Click here to switch to the map view.

The map label for this gene is serS

Identifier: 209695311

GI number: 209695311

Start: 1979589

End: 1980896

Strand: Direct

Name: serS

Synonym: VSAL_I1844

Alternate gene names: 209695311

Gene position: 1979589-1980896 (Clockwise)

Preceding gene: 209695310

Following gene: 209695314

Centisome position: 59.53

GC content: 43.2

Gene sequence:

>1308_bases
ATGCTTGATTCAAAATTACTTCGTACAGAGCTGGATGAAACAGCAGAGAAACTGGCACGTCGTGGCTTTAAGCTAGACGT
AGAGACACTTCGCACCCTTGAAGAACAACGTAAATCTCTTCAAGTTATCACGGAAGATCTTCAAGCGCAGCGTAATTCCC
GTTCGAAGTCCATTGGTCAAGCAAAAGCGAAGGGCGATCATGAAGAAGCAGATCGCATCATGGCTGATGTTGCAACATTA
GGTTCAGAACTAGATGATGCAAAAGCAGGACTTGCTGAGCTTCAACAACAAATTGAAAGCATCGCTTTGTCAGTACCAAA
CCTTCCTGATGAGTCAGTACCATATGGTAAAGATGAAGATGAAAACGTAGAAGTATTACGTTGGGGTACACCGCTAACGT
ACGATTTTGAAGTGAGAGATCACGTTGCTCTTGGTGAGCTTGCGGATGGTCTTGATTTCGCAAGTGCAGTTAAAATCTCA
GGCTCTCGTTTCATCGTTATGAAAGGTCAGTTTGCGCGTTTACACCGTGCTTTATCGCAATTTATGCTTGATCTTCATAC
TGAAGAGCACGGTTACATGGAAATGTATGTACCTTACTTAGTTAACCACGACAGCCTATATGGTACTGGTCAACTGCCTA
AGTTTGGTGAAGACTTATTCCATACAAGTCCGCTAACAGAGCAAGTAAGTGATGTTCCTCTTAAGATGCTATCTCTTATC
CCTACAGCGGAAGTGCCAGTAACAAACATGGTACGTGACACGATTACTGAAGAAGCTGATCTTCCACTGAAAATGACGGC
ACATACACCGTGTTTCCGTTCTGAAGCAGGATCTTACGGTCGTGATACTCGTGGTCTTATTCGTATGCACCAATTCGACA
AAGTTGAATTAGTTCAAATCACGAAACCAGAAGATTCAATGGCTGCTCTTGAAGAACTAACAGGTCATGCTGAGAAAGTA
CTTCAACTGCTTGAACTTCCTTACCGTAAAGTGATTCTTTGTACTGGTGATATGGGCTTCGGTTCTCGTAAAACATACGA
CTTAGAAGTATGGGTTCCAGCACAAGAAACGTACCGTGAGATTTCTTCTTGTTCAAACATGTGGGATTTCCAAGCGCGTC
GTATGCAAGCGCGTTTCCGTCGTCAAGGTGAGAAGAAACCAGAATTGGTTCATACACTAAACGGTTCTGGTCTTGCTGTA
GGTCGTACAATGGTTGCGATTCTAGAGAACTTCCAACAAGCTGATGGCAAAATTGCAATTCCTGAAGTACTGCGTAAGTA
CATGAATGGTGTTGAGTTCATCGGTTAA

Upstream 100 bases:

>100_bases
TCAAATCGCAATTTTGAACTGAAAATTGCACAAAATTTTATTTTTAAGTGGGTTCTATTTACTTTGAACGCACAATGACC
AATAAGGCATAGGATTACAA

Downstream 100 bases:

>100_bases
TCTGTTTTTCAAATTAATGTGTATTTGATAAATAGATAAATAGAAATGTAAGCCCCTTTATTGGTTATCCAGTAAAGGGG
CTTTTTTTGATCTTTTAAGG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDSKLLRTELDETAEKLARRGFKLDVETLRTLEEQRKSLQVITEDLQAQRNSRSKSIGQAKAKGDHEEADRIMADVATL
GSELDDAKAGLAELQQQIESIALSVPNLPDESVPYGKDEDENVEVLRWGTPLTYDFEVRDHVALGELADGLDFASAVKIS
GSRFIVMKGQFARLHRALSQFMLDLHTEEHGYMEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKMLSLI
PTAEVPVTNMVRDTITEEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSRKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRQGEKKPELVHTLNGSGLAV
GRTMVAILENFQQADGKIAIPEVLRKYMNGVEFIG

