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The map label for this gene is 21226563

Identifier: 21226563

GI number: 21226563

Start: 581768

End: 582811

Strand: Reverse

Name: 21226563

Synonym: MM_0461

Alternate gene names: NA

Gene position: 582811-581768 (Counterclockwise)

Preceding gene: 21226564

Following gene: 21226559

Centisome position: 14.23

GC content: 41.86

Gene sequence:

>1044_bases
ATGCAGGAGATTATTTTTATCGATGAAGGCAGCTTCCCCACACCTGAAGGTGTCACAAGGGAGTGGGTGCAGGGTGCGGC
GGAAAACCGGGATGAAGATGAAAAACTCTTTTCAATAATAAGAGAGGCTTTTCAGATAAAAATTGATGCGGGAGTGCAAG
TTCCCACATATCCCCAGTTCAGAGACATGATTGGGCAGTTTTTTGATATCATAAAAGACGAAAAAAACTGTCATGAGCCT
TATGTGTTGAAAGAGGAACGTGCGACTATCCTTGAGCTGGAAGCAATTGATGAAGTTGCAAAGCAGTATAAAATAGAGAC
CGGAAAAACTCTCGAAGTCAGGGTCTGTATCGCAGGCCCTACGGATATGTATTATCAGGCTTTTGGGGCAACGGCTTTTG
TAGACGTATATGATATCCTTGCTAAGGATATCGAGAAATTCATCAAACAGGCATTTAAAACAGCAAAAAATTTCAAAATT
AAAGTTATAGCTCTGGATGAAATCGGCCTTGGGTTAAATGATAAAATTCAGTTTTCCGACGATGAAATTATATCGGCTCT
TACCGTTGCCTCTACCTTTGCCAGGCAGCAAGGGGCAGATGTTGAAATTCATGTATATTCCCCATTGAAGTATGAGCTTA
TATGCGAGACCCCTATCAATGTCATAGGATTTGAGTACGCTGGAAACCCTTCCTACATTGACCTTCTGGACAGAAAAGTG
CTGGAAGATTCTGATGCTTATGCAGGGGTCGGGATATCACGGACCGATATTTTCAGCCTTATAAGTATTGTCAATGAAAA
GTATGGAATTAATGCCTGGAAGGATAAGGAATACATGCAAAAAATAGTAACCGAGCTCGAGACTCCGGATATTATAAAAA
AGAGGCTTGAAACAGCTTATTCGGTTCTCGGGGACCGCATAAAGTATGCGAACCCGGACTGCGGGCTTGCATTCTGGCCG
GACCAGGAACTTGCTTTCAGGCTCCTTGAGAATACAGCAAAAGCTGTTAACGAATTTAATGCAGAAGGAATAATTAACAA
ATAA

Upstream 100 bases:

>100_bases
TTTTTCTTTAGCGTCTAGCAGTGTGAAAATTAGAAAATCCTAATTGTGACACCAGAACAATTTCAATATCTTTAAGATTC
TATCTCCCTTAATATCCAGC

Downstream 100 bases:

>100_bases
ATTGGGCTGAGACCTTTCTTTTTATTCGACTGTGAGTACCCAGTGTACGCCTTAAAAAATTGTAAGATTAATCTTCAGAA
AGGAATTTGAGATTAATCCT

Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase

Products: tetrahydropteroyltri-L-glutamate; L-methionine

Alternate protein names: Methionine Synthase Vitamin-B12 Independent

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MQEIIFIDEGSFPTPEGVTREWVQGAAENRDEDEKLFSIIREAFQIKIDAGVQVPTYPQFRDMIGQFFDIIKDEKNCHEP
YVLKEERATILELEAIDEVAKQYKIETGKTLEVRVCIAGPTDMYYQAFGATAFVDVYDILAKDIEKFIKQAFKTAKNFKI
KVIALDEIGLGLNDKIQFSDDEIISALTVASTFARQQGADVEIHVYSPLKYELICETPINVIGFEYAGNPSYIDLLDRKV
LEDSDAYAGVGISRTDIFSLISIVNEKYGINAWKDKEYMQKIVTELETPDIIKKRLETAYSVLGDRIKYANPDCGLAFWP
DQELAFRLLENTAKAVNEFNAEGIINK

Sequences:

>Translated_347_residues
MQEIIFIDEGSFPTPEGVTREWVQGAAENRDEDEKLFSIIREAFQIKIDAGVQVPTYPQFRDMIGQFFDIIKDEKNCHEP
YVLKEERATILELEAIDEVAKQYKIETGKTLEVRVCIAGPTDMYYQAFGATAFVDVYDILAKDIEKFIKQAFKTAKNFKI
KVIALDEIGLGLNDKIQFSDDEIISALTVASTFARQQGADVEIHVYSPLKYELICETPINVIGFEYAGNPSYIDLLDRKV
LEDSDAYAGVGISRTDIFSLISIVNEKYGINAWKDKEYMQKIVTELETPDIIKKRLETAYSVLGDRIKYANPDCGLAFWP
DQELAFRLLENTAKAVNEFNAEGIINK
>Mature_347_residues
MQEIIFIDEGSFPTPEGVTREWVQGAAENRDEDEKLFSIIREAFQIKIDAGVQVPTYPQFRDMIGQFFDIIKDEKNCHEP
YVLKEERATILELEAIDEVAKQYKIETGKTLEVRVCIAGPTDMYYQAFGATAFVDVYDILAKDIEKFIKQAFKTAKNFKI
KVIALDEIGLGLNDKIQFSDDEIISALTVASTFARQQGADVEIHVYSPLKYELICETPINVIGFEYAGNPSYIDLLDRKV
LEDSDAYAGVGISRTDIFSLISIVNEKYGINAWKDKEYMQKIVTELETPDIIKKRLETAYSVLGDRIKYANPDCGLAFWP
DQELAFRLLENTAKAVNEFNAEGIINK

Specific function: Unknown

COG id: COG0620

COG function: function code E; Methionine synthase II (cobalamin-independent)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.14

Molecular weight: Translated: 39385; Mature: 39385

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIIFIDEGSFPTPEGVTREWVQGAAENRDEDEKLFSIIREAFQIKIDAGVQVPTYPQF
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCCHHH
RDMIGQFFDIIKDEKNCHEPYVLKEERATILELEAIDEVAKQYKIETGKTLEVRVCIAGP
HHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
TDMYYQAFGATAFVDVYDILAKDIEKFIKQAFKTAKNFKIKVIALDEIGLGLNDKIQFSD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEECH
DEIISALTVASTFARQQGADVEIHVYSPLKYELICETPINVIGFEYAGNPSYIDLLDRKV
HHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
LEDSDAYAGVGISRTDIFSLISIVNEKYGINAWKDKEYMQKIVTELETPDIIKKRLETAY
HCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
SVLGDRIKYANPDCGLAFWPDQELAFRLLENTAKAVNEFNAEGIINK
HHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQEIIFIDEGSFPTPEGVTREWVQGAAENRDEDEKLFSIIREAFQIKIDAGVQVPTYPQF
CCEEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHEEEECCCCCCCCCHHH
RDMIGQFFDIIKDEKNCHEPYVLKEERATILELEAIDEVAKQYKIETGKTLEVRVCIAGP
HHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECC
TDMYYQAFGATAFVDVYDILAKDIEKFIKQAFKTAKNFKIKVIALDEIGLGLNDKIQFSD
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEECH
DEIISALTVASTFARQQGADVEIHVYSPLKYELICETPINVIGFEYAGNPSYIDLLDRKV
HHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHH
LEDSDAYAGVGISRTDIFSLISIVNEKYGINAWKDKEYMQKIVTELETPDIIKKRLETAY
HCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHH
SVLGDRIKYANPDCGLAFWPDQELAFRLLENTAKAVNEFNAEGIINK
HHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5-methyltetrahydropteroyltri-L-glutamate; L-homocysteine

Specific reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA