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The map label for this gene is cdh [C]

Identifier: 21241012

GI number: 21241012

Start: 286912

End: 287922

Strand: Direct

Name: cdh [C]

Synonym: XAC0238

Alternate gene names: 21241012

Gene position: 286912-287922 (Clockwise)

Preceding gene: 77748519

Following gene: 21241013

Centisome position: 5.54

GC content: 65.48

Gene sequence:

>1011_bases
ATGAAGGTATTGGTGACCGGTGGTGGCGGCTTTCTTGGCCAGGCGTTGTGCCGCGGCCTGCGCGCGCGTGGGCACGAGGT
GGTGAGCTTCCAGCGCGGCGATTACCCGGTGCTGCAACGCCTGGGCGTGGGCCAGATCCGCGGCGACCTGGCCGACCCGC
AGGCGGTGCGGCACGCCTTCGCTGGTATCGATGCGGTGTTCCACAATGCCGCCAAGGCCGGCGCATGGGGCAGTTACGAC
AGCTATCACCAGGCCAATGTGGTGGGTACGCAGAACGTGATCGAGGCCTGTCGCGCCAATGGCGTGCCGCGGCTGATCTA
TACCTCCACGCCCAGCGTCACCCATCGCGCCACCAACCCGGTGGAAGGACTCGGTGCCGATGAAGTGCCGTATGGCGACG
ATCTGCGCGCCGCCTACGCGGCGACCAAGGCCATTGCCGAACGTGCAGTGCTGGCCGCCAACGATGCCCAGTTGGCGACA
GTGGCACTGCGACCGCGCCTGATCTGGGGGCCGGGCGACAATCATTTGTTGCCGCGCCTGGCAGCGCGTGCGCGTGCCGG
GCGGCTGCGCATGGTCGGCGATGGCGGCAATCTGGTCGACAGCACGTACATCGACAACGCCGCGCAGGCGCATTTCGATG
CGTTCGAACACCTTGCCGTGGGCGCTGCCTGCGCGGGCAGGGCGTACTTCATTTCCAACGGCGAACCGCTGCCGATGCGC
GAGTTGCTCAATCGATTGCTGGCTGCGGTGGATGCGCCGGCGGTCACGTGCTCGCTGTCGTTCAACACCGCCTACCGCAT
CGGTGCGGTGTGCGAGACGCTATGGCCACTGTTGCGTCTGCCAGGCGAAGTGCCGTTGACGCGTTTTCTGGTGGAACAGC
TGTGTACGCCGCATTGGTACAGCATGGAGCCGGCACGTCGCGACTTCGGCTATGTACCGCGCATCAGCATCGAAGAAGGC
CTGCAACGGCTGCGATCCTCATCTTCCAACGACATCGCCATCACCCGATAA

Upstream 100 bases:

>100_bases
TCGTCGACGTCCAGACTGCATGGCTACGCGTCGACGAGCAGATCGCCAAGTCGGGTGTGGCCGGCTATGGTGTCGTCCCT
CAGAGGCGAGGTGTGGTGCG

Downstream 100 bases:

>100_bases
AGACCGGCATATCCACAAGATACGTCTGCGCCGATTCGGCACGACAACTTCTGGATACCTTGCCATGCTGCATTACGCCA
TCATCTTCTTCGTCATCGCC

Product: NAD(P)H steroid dehydrogenase

Products: NA

Alternate protein names: Cholesterol dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3-beta-HSD; 3BHSD; 3-beta hydroxysterol dehydrogenase; 3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase; Steroid Delta-isomerase; Delta-5-3-ketosteroid isomerase [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MKVLVTGGGGFLGQALCRGLRARGHEVVSFQRGDYPVLQRLGVGQIRGDLADPQAVRHAFAGIDAVFHNAAKAGAWGSYD
SYHQANVVGTQNVIEACRANGVPRLIYTSTPSVTHRATNPVEGLGADEVPYGDDLRAAYAATKAIAERAVLAANDAQLAT
VALRPRLIWGPGDNHLLPRLAARARAGRLRMVGDGGNLVDSTYIDNAAQAHFDAFEHLAVGAACAGRAYFISNGEPLPMR
ELLNRLLAAVDAPAVTCSLSFNTAYRIGAVCETLWPLLRLPGEVPLTRFLVEQLCTPHWYSMEPARRDFGYVPRISIEEG
LQRLRSSSSNDIAITR

Sequences:

