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The map label for this gene is atpI [H]

Identifier: 21226887

GI number: 21226887

Start: 937143

End: 939110

Strand: Reverse

Name: atpI [H]

Synonym: MM_0785

Alternate gene names: 21226887

Gene position: 939110-937143 (Counterclockwise)

Preceding gene: 21226888

Following gene: 21226886

Centisome position: 22.93

GC content: 43.09

Gene sequence:

>1968_bases
TTGAGAGGGCGGTCCTTAATGAGTAGACCTAAAGAGATGACAAGGGCCGTTATTGTCGGGCATAAAAGCATTTTAGAAGA
AACCATCGATGCATTACATGATATTAATCTCTTTCACATAGAAGATTTTGTCGAAGACGAGTCTGGTTTTAAGATCAGCA
AGCCATTTAAAAACGGAGAAGAAGTCTCGAAAAAGCTTGTGAAGATCCGTTCCATCGCCAATTATTTGGGGATTGAAAGC
AAAAAACCGGTAGTTCAGAAATCTGACGCTGTTCTGCGCGAACTTGACACGAAGTTGAATGAACTGGATAGGACAATTTC
AGCTAAGACGGAAACAATCTCCCAGCTTGAAAATGAATTGAAAGACCTGGATGCCCAGAAAAGGGAAATCCTGCCTTATC
TGTCCATTAATCTCGACTTCGAATATTACCGTGGCTACGAAAGCCTCAAGGTTTTCGCAGGTACTGTAAAAGGTAGCCTG
GAAGAAAGTCAGATTTCGAGCATCACCAAAGCTTACGAGCTGTACTATGACCCTCAGTCAAAAGCAGTTGTACTGTTTGT
AGCTAAAAATGATGCCGACAAAGTTTACGAATTACTTCAGGGTCTTGGATTCAAAGAACTTAGAGTTCCGGAAAGAGGTG
GTGTCCCAAGCGAGCTGTTAAGGTTCATTGAACAGAAAGAAGCCGAAGTCACCAGAAGGATCGAATCCTTAAAAGGCGAA
ATCGAGTCCTTGAAAGTCAAGTACGCCGATTTCATCCTTGCCAGCGACGAGGTTCTGAGTATCGAGAGTCAGAAAGCAGA
ACTGCCTCTTAGAATAGCTACATCTGCAAACGCATTCATAATCGACGGATGGACTGCCACCGAGGATTTTGATAAGATTG
TAAGTGTAGTTAACAGTGCCACTAATGGCAAGGCATATGTTACAAGCCTCGAACTTCATCACGAGGAAGAAGAACATGCC
CCTGTCAAATACAACAATTCAAAAGTTGTGGCACCGATGCAGGAAATTATGGATCTGTATTCCAGGCCCAAATATACTGA
ACTCGACCCATCTTCAGCGATTTTCATAACCTTCCCGCTGATATATGGTATGATTCTCGGAGACATCGGATATGCAATAA
TATTGGGGTCACTTGCTCTGGCAATTAAAAAACTGGTAAAGTCAGATGCAGTGAAGCCTCTAATGAATATTCTTATCTAT
TGTCAGATATGGACAATTATCTTTGGAGTTCTTTATGGTGAGTTCCTTGGATTCTCGCTTGCAAGTTCACATACCGCACA
TGGTATGGCAGCAGGTTTGATTCCGGGCTGGGAAACTATAACTCTCTTCGAAAGCATAGGAGGCGAGGAATTTACTTTCC
CAATCCACAGGTCTCACATGGTAATGACTATGATAGCAATAAGTGTCTTGGTAGGACTGATTCACTTAAATCTCGGTTTC
CTGTTCGGGTTTTCAAACATCGCCAGGCACCACGGGATTAAACACGCGGTCCTAGAAAAAGGCAGTTGGATCATTATCGA
GCTTGGTGTGCTCGTTGCAGTTCTCGGCTATTTTGGCGGCATTCAAGTGTTCACCTATGCAGGTGCTCTTATTCTAGTTA
TCGGAGTTGTGATGCTCACCATGGGTGAAGGTATCAAAGGTCCGATCGAGTTGCCATCTCTTATGGGTAATGCACTTTCG
TATGCTCGTATTATCGCAGTCGGTCTGTCTTCGATTTACATTGCAGGTACGGTAAATGATATTGCTTTCGAAATGATTTG
GCCTGATCACTCTCAGATCGGTGCCGCAGCAATAGCTGCAATAATTGTATTCATACTCGGACATGGTCTTAACACTATTC
TGAGTATCATCGCTCCTGGACTGCACGCACTCAGGTTGCAGTATGTAGAATTCTTTGGAAAATTCTATGAAGGCGGGGGC
AGAAAATTCAATCCATTCGGATACATAAGAAAATACACGGAGGAATAA

