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The map label for this gene is yfcY [H]

Identifier: 21240987

GI number: 21240987

Start: 260718

End: 262013

Strand: Direct

Name: yfcY [H]

Synonym: XAC0213

Alternate gene names: 21240987

Gene position: 260718-262013 (Clockwise)

Preceding gene: 21240984

Following gene: 21240991

Centisome position: 5.04

GC content: 68.52

Gene sequence:

>1296_bases
ATGCCAGGTCAACCGATGCCCGCAGCCCGTCCCGTCGCCATTCTGGGCGGCGTTCGTATCCCGTTCTGTCGTCAGAACAC
CGCCTACGCGGACGTGGGCAACCTGGGCATGTCGGTGCGCACGCTGGGCGCGTTGGTCGAGCGCTTCGGGTTGCATGGGC
AGCAATTGGGCGAAGTGGCGATGGGCGCGGTGATCAAGCACTCCGCGGACTGGAACCTGGCGCGCGAGGCGGCGCTGTCG
TCGGGTCTGTCGCCGCTGACGCCGGGCATCACCCTGCAGCGCGCCTGCGGCACCAGCCTGGATTCGGTCATCACCATCGC
CAACAAGATCGCGCTGGGGCAGATCGACTCGGGCATCGGCGGCGGCTCCGACACCACCTCCGAAGTGCCGATCGTGTACG
GCAAGAAGTTGCGCGCACGGCTGCTGGCCGCCAACCGCGCCAAGGCCACCGGCGACAAGCTCAGGGCGCTGCTGCGCGGC
TTCAAGCTGGCCGAGCTCAAGCCCGAATTCCCCGGCGTGGCCGAGCCGCGCACCGGCAAGAGCATGGGCGACCATTGCGA
GGACATGGCCAAGGAATGGAACATCTCGCGCGATTCGCAGGACGAATGGGCGGTGGCCTCGCACCACAAGCTGGCCGCTG
CCTATGAGCGCGGTTTCTTCGACGCGCTGATCGCGCCGTTCCGCGGCGTCTCGCGCGACAACATCCTGCGCGCCGACACC
TCGCTGGAAAAACTCGCGACCTTGCGACCGGCCTTCGACAAGACCTCCGGCCGTGGCACGTTGACCGCTGCCAATTCCAC
CCCGCTCACCGATGGCGCCGCCGCGGTGCTGCTCTCCAGCGAAGCCTGGGCGTTGGCGCATGGCCACACGCCGATGGCCT
ACCTGCGCGATGCACAGGTGGCGGCAGTCGACTTCGTGCATGGCGAAGGCCTGCTGATGGCGCCCACCATTGCGGTGCCG
CAGATGCTGGCGCGCCAGGGCCTGACCCTGCAGGACTTCGATATCTACGAAATCCACGAGGCCTTCGCCGCGCAGGTGCT
GTGCACGCTGCGCGCGTGGGAGAGCGAGGACTACTGCCGCAACCGGCTGGGCCTGGACGCGCCGCTGGGCCGCATCGACC
CGGACAAGATCAATCCGCTGGGCTCGTCGCTGGCCACCGGCCATCCATTCGCCGCCACTGGCGCACGCGTGGTGGCCACC
GCTGCCAAGCAGTTGGAAGAGCGCGGCGGCGGCCGCGCGTTGATTTCGATCTGCACCGCCGGCGGCATGGGCGTGGTGGC
CATCGTCGAGCGCTGA

Upstream 100 bases:

>100_bases
GGTCTTGCTCATGATTCGCGGTTGGCCCATCACGGGGTCGAAGCTACACTGCGGCCATTATGCCTGCCGGCCCTGTGCAG
GCCATGTCCCCGAGTCCCCC

Downstream 100 bases:

>100_bases
TGCCACTGCGCGGTACGGGATTGGGCATGGGTGATCCGGGATTCGCAGGCGCAGTCGCCGCCTTTGCGAATCCTCTCCTT
CATTCCATCGCTGCGCGTGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: ACSs; Acetyl-CoA acyltransferase; Acyl-CoA ligase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MPGQPMPAARPVAILGGVRIPFCRQNTAYADVGNLGMSVRTLGALVERFGLHGQQLGEVAMGAVIKHSADWNLAREAALS
SGLSPLTPGITLQRACGTSLDSVITIANKIALGQIDSGIGGGSDTTSEVPIVYGKKLRARLLAANRAKATGDKLRALLRG
FKLAELKPEFPGVAEPRTGKSMGDHCEDMAKEWNISRDSQDEWAVASHHKLAAAYERGFFDALIAPFRGVSRDNILRADT
SLEKLATLRPAFDKTSGRGTLTAANSTPLTDGAAAVLLSSEAWALAHGHTPMAYLRDAQVAAVDFVHGEGLLMAPTIAVP
QMLARQGLTLQDFDIYEIHEAFAAQVLCTLRAWESEDYCRNRLGLDAPLGRIDPDKINPLGSSLATGHPFAATGARVVAT
AAKQLEERGGGRALISICTAGGMGVVAIVER

Sequences:

