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The map label for this gene is norM [H]

Identifier: 209695024

GI number: 209695024

Start: 1618507

End: 1619874

Strand: Direct

Name: norM [H]

Synonym: VSAL_I1516

Alternate gene names: 209695024

Gene position: 1618507-1619874 (Clockwise)

Preceding gene: 209695021

Following gene: 209695025

Centisome position: 48.67

GC content: 42.69

Gene sequence:

>1368_bases
ATGAAAAAGATCTTAGCTTTAGCATTCCCTCTTATCATCTCTCAATTGGTTTCGATGGCACTGGTGCTTACCGATGTGTG
GATGATGTCGCGTTTAAGTGTTTCTGCCTTAGCGGGAGGTGGATTAGGTGCTTCTATTTATTTTTTCATTTTTATTATCG
CAAGCAGTACTGTGGGCTGCGTTGCGAACTTAATTGCCATCGCTTATGGCCAACGTTTGGCAAGACCTGAATACGGAAAC
CAACAAATTCGCTTTGCGGTAAAAGGGGCGGTTTTATTGTCTGCGGTGCTCAGCGTTATCTTAATGTTCAGTTTTTCATA
CGCTCCCGTGATACTAAAAGCGGCAAATCAACCTGAAGAGATGATCACGCTCGCGATGGAATACGTGCATGCGTTGAAAT
GGGTGATGTTTCCGTCGTTAATTTTACTCGTGTTACGCGGCTTAACCAGTGCGTTGGGAAACGTAAGATCCATCATGGTG
ATGTCTGTTATTACCGTTATCCTAAATGTCCCTATTAGTTATGTTTTAACGTTTCAATTGGGAATGGGATTAACCGGTTT
AGGTTTGGGTACCGCTGTAGCTGCTTTTGTTGTGATGATTGGTTATGGTATGTGGGTCTTTAAGCATCATGAATATCAAG
AGTTTGCACCATGGCGCAATAGAGAGGAATATTCACTTAAATTGATGGCACCTTTATTGGTGATGGGATTGCCTATTGCA
TTAGCCGCATTACTTGAGCATGGGTTAATTTATGGCGGTACACTGATGGCGGGCACTATCAGTATTGCGTCTTTAGCTTT
GCACCAAATCTTACTGCAATGTTTAAGCTTTACATGGAATTTTAATTTTGGATTTTCGCAAGCCGCGGCTATATTAGTCG
GGCGTGATTTTGGCTCAGAAAATTATGCAGGCATAAAACAAACGTCATTGCATAGTTTTTTACTTGTGACGGTACTCAGT
GTCTTCCTCTCCACGGTATTTATTCTTTGGCCTGAGGTTATTGCTGATTTATTCCTGCTTGATGATGGCACGAATAACAT
GTCAGCACTGTTGTCTTCTGTTATCTGGGTGGTGGCGTTGTGTTTTATTGTGGATGCATGGCAATTATTAGCGATTAACT
TATTGCGAGGAATGAAGATAGTCTCAATGCCTACGGTGATGACAGCGATTGGGTATTGGGTATTTGGTTTGCCTGCGGCG
TGGTTTTTGATGCCATTGTTCGGGCTTGCCGGAATTTGGGCAGGTATTGGCGTTGGATTAGGCGTTACCGGGGTGTTATT
ACTGATGCATTTAACGGTTGCTATTCGTCGCTACGGAAATGTGAGTTCTCTACCTATTCATACTGCAAATGCTTCTGGTA
AGATTTGA

Upstream 100 bases:

>100_bases
CCTTTTAACCCTTAAGTTTGCCATTAATCACAGTGCCTATTTCTTAATTAAATAAGAGGTTTGGCTTAGTTAACTTAGCG
ATAAAGAATTAACCTTATTT

Downstream 100 bases:

>100_bases
TTGCCTTCATTTTTAAGGTAGATTCGAGTTCCTTTTATAAGACAGTGTTACGGATATCTACAATGAACAAAGATGCAGCG
ACAATTGCTGGACAAGCAGT

Product: multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKILALAFPLIISQLVSMALVLTDVWMMSRLSVSALAGGGLGASIYFFIFIIASSTVGCVANLIAIAYGQRLARPEYGN
QQIRFAVKGAVLLSAVLSVILMFSFSYAPVILKAANQPEEMITLAMEYVHALKWVMFPSLILLVLRGLTSALGNVRSIMV
MSVITVILNVPISYVLTFQLGMGLTGLGLGTAVAAFVVMIGYGMWVFKHHEYQEFAPWRNREEYSLKLMAPLLVMGLPIA
LAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGSENYAGIKQTSLHSFLLVTVLS
VFLSTVFILWPEVIADLFLLDDGTNNMSALLSSVIWVVALCFIVDAWQLLAINLLRGMKIVSMPTVMTAIGYWVFGLPAA
WFLMPLFGLAGIWAGIGVGLGVTGVLLLMHLTVAIRRYGNVSSLPIHTANASGKI

Sequences:

>Translated_455_residues
MKKILALAFPLIISQLVSMALVLTDVWMMSRLSVSALAGGGLGASIYFFIFIIASSTVGCVANLIAIAYGQRLARPEYGN
QQIRFAVKGAVLLSAVLSVILMFSFSYAPVILKAANQPEEMITLAMEYVHALKWVMFPSLILLVLRGLTSALGNVRSIMV
MSVITVILNVPISYVLTFQLGMGLTGLGLGTAVAAFVVMIGYGMWVFKHHEYQEFAPWRNREEYSLKLMAPLLVMGLPIA
LAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGSENYAGIKQTSLHSFLLVTVLS
VFLSTVFILWPEVIADLFLLDDGTNNMSALLSSVIWVVALCFIVDAWQLLAINLLRGMKIVSMPTVMTAIGYWVFGLPAA
WFLMPLFGLAGIWAGIGVGLGVTGVLLLMHLTVAIRRYGNVSSLPIHTANASGKI
>Mature_455_residues
MKKILALAFPLIISQLVSMALVLTDVWMMSRLSVSALAGGGLGASIYFFIFIIASSTVGCVANLIAIAYGQRLARPEYGN
QQIRFAVKGAVLLSAVLSVILMFSFSYAPVILKAANQPEEMITLAMEYVHALKWVMFPSLILLVLRGLTSALGNVRSIMV
MSVITVILNVPISYVLTFQLGMGLTGLGLGTAVAAFVVMIGYGMWVFKHHEYQEFAPWRNREEYSLKLMAPLLVMGLPIA
LAALLEHGLIYGGTLMAGTISIASLALHQILLQCLSFTWNFNFGFSQAAAILVGRDFGSENYAGIKQTSLHSFLLVTVLS
VFLSTVFILWPEVIADLFLLDDGTNNMSALLSSVIWVVALCFIVDAWQLLAINLLRGMKIVSMPTVMTAIGYWVFGLPAA
WFLMPLFGLAGIWAGIGVGLGVTGVLLLMHLTVAIRRYGNVSSLPIHTANASGKI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI48994890, Length=444, Percent_Identity=25.6756756756757, Blast_Score=102, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49252; Mature: 49252

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]