Upstream 100 bases:

>100_bases
AGAGATAAGATCGTCAACGATGGTGAAAAAAACGCAATAGCCATGTCCCAAAAAGCTCAAGCTAATATCGACAAATCCGT
CAATTACCTAGTACAGGAGT

Downstream 100 bases:

>100_bases
AAACATGGTAGACGCAGCATCAACAGGTCTCTTTTTGGACGCAGCAGGAATGAAAGCACTCGGTGCAGCAATCGCAATCG
CAGTAACTGGTCTTGCATCT

Product: V-type ATP synthase subunit I

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit I [H]

Number of amino acids: Translated: 655; Mature: 655

Protein sequence:

>655_residues
MRGRSLMSRPKEMTRAVIVGHKSILEETIDALHDINLFHIEDFVEDESGFKISKPFKNGEEVSKKLVKIRSIANYLGIES
KKPVVQKSDAVLRELDTKLNELDRTISAKTETISQLENELKDLDAQKREILPYLSINLDFEYYRGYESLKVFAGTVKGSL
EESQISSITKAYELYYDPQSKAVVLFVAKNDADKVYELLQGLGFKELRVPERGGVPSELLRFIEQKEAEVTRRIESLKGE
IESLKVKYADFILASDEVLSIESQKAELPLRIATSANAFIIDGWTATEDFDKIVSVVNSATNGKAYVTSLELHHEEEEHA
PVKYNNSKVVAPMQEIMDLYSRPKYTELDPSSAIFITFPLIYGMILGDIGYAIILGSLALAIKKLVKSDAVKPLMNILIY
CQIWTIIFGVLYGEFLGFSLASSHTAHGMAAGLIPGWETITLFESIGGEEFTFPIHRSHMVMTMIAISVLVGLIHLNLGF
LFGFSNIARHHGIKHAVLEKGSWIIIELGVLVAVLGYFGGIQVFTYAGALILVIGVVMLTMGEGIKGPIELPSLMGNALS
YARIIAVGLSSIYIAGTVNDIAFEMIWPDHSQIGAAAIAAIIVFILGHGLNTILSIIAPGLHALRLQYVEFFGKFYEGGG
RKFNPFGYIRKYTEE

Sequences:

>Translated_655_residues
MRGRSLMSRPKEMTRAVIVGHKSILEETIDALHDINLFHIEDFVEDESGFKISKPFKNGEEVSKKLVKIRSIANYLGIES
KKPVVQKSDAVLRELDTKLNELDRTISAKTETISQLENELKDLDAQKREILPYLSINLDFEYYRGYESLKVFAGTVKGSL
EESQISSITKAYELYYDPQSKAVVLFVAKNDADKVYELLQGLGFKELRVPERGGVPSELLRFIEQKEAEVTRRIESLKGE
IESLKVKYADFILASDEVLSIESQKAELPLRIATSANAFIIDGWTATEDFDKIVSVVNSATNGKAYVTSLELHHEEEEHA
PVKYNNSKVVAPMQEIMDLYSRPKYTELDPSSAIFITFPLIYGMILGDIGYAIILGSLALAIKKLVKSDAVKPLMNILIY
CQIWTIIFGVLYGEFLGFSLASSHTAHGMAAGLIPGWETITLFESIGGEEFTFPIHRSHMVMTMIAISVLVGLIHLNLGF
LFGFSNIARHHGIKHAVLEKGSWIIIELGVLVAVLGYFGGIQVFTYAGALILVIGVVMLTMGEGIKGPIELPSLMGNALS
YARIIAVGLSSIYIAGTVNDIAFEMIWPDHSQIGAAAIAAIIVFILGHGLNTILSIIAPGLHALRLQYVEFFGKFYEGGG
RKFNPFGYIRKYTEE
>Mature_655_residues
MRGRSLMSRPKEMTRAVIVGHKSILEETIDALHDINLFHIEDFVEDESGFKISKPFKNGEEVSKKLVKIRSIANYLGIES
KKPVVQKSDAVLRELDTKLNELDRTISAKTETISQLENELKDLDAQKREILPYLSINLDFEYYRGYESLKVFAGTVKGSL
EESQISSITKAYELYYDPQSKAVVLFVAKNDADKVYELLQGLGFKELRVPERGGVPSELLRFIEQKEAEVTRRIESLKGE
IESLKVKYADFILASDEVLSIESQKAELPLRIATSANAFIIDGWTATEDFDKIVSVVNSATNGKAYVTSLELHHEEEEHA
PVKYNNSKVVAPMQEIMDLYSRPKYTELDPSSAIFITFPLIYGMILGDIGYAIILGSLALAIKKLVKSDAVKPLMNILIY
CQIWTIIFGVLYGEFLGFSLASSHTAHGMAAGLIPGWETITLFESIGGEEFTFPIHRSHMVMTMIAISVLVGLIHLNLGF
LFGFSNIARHHGIKHAVLEKGSWIIIELGVLVAVLGYFGGIQVFTYAGALILVIGVVMLTMGEGIKGPIELPSLMGNALS
YARIIAVGLSSIYIAGTVNDIAFEMIWPDHSQIGAAAIAAIIVFILGHGLNTILSIIAPGLHALRLQYVEFFGKFYEGGG
RKFNPFGYIRKYTEE