>Translated_431_residues
MPGQPMPAARPVAILGGVRIPFCRQNTAYADVGNLGMSVRTLGALVERFGLHGQQLGEVAMGAVIKHSADWNLAREAALS
SGLSPLTPGITLQRACGTSLDSVITIANKIALGQIDSGIGGGSDTTSEVPIVYGKKLRARLLAANRAKATGDKLRALLRG
FKLAELKPEFPGVAEPRTGKSMGDHCEDMAKEWNISRDSQDEWAVASHHKLAAAYERGFFDALIAPFRGVSRDNILRADT
SLEKLATLRPAFDKTSGRGTLTAANSTPLTDGAAAVLLSSEAWALAHGHTPMAYLRDAQVAAVDFVHGEGLLMAPTIAVP
QMLARQGLTLQDFDIYEIHEAFAAQVLCTLRAWESEDYCRNRLGLDAPLGRIDPDKINPLGSSLATGHPFAATGARVVAT
AAKQLEERGGGRALISICTAGGMGVVAIVER
>Mature_430_residues
PGQPMPAARPVAILGGVRIPFCRQNTAYADVGNLGMSVRTLGALVERFGLHGQQLGEVAMGAVIKHSADWNLAREAALSS
GLSPLTPGITLQRACGTSLDSVITIANKIALGQIDSGIGGGSDTTSEVPIVYGKKLRARLLAANRAKATGDKLRALLRGF
KLAELKPEFPGVAEPRTGKSMGDHCEDMAKEWNISRDSQDEWAVASHHKLAAAYERGFFDALIAPFRGVSRDNILRADTS
LEKLATLRPAFDKTSGRGTLTAANSTPLTDGAAAVLLSSEAWALAHGHTPMAYLRDAQVAAVDFVHGEGLLMAPTIAVPQ
MLARQGLTLQDFDIYEIHEAFAAQVLCTLRAWESEDYCRNRLGLDAPLGRIDPDKINPLGSSLATGHPFAATGARVVATA
AKQLEERGGGRALISICTAGGMGVVAIVER

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4504327, Length=429, Percent_Identity=38.6946386946387, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI4501853, Length=445, Percent_Identity=31.0112359550562, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI148539872, Length=434, Percent_Identity=29.0322580645161, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI167614485, Length=440, Percent_Identity=27.9545454545455, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4557237, Length=442, Percent_Identity=27.3755656108597, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI194353979, Length=105, Percent_Identity=40.9523809523809, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=39.1727493917275, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788554, Length=433, Percent_Identity=33.0254041570439, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1787663, Length=435, Percent_Identity=32.183908045977, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI87082165, Length=430, Percent_Identity=29.5348837209302, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI48994986, Length=433, Percent_Identity=30.2540415704388, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17551802, Length=427, Percent_Identity=38.8758782201405, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI25147385, Length=426, Percent_Identity=27.6995305164319, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17535921, Length=432, Percent_Identity=26.8518518518519, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI133906874, Length=429, Percent_Identity=27.039627039627, Blast_Score=129, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322031, Length=376, Percent_Identity=32.9787234042553, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6325229, Length=391, Percent_Identity=29.156010230179, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=38.8505747126437, Blast_Score=287, Evalue=9e-78,
Organism=Drosophila melanogaster, GI24655093, Length=429, Percent_Identity=27.7389277389277, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24640423, Length=432, Percent_Identity=27.0833333333333, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=26.7175572519084, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012806
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 45561; Mature: 45429

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGQPMPAARPVAILGGVRIPFCRQNTAYADVGNLGMSVRTLGALVERFGLHGQQLGEVA
CCCCCCCCCCCEEEECCCCCCEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
MGAVIKHSADWNLAREAALSSGLSPLTPGITLQRACGTSLDSVITIANKIALGQIDSGIG
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHHHCCCCCCCC
GGSDTTSEVPIVYGKKLRARLLAANRAKATGDKLRALLRGFKLAELKPEFPGVAEPRTGK
CCCCCCCCCCEEECHHHHHHHHHHCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCCC
SMGDHCEDMAKEWNISRDSQDEWAVASHHKLAAAYERGFFDALIAPFRGVSRDNILRADT
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
SLEKLATLRPAFDKTSGRGTLTAANSTPLTDGAAAVLLSSEAWALAHGHTPMAYLRDAQV
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEECCCCCHHHHCCCCE
AAVDFVHGEGLLMAPTIAVPQMLARQGLTLQDFDIYEIHEAFAAQVLCTLRAWESEDYCR
EEEEEEECCCEEECCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHH
NRLGLDAPLGRIDPDKINPLGSSLATGHPFAATGARVVATAAKQLEERGGGRALISICTA
HHCCCCCCCCCCCHHHCCCCCCHHCCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEEEECC
GGMGVVAIVER
CCCEEEEEEEC
>Mature Secondary Structure 
PGQPMPAARPVAILGGVRIPFCRQNTAYADVGNLGMSVRTLGALVERFGLHGQQLGEVA
CCCCCCCCCCEEEECCCCCCEECCCCCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHH
MGAVIKHSADWNLAREAALSSGLSPLTPGITLQRACGTSLDSVITIANKIALGQIDSGIG
HHHHHHCCCCCHHHHHHHHHCCCCCCCCCCEEHHHHCCCHHHHHHHHHHHHHCCCCCCCC
GGSDTTSEVPIVYGKKLRARLLAANRAKATGDKLRALLRGFKLAELKPEFPGVAEPRTGK
CCCCCCCCCCEEECHHHHHHHHHHCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCCC
SMGDHCEDMAKEWNISRDSQDEWAVASHHKLAAAYERGFFDALIAPFRGVSRDNILRADT
CHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
SLEKLATLRPAFDKTSGRGTLTAANSTPLTDGAAAVLLSSEAWALAHGHTPMAYLRDAQV
HHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCEEEECCCCCHHHHCCCCE
AAVDFVHGEGLLMAPTIAVPQMLARQGLTLQDFDIYEIHEAFAAQVLCTLRAWESEDYCR
EEEEEEECCCEEECCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHCCCHHHHH
NRLGLDAPLGRIDPDKINPLGSSLATGHPFAATGARVVATAAKQLEERGGGRALISICTA
HHCCCCCCCCCCCHHHCCCCCCHHCCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEEEECC
GGMGVVAIVER
CCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA