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The map label for this gene is ubiB

Identifier: 21241016

GI number: 21241016

Start: 289568

End: 291241

Strand: Direct

Name: ubiB

Synonym: XAC0242

Alternate gene names: 21241016

Gene position: 289568-291241 (Clockwise)

Preceding gene: 21241015

Following gene: 21241017

Centisome position: 5.59

GC content: 65.89

Gene sequence:

>1674_bases
ATGAAGGCGATCCTGCGGGCCAGCCGCATCGGCCGGGTGATCCTGCGCTATCGCCTGGACGCCTTGCTGGAAGGCACCCC
GGCCGAGCGCTGGCTGCGTTTGGCCAAACCCTTCGTGCCGCGTGCCAGCGCCGAAATCGCCGCGCAATCGCGCGGTGCGC
GGCTGCGCTTGGCGCTGCAGGAGCTGGGACCGATCTTCGTCAAGTTCGGGCAGATTCTGTCCACCCGGCGCGATCTGATT
CCGGCCGACGTGGCCGAAGAACTCACCTTGCTGCAGGACCGGGTCAAGCCATTCGATGGCCAGGCCGCGCGCCTGATCGT
CGAAGCCGCACTCGGCCTGCCGGTGAGCGTGGCGTTTGCCAGCTTCGATACCGTGCCGCTGGCCTCGGCGTCCATTGCGC
AGGTGCATGCAGCCACATTGCCGCCCGATGCCAACGGCGTGCGCCGCGAAGTGGTGGTCAAGGTGCTGCGCCCGGAGATC
GAGCGCCAGATCGACGCCGATATCGCGTTGCTGCACTCGCTGGCCACCTTGGTCGAGCGCACCCACCCGCGTGCCGACAA
GATCCGTCCGCGCGAAGTGGTGGCCGAGATCGAAGGCACGCTGGCCGCCGAACTGGATCTGCAGCGCGAAGGCGCCAACG
CCAGCGTGTTGCGCCGGTTCTGGGAAGGCTCGGACGATCTGTATGTGCCGGAAGTGATCTGGTCGCACACTGCTGAGCGC
GCGCTCACGCTGGAGCGCGTGTACGGCATTCCGTCCGACGACATCGCCAAGCTCGACGCGGCCGGCATCGATCGCAAGGC
GCTCGCGGCCAAAGGCGTGCGCGTGTTCTACACCCAGGTATTTCGCGACAACTTCTTCCACGCCGATGCGCACGCCGGCA
ACATCTGGGTCGATTCGGATCCGGAACGCCGCCTCAATCCGCGCTTCATCGCGCTGGATTTCGGCATCATGGGCCAGCTC
TCGCAGGAAGATCAGTACTACCTGGCGGAGAACTTCATGGCGATCTTCCATAAGGATTACCGCCGCATGGCCGAGTTGCA
CGTGGAGGCTGGCTGGATGCCCAGCAACGTGCGCATCGACGAACTGGAAGCGGCAGCGCGCTCGGTGTGCGAGCCGTATT
TCAACCGCCCGCTGTCGGAGATTTCGCTGGCGCAGGTGCTGATCAAATTGTTCCGCGTGGCGCAGCGGTACGAGTTGACG
TTGCAGCCGCAGCTGATCCTGCTGCAGAAAACGCTGCTCAATATCGAAGGCGTGGGCCGGCAACTGGACCCCAGGCTGGA
TATCTGGGCGGTGGCGCGACCGGTGCTCGAACGCATCCTGCGCGAGCGTTACAGCCCGCGCCGCGTGCTGCGCGAACTGA
GCAAGCGTCTGCCGGAGATCATGACCCATGCGCCGGACATGCCGCGGCTGGTGTACAGCTGGCTGACGCAGCAGGTGGAG
GGTCGCCATCAGATCGCCATCCGCTCGCCCGAATTGCTTGCCCTGGACCTGAGCCTGCGCAAGCTGCAAACCCGCGTGGT
GACCGCCATCACCGGCAGCGGGTTACTGGTTGTCGCGGCCGTGCTGTACGGCCTACATCCGGATGGCTGGTATCTGGGCA
CGGTGCCGGTGTGGAGCTGGATCAGCGGCGGCGCCGGTTCGGCCGCGCTGCTGGTCGCCTGGTTGCGGCGATAG

