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The map label for this gene is gndA [H]

Identifier: 21241451

GI number: 21241451

Start: 805900

End: 806841

Strand: Direct

Name: gndA [H]

Synonym: XAC0680

Alternate gene names: 21241451

Gene position: 805900-806841 (Clockwise)

Preceding gene: 21241450

Following gene: 21241453

Centisome position: 15.57

GC content: 64.86

Gene sequence:

>942_bases
ATGGAACTGGGTATGGTGGGACTGGGCCGCATGGGCGCCAACATGGCCGAGCGCTTGGTCAATGGTGGGCATCGCGTGCA
TGGCTACGATCCGGGCGCGAACGCGCGCACCAGCGCGCAAGCCAAGGGCATCGTCACCGCCGATGCGCTGGCAGCGCTGG
TGTCCGCACTGCCGAGCCCGCGCGTGGTGTGGTTGATGGTGCCGGCCGGCAAGATCGTCGATGACACGCTGGCGCAGCTG
CTGCCCTTGCTGCAGGCCGGCGACATCGTCATCGATGGCGGCAATTCGTACTACAAGGATTCGCAGCGGCGTGCGGCATT
GCTGCAGGCCAGTGGCATCGCGTTTGTCGATTGCGGCACCAGCGGTGGCATCTGGGGTCTGCAGGAAGGCTATAGCCTGA
TGGTGGGTGGCGACGAAGCGGCGGTGACGGGGTTGCATCCGATCCTGGCAACGCTCGCGCCGGCGCCGGACAAGGGCTGG
GGACGGGTTGGCCCGAGCGGTGCAGGCCACTTCACCAAGATGGTCCACAACGGCATCGAATACGGAATGATGCAGGCCTA
TGCGGAAGGCTTCGCGCTGATGCAGCACAAGGCCGATTTTGCGCTGGATCTGCACCAGGTTGCCGAAATCTGGCGCGATG
GCAGCGTGGTGCGTTCGTGGTTGCTGGATCTGACGGCCGACGCGTTGACGCATAACCCGACCATGGCCGGCATCGCGCCG
TTCGTGGCCGATTCGGGCGAAGGCCGCTGGACGGTTGCAGAAGCGATCGATCTGGAAGTCTCTGCACCGGTCATCACGTT
GTCGCTGATGGAGCGGCTGCGCTCGCGCGACAAGGATTCGTTTACCGACAAGCTGCTCGCGGCGATGCGCAATCAGTTCG
GCGGCCACGCGGTGATGACCACGACCTCGGCAGCGCCGACGATCGGTAGCAAGGACGCGTAA

Upstream 100 bases:

>100_bases
GCAGCGCCGCCACCGTCGCGGAACAATCATTTGAGAATTCCGCCACGCCAGCGTACGCCGAGCGTGGCACCCTGCACTGA
TCAGATCATGAGGAGCGATT

Downstream 100 bases:

>100_bases
GGGCTGGGATGCGATGGCTGTGCGCGCCGGATCGCGGCGCGCACTGTTGGAAGTACAGAACCGTCTCAGCGTGATCAGTC
GCGCGCGGCATCCAGCCACT

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MELGMVGLGRMGANMAERLVNGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPSPRVVWLMVPAGKIVDDTLAQL
LPLLQAGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGTSGGIWGLQEGYSLMVGGDEAAVTGLHPILATLAPAPDKGW
GRVGPSGAGHFTKMVHNGIEYGMMQAYAEGFALMQHKADFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMTTTSAAPTIGSKDA

Sequences:

>Translated_313_residues
MELGMVGLGRMGANMAERLVNGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPSPRVVWLMVPAGKIVDDTLAQL
LPLLQAGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGTSGGIWGLQEGYSLMVGGDEAAVTGLHPILATLAPAPDKGW
GRVGPSGAGHFTKMVHNGIEYGMMQAYAEGFALMQHKADFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMTTTSAAPTIGSKDA
>Mature_313_residues
MELGMVGLGRMGANMAERLVNGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPSPRVVWLMVPAGKIVDDTLAQL
LPLLQAGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGTSGGIWGLQEGYSLMVGGDEAAVTGLHPILATLAPAPDKGW
GRVGPSGAGHFTKMVHNGIEYGMMQAYAEGFALMQHKADFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMTTTSAAPTIGSKDA

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=313, Percent_Identity=37.0607028753994, Blast_Score=153, Evalue=2e-37,
Organism=Escherichia coli, GI1788341, Length=292, Percent_Identity=35.2739726027397, Blast_Score=158, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17542558, Length=301, Percent_Identity=36.2126245847176, Blast_Score=155, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321695, Length=303, Percent_Identity=35.6435643564356, Blast_Score=162, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6321977, Length=326, Percent_Identity=34.6625766871166, Blast_Score=154, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24639279, Length=300, Percent_Identity=37.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24655230, Length=244, Percent_Identity=28.2786885245902, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922568, Length=244, Percent_Identity=28.2786885245902, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32892; Mature: 32892

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGMVGLGRMGANMAERLVNGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPSP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
RVVWLMVPAGKIVDDTLAQLLPLLQAGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGT
CEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCC
SGGIWGLQEGYSLMVGGDEAAVTGLHPILATLAPAPDKGWGRVGPSGAGHFTKMVHNGIE
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YGMMQAYAEGFALMQHKADFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMT
HHCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEE
TTSAAPTIGSKDA
ECCCCCCCCCCCC
>Mature Secondary Structure
MELGMVGLGRMGANMAERLVNGGHRVHGYDPGANARTSAQAKGIVTADALAALVSALPSP
CCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCC
RVVWLMVPAGKIVDDTLAQLLPLLQAGDIVIDGGNSYYKDSQRRAALLQASGIAFVDCGT
CEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCEEEEECCC
SGGIWGLQEGYSLMVGGDEAAVTGLHPILATLAPAPDKGWGRVGPSGAGHFTKMVHNGIE
CCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
YGMMQAYAEGFALMQHKADFALDLHQVAEIWRDGSVVRSWLLDLTADALTHNPTMAGIAP
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
FVADSGEGRWTVAEAIDLEVSAPVITLSLMERLRSRDKDSFTDKLLAAMRNQFGGHAVMT
HHCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEEEE
TTSAAPTIGSKDA
ECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]