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The map label for this gene is eif2g [H]

Identifier: 21226696

GI number: 21226696

Start: 725742

End: 727037

Strand: Direct

Name: eif2g [H]

Synonym: MM_0594

Alternate gene names: 21226696

Gene position: 725742-727037 (Clockwise)

Preceding gene: 21226695

Following gene: 21226697

Centisome position: 17.72

GC content: 47.76

Gene sequence:

>1296_bases
ATGCACAGATTTCGGAAAAATACCTGCCTTATATCAGATTATTTTCACTCTACTGGAGGAAACTACAACTTGAGTCAGCC
CTGTGTTAATATCGGCATGGTAGGTCATGTCGACCATGGAAAAACCACACTTGTTAGAGCTTTATCCGGCGTGTGGACGG
ATACGCATAGTGAAGAAGTAAAAAGAGGAATTTCGATAAGATTGGGGTATGCAGATTCCCCATTCATGAAATGCCCGAAA
TGTCCTGAACCTCAGTGTTATACTGTCGAAAAAACCTGCCCTAACTGCGGAGAAAAAACGGAAGAGCACAGGACAGTTTC
CTTTGTAGACGCTCCCGGGCACGAAACCCTGATGGCAACCATGCTTTCCGGTGCTGCAATTATGGACGGGGCAGTGCTTG
TAATTGCCGCAAACGAAGACTGCCCGCAGCCCCAGACAAAGGAACACCTCATGGCCCTGGACATCATCGGGATTAAAAAC
ATTGTTATAGTCCAGAATAAAATCGACCTTGTGTCAAGGGAAAAAATTATCGAGAACTACCACCAGATAAAAGAGTTTGT
CAAGGGCACTGTTGCCGAAAATGCACCTGTAATCCCTATTTCTGCCCAGCAGAATATTAATATTGATATTCTCATCGACG
CCCTGGAAACCCAGATCCCGACTCCTTCCCATAAAGTAGATAAGCCAGCCAGCATGCTGATTGCCCGGTCTTTTGACATT
AATAAACCAGGTGCTTCAATTGAGGAAATCCGCGGAGGAGTTATAGGAGGAACCCTTACCGAGGGCGTGCTTCATCCCGG
AGACGAGCTTGAAATCAGGCCTGGAATAAAGGTCACAACAGAAGGCAGCACCAGATGGATCCCTATTTTGACCACGGTTT
CATCAATTTATGCAGGAGCAACAAAGGTAGATGAAGCAACCCCCGGAGGGCTTCTTGCCGTAGGAACTTATCTTGACCCT
ACCCTGACAAAGGGAGACTCCCTTACGGGGCAGATGGCAGGTGTTCCGGGTACCCTTCCTGAAACAAGGCACCAGTTTGT
TATGGAGCTTCATCTTCTGGACAGGGTTGTGGGAGTTACCAGGGAAGAGAAAATTAATGAAATCAAGACCAGTGAACCCC
TTATGCTCAACATAGGAACCGCTACAACTGTAGGTGTGGTCACAAGTGCCCGGAAGAATGAAGCTCAGGTGGCACTCAAG
CGTCCGATAAGTGCAGCCATAGGAGCTATGGTTGCGATCAGCAGGAGAGTCGATTCCCGCTGGCGGCTCATTGGAGTAGG
GGTAATAAAGAGTTGA

Upstream 100 bases:

>100_bases
AGTTACAATTACAATAAACCAAGGATCACATAATAAAATTAAGAATCAGACCAGGTTTGAAATTGAAATCTGAAAGCCCC
AGGGAAGAAAAAAGTCCTGA

Downstream 100 bases:

>100_bases
AAATTATAATTGACACCAACGGATTCATGATCCCTGTCCAGTTCGGAGTGGATATCTTTGAAGAGCTGAAAAGGCTGGGT
TTTAATGAGTTCTATGTGCC

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MHRFRKNTCLISDYFHSTGGNYNLSQPCVNIGMVGHVDHGKTTLVRALSGVWTDTHSEEVKRGISIRLGYADSPFMKCPK
CPEPQCYTVEKTCPNCGEKTEEHRTVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEDCPQPQTKEHLMALDIIGIKN
IVIVQNKIDLVSREKIIENYHQIKEFVKGTVAENAPVIPISAQQNINIDILIDALETQIPTPSHKVDKPASMLIARSFDI
NKPGASIEEIRGGVIGGTLTEGVLHPGDELEIRPGIKVTTEGSTRWIPILTTVSSIYAGATKVDEATPGGLLAVGTYLDP
TLTKGDSLTGQMAGVPGTLPETRHQFVMELHLLDRVVGVTREEKINEIKTSEPLMLNIGTATTVGVVTSARKNEAQVALK
RPISAAIGAMVAISRRVDSRWRLIGVGVIKS

Sequences:

>Translated_431_residues
MHRFRKNTCLISDYFHSTGGNYNLSQPCVNIGMVGHVDHGKTTLVRALSGVWTDTHSEEVKRGISIRLGYADSPFMKCPK
CPEPQCYTVEKTCPNCGEKTEEHRTVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEDCPQPQTKEHLMALDIIGIKN
IVIVQNKIDLVSREKIIENYHQIKEFVKGTVAENAPVIPISAQQNINIDILIDALETQIPTPSHKVDKPASMLIARSFDI
NKPGASIEEIRGGVIGGTLTEGVLHPGDELEIRPGIKVTTEGSTRWIPILTTVSSIYAGATKVDEATPGGLLAVGTYLDP
TLTKGDSLTGQMAGVPGTLPETRHQFVMELHLLDRVVGVTREEKINEIKTSEPLMLNIGTATTVGVVTSARKNEAQVALK
RPISAAIGAMVAISRRVDSRWRLIGVGVIKS
>Mature_431_residues
MHRFRKNTCLISDYFHSTGGNYNLSQPCVNIGMVGHVDHGKTTLVRALSGVWTDTHSEEVKRGISIRLGYADSPFMKCPK
CPEPQCYTVEKTCPNCGEKTEEHRTVSFVDAPGHETLMATMLSGAAIMDGAVLVIAANEDCPQPQTKEHLMALDIIGIKN
IVIVQNKIDLVSREKIIENYHQIKEFVKGTVAENAPVIPISAQQNINIDILIDALETQIPTPSHKVDKPASMLIARSFDI
NKPGASIEEIRGGVIGGTLTEGVLHPGDELEIRPGIKVTTEGSTRWIPILTTVSSIYAGATKVDEATPGGLLAVGTYLDP
TLTKGDSLTGQMAGVPGTLPETRHQFVMELHLLDRVVGVTREEKINEIKTSEPLMLNIGTATTVGVVTSARKNEAQVALK
RPISAAIGAMVAISRRVDSRWRLIGVGVIKS

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasmic, and membrane-associated [C]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503507, Length=428, Percent_Identity=43.4579439252336, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI34147630, Length=264, Percent_Identity=31.4393939393939, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI54607086, Length=275, Percent_Identity=30.1818181818182, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1789737, Length=347, Percent_Identity=28.5302593659942, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790412, Length=350, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI2367247, Length=402, Percent_Identity=26.3681592039801, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17509919, Length=422, Percent_Identity=45.4976303317536, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI25141371, Length=353, Percent_Identity=33.7110481586402, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17556456, Length=310, Percent_Identity=30.3225806451613, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17506081, Length=258, Percent_Identity=26.7441860465116, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320863, Length=421, Percent_Identity=43.7054631828979, Blast_Score=364, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324761, Length=332, Percent_Identity=33.1325301204819, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24647046, Length=421, Percent_Identity=42.9928741092637, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24647048, Length=421, Percent_Identity=42.9928741092637, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19921738, Length=252, Percent_Identity=32.9365079365079, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281363316, Length=263, Percent_Identity=31.1787072243346, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17864358, Length=263, Percent_Identity=31.1787072243346, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI19922690, Length=257, Percent_Identity=29.1828793774319, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: 20568 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 46620; Mature: 46620

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRFRKNTCLISDYFHSTGGNYNLSQPCVNIGMVGHVDHGKTTLVRALSGVWTDTHSEEV
CCCCCCCEEEEEHHHHCCCCCCCCCCCHHEECEEEECCCCHHHHHHHHHHCCCCCCHHHH
KRGISIRLGYADSPFMKCPKCPEPQCYTVEKTCPNCGEKTEEHRTVSFVDAPGHETLMAT
HCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
MLSGAAIMDGAVLVIAANEDCPQPQTKEHLMALDIIGIKNIVIVQNKIDLVSREKIIENY
HHCCCEEECCEEEEEECCCCCCCCCHHHHEEEEEEECCCEEEEEECCHHHHHHHHHHHHH
HQIKEFVKGTVAENAPVIPISAQQNINIDILIDALETQIPTPSHKVDKPASMLIARSFDI
HHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEHHHCCCCCCCCCCCCHHEEEEEECCC
NKPGASIEEIRGGVIGGTLTEGVLHPGDELEIRPGIKVTTEGSTRWIPILTTVSSIYAGA
CCCCCCHHHHCCCEECCHHHHCCCCCCCCEEECCCEEEEECCCCEEEEHHHHHHHHHCCC
TKVDEATPGGLLAVGTYLDPTLTKGDSLTGQMAGVPGTLPETRHQFVMELHLLDRVVGVT
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
REEKINEIKTSEPLMLNIGTATTVGVVTSARKNEAQVALKRPISAAIGAMVAISRRVDSR
HHHHHHHHCCCCCEEEECCCCEEEHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCC
WRLIGVGVIKS
EEEEEEEEECC
>Mature Secondary Structure
MHRFRKNTCLISDYFHSTGGNYNLSQPCVNIGMVGHVDHGKTTLVRALSGVWTDTHSEEV
CCCCCCCEEEEEHHHHCCCCCCCCCCCHHEECEEEECCCCHHHHHHHHHHCCCCCCHHHH
KRGISIRLGYADSPFMKCPKCPEPQCYTVEKTCPNCGEKTEEHRTVSFVDAPGHETLMAT
HCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCHHHHHHH
MLSGAAIMDGAVLVIAANEDCPQPQTKEHLMALDIIGIKNIVIVQNKIDLVSREKIIENY
HHCCCEEECCEEEEEECCCCCCCCCHHHHEEEEEEECCCEEEEEECCHHHHHHHHHHHHH
HQIKEFVKGTVAENAPVIPISAQQNINIDILIDALETQIPTPSHKVDKPASMLIARSFDI
HHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEHHHCCCCCCCCCCCCHHEEEEEECCC
NKPGASIEEIRGGVIGGTLTEGVLHPGDELEIRPGIKVTTEGSTRWIPILTTVSSIYAGA
CCCCCCHHHHCCCEECCHHHHCCCCCCCCEEECCCEEEEECCCCEEEEHHHHHHHHHCCC
TKVDEATPGGLLAVGTYLDPTLTKGDSLTGQMAGVPGTLPETRHQFVMELHLLDRVVGVT
CCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
REEKINEIKTSEPLMLNIGTATTVGVVTSARKNEAQVALKRPISAAIGAMVAISRRVDSR
HHHHHHHHCCCCCEEEECCCCEEEHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHCCC
WRLIGVGVIKS
EEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]