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The map label for this gene is hscA [H]

Identifier: 209695296

GI number: 209695296

Start: 1952087

End: 1953907

Strand: Direct

Name: hscA [H]

Synonym: VSAL_I1826

Alternate gene names: 209695296

Gene position: 1952087-1953907 (Clockwise)

Preceding gene: 209695295

Following gene: 209695297

Centisome position: 58.71

GC content: 44.15

Gene sequence:

>1821_bases
ATGGAACAAGCTAAATTCAGTATTGGTATCGATTTAGGTACAACTCACTGTGTACTTTCTTATGTTGATTTACACGATGA
AGGCGCAAGTGTTCAAGTCATGCCAATTCCACAATTGACAGCGCCAGGTCAAGTAGAAGAAAAAGCACAACTGCCTTCAT
TTATGTATCAAGCGCATGACGCAGAATTGCTTGAAGGCGATACAAGCCTTCCTTGGACAACAAAGCCAAATGCAATCGTT
GGTAATATTGCTCGTAACCTTGGTAGCAAAACCCCTATTCGTTTAATCGCCAGTGCAAAAAGTTGGTTATGCCATGCCGG
TGTGAATCGTCGTGACGCTTTCTTGCCATTAAACAGCCCAGAAGAAGTGATCAAAGCGTCACCTCTTGAAGTCACTAAAC
GTTATTTAGAGCATCTTCAAAATGCGTGGGATTACCAAAACCCTGAGCACCCTCTAAATGAACAAGACATTACGCTTACG
GTTCCTGCATCGTTTGACCCTGCTGCTCGTGATTTAACAGCAGAAGCAGCAAACAATCTTGGTTTCCGTAATCTTACGTT
ATTAGAAGAGCCGCAAGCCGCAGTCTATAGTTGGATTAAGAACAACGGTGAATCATGGCGTGAACAAGTATCGATCGGCG
ATGTTATCCTTGTGGTCGATATTGGCGGCGGTACAACCGATTTATCTTTAGTTGCGGTAACTGAAGAAGAAGGTAATTTG
AGCCTAAACCGTGTTGCGGTAGGTGACCACATTCTTCTTGGTGGTGACAATATGGATTTGGCTCTGGCTTATCGTCTAAA
GATGAAGCTAGCGCAAGAAGGTAAGCAACTTCAACCTTGGCAAATTCAAGTCATGACACATGCGTGTCGTGATGCAAAAG
AAGCCCTTCTTAACGATTCAGAGTTACGCTCAGTGCCAATTGTGGTTCCTAGCCGTGGATCTAAATTGTTAGGTAGTACA
CTTCAAACAGAACTGACTCAAGAAGAAGTTCAACAAACATTGGTTGAAGGTTTCTTCCCTGTCGTTCCTGTTACTGAACA
TCCTGTGCAATCTGCGCGTGGCGCATTAACTCAAATGGGTCTGCCTTACGCTCAAGATGCTGCTGTCACTCGTCACCTTG
CAAGCTTTTTAACTCGTCAACAAGCGGCAACGGATGATGTATTTGGTCAGCAAAATGAATCTGACTTTATTAAGCCAACT
GCAATACTTCTTAACGGTGGGGTTTTAAAATCAAACCTTCTTGCAGAACGCTTGTTGGGCATTATTAATGATTGGCTAAT
TGATGCAGAAGCTGAAGACGCAAAACTACTTGAAGGGTTAGACCTTGACTTAGCGGTTGCTTCTGGCGCGTCTTATTATG
GCTCGGTTCGTACAGGTAAAGGCGTTCGTATCCGTGGTGGTATCGCATCAAGCTATTATGTTGGAATTGAAAGTTCTATG
CCTGCAATTCCAGGAATGGAACCACCAATGGAAGCATTATGTGTTGCCCCATTTGGTATGGAAGAAGGTTCTAACGCTGA
TGTTCCTAGCCAACAATTTGGTTTGGTTATAGGGCAGCCTGTACAATTCAAATTCTATGGGTCAACGACTCGTCGAGATG
ATCAAGCAGGCACTCACCTTGATTTCTGGATGCCAGAAGAACTAGACGAACTGCCCGCAATTCAAGTCACGCTACCGGTC
ACAGAAGGTCGCTCTGCGGGTGAAGTGGTTCCTGTTCGTCTTGCGTCAAAAGTGACTGAACTTGGTACTTTGTATCTTGA
AGCCATTGCCATTGATAGTGGTGAAAAATGGCACGTTGAGTTTAATGTTCGTGAAGCGTAA