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane [H]

COG id: COG1269

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit I

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the V-ATPase 116 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI19924145, Length=256, Percent_Identity=21.484375, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002490 [H]

Pfam domain/function: PF01496 V_ATPase_I [H]

EC number: 3.6.3.14

Molecular weight: Translated: 72665; Mature: 72665

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRSLMSRPKEMTRAVIVGHKSILEETIDALHDINLFHIEDFVEDESGFKISKPFKNGE
CCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCEEECCCCCHH
EVSKKLVKIRSIANYLGIESKKPVVQKSDAVLRELDTKLNELDRTISAKTETISQLENEL
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLDAQKREILPYLSINLDFEYYRGYESLKVFAGTVKGSLEESQISSITKAYELYYDPQS
HHCCCHHHHCCCEEEEEECHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCC
KAVVLFVAKNDADKVYELLQGLGFKELRVPERGGVPSELLRFIEQKEAEVTRRIESLKGE
CEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IESLKVKYADFILASDEVLSIESQKAELPLRIATSANAFIIDGWTATEDFDKIVSVVNSA
HHHHHHHHHHHEEECCCEEEECCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHCC
TNGKAYVTSLELHHEEEEHAPVKYNNSKVVAPMQEIMDLYSRPKYTELDPSSAIFITFPL
CCCCEEEEEEEECCCCCCCCCEEECCCEEEHHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
IYGMILGDIGYAIILGSLALAIKKLVKSDAVKPLMNILIYCQIWTIIFGVLYGEFLGFSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASSHTAHGMAAGLIPGWETITLFESIGGEEFTFPIHRSHMVMTMIAISVLVGLIHLNLGF
HCCCCCCCHHHCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LFGFSNIARHHGIKHAVLEKGSWIIIELGVLVAVLGYFGGIQVFTYAGALILVIGVVMLT
HHHHHHHHHHCCCHHHHHCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
MGEGIKGPIELPSLMGNALSYARIIAVGLSSIYIAGTVNDIAFEMIWPDHSQIGAAAIAA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHEEEEECCCCHHHHHHHHHH
IIVFILGHGLNTILSIIAPGLHALRLQYVEFFGKFYEGGGRKFNPFGYIRKYTEE
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MRGRSLMSRPKEMTRAVIVGHKSILEETIDALHDINLFHIEDFVEDESGFKISKPFKNGE
CCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHCCCCCCEEECCCCCHH
EVSKKLVKIRSIANYLGIESKKPVVQKSDAVLRELDTKLNELDRTISAKTETISQLENEL
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KDLDAQKREILPYLSINLDFEYYRGYESLKVFAGTVKGSLEESQISSITKAYELYYDPQS
HHCCCHHHHCCCEEEEEECHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEECCCC
KAVVLFVAKNDADKVYELLQGLGFKELRVPERGGVPSELLRFIEQKEAEVTRRIESLKGE
CEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IESLKVKYADFILASDEVLSIESQKAELPLRIATSANAFIIDGWTATEDFDKIVSVVNSA
HHHHHHHHHHHEEECCCEEEECCCCCCCCEEEECCCCEEEEECCCCHHHHHHHHHHHHCC
TNGKAYVTSLELHHEEEEHAPVKYNNSKVVAPMQEIMDLYSRPKYTELDPSSAIFITFPL
CCCCEEEEEEEECCCCCCCCCEEECCCEEEHHHHHHHHHHCCCCCCCCCCCCEEEEHHHH
IYGMILGDIGYAIILGSLALAIKKLVKSDAVKPLMNILIYCQIWTIIFGVLYGEFLGFSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASSHTAHGMAAGLIPGWETITLFESIGGEEFTFPIHRSHMVMTMIAISVLVGLIHLNLGF
HCCCCCCCHHHCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
LFGFSNIARHHGIKHAVLEKGSWIIIELGVLVAVLGYFGGIQVFTYAGALILVIGVVMLT
HHHHHHHHHHCCCHHHHHCCCCEEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHH
MGEGIKGPIELPSLMGNALSYARIIAVGLSSIYIAGTVNDIAFEMIWPDHSQIGAAAIAA
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHEEEEECCCCHHHHHHHHHH
IIVFILGHGLNTILSIIAPGLHALRLQYVEFFGKFYEGGGRKFNPFGYIRKYTEE
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]