>Translated_336_residues
MKVLVTGGGGFLGQALCRGLRARGHEVVSFQRGDYPVLQRLGVGQIRGDLADPQAVRHAFAGIDAVFHNAAKAGAWGSYD
SYHQANVVGTQNVIEACRANGVPRLIYTSTPSVTHRATNPVEGLGADEVPYGDDLRAAYAATKAIAERAVLAANDAQLAT
VALRPRLIWGPGDNHLLPRLAARARAGRLRMVGDGGNLVDSTYIDNAAQAHFDAFEHLAVGAACAGRAYFISNGEPLPMR
ELLNRLLAAVDAPAVTCSLSFNTAYRIGAVCETLWPLLRLPGEVPLTRFLVEQLCTPHWYSMEPARRDFGYVPRISIEEG
LQRLRSSSSNDIAITR
>Mature_336_residues
MKVLVTGGGGFLGQALCRGLRARGHEVVSFQRGDYPVLQRLGVGQIRGDLADPQAVRHAFAGIDAVFHNAAKAGAWGSYD
SYHQANVVGTQNVIEACRANGVPRLIYTSTPSVTHRATNPVEGLGADEVPYGDDLRAAYAATKAIAERAVLAANDAQLAT
VALRPRLIWGPGDNHLLPRLAARARAGRLRMVGDGGNLVDSTYIDNAAQAHFDAFEHLAVGAACAGRAYFISNGEPLPMR
ELLNRLLAAVDAPAVTCSLSFNTAYRIGAVCETLWPLLRLPGEVPLTRFLVEQLCTPHWYSMEPARRDFGYVPRISIEEG
LQRLRSSSSNDIAITR

Specific function: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-beta-HSD family [H]

Homologues:

Organism=Homo sapiens, GI193211614, Length=333, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI8393516, Length=333, Percent_Identity=33.3333333333333, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI310132178, Length=329, Percent_Identity=35.258358662614, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI310113012, Length=329, Percent_Identity=35.258358662614, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI239745448, Length=329, Percent_Identity=34.9544072948328, Blast_Score=134, Evalue=8e-32,
Organism=Homo sapiens, GI116268111, Length=356, Percent_Identity=32.8651685393258, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI4504507, Length=351, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI260763931, Length=350, Percent_Identity=30.5714285714286, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4504509, Length=350, Percent_Identity=30.5714285714286, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI19923621, Length=350, Percent_Identity=31.7142857142857, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI218563686, Length=183, Percent_Identity=36.6120218579235, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI218563684, Length=183, Percent_Identity=36.6120218579235, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI87081792, Length=335, Percent_Identity=28.0597014925373, Blast_Score=108, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17570557, Length=330, Percent_Identity=29.6969696969697, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193211272, Length=341, Percent_Identity=25.5131964809384, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17509709, Length=372, Percent_Identity=25.2688172043011, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321437, Length=347, Percent_Identity=33.4293948126801, Blast_Score=132, Evalue=6e-32,
Organism=Drosophila melanogaster, GI21355349, Length=277, Percent_Identity=32.4909747292419, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =1.1.1.145; =5.3.3.1 [H]

Molecular weight: Translated: 36180; Mature: 36180

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLVTGGGGFLGQALCRGLRARGHEVVSFQRGDYPVLQRLGVGQIRGDLADPQAVRHAF
CEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCHHHHCCCCCHHHHHHHH
AGIDAVFHNAAKAGAWGSYDSYHQANVVGTQNVIEACRANGVPRLIYTSTPSVTHRATNP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
VEGLGADEVPYGDDLRAAYAATKAIAERAVLAANDAQLATVALRPRLIWGPGDNHLLPRL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCHHHHH
AARARAGRLRMVGDGGNLVDSTYIDNAAQAHFDAFEHLAVGAACAGRAYFISNGEPLPMR
HHHHCCCCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHH
ELLNRLLAAVDAPAVTCSLSFNTAYRIGAVCETLWPLLRLPGEVPLTRFLVEQLCTPHWY
HHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
SMEPARRDFGYVPRISIEEGLQRLRSSSSNDIAITR
CCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEC
>Mature Secondary Structure
MKVLVTGGGGFLGQALCRGLRARGHEVVSFQRGDYPVLQRLGVGQIRGDLADPQAVRHAF
CEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCHHHHCCCCCHHHHHHHH
AGIDAVFHNAAKAGAWGSYDSYHQANVVGTQNVIEACRANGVPRLIYTSTPSVTHRATNP
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
VEGLGADEVPYGDDLRAAYAATKAIAERAVLAANDAQLATVALRPRLIWGPGDNHLLPRL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEECCCCCCHHHHH
AARARAGRLRMVGDGGNLVDSTYIDNAAQAHFDAFEHLAVGAACAGRAYFISNGEPLPMR
HHHHCCCCEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCHH
ELLNRLLAAVDAPAVTCSLSFNTAYRIGAVCETLWPLLRLPGEVPLTRFLVEQLCTPHWY
HHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCC
SMEPARRDFGYVPRISIEEGLQRLRSSSSNDIAITR
CCCHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]