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The map label for this gene is pheA [H]

Identifier: 21226472

GI number: 21226472

Start: 474376

End: 475440

Strand: Direct

Name: pheA [H]

Synonym: MM_0370

Alternate gene names: 21226472

Gene position: 474376-475440 (Clockwise)

Preceding gene: 21226471

Following gene: 21226473

Centisome position: 11.58

GC content: 44.51

Gene sequence:

>1065_bases
TTGCGATTAAATCACAACTCCTATGAAATCTTCGATTTCATGCGATCCCGAAGCGCAATTGGGGTGCTATCAAAAATTAT
TATTACCATCCCCCCAATTAACCTTCGGATGATTATAGGCGTCATGGGGCCGGAAGGCTCTTATTCGGAAAGGGCTGCAA
AATTATGGGCTCGGAAAAATGGGCTGAGGGGCGCAGAGTTTCACTACTTCGCAGATATAGAAGATGCTTTTCTGGCTGCA
GTGGGAGGGAAAACAGATATCTCAGTAGTCCCTGTAGAAAACTCCATCGAAGGTTCCGTAGGAGTCACTCTTGACCTCCT
TCTTGAAAACGAGGCTGTCATTATTGGAGAAATAGTCGTCAAAATCGAGCACTGCCTCCTTTCTAAAGGCGAGCCTGAGA
AGATCAGGGTTATTCTTTCCCACCCCCAGGGGCTTGCCCAGTGCAGGCATTTCCTGAAGACACATTTTCCTGAAGCTGAA
CTCAGGAGTACGGGCAGCACTTCCCACGCAGCCCGGCTGGCAGGAGAGTTTGAGGAAATGGCAGCAATTGCGTCTCCTGA
AGCTGCGGAACGTTACGGGCTCAAAATCCTGCTCTCAAATGTTCAGGACAGGAAAGAAAACCATACACGCTTTATTGTGG
TCAGGGGCGGAGAAAAAGTTTTATCCGGGAAAATTAAGGGAAAAGCAGATTCCGGTGAAAAATTGAACACAGTTTTCGGC
AGGAATGCAGAGCATAAGTTATGTTCTGAAACGGAAACCGGAACAGAAAATTCCAGTTCTTATGCATTCAAAACGTCTCT
TATAGTATATCTGGAAAAAGACAGGCCAGGTGCTTTATACGAGCCTCTGGGATTTTTTGCAAAAAGAGGGATCAACCTTA
CAAAAATAGAATCAAGACCTTCTAAAAAAGAGCTGGGGGATTACTACTTCTATATCGACCTTGAAGGAAACATAAGCGAT
GTGCTTATAAAAGATGCCTTAGAAGATATAAAATCAAAAGCTAGTAAGAAATCAAGGTCCAGCACATTAAAGGTACTGGG
TTCCTATCCAGCTTTCAAGAAGTGA

Upstream 100 bases:

>100_bases
TAATTACTCACAAATTCGTCCTCTTGAGCTAAGCTCACTGTCATAACCCATCAATTAGTCTGCTTGAGCGAGCGAAGCGA
GTGAAACAGACCGCGTACTG

Downstream 100 bases:

>100_bases
ACGGAAAGATTAAAAATGGTTAAATACCTTAAAAAACTTAGTAAAGTTTGCGCGATGTGATGATTTGGATCTTGAAATAT
CAATAAAAAAGTATGAATCT

Product: chorismate mutase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MRLNHNSYEIFDFMRSRSAIGVLSKIIITIPPINLRMIIGVMGPEGSYSERAAKLWARKNGLRGAEFHYFADIEDAFLAA
VGGKTDISVVPVENSIEGSVGVTLDLLLENEAVIIGEIVVKIEHCLLSKGEPEKIRVILSHPQGLAQCRHFLKTHFPEAE
LRSTGSTSHAARLAGEFEEMAAIASPEAAERYGLKILLSNVQDRKENHTRFIVVRGGEKVLSGKIKGKADSGEKLNTVFG
RNAEHKLCSETETGTENSSSYAFKTSLIVYLEKDRPGALYEPLGFFAKRGINLTKIESRPSKKELGDYYFYIDLEGNISD
VLIKDALEDIKSKASKKSRSSTLKVLGSYPAFKK

Sequences:

>Translated_354_residues
MRLNHNSYEIFDFMRSRSAIGVLSKIIITIPPINLRMIIGVMGPEGSYSERAAKLWARKNGLRGAEFHYFADIEDAFLAA
VGGKTDISVVPVENSIEGSVGVTLDLLLENEAVIIGEIVVKIEHCLLSKGEPEKIRVILSHPQGLAQCRHFLKTHFPEAE
LRSTGSTSHAARLAGEFEEMAAIASPEAAERYGLKILLSNVQDRKENHTRFIVVRGGEKVLSGKIKGKADSGEKLNTVFG
RNAEHKLCSETETGTENSSSYAFKTSLIVYLEKDRPGALYEPLGFFAKRGINLTKIESRPSKKELGDYYFYIDLEGNISD
VLIKDALEDIKSKASKKSRSSTLKVLGSYPAFKK
>Mature_354_residues
MRLNHNSYEIFDFMRSRSAIGVLSKIIITIPPINLRMIIGVMGPEGSYSERAAKLWARKNGLRGAEFHYFADIEDAFLAA
VGGKTDISVVPVENSIEGSVGVTLDLLLENEAVIIGEIVVKIEHCLLSKGEPEKIRVILSHPQGLAQCRHFLKTHFPEAE
LRSTGSTSHAARLAGEFEEMAAIASPEAAERYGLKILLSNVQDRKENHTRFIVVRGGEKVLSGKIKGKADSGEKLNTVFG
RNAEHKLCSETETGTENSSSYAFKTSLIVYLEKDRPGALYEPLGFFAKRGINLTKIESRPSKKELGDYYFYIDLEGNISD
VLIKDALEDIKSKASKKSRSSTLKVLGSYPAFKK

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=322, Percent_Identity=28.2608695652174, Blast_Score=119, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010957
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01842 ACT; PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 39124; Mature: 39124

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNHNSYEIFDFMRSRSAIGVLSKIIITIPPINLRMIIGVMGPEGSYSERAAKLWARKN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHC
GLRGAEFHYFADIEDAFLAAVGGKTDISVVPVENSIEGSVGVTLDLLLENEAVIIGEIVV
CCCCCCEEEEECCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCEEEEHHHHH
KIEHCLLSKGEPEKIRVILSHPQGLAQCRHFLKTHFPEAELRSTGSTSHAARLAGEFEEM
HHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHH
AAIASPEAAERYGLKILLSNVQDRKENHTRFIVVRGGEKVLSGKIKGKADSGEKLNTVFG
HHHCCCHHHHHHHHHHEEHHHHHHCCCCCEEEEEECCCEEEECEECCCCCCCCHHHHHHC
RNAEHKLCSETETGTENSSSYAFKTSLIVYLEKDRPGALYEPLGFFAKRGINLTKIESRP
CCCCCHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCC
SKKELGDYYFYIDLEGNISDVLIKDALEDIKSKASKKSRSSTLKVLGSYPAFKK
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MRLNHNSYEIFDFMRSRSAIGVLSKIIITIPPINLRMIIGVMGPEGSYSERAAKLWARKN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHC
GLRGAEFHYFADIEDAFLAAVGGKTDISVVPVENSIEGSVGVTLDLLLENEAVIIGEIVV
CCCCCCEEEEECCHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCEEEEHHHHH
KIEHCLLSKGEPEKIRVILSHPQGLAQCRHFLKTHFPEAELRSTGSTSHAARLAGEFEEM
HHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHH
AAIASPEAAERYGLKILLSNVQDRKENHTRFIVVRGGEKVLSGKIKGKADSGEKLNTVFG
HHHCCCHHHHHHHHHHEEHHHHHHCCCCCEEEEEECCCEEEECEECCCCCCCCHHHHHHC
RNAEHKLCSETETGTENSSSYAFKTSLIVYLEKDRPGALYEPLGFFAKRGINLTKIESRP
CCCCCHHHCCCCCCCCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHHHCCCCEEEECCCC
SKKELGDYYFYIDLEGNISDVLIKDALEDIKSKASKKSRSSTLKVLGSYPAFKK
CCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]