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The map label for this gene is huvC [H]

Identifier: 209695234

GI number: 209695234

Start: 1868428

End: 1869465

Strand: Direct

Name: huvC [H]

Synonym: VSAL_I1755

Alternate gene names: 209695234

Gene position: 1868428-1869465 (Clockwise)

Preceding gene: 209695233

Following gene: 209695235

Centisome position: 56.19

GC content: 39.5

Gene sequence:

>1038_bases
ATGTTTTTAAAATATCTCTCATTTTCAAAATTAATGCTCATTGGTTTTAGCATTTTATTTTTAACCACATTATCCTCTAT
CGCCGTTGGGCCAATGAATATTACGTTGGCCGATAGCTTTAGTAGCTTATTACCGGGTACCAGAAATATCCCTGCTCATA
TTGATTTAATCATTCATCAAGTTAGGTTACCAAGAACATTATTATGTATGTTGGTCGGCGCTATTTTGGCAATTTCTGGC
GTAGTAATGCAGGGCTTGTTCCGTAATCCATTAGCGGAACCTGGCATTATTGGAGTCTCTGCAGGCGCAGCTCTTGGAGC
AGCATTAGCTATTGTCTCTTTTTCATCAATCAGTACCAGCTACCCTATTTTTATGAACTTTGCTGCTATCCCAATGTTTG
CTTTCTTAGGGGGGGCATTAACAACCGTTATCGTTTATCGATTAGGTACGAGTCAGTTTGGAACCTCGATTACGGTTATG
CTATTGGCTGGGGTTGCTATTAGTGCATTATCTGGTGCAGGGATTGGCTATTTGAATTTTATCGCTGATGACCAAATGCT
GCGAGATTTGTCATTATGGTCAATGGGATCATTGGCAGGTGCATCTTGGCAAGATCTACTCCTCGCCTTTTTGGGCTTAG
TCATATTACTCACTATTTTCATGAAAAATGCAGCGGGATTAAATGCGCTATTACTCGGTGAAGCTGAAGCAAAACATTTA
GGTATTAATGTACAGTCTTTAAAAAAGCGAATGATAATTTTAAGCGCTATCGGTATTGGTATTACGGTTAGTTTATCTGG
CATGATTGGCTTTATTGGTTTAATCATTCCACATTTAGGTCGTATGATGACAGGTCCTAATCATCGTACTTTATTACCAT
TATCAGCTCTATTAGGCGGATTATTACTTACCTGTGCTGATATGTTCGCTCGTGTTGCTGTCAGCCCTGCAGAGTTACCT
GTCGGCATTGTAACTGCTATTATTGGTGCTCCTTTCTTTTTATATTTACTGTTTACTCAGCGCGGAAAGTTCTCATGA

Upstream 100 bases:

>100_bases
AACCATTAATGGATCTGCACTTGTTGGTGGACTCGGTCTTGCCAGTTTAGATGAAGCCGCTCGCTTAAATTTTCTTCTTT
ATCCCCAGCAGAATTAAATT

Downstream 100 bases:

>100_bases
ATCTCATCTCTACCGCTATTTCAGCAAAAAACATTACCTGCTATTTAAATAATAAATTAATTCTAGATGATCTTAATCTT
GATCTTCATTGTGGAGAGGT

Product: heme transporter protein HuvC, transmembrane permease component

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MFLKYLSFSKLMLIGFSILFLTTLSSIAVGPMNITLADSFSSLLPGTRNIPAHIDLIIHQVRLPRTLLCMLVGAILAISG
VVMQGLFRNPLAEPGIIGVSAGAALGAALAIVSFSSISTSYPIFMNFAAIPMFAFLGGALTTVIVYRLGTSQFGTSITVM
LLAGVAISALSGAGIGYLNFIADDQMLRDLSLWSMGSLAGASWQDLLLAFLGLVILLTIFMKNAAGLNALLLGEAEAKHL
GINVQSLKKRMIILSAIGIGITVSLSGMIGFIGLIIPHLGRMMTGPNHRTLLPLSALLGGLLLTCADMFARVAVSPAELP
VGIVTAIIGAPFFLYLLFTQRGKFS

Sequences:

>Translated_345_residues
MFLKYLSFSKLMLIGFSILFLTTLSSIAVGPMNITLADSFSSLLPGTRNIPAHIDLIIHQVRLPRTLLCMLVGAILAISG
VVMQGLFRNPLAEPGIIGVSAGAALGAALAIVSFSSISTSYPIFMNFAAIPMFAFLGGALTTVIVYRLGTSQFGTSITVM
LLAGVAISALSGAGIGYLNFIADDQMLRDLSLWSMGSLAGASWQDLLLAFLGLVILLTIFMKNAAGLNALLLGEAEAKHL
GINVQSLKKRMIILSAIGIGITVSLSGMIGFIGLIIPHLGRMMTGPNHRTLLPLSALLGGLLLTCADMFARVAVSPAELP
VGIVTAIIGAPFFLYLLFTQRGKFS
>Mature_345_residues
MFLKYLSFSKLMLIGFSILFLTTLSSIAVGPMNITLADSFSSLLPGTRNIPAHIDLIIHQVRLPRTLLCMLVGAILAISG
VVMQGLFRNPLAEPGIIGVSAGAALGAALAIVSFSSISTSYPIFMNFAAIPMFAFLGGALTTVIVYRLGTSQFGTSITVM
LLAGVAISALSGAGIGYLNFIADDQMLRDLSLWSMGSLAGASWQDLLLAFLGLVILLTIFMKNAAGLNALLLGEAEAKHL
GINVQSLKKRMIILSAIGIGITVSLSGMIGFIGLIIPHLGRMMTGPNHRTLLPLSALLGGLLLTCADMFARVAVSPAELP
VGIVTAIIGAPFFLYLLFTQRGKFS

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=295, Percent_Identity=39.3220338983051, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1790740, Length=285, Percent_Identity=37.8947368421053, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790741, Length=307, Percent_Identity=33.2247557003257, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1786805, Length=322, Percent_Identity=35.7142857142857, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786347, Length=282, Percent_Identity=31.2056737588652, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1786804, Length=314, Percent_Identity=26.4331210191083, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36273; Mature: 36273

Theoretical pI: Translated: 10.17; Mature: 10.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLKYLSFSKLMLIGFSILFLTTLSSIAVGPMNITLADSFSSLLPGTRNIPAHIDLIIHQ
CEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHCCCCCCCCHHHHHHHHH
VRLPRTLLCMLVGAILAISGVVMQGLFRNPLAEPGIIGVSAGAALGAALAIVSFSSISTS
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCC
YPIFMNFAAIPMFAFLGGALTTVIVYRLGTSQFGTSITVMLLAGVAISALSGAGIGYLNF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHCCCCCHHHHH
IADDQMLRDLSLWSMGSLAGASWQDLLLAFLGLVILLTIFMKNAAGLNALLLGEAEAKHL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
GINVQSLKKRMIILSAIGIGITVSLSGMIGFIGLIIPHLGRMMTGPNHRTLLPLSALLGG
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHH
LLLTCADMFARVAVSPAELPVGIVTAIIGAPFFLYLLFTQRGKFS
HHHHHHHHHHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFLKYLSFSKLMLIGFSILFLTTLSSIAVGPMNITLADSFSSLLPGTRNIPAHIDLIIHQ
CEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHCCCCCCCCHHHHHHHHH
VRLPRTLLCMLVGAILAISGVVMQGLFRNPLAEPGIIGVSAGAALGAALAIVSFSSISTS
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCC
YPIFMNFAAIPMFAFLGGALTTVIVYRLGTSQFGTSITVMLLAGVAISALSGAGIGYLNF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCHHHHHHHHHHHHHHHHCCCCCHHHHH
IADDQMLRDLSLWSMGSLAGASWQDLLLAFLGLVILLTIFMKNAAGLNALLLGEAEAKHL
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHH
GINVQSLKKRMIILSAIGIGITVSLSGMIGFIGLIIPHLGRMMTGPNHRTLLPLSALLGG
CCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHH
LLLTCADMFARVAVSPAELPVGIVTAIIGAPFFLYLLFTQRGKFS
HHHHHHHHHHHHHCCHHHCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]