Upstream 100 bases:

>100_bases
CCGAGCTCGAGGCGTTCCACGACGACGTGGACGAACTGCGCGATGACGTCGAACGGCTGGCCGCGCGCGTAAGCCGCCTG
CGTGCGAGCGGAGGCGCGGC

Downstream 100 bases:

>100_bases
GAGACGACCATGTCCGACGCAACCGATGCCTTGGACGCAAGCACACCGGTTGCCGGGATTGCCGCGCTGGATGCGCCACC
GCGCACGCAACATTCCAGCT

Product: ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAAQSRGARLRLALQELGPIFVKFGQILSTRRDLI
PADVAEELTLLQDRVKPFDGQAARLIVEAALGLPVSVAFASFDTVPLASASIAQVHAATLPPDANGVRREVVVKVLRPEI
ERQIDADIALLHSLATLVERTHPRADKIRPREVVAEIEGTLAAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAER
ALTLERVYGIPSDDIAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSDPERRLNPRFIALDFGIMGQL
SQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRIDELEAAARSVCEPYFNRPLSEISLAQVLIKLFRVAQRYELT
LQPQLILLQKTLLNIEGVGRQLDPRLDIWAVARPVLERILRERYSPRRVLRELSKRLPEIMTHAPDMPRLVYSWLTQQVE
GRHQIAIRSPELLALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSWISGGAGSAALLVAWLRR

Sequences:

>Translated_557_residues
MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAAQSRGARLRLALQELGPIFVKFGQILSTRRDLI
PADVAEELTLLQDRVKPFDGQAARLIVEAALGLPVSVAFASFDTVPLASASIAQVHAATLPPDANGVRREVVVKVLRPEI
ERQIDADIALLHSLATLVERTHPRADKIRPREVVAEIEGTLAAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAER
ALTLERVYGIPSDDIAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSDPERRLNPRFIALDFGIMGQL
SQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRIDELEAAARSVCEPYFNRPLSEISLAQVLIKLFRVAQRYELT
LQPQLILLQKTLLNIEGVGRQLDPRLDIWAVARPVLERILRERYSPRRVLRELSKRLPEIMTHAPDMPRLVYSWLTQQVE
GRHQIAIRSPELLALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSWISGGAGSAALLVAWLRR
>Mature_557_residues
MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAAQSRGARLRLALQELGPIFVKFGQILSTRRDLI
PADVAEELTLLQDRVKPFDGQAARLIVEAALGLPVSVAFASFDTVPLASASIAQVHAATLPPDANGVRREVVVKVLRPEI
ERQIDADIALLHSLATLVERTHPRADKIRPREVVAEIEGTLAAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAER
ALTLERVYGIPSDDIAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSDPERRLNPRFIALDFGIMGQL
SQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRIDELEAAARSVCEPYFNRPLSEISLAQVLIKLFRVAQRYELT
LQPQLILLQKTLLNIEGVGRQLDPRLDIWAVARPVLERILRERYSPRRVLRELSKRLPEIMTHAPDMPRLVYSWLTQQVE
GRHQIAIRSPELLALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSWISGGAGSAALLVAWLRR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily

Homologues:

Organism=Homo sapiens, GI41393593, Length=278, Percent_Identity=32.0143884892086, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI40254938, Length=349, Percent_Identity=27.2206303724928, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI217035081, Length=227, Percent_Identity=29.9559471365639, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI32261307, Length=338, Percent_Identity=24.2603550295858, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI34147522, Length=293, Percent_Identity=25.938566552901, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI2367309, Length=551, Percent_Identity=46.2794918330309, Blast_Score=448, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17559152, Length=346, Percent_Identity=24.8554913294798, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=373, Percent_Identity=28.4182305630027, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323282, Length=298, Percent_Identity=26.510067114094, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6325148, Length=443, Percent_Identity=22.3476297968397, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321319, Length=315, Percent_Identity=26.031746031746, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24662575, Length=283, Percent_Identity=29.3286219081272, Blast_Score=114, Evalue=3e-25,
Organism=Drosophila melanogaster, GI22024280, Length=287, Percent_Identity=25.4355400696864, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI18859849, Length=282, Percent_Identity=28.3687943262411, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UBIB_XANAC (Q8PQT0)

Other databases:

- EMBL:   AE008923
- RefSeq:   NP_640598.1
- ProteinModelPortal:   Q8PQT0
- GeneID:   1154313
- GenomeReviews:   AE008923_GR
- KEGG:   xac:XAC0242
- NMPDR:   fig|190486.1.peg.242
- HOGENOM:   HBG593509
- OMA:   RIQRVVI
- ProtClustDB:   PRK04750
- BioCyc:   XAXO190486:XAC0242-MONOMER
- HAMAP:   MF_00414
- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232
- TIGRFAMs:   TIGR01982

Pfam domain/function: PF03109 ABC1; SSF56112 Kinase_like

EC number: NA

Molecular weight: Translated: 62634; Mature: 62634

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc9befb0)-; HASH(0xc97a700)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAAQSRGARLRLALQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEHH
ELGPIFVKFGQILSTRRDLIPADVAEELTLLQDRVKPFDGQAARLIVEAALGLPVSVAFA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEHHH
SFDTVPLASASIAQVHAATLPPDANGVRREVVVKVLRPEIERQIDADIALLHSLATLVER
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THPRADKIRPREVVAEIEGTLAAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAER
CCCCCCCCCHHHHHHHHHCHHHEEEECCCCCCCHHHHHHHHCCCCCEECHHHHHHHHHHH
ALTLERVYGIPSDDIAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSD
HHHHHHHCCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCEECCCCCCCEEECCC
PERRLNPRFIALDFGIMGQLSQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRID
CCCCCCCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ELEAAARSVCEPYFNRPLSEISLAQVLIKLFRVAQRYELTLQPQLILLQKTLLNIEGVGR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEECCCHHHHHHHHHHHHHCCCC
QLDPRLDIWAVARPVLERILRERYSPRRVLRELSKRLPEIMTHAPDMPRLVYSWLTQQVE
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GRHQIAIRSPELLALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSW
CCCEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEECHHHHHH
ISGGAGSAALLVAWLRR
HCCCCCHHHHHHHHHHH
>Mature Secondary Structure
MKAILRASRIGRVILRYRLDALLEGTPAERWLRLAKPFVPRASAEIAAQSRGARLRLALQ
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEHH
ELGPIFVKFGQILSTRRDLIPADVAEELTLLQDRVKPFDGQAARLIVEAALGLPVSVAFA
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEHHH
SFDTVPLASASIAQVHAATLPPDANGVRREVVVKVLRPEIERQIDADIALLHSLATLVER
CCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
THPRADKIRPREVVAEIEGTLAAELDLQREGANASVLRRFWEGSDDLYVPEVIWSHTAER
CCCCCCCCCHHHHHHHHHCHHHEEEECCCCCCCHHHHHHHHCCCCCEECHHHHHHHHHHH
ALTLERVYGIPSDDIAKLDAAGIDRKALAAKGVRVFYTQVFRDNFFHADAHAGNIWVDSD
HHHHHHHCCCCCHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHCCCEECCCCCCCEEECCC
PERRLNPRFIALDFGIMGQLSQEDQYYLAENFMAIFHKDYRRMAELHVEAGWMPSNVRID
CCCCCCCEEEEEECCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ELEAAARSVCEPYFNRPLSEISLAQVLIKLFRVAQRYELTLQPQLILLQKTLLNIEGVGR
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCEECCCHHHHHHHHHHHHHCCCC
QLDPRLDIWAVARPVLERILRERYSPRRVLRELSKRLPEIMTHAPDMPRLVYSWLTQQVE
CCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
GRHQIAIRSPELLALDLSLRKLQTRVVTAITGSGLLVVAAVLYGLHPDGWYLGTVPVWSW
CCCEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEECHHHHHH
ISGGAGSAALLVAWLRR
HCCCCCHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217