Upstream 100 bases:

>100_bases
CATTAATCCACAAAGGCTGGAAAGTGGCAGAAGTAAAACTGCCTAAACTCGCTGACGGTTATGATGCAACAATTGTTGCT
CCAGCAGAGGTAGAACTGTA

Downstream 100 bases:

>100_bases
TTCTATTATTCTTCATTAATACGTTACTTAAGAGTTCAGTCACCATTATGGGGGCTGAACTCTTTTACTATATGCTCTTT
GTTTCTTTATCGCTGTCGCC

Product: heat-shock chaperone protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MEQAKFSIGIDLGTTHCVLSYVDLHDEGASVQVMPIPQLTAPGQVEEKAQLPSFMYQAHDAELLEGDTSLPWTTKPNAIV
GNIARNLGSKTPIRLIASAKSWLCHAGVNRRDAFLPLNSPEEVIKASPLEVTKRYLEHLQNAWDYQNPEHPLNEQDITLT
VPASFDPAARDLTAEAANNLGFRNLTLLEEPQAAVYSWIKNNGESWREQVSIGDVILVVDIGGGTTDLSLVAVTEEEGNL
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDSELRSVPIVVPSRGSKLLGST
LQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMGLPYAQDAAVTRHLASFLTRQQAATDDVFGQQNESDFIKPT
AILLNGGVLKSNLLAERLLGIINDWLIDAEAEDAKLLEGLDLDLAVASGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
PAIPGMEPPMEALCVAPFGMEEGSNADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHLDFWMPEELDELPAIQVTLPV
TEGRSAGEVVPVRLASKVTELGTLYLEAIAIDSGEKWHVEFNVREA

Sequences:

>Translated_606_residues
MEQAKFSIGIDLGTTHCVLSYVDLHDEGASVQVMPIPQLTAPGQVEEKAQLPSFMYQAHDAELLEGDTSLPWTTKPNAIV
GNIARNLGSKTPIRLIASAKSWLCHAGVNRRDAFLPLNSPEEVIKASPLEVTKRYLEHLQNAWDYQNPEHPLNEQDITLT
VPASFDPAARDLTAEAANNLGFRNLTLLEEPQAAVYSWIKNNGESWREQVSIGDVILVVDIGGGTTDLSLVAVTEEEGNL
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDSELRSVPIVVPSRGSKLLGST
LQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMGLPYAQDAAVTRHLASFLTRQQAATDDVFGQQNESDFIKPT
AILLNGGVLKSNLLAERLLGIINDWLIDAEAEDAKLLEGLDLDLAVASGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
PAIPGMEPPMEALCVAPFGMEEGSNADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHLDFWMPEELDELPAIQVTLPV
TEGRSAGEVVPVRLASKVTELGTLYLEAIAIDSGEKWHVEFNVREA
>Mature_606_residues
MEQAKFSIGIDLGTTHCVLSYVDLHDEGASVQVMPIPQLTAPGQVEEKAQLPSFMYQAHDAELLEGDTSLPWTTKPNAIV
GNIARNLGSKTPIRLIASAKSWLCHAGVNRRDAFLPLNSPEEVIKASPLEVTKRYLEHLQNAWDYQNPEHPLNEQDITLT
VPASFDPAARDLTAEAANNLGFRNLTLLEEPQAAVYSWIKNNGESWREQVSIGDVILVVDIGGGTTDLSLVAVTEEEGNL
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDSELRSVPIVVPSRGSKLLGST
LQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMGLPYAQDAAVTRHLASFLTRQQAATDDVFGQQNESDFIKPT
AILLNGGVLKSNLLAERLLGIINDWLIDAEAEDAKLLEGLDLDLAVASGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
PAIPGMEPPMEALCVAPFGMEEGSNADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHLDFWMPEELDELPAIQVTLPV
TEGRSAGEVVPVRLASKVTELGTLYLEAIAIDSGEKWHVEFNVREA

Specific function: Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by hscB [H]

COG id: COG0443

COG function: function code O; Molecular chaperone

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 70 family [H]

Homologues:

Organism=Escherichia coli, GI1786196, Length=307, Percent_Identity=25.7328990228013, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17534015, Length=354, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17534013, Length=354, Percent_Identity=24.2937853107345, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 320 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 500 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stati

