECCCCCHHHHH
ESFDAIVAALTRLDEDHTLLVQSGKPVGVFRTHADAPRVLIANSNLVPRWANWDHFNELD
HHHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCEEEEECCCCCCCCCCCCHHHHHH
QKGLAMYGQMTAGSWIYIGAQGIVQGTYETFVEMGRQHYDGNLAGKWLFTGGLGGMGGAQ
HHHHHEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
PLAAVMAGASCLAVECRRSSIDMRLRTGYLDTWTDSLDEALRLIEESCTARKPLSVGLLG
HHHHHHCCCHHEEEEHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEECHHH
NVADVLDELLLRGIRPDLLTDQTSAHDPVNGYLPQGWSVEEWDAKRVSAPKEVEAAARDS
HHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHH
MANHIRAMLTFHALGVPTVDYGNNLRQMALEAGVDNAFDFPGFVPAYIRPLFCRGIGPFR
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCEE
WVALSGDPDDIAKTDAKVKELIPDDAHLHRWLDMAADKIAFQGLPARICWVGLGDRHRLG
EEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC
LAFNAMVRSGELKAPVVIGRDHLDSGSVASPNRETEAMADGSDAVSDWPLLNALLNTASG
CEEEHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCC
ATWVSLHHGGGVGMGFSQHAGMVIVCDGSEAADKRLERVLWNDPATGVMRHADAGYAIAT
CEEEEEECCCCCCCCHHCCCCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEH
DCAKAKGLDLPGILR
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217