Click here to switch to the map view.

The map label for this gene is trxA [H]

Identifier: 21226538

GI number: 21226538

Start: 556054

End: 556320

Strand: Reverse

Name: trxA [H]

Synonym: MM_0436

Alternate gene names: 21226538

Gene position: 556320-556054 (Counterclockwise)

Preceding gene: 21226539

Following gene: 21226537

Centisome position: 13.58

GC content: 46.07

Gene sequence:

>267_bases
ATGAAACCGATGTTATTGGACTTTTCCGCAACATGGTGTGGACCTTGCAGAATGCAAAAACCTATTCTTGAAGAGCTCGA
GAAAAAGTACGGGGATAAAGTTGAGTTTAAAGTTGTCGATGTGGATGAAAACCAGGAGCTTGCCTCAAAGTACGGCATAC
ACGCTGTCCCGACCCTGATCATTCAGAAGGATGGGACTGAAGTGAAGCGTTTTATGGGTGTGACTCAGGGCAGTGTACTG
GCTGCTGAACTCGATAAGCTTCTCTGA

Upstream 100 bases:

>100_bases
CCGTACGGACGCATGTATACGATCCCTTCGTGCGCTGACCGGAGTAGATAAGCTAAGAACAGAAAAAGTCTCAGACGTTT
CAAGTATTGCAGGTGATTTT

Downstream 100 bases:

>100_bases
CCCCTTTATTCTTCTGAAAAAGCTGCCCTGGTTCGGGGAACCTGAGGGCGCCAAACTTTTTCCCGATTTCTTTTTAGGAT
ACTCTTTTGAAGTACTCATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 88; Mature: 88

Protein sequence:

>88_residues
MKPMLLDFSATWCGPCRMQKPILEELEKKYGDKVEFKVVDVDENQELASKYGIHAVPTLIIQKDGTEVKRFMGVTQGSVL
AAELDKLL

Sequences:

>Translated_88_residues
MKPMLLDFSATWCGPCRMQKPILEELEKKYGDKVEFKVVDVDENQELASKYGIHAVPTLIIQKDGTEVKRFMGVTQGSVL
AAELDKLL
>Mature_88_residues
MKPMLLDFSATWCGPCRMQKPILEELEKKYGDKVEFKVVDVDENQELASKYGIHAVPTLIIQKDGTEVKRFMGVTQGSVL
AAELDKLL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=86, Percent_Identity=40.6976744186046, Blast_Score=73, Evalue=4e-14,
Organism=Homo sapiens, GI50592994, Length=87, Percent_Identity=41.3793103448276, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788936, Length=86, Percent_Identity=38.3720930232558, Blast_Score=71, Evalue=2e-14,
Organism=Escherichia coli, GI87082331, Length=85, Percent_Identity=38.8235294117647, Blast_Score=69, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=75, Percent_Identity=37.3333333333333, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=72, Percent_Identity=43.0555555555556, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507705, Length=76, Percent_Identity=36.8421052631579, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=75, Percent_Identity=40, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=75, Percent_Identity=40, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=78, Percent_Identity=41.025641025641, Blast_Score=73, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=78, Percent_Identity=38.4615384615385, Blast_Score=69, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319925, Length=76, Percent_Identity=38.1578947368421, Blast_Score=65, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=44.5945945945946, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=44.5945945945946, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639826, Length=72, Percent_Identity=38.8888888888889, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=72, Percent_Identity=41.6666666666667, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573567, Length=85, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24658597, Length=70, Percent_Identity=41.4285714285714, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17530795, Length=75, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 9914; Mature: 9914

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPMLLDFSATWCGPCRMQKPILEELEKKYGDKVEFKVVDVDENQELASKYGIHAVPTLI
CCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCEEE
IQKDGTEVKRFMGVTQGSVLAAELDKLL
EECCCHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MKPMLLDFSATWCGPCRMQKPILEELEKKYGDKVEFKVVDVDENQELASKYGIHAVPTLI
CCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHCCCCCCCEEE
IQKDGTEVKRFMGVTQGSVLAAELDKLL
EECCCHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]