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018181
- InterPro:   IPR001023
- InterPro:   IPR013126
- InterPro:   IPR010236 [H]

Pfam domain/function: PF00012 HSP70 [H]

EC number: NA

Molecular weight: Translated: 65933; Mature: 65933

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00297 HSP70_1 ; PS00329 HSP70_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQAKFSIGIDLGTTHCVLSYVDLHDEGASVQVMPIPQLTAPGQVEEKAQLPSFMYQAHD
CCCCEEEEEEECCCHHHEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHCCHHHHHHCC
AELLEGDTSLPWTTKPNAIVGNIARNLGSKTPIRLIASAKSWLCHAGVNRRDAFLPLNSP
CHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCCEEECCCCH
EEVIKASPLEVTKRYLEHLQNAWDYQNPEHPLNEQDITLTVPASFDPAARDLTAEAANNL
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCC
GFRNLTLLEEPQAAVYSWIKNNGESWREQVSIGDVILVVDIGGGTTDLSLVAVTEEEGNL
CCCEEEEECCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCE
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDS
EEEEEEECCEEEECCCCCCEEEEHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCC
ELRSVPIVVPSRGSKLLGSTLQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMG
HHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC
LPYAQDAAVTRHLASFLTRQQAATDDVFGQQNESDFIKPTAILLNGGVLKSNLLAERLLG
CCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
IINDWLIDAEAEDAKLLEGLDLDLAVASGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
HHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCEECCCCEEEECCCCCEEEEEECCCC
PAIPGMEPPMEALCVAPFGMEEGSNADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHL
CCCCCCCCCHHHEEECCCCCCCCCCCCCCHHHCCEEECCCEEEEEECCCCCCCCCCCCEE
DFWMPEELDELPAIQVTLPVTEGRSAGEVVPVRLASKVTELGTLYLEAIAIDSGEKWHVE
ECCCCHHHHHCCEEEEEEEECCCCCCCCEEEHHHHHHHHHHHHEEEEEEEECCCCEEEEE
FNVREA
EEEECC
>Mature Secondary Structure
MEQAKFSIGIDLGTTHCVLSYVDLHDEGASVQVMPIPQLTAPGQVEEKAQLPSFMYQAHD
CCCCEEEEEEECCCHHHEEEEEEECCCCCEEEEEECCCCCCCCCCHHHHHCCHHHHHHCC
AELLEGDTSLPWTTKPNAIVGNIARNLGSKTPIRLIASAKSWLCHAGVNRRDAFLPLNSP
CHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHCCCCCCCEEECCCCH
EEVIKASPLEVTKRYLEHLQNAWDYQNPEHPLNEQDITLTVPASFDPAARDLTAEAANNL
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHCC
GFRNLTLLEEPQAAVYSWIKNNGESWREQVSIGDVILVVDIGGGTTDLSLVAVTEEEGNL
CCCEEEEECCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCEEEEEEEECCCCE
SLNRVAVGDHILLGGDNMDLALAYRLKMKLAQEGKQLQPWQIQVMTHACRDAKEALLNDS
EEEEEEECCEEEECCCCCCEEEEHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCC
ELRSVPIVVPSRGSKLLGSTLQTELTQEEVQQTLVEGFFPVVPVTEHPVQSARGALTQMG
HHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCC
LPYAQDAAVTRHLASFLTRQQAATDDVFGQQNESDFIKPTAILLNGGVLKSNLLAERLLG
CCCHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHH
IINDWLIDAEAEDAKLLEGLDLDLAVASGASYYGSVRTGKGVRIRGGIASSYYVGIESSM
HHHHHHCCCCCCHHHHHCCCCCEEEEECCCCCCCCEECCCCEEEECCCCCEEEEEECCCC
PAIPGMEPPMEALCVAPFGMEEGSNADVPSQQFGLVIGQPVQFKFYGSTTRRDDQAGTHL
CCCCCCCCCHHHEEECCCCCCCCCCCCCCHHHCCEEECCCEEEEEECCCCCCCCCCCCEE
DFWMPEELDELPAIQVTLPVTEGRSAGEVVPVRLASKVTELGTLYLEAIAIDSGEKWHVE
ECCCCHHHHHCCEEEEEEEECCCCCCCCEEEHHHHHHHHHHHHEEEEEEEECCCCEEEEE
FNVREA
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA