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The map label for this gene is mscS [H]

Identifier: 21226338

GI number: 21226338

Start: 318992

End: 319879

Strand: Direct

Name: mscS [H]

Synonym: MM_0236

Alternate gene names: 21226338

Gene position: 318992-319879 (Clockwise)

Preceding gene: 21226334

Following gene: 21226340

Centisome position: 7.79

GC content: 44.48

Gene sequence:

>888_bases
ATGGACGGCGTAATAAGCAGTGGAATTATAGAACATGTGATTCCGTATACTGATATAACAGTGTCCAGAGTGATCTTTTC
ACTGGCATTACTGGTTGCCGGGCTTGTTCTGGTAAAACTTCTTGTGCGTATTTTCAGGAGAGGGATCGAAAAAACAAAAC
TGCCTGCCCTTACCACGCAGTTTCTTGGGCATTTTCTGAAAATCCTTCTGTGTGTTGTGGTTGTCCTGATATTTTTAAAG
AGCCTGGGTTTTGATGTGGACAGTTACGTGGTAGGGCTTTCTGCGGTTATAGGTCTGGTCCTTGGGCTTGGTATGCAGGA
CACCTTTACAAACATAGCAGCCGGGGTATGGGTTGCTGCGATCAGACCCGTTGACACCGGAGAAATGGTAACTGTAAACG
GGCAGACGGGAAAAGTAAAATCCGTAGGAATTATGTCAACTGAACTCCTGACGCCTGACAACCAGCTTATAACAATCCCG
AATAAGCTTGTCTGGGGGAGTTCAATTGTCAACATGACCCGTATGCCAACAAGAAGAGCTTCAGTGGATGTGGGAATCAG
CTATAATTCAGACCTTGAAAAAGCTGTCAAAATAGCCATGGACCTTATGAAAGGTTACCCCCCTGTACTTCAGGACCCGG
AACCCTCAGTGGTTACTACAGAGCTTGCGAATTCTTCCGTAAATCTGCAGCTCAGGGCATGGGCAAAGACCGGGGACCTT
ATGGCGGTAAAGAATTATCTTACTGCCGGAATTTTTGAGGCTTACAGAAGAGAAGGAATTGAAATACCCTTCCCACAGAT
GGACATTTATATAAAAGAATCAAAGGAAACAAGAAAAGAGATTATGGAAATTCAAACAGCAAACTCCGGCATAAGAGCAT
ACGAATAA

Upstream 100 bases:

>100_bases
TCCGCTGATTAAGGTCAGGAATCACTGGATGTAAGATAAAAACGTTTCCAACTTTTCTGATTTGGGATAAAAGATCTGTG
AAATAAAAAGGAGATAAAAA

Downstream 100 bases:

>100_bases
AATTAGAAAAAATTAGGAAGAATCGAAAAATTAGAAAGAATTAAAAAAAATTAGAAAGAATTAAAAAAAATTAGAAAGAA
TTGAAAAATTAGAAAGAATT

Product: putative mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MDGVISSGIIEHVIPYTDITVSRVIFSLALLVAGLVLVKLLVRIFRRGIEKTKLPALTTQFLGHFLKILLCVVVVLIFLK
SLGFDVDSYVVGLSAVIGLVLGLGMQDTFTNIAAGVWVAAIRPVDTGEMVTVNGQTGKVKSVGIMSTELLTPDNQLITIP
NKLVWGSSIVNMTRMPTRRASVDVGISYNSDLEKAVKIAMDLMKGYPPVLQDPEPSVVTTELANSSVNLQLRAWAKTGDL
MAVKNYLTAGIFEAYRREGIEIPFPQMDIYIKESKETRKEIMEIQTANSGIRAYE

Sequences:

>Translated_295_residues
MDGVISSGIIEHVIPYTDITVSRVIFSLALLVAGLVLVKLLVRIFRRGIEKTKLPALTTQFLGHFLKILLCVVVVLIFLK
SLGFDVDSYVVGLSAVIGLVLGLGMQDTFTNIAAGVWVAAIRPVDTGEMVTVNGQTGKVKSVGIMSTELLTPDNQLITIP
NKLVWGSSIVNMTRMPTRRASVDVGISYNSDLEKAVKIAMDLMKGYPPVLQDPEPSVVTTELANSSVNLQLRAWAKTGDL
MAVKNYLTAGIFEAYRREGIEIPFPQMDIYIKESKETRKEIMEIQTANSGIRAYE
>Mature_295_residues
MDGVISSGIIEHVIPYTDITVSRVIFSLALLVAGLVLVKLLVRIFRRGIEKTKLPALTTQFLGHFLKILLCVVVVLIFLK
SLGFDVDSYVVGLSAVIGLVLGLGMQDTFTNIAAGVWVAAIRPVDTGEMVTVNGQTGKVKSVGIMSTELLTPDNQLITIP
NKLVWGSSIVNMTRMPTRRASVDVGISYNSDLEKAVKIAMDLMKGYPPVLQDPEPSVVTTELANSSVNLQLRAWAKTGDL
MAVKNYLTAGIFEAYRREGIEIPFPQMDIYIKESKETRKEIMEIQTANSGIRAYE

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=255, Percent_Identity=31.3725490196078, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1786670, Length=260, Percent_Identity=28.0769230769231, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787591, Length=266, Percent_Identity=24.0601503759398, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367355, Length=288, Percent_Identity=23.9583333333333, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 32304; Mature: 32304

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGVISSGIIEHVIPYTDITVSRVIFSLALLVAGLVLVKLLVRIFRRGIEKTKLPALTTQ
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHH
FLGHFLKILLCVVVVLIFLKSLGFDVDSYVVGLSAVIGLVLGLGMQDTFTNIAAGVWVAA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IRPVDTGEMVTVNGQTGKVKSVGIMSTELLTPDNQLITIPNKLVWGSSIVNMTRMPTRRA
CCCCCCCCEEEEECCCCCEEEEEEEEEEEECCCCCEEECCCHHHCCHHHHHHHCCCCCCC
SVDVGISYNSDLEKAVKIAMDLMKGYPPVLQDPEPSVVTTELANSSVNLQLRAWAKTGDL
CEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCH
MAVKNYLTAGIFEAYRREGIEIPFPQMDIYIKESKETRKEIMEIQTANSGIRAYE
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MDGVISSGIIEHVIPYTDITVSRVIFSLALLVAGLVLVKLLVRIFRRGIEKTKLPALTTQ
CCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHH
FLGHFLKILLCVVVVLIFLKSLGFDVDSYVVGLSAVIGLVLGLGMQDTFTNIAAGVWVAA
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IRPVDTGEMVTVNGQTGKVKSVGIMSTELLTPDNQLITIPNKLVWGSSIVNMTRMPTRRA
CCCCCCCCEEEEECCCCCEEEEEEEEEEEECCCCCEEECCCHHHCCHHHHHHHCCCCCCC
SVDVGISYNSDLEKAVKIAMDLMKGYPPVLQDPEPSVVTTELANSSVNLQLRAWAKTGDL
CEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEEEEEECCCCCH
MAVKNYLTAGIFEAYRREGIEIPFPQMDIYIKESKETRKEIMEIQTANSGIRAYE
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]