Sequences:

>Translated_435_residues
MLDSKLLRTELDETAEKLARRGFKLDVETLRTLEEQRKSLQVITEDLQAQRNSRSKSIGQAKAKGDHEEADRIMADVATL
GSELDDAKAGLAELQQQIESIALSVPNLPDESVPYGKDEDENVEVLRWGTPLTYDFEVRDHVALGELADGLDFASAVKIS
GSRFIVMKGQFARLHRALSQFMLDLHTEEHGYMEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKMLSLI
PTAEVPVTNMVRDTITEEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSRKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRQGEKKPELVHTLNGSGLAV
GRTMVAILENFQQADGKIAIPEVLRKYMNGVEFIG
>Mature_435_residues
MLDSKLLRTELDETAEKLARRGFKLDVETLRTLEEQRKSLQVITEDLQAQRNSRSKSIGQAKAKGDHEEADRIMADVATL
GSELDDAKAGLAELQQQIESIALSVPNLPDESVPYGKDEDENVEVLRWGTPLTYDFEVRDHVALGELADGLDFASAVKIS
GSRFIVMKGQFARLHRALSQFMLDLHTEEHGYMEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKMLSLI
PTAEVPVTNMVRDTITEEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSRKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRQGEKKPELVHTLNGSGLAV
GRTMVAILENFQQADGKIAIPEVLRKYMNGVEFIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=333, Percent_Identity=36.6366366366366, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI8923421, Length=409, Percent_Identity=29.3398533007335, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI225579074, Length=340, Percent_Identity=30, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=73.7931034482759, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=432, Percent_Identity=30.3240740740741, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI17542084, Length=334, Percent_Identity=28.4431137724551, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321799, Length=416, Percent_Identity=31.4903846153846, Blast_Score=202, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320226, Length=409, Percent_Identity=31.5403422982885, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24581334, Length=345, Percent_Identity=36.8115942028986, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI17737985, Length=364, Percent_Identity=30.7692307692308, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ALISL (B6ENN5)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002263240.1
- GeneID:   6987417
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I1844
- HOGENOM:   HBG629391
- OMA:   FQARRIR
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49009; Mature: 49009

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 296-296 BINDING 396-396

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRTELDETAEKLARRGFKLDVETLRTLEEQRKSLQVITEDLQAQRNSRSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGDHEEADRIMADVATLGSELDDAKAGLAELQQQIESIALSVPNLPDESVPYGKDED
HHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ENVEVLRWGTPLTYDFEVRDHVALGELADGLDFASAVKISGSRFIVMKGQFARLHRALSQ
CCEEEEECCCCEEEEECCCCHHHHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHH
FMLDLHTEEHGYMEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKMLSLI
HHHHHHCCCCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHC
PTAEVPVTNMVRDTITEEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEE
TKPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSRKTYDLEVWVPAQETYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRQGEKKPELVHTLNGSGLAVGRTMVAILENFQQADGKIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCEEH
PEVLRKYMNGVEFIG
HHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDSKLLRTELDETAEKLARRGFKLDVETLRTLEEQRKSLQVITEDLQAQRNSRSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGDHEEADRIMADVATLGSELDDAKAGLAELQQQIESIALSVPNLPDESVPYGKDED
HHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
ENVEVLRWGTPLTYDFEVRDHVALGELADGLDFASAVKISGSRFIVMKGQFARLHRALSQ
CCEEEEECCCCEEEEECCCCHHHHHHHHCCCCHHHHEEECCCEEEEECCHHHHHHHHHHH
FMLDLHTEEHGYMEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKMLSLI
HHHHHHCCCCCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHC
PTAEVPVTNMVRDTITEEADLPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEE
TKPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSRKTYDLEVWVPAQETYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRQGEKKPELVHTLNGSGLAVGRTMVAILENFQQADGKIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCCCHHHHHHHHHHHHHHHHCCCCEEH
PEVLRKYMNGVEFIG
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA