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The map label for this gene is gds [H]

Identifier: 21226891

GI number: 21226891

Start: 942865

End: 943752

Strand: Reverse

Name: gds [H]

Synonym: MM_0789

Alternate gene names: 21226891

Gene position: 943752-942865 (Counterclockwise)

Preceding gene: 21226892

Following gene: 21226890

Centisome position: 23.04

GC content: 44.59

Gene sequence:

>888_bases
ATGCCCGTCAAAGTACACGGAGTAATACTGATGAATATTGAAGAATGGGAAGAATACAGATATGTAGAAGCCGGAATAAA
AGAATCTATCACTCTTATAGAGGATCCTGGCTTAAAAAAAATGGTTGAGCATGTCTGTCATTCCGGAGGAAAAAGAATTC
GGCCAATTATCCTCCTTCTGGTCAGCGAGATCTGTTCAGGCTCGTATTCCCGGAGCCTTAATGCAGCTCTGGCAGTTGAA
ATGATGCATTCGGCTTCCTTAATTCACGATGACCTGCTGGATCAGGGGCTTGTCCGAAGAAACCTGCCTTCGGCTCCTGA
AAAATTCGGGCCTTCAGGAGCCCTGCTCTGCGGAGACTATCTTATTGCAAAATCAATTGCTTTCATTTCTCCTTATGGGG
AAAAAGTTATTCAGGACTTTGGGAAAGCAGGGATGGACATGGCAGAAGGAGAAGTCCTTGACCTGAAGCTTGAAGATGAG
AGTTTCGGAGAAAATGATTACTTTAAATGCATCTATAAAAAGACGGCTTCTCTATTCGCAATCAGTGCATCCATCGGGGC
TTATACGGGCGGAGCTGAAGAAGAGCTTGCAGAACGTTTCAGTCATTTCGGAAATGCCCTCGGAACGGCATACCAGATTG
TTGATGATATCCTTGAATTCCTTGAGGTTGTCGAGGGAAAGGAGTCTAAATTCACATCCGAAACCCTGCCGCACATCTAT
ATGAAAAGCACGTCAAAGGAAGAAGCTCTCAAAAAGTCAATTGACTGCGTAAAGTTGCATGTTGCTGCCGCAAAAGAAAC
CCTCGAAACGTTCAGAGAATGTCCTGCAAGAGACAAGCTGTTCCAGATTACGGATTATATAACCGTCGACATGCTTGAGA
ACCTCTGA

Upstream 100 bases:

>100_bases
TAGGGAACTTACCTTCCAACCTTGCTGAAGGAAAACAGGTGACCATCAGAGGATCAATGATTTCCGAATCTACCTTTGAG
GCAAATAAGATAGTTACCGG

Downstream 100 bases:

>100_bases
CAAACCTTAAACTGTCCTGAAAAATGAATTGGTTCTTTAAAATGAATTGGTTCTTTAAAATGAATTGGTTCTTTAAAATG
AATTGGTTCTTTAAAATGAA

Product: farnesyltranstransferase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPVKVHGVILMNIEEWEEYRYVEAGIKESITLIEDPGLKKMVEHVCHSGGKRIRPIILLLVSEICSGSYSRSLNAALAVE
MMHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDYLIAKSIAFISPYGEKVIQDFGKAGMDMAEGEVLDLKLEDE
SFGENDYFKCIYKKTASLFAISASIGAYTGGAEEELAERFSHFGNALGTAYQIVDDILEFLEVVEGKESKFTSETLPHIY
MKSTSKEEALKKSIDCVKLHVAAAKETLETFRECPARDKLFQITDYITVDMLENL

Sequences:

>Translated_295_residues
MPVKVHGVILMNIEEWEEYRYVEAGIKESITLIEDPGLKKMVEHVCHSGGKRIRPIILLLVSEICSGSYSRSLNAALAVE
MMHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDYLIAKSIAFISPYGEKVIQDFGKAGMDMAEGEVLDLKLEDE
SFGENDYFKCIYKKTASLFAISASIGAYTGGAEEELAERFSHFGNALGTAYQIVDDILEFLEVVEGKESKFTSETLPHIY
MKSTSKEEALKKSIDCVKLHVAAAKETLETFRECPARDKLFQITDYITVDMLENL
>Mature_294_residues
PVKVHGVILMNIEEWEEYRYVEAGIKESITLIEDPGLKKMVEHVCHSGGKRIRPIILLLVSEICSGSYSRSLNAALAVEM
MHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDYLIAKSIAFISPYGEKVIQDFGKAGMDMAEGEVLDLKLEDES
FGENDYFKCIYKKTASLFAISASIGAYTGGAEEELAERFSHFGNALGTAYQIVDDILEFLEVVEGKESKFTSETLPHIYM
KSTSKEEALKKSIDCVKLHVAAAKETLETFRECPARDKLFQITDYITVDMLENL

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=216, Percent_Identity=32.8703703703704, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI1789578, Length=216, Percent_Identity=31.9444444444444, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786623, Length=260, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17505681, Length=221, Percent_Identity=27.6018099547511, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24651612, Length=202, Percent_Identity=29.7029702970297, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 32747; Mature: 32616

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVKVHGVILMNIEEWEEYRYVEAGIKESITLIEDPGLKKMVEHVCHSGGKRIRPIILLL
CCEEEEEEEEEEHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHH
VSEICSGSYSRSLNAALAVEMMHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHH
LIAKSIAFISPYGEKVIQDFGKAGMDMAEGEVLDLKLEDESFGENDYFKCIYKKTASLFA
HHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHE
ISASIGAYTGGAEEELAERFSHFGNALGTAYQIVDDILEFLEVVEGKESKFTSETLPHIY
EEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHH
MKSTSKEEALKKSIDCVKLHVAAAKETLETFRECPARDKLFQITDYITVDMLENL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVKVHGVILMNIEEWEEYRYVEAGIKESITLIEDPGLKKMVEHVCHSGGKRIRPIILLL
CEEEEEEEEEEHHHHHHHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHH
VSEICSGSYSRSLNAALAVEMMHSASLIHDDLLDQGLVRRNLPSAPEKFGPSGALLCGDY
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCHHHHH
LIAKSIAFISPYGEKVIQDFGKAGMDMAEGEVLDLKLEDESFGENDYFKCIYKKTASLFA
HHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHE
ISASIGAYTGGAEEELAERFSHFGNALGTAYQIVDDILEFLEVVEGKESKFTSETLPHIY
EEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCHHH
MKSTSKEEALKKSIDCVKLHVAAAKETLETFRECPARDKLFQITDYITVDMLENL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8182085 [H]