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The map label for this gene is aceE [H]

Identifier: 21241347

GI number: 21241347

Start: 678352

End: 681039

Strand: Direct

Name: aceE [H]

Synonym: XAC0576

Alternate gene names: 21241347

Gene position: 678352-681039 (Clockwise)

Preceding gene: 21241346

Following gene: 21241348

Centisome position: 13.11

GC content: 65.66

Gene sequence:

>2688_bases
ATGAACTGGTTGAACGAAGTGCTGCACAACGATCCGAACCCGCTCGAGACGCAGGAGTGGCTCGAATCGATCAAGGCCGT
CATCGACGTCGAAGGCCCGGAGCGCGCCCATCAGCTGCTGGAAGGCATGGTCGAACAGACCCGCCGCGCCGGCGCCTACC
TGCCGTTCTCGCCCACCACCGAGTACGTCAACACCATCTCCCCGGCCAACGAGGCCAAGCACCCCGGCGACTCCGCGCTG
GAGTGGAAGATCCGCTCGATCATCCGCTGGAACGCCATGGCCACGGTCGTGCGGGCCAACCGCAAGCCGGGTGACCTGGG
CGGCCACATCGCCTCGTTCGCCTCCAGCGCCACGCTCTACGACGTGGGCTTCAACCACTTCTGGCGCGCGCCCTCGGACA
ACCATCCGGGCGATCTGCTGTTCATCCAGGGCCATAGCGCCCCGGGCATCTACGCCCGCGCCTTCCTCGAAGGCCGCATC
AGCCAGTCCCAGCTGGACAACTTCCGCATGGAAGTGGACGGCCAGGGCATCTCGTCCTACCCGCACCCGTGGCTGATGCC
CGAGTTCTGGCAGACCCCCACCGTGTCGATGGGCCTGGGCCCGCTGGCCGCCATCTACCAGGCGCAGTTCATGCGCTACC
TGGAAAACCGCGGCCTGATCGAGAAGTCCGACCGCAAGGTGTGGTGCTTCATCGGCGACGGCGAGAGCGACGAGCCGGAA
ACCCTCGGCGCCATCGCGCTGGCCGGCCGCGAAGGCCTGGACAACCTCATCTTCGTGGTCAACTGCAATCTGCAGCGCCT
GGACGGCCCGGTGCGCGGCAACGGCAAGATCATCCAGGAACTGGAAGGCGTGTTCCGTGGCGGCGGCTGGAACGTCATCA
AGCTGCTCTGGGGCGGCTACTGGGACGCCCTGCTGGCCAAGGACAGCGACGGCGTGCTGCGCAAGCTGATGATGGAAACC
GTCGACGGCGAATACCAGAACTGCAAGGCCTTCGGCGGCGCCTACACCCGCGCCAATTTCTTCGGCAAGTACCCGGAGAC
CGCGGCCATGGTGGCCGGCCTGTCCGACGACGACATCTGGCGCCTGAACCGTGGCGGCCACGACCCGCACAAGGTGTACG
CCGCCTATCACCAGGCCGTGAACACCACCGGCATGCCCACCGTGATCCTGGCCAAGACGGTCAAGGGCTACGGCATGGGT
TCGGCCGGTGAGGCGCTCAACCCCACCCACCAGACCAAGAAGCTCGACGACGCGGCGGTCAAGCACTTCCGCGACCGCTT
CAACATCCCGGTGACCGACGCCCAGCTGGAAGACGGCCAGGTGCCGTTCTACCACCCCGGCGAAGATTCCCCGGAAGTGC
AGTACCTGAAAGAACGCCGCAGCGTGCTCGGCGGCTTCCTGCCCTCGCGCCGCCCCAAGGCCAGCAAGTCGTTCGTGGCG
CCCACGCTCGACAAGTTCGAGCGCCTGCTCAAGGACAGCGGCGAGCGCAGCTATTCCACCACCATGTCCTTCGTGCAGAG
CCTCAACATCGCCCTGCGCGACAAGGAACTGGGCCCGCGCATCGTGCCGATCGTGGCCGATGAGGCGCGCACCTTCGGCA
TGGAAGGCATGTTCCGCCAGATCGGCATCTATGCCCCGTTCGGCCAGAAGTACAAGCCGGTCGATGCCGACCAGCTGATG
TACTACCGCGAAGACCAGACCGGCCAGGTGCTGCAGCAGGGCATCAGCGAGCCGGGCGCCATCGCCTCGTGGATGGCCGC
CGGCACCAGCTACTCGGTGTCCGACGTGCCGATGCTGCCGTTCTACATCTACTACTCCATGTTCGGCTTCCAGCGCGTGG
GCGACATCGCCTGGCAGGCAGCGGACATGCGCACGCGTGGCTTCCTGCTCGGCGGCACCGCCGGCCGCACCACGCTCAAT
GGCGAAGGCCTGCAGCACGAAGACGGCTTCAGCCAGGTCATTGCCGGCTCCATCCCGAACGTGCGTAGCTACGACCCGAC
CTTCGGTTTCGAAGTCACCGTCATCATGCAGCACGGCATGAAGGCGATGATGGAAGACCAGGTCGACGAGTACTACTACA
TCACCCTGATGAACGAGAACTACGCCCACCCCGGCATGCCGGACGGCGCAGCCGAGGGCATCATCAAGGGCATGTACCTG
CTCAAGGATGCCGGCAAGCCCAAGAAGGGCGAGCTGCGCGTGCAGCTGCTGGGTAGCGGCACCATCCTCCGCGAGGCCAT
CGCCGCCGCCGAGCTGCTGGACAAGGACTTCGGCGTCACCGCCGACATCTGGTCCTGCCCCAGCCTCAACGAAGTGCGCC
GCGACGGCTACGCCGTAGAACGCTGGAACCGCCTGCACCCGGAGGCCGAACAGCGCAAGCCCTACGTCACCCAGCTGCTG
GAAGGCCGCCAGGGCCCGGCCGTCGCCGCAACCGACTACGTACGCGCCTTCGCCGACCAGATCCGCGCCTTCGTCCCGAT
GACCTACACCGTCCTCGGCACGGATGGGTTCGGCCGTTCGGATACGCGTGCGAATCTGCGCCGCTTCTTTGAAGTGGACC
GTTACTACATCGCGCATGCGGCGATTGCCGCGCTGGCGAAGGATGGGAAGATGACGGGCAAGGATGTGGCCCGGGCGATC
AAGCAGTACAAGATTGATCCGGAGAAAGCGAATCCTGTTGGGGTTTGA

Upstream 100 bases:

>100_bases
CCCGTAGCGAGGAATGGCAACAGGTGCGTGCGGTACACTTGGGGGTTCACGAATTCACGATGTCGACACACCCGCGGGGT
GTGTCCCCCCGGGAGCGCTA

Downstream 100 bases:

>100_bases
TCTTCTCAAAGGTGAGTCAATCGAAAGGGCGGCCGCAAGGTCGCCCTTTCGCGCTATAACCACGTCGTTTCCCCTTGGTC
TCAATCCCCGCGACTCGTAG

Product: pyruvate dehydrogenase subunit E1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 895; Mature: 895

Protein sequence:

>895_residues
MNWLNEVLHNDPNPLETQEWLESIKAVIDVEGPERAHQLLEGMVEQTRRAGAYLPFSPTTEYVNTISPANEAKHPGDSAL
EWKIRSIIRWNAMATVVRANRKPGDLGGHIASFASSATLYDVGFNHFWRAPSDNHPGDLLFIQGHSAPGIYARAFLEGRI
SQSQLDNFRMEVDGQGISSYPHPWLMPEFWQTPTVSMGLGPLAAIYQAQFMRYLENRGLIEKSDRKVWCFIGDGESDEPE
TLGAIALAGREGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGGYWDALLAKDSDGVLRKLMMET
VDGEYQNCKAFGGAYTRANFFGKYPETAAMVAGLSDDDIWRLNRGGHDPHKVYAAYHQAVNTTGMPTVILAKTVKGYGMG
SAGEALNPTHQTKKLDDAAVKHFRDRFNIPVTDAQLEDGQVPFYHPGEDSPEVQYLKERRSVLGGFLPSRRPKASKSFVA
PTLDKFERLLKDSGERSYSTTMSFVQSLNIALRDKELGPRIVPIVADEARTFGMEGMFRQIGIYAPFGQKYKPVDADQLM
YYREDQTGQVLQQGISEPGAIASWMAAGTSYSVSDVPMLPFYIYYSMFGFQRVGDIAWQAADMRTRGFLLGGTAGRTTLN
GEGLQHEDGFSQVIAGSIPNVRSYDPTFGFEVTVIMQHGMKAMMEDQVDEYYYITLMNENYAHPGMPDGAAEGIIKGMYL
LKDAGKPKKGELRVQLLGSGTILREAIAAAELLDKDFGVTADIWSCPSLNEVRRDGYAVERWNRLHPEAEQRKPYVTQLL
EGRQGPAVAATDYVRAFADQIRAFVPMTYTVLGTDGFGRSDTRANLRRFFEVDRYYIAHAAIAALAKDGKMTGKDVARAI
KQYKIDPEKANPVGV

Sequences:

>Translated_895_residues
MNWLNEVLHNDPNPLETQEWLESIKAVIDVEGPERAHQLLEGMVEQTRRAGAYLPFSPTTEYVNTISPANEAKHPGDSAL
EWKIRSIIRWNAMATVVRANRKPGDLGGHIASFASSATLYDVGFNHFWRAPSDNHPGDLLFIQGHSAPGIYARAFLEGRI
SQSQLDNFRMEVDGQGISSYPHPWLMPEFWQTPTVSMGLGPLAAIYQAQFMRYLENRGLIEKSDRKVWCFIGDGESDEPE
TLGAIALAGREGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGGYWDALLAKDSDGVLRKLMMET
VDGEYQNCKAFGGAYTRANFFGKYPETAAMVAGLSDDDIWRLNRGGHDPHKVYAAYHQAVNTTGMPTVILAKTVKGYGMG
SAGEALNPTHQTKKLDDAAVKHFRDRFNIPVTDAQLEDGQVPFYHPGEDSPEVQYLKERRSVLGGFLPSRRPKASKSFVA
PTLDKFERLLKDSGERSYSTTMSFVQSLNIALRDKELGPRIVPIVADEARTFGMEGMFRQIGIYAPFGQKYKPVDADQLM
YYREDQTGQVLQQGISEPGAIASWMAAGTSYSVSDVPMLPFYIYYSMFGFQRVGDIAWQAADMRTRGFLLGGTAGRTTLN
GEGLQHEDGFSQVIAGSIPNVRSYDPTFGFEVTVIMQHGMKAMMEDQVDEYYYITLMNENYAHPGMPDGAAEGIIKGMYL
LKDAGKPKKGELRVQLLGSGTILREAIAAAELLDKDFGVTADIWSCPSLNEVRRDGYAVERWNRLHPEAEQRKPYVTQLL
EGRQGPAVAATDYVRAFADQIRAFVPMTYTVLGTDGFGRSDTRANLRRFFEVDRYYIAHAAIAALAKDGKMTGKDVARAI
KQYKIDPEKANPVGV
>Mature_895_residues
MNWLNEVLHNDPNPLETQEWLESIKAVIDVEGPERAHQLLEGMVEQTRRAGAYLPFSPTTEYVNTISPANEAKHPGDSAL
EWKIRSIIRWNAMATVVRANRKPGDLGGHIASFASSATLYDVGFNHFWRAPSDNHPGDLLFIQGHSAPGIYARAFLEGRI
SQSQLDNFRMEVDGQGISSYPHPWLMPEFWQTPTVSMGLGPLAAIYQAQFMRYLENRGLIEKSDRKVWCFIGDGESDEPE
TLGAIALAGREGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGGYWDALLAKDSDGVLRKLMMET
VDGEYQNCKAFGGAYTRANFFGKYPETAAMVAGLSDDDIWRLNRGGHDPHKVYAAYHQAVNTTGMPTVILAKTVKGYGMG
SAGEALNPTHQTKKLDDAAVKHFRDRFNIPVTDAQLEDGQVPFYHPGEDSPEVQYLKERRSVLGGFLPSRRPKASKSFVA
PTLDKFERLLKDSGERSYSTTMSFVQSLNIALRDKELGPRIVPIVADEARTFGMEGMFRQIGIYAPFGQKYKPVDADQLM
YYREDQTGQVLQQGISEPGAIASWMAAGTSYSVSDVPMLPFYIYYSMFGFQRVGDIAWQAADMRTRGFLLGGTAGRTTLN
GEGLQHEDGFSQVIAGSIPNVRSYDPTFGFEVTVIMQHGMKAMMEDQVDEYYYITLMNENYAHPGMPDGAAEGIIKGMYL
LKDAGKPKKGELRVQLLGSGTILREAIAAAELLDKDFGVTADIWSCPSLNEVRRDGYAVERWNRLHPEAEQRKPYVTQLL
EGRQGPAVAATDYVRAFADQIRAFVPMTYTVLGTDGFGRSDTRANLRRFFEVDRYYIAHAAIAALAKDGKMTGKDVARAI
KQYKIDPEKANPVGV

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG2609

COG function: function code C; Pyruvate dehydrogenase complex, dehydrogenase (E1) component

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI133778974, Length=226, Percent_Identity=30.9734513274336, Blast_Score=74, Evalue=8e-13,
Organism=Escherichia coli, GI1786304, Length=892, Percent_Identity=56.5022421524664, Blast_Score=1044, Evalue=0.0,

Paralogues:

None

Copy number: 1140 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 400 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004660
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 99535; Mature: 99535

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLNEVLHNDPNPLETQEWLESIKAVIDVEGPERAHQLLEGMVEQTRRAGAYLPFSPTT
CCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
EYVNTISPANEAKHPGDSALEWKIRSIIRWNAMATVVRANRKPGDLGGHIASFASSATLY
HHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCEEE
DVGFNHFWRAPSDNHPGDLLFIQGHSAPGIYARAFLEGRISQSQLDNFRMEVDGQGISSY
ECCHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHCEEEEECCCCCCCC
PHPWLMPEFWQTPTVSMGLGPLAAIYQAQFMRYLENRGLIEKSDRKVWCFIGDGESDEPE
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCCCH
TLGAIALAGREGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGGY
HHHHEEECCCCCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCH
WDALLAKDSDGVLRKLMMETVDGEYQNCKAFGGAYTRANFFGKYPETAAMVAGLSDDDIW
HHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCCCEE
RLNRGGHDPHKVYAAYHQAVNTTGMPTVILAKTVKGYGMGSAGEALNPTHQTKKLDDAAV
ECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
KHFRDRFNIPVTDAQLEDGQVPFYHPGEDSPEVQYLKERRSVLGGFLPSRRPKASKSFVA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PTLDKFERLLKDSGERSYSTTMSFVQSLNIALRDKELGPRIVPIVADEARTFGMEGMFRQ
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCHHHHCHHHHHHH
IGIYAPFGQKYKPVDADQLMYYREDQTGQVLQQGISEPGAIASWMAAGTSYSVSDVPMLP
HCEECCCCCCCCCCCHHHHEEEECCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHH
FYIYYSMFGFQRVGDIAWQAADMRTRGFLLGGTAGRTTLNGEGLQHEDGFSQVIAGSIPN
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHCCCCC
VRSYDPTFGFEVTVIMQHGMKAMMEDQVDEYYYITLMNENYAHPGMPDGAAEGIIKGMYL
CCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LKDAGKPKKGELRVQLLGSGTILREAIAAAELLDKDFGVTADIWSCPSLNEVRRDGYAVE
HHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHCCCHHH
RWNRLHPEAEQRKPYVTQLLEGRQGPAVAATDYVRAFADQIRAFVPMTYTVLGTDGFGRS
HHHHCCCCHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCC
DTRANLRRFFEVDRYYIAHAAIAALAKDGKMTGKDVARAIKQYKIDPEKANPVGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNWLNEVLHNDPNPLETQEWLESIKAVIDVEGPERAHQLLEGMVEQTRRAGAYLPFSPTT
CCHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCH
EYVNTISPANEAKHPGDSALEWKIRSIIRWNAMATVVRANRKPGDLGGHIASFASSATLY
HHHHCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCEEE
DVGFNHFWRAPSDNHPGDLLFIQGHSAPGIYARAFLEGRISQSQLDNFRMEVDGQGISSY
ECCHHHHCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHCEEEEECCCCCCCC
PHPWLMPEFWQTPTVSMGLGPLAAIYQAQFMRYLENRGLIEKSDRKVWCFIGDGESDEPE
CCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCEEEEEECCCCCCCCH
TLGAIALAGREGLDNLIFVVNCNLQRLDGPVRGNGKIIQELEGVFRGGGWNVIKLLWGGY
HHHHEEECCCCCCCCEEEEEECCHHHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHCCH
WDALLAKDSDGVLRKLMMETVDGEYQNCKAFGGAYTRANFFGKYPETAAMVAGLSDDDIW
HHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHCCCCCCHHHHHCCCCCCCEE
RLNRGGHDPHKVYAAYHQAVNTTGMPTVILAKTVKGYGMGSAGEALNPTHQTKKLDDAAV
ECCCCCCCHHHHHHHHHHHHCCCCCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
KHFRDRFNIPVTDAQLEDGQVPFYHPGEDSPEVQYLKERRSVLGGFLPSRRPKASKSFVA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PTLDKFERLLKDSGERSYSTTMSFVQSLNIALRDKELGPRIVPIVADEARTFGMEGMFRQ
CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCCEEEEEEECCHHHHCHHHHHHH
IGIYAPFGQKYKPVDADQLMYYREDQTGQVLQQGISEPGAIASWMAAGTSYSVSDVPMLP
HCEECCCCCCCCCCCHHHHEEEECCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCHHH
FYIYYSMFGFQRVGDIAWQAADMRTRGFLLGGTAGRTTLNGEGLQHEDGFSQVIAGSIPN
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCEECCCCCCCCCCHHHHHHCCCCC
VRSYDPTFGFEVTVIMQHGMKAMMEDQVDEYYYITLMNENYAHPGMPDGAAEGIIKGMYL
CCCCCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LKDAGKPKKGELRVQLLGSGTILREAIAAAELLDKDFGVTADIWSCPSLNEVRRDGYAVE
HHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEECCCCCCCHHHHHHCCCHHH
RWNRLHPEAEQRKPYVTQLLEGRQGPAVAATDYVRAFADQIRAFVPMTYTVLGTDGFGRS
HHHHCCCCHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCC
DTRANLRRFFEVDRYYIAHAAIAALAKDGKMTGKDVARAIKQYKIDPEKANPVGV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9171401; 10984043 [H]