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The map label for this gene is ndh [H]

Identifier: 209694845

GI number: 209694845

Start: 1422124

End: 1423413

Strand: Direct

Name: ndh [H]

Synonym: VSAL_I1311

Alternate gene names: 209694845

Gene position: 1422124-1423413 (Clockwise)

Preceding gene: 209694844

Following gene: 209694846

Centisome position: 42.77

GC content: 40.47

Gene sequence:

>1290_bases
ATGACTAAGATTGTTATTGTTGGTGGTGGAGCTGGTGGTTTAGAGCTTGCTACTAAGTTTGGTCGTACACTGGGTCGCAA
AGGCCGTGCTGAAGTGACGTTGGTTGATCGTAAAACGAGCCATTTATGGAAACCATTACTGCATGAAGTAGCTACAGGGT
CTTTGGATGAAGGTGTTGATGCAATCAGTTACCGTGCACATGCTAAAAACCATTCATTTGATTTTCAAATGGGCAGCTTG
TGCGATATTGACCGTGAGAAAAAACAAATCAAGTTAGCTGTCATTAAAGATGAGCATGGTGAAGTTATTGTTCCTGTTCG
TCATATTGATTATGATTTCTTGATCCTTGCTATTGGTTCAACATCAAATGATTTTAATACACCGGGCGTTCGCGATAATT
GTATTTTCTTAGACAGTCCTGAACAAGCGAATCGTTTCCGTACTGAAATGAATAATCAATTCTTGAAGTTACATTCGCAT
CCAACACAAAAAACGGTAGATATTGCGATCGTTGGCGCGGGTGCGACAGGTGTTGAGCTTTCTGCTGAATTGCATAATGC
GGTTAAAGAACTTCGTTCTTACGGATTTGGTGATTTAGATTCAAGTAAATTGAATGTAAGCCTAGTGGAAGCGGGTGAAC
GTATTCTTCCTGCTCTTCCTCCTCGTATTTCGGCTTCTGCACACAGTGAATTAACGAAACTTGGTGTGAATGTACGTACG
GCAACGATGGTAACAAAAGCCGATTCAGAAGGTTTACATACTAAAGATGGTGACGTTATTCCTGCACAAATCATGGTATG
GGCTGCGGGTATTAAAGCGCCTGATTTCATGAAAGACATCGCAGGTCTTGAAACGAATCGAATCAATCAACTTGTTGTTA
AACCAACATTACAAACAACACGTGATGATTGTATTTTTGTTATTGGTGACTTGGCATCATGCCAACAAGCGGACGGTAGT
TTTGTTCCACCTCGTGCTCAATCTGCTCATCAAATGGCAAGCCATGCGTTTAAGAATATCGTCGCTAAGATGACTGATCG
TGAAATGAAACCATACGTTTATAAAGATCATGGTTCTTTAGTGTCATTAAGCAACTTCTCAACGGTTGGTAGCTTAATGG
GTAACCTAACTAAAGGCTCAATGATGATTGAAGGTCGTATTGCTCGTATTGTGTATATTTCACTTTATCGCATGCATCAA
GTTGCCTTACATGGTGTCTTTAAAACAGCACTGATCGTGCTTGTTGGTCGTATTAATCGAGTATTACGTCCAAACCTAAA
ACTTCACTAA

Upstream 100 bases:

>100_bases
CTCTCTTTTACTATATGTAATAAAACATGTTGAGAGCATCAATTTTTTAATCTGAGTATTCGGGTTAATACACTTTTTTA
TTTTTTAGAGGAAGATTGCA

Downstream 100 bases:

>100_bases
TTCGGTCGTTTTAAAAATAAATGAGTAAAAAGGCAGAAGTACTTTGGTATTTCTGCTTTTTTTTATGATTGAGTAACAAA
AAATGTGCGCTAACTCACCA

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKTSHLWKPLLHEVATGSLDEGVDAISYRAHAKNHSFDFQMGSL
CDIDREKKQIKLAVIKDEHGEVIVPVRHIDYDFLILAIGSTSNDFNTPGVRDNCIFLDSPEQANRFRTEMNNQFLKLHSH
PTQKTVDIAIVGAGATGVELSAELHNAVKELRSYGFGDLDSSKLNVSLVEAGERILPALPPRISASAHSELTKLGVNVRT
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTRDDCIFVIGDLASCQQADGS
FVPPRAQSAHQMASHAFKNIVAKMTDREMKPYVYKDHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARIVYISLYRMHQ
VALHGVFKTALIVLVGRINRVLRPNLKLH

Sequences:

>Translated_429_residues
MTKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKTSHLWKPLLHEVATGSLDEGVDAISYRAHAKNHSFDFQMGSL
CDIDREKKQIKLAVIKDEHGEVIVPVRHIDYDFLILAIGSTSNDFNTPGVRDNCIFLDSPEQANRFRTEMNNQFLKLHSH
PTQKTVDIAIVGAGATGVELSAELHNAVKELRSYGFGDLDSSKLNVSLVEAGERILPALPPRISASAHSELTKLGVNVRT
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTRDDCIFVIGDLASCQQADGS
FVPPRAQSAHQMASHAFKNIVAKMTDREMKPYVYKDHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARIVYISLYRMHQ
VALHGVFKTALIVLVGRINRVLRPNLKLH
>Mature_428_residues
TKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKTSHLWKPLLHEVATGSLDEGVDAISYRAHAKNHSFDFQMGSLC
DIDREKKQIKLAVIKDEHGEVIVPVRHIDYDFLILAIGSTSNDFNTPGVRDNCIFLDSPEQANRFRTEMNNQFLKLHSHP
TQKTVDIAIVGAGATGVELSAELHNAVKELRSYGFGDLDSSKLNVSLVEAGERILPALPPRISASAHSELTKLGVNVRTA
TMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTRDDCIFVIGDLASCQQADGSF
VPPRAQSAHQMASHAFKNIVAKMTDREMKPYVYKDHGSLVSLSNFSTVGSLMGNLTKGSMMIEGRIARIVYISLYRMHQV
ALHGVFKTALIVLVGRINRVLRPNLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=430, Percent_Identity=72.3255813953488, Blast_Score=627, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323794, Length=351, Percent_Identity=29.0598290598291, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320118, Length=367, Percent_Identity=26.9754768392371, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323515, Length=445, Percent_Identity=26.2921348314607, Blast_Score=91, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 46949; Mature: 46818

Theoretical pI: Translated: 9.29; Mature: 9.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKTSHLWKPLLHEVATGSLDEGVD
CEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHCCCH
AISYRAHAKNHSFDFQMGSLCDIDREKKQIKLAVIKDEHGEVIVPVRHIDYDFLILAIGS
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCEEEEEEEECC
TSNDFNTPGVRDNCIFLDSPEQANRFRTEMNNQFLKLHSHPTQKTVDIAIVGAGATGVEL
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCEE
SAELHNAVKELRSYGFGDLDSSKLNVSLVEAGERILPALPPRISASAHSELTKLGVNVRT
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCHHHHHHHHHCCCEEE
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTT
EEEEEECCCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCHHCC
RDDCIFVIGDLASCQQADGSFVPPRAQSAHQMASHAFKNIVAKMTDREMKPYVYKDHGSL
CCCEEEEEECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCE
VSLSNFSTVGSLMGNLTKGSMMIEGRIARIVYISLYRMHQVALHGVFKTALIVLVGRINR
EEECCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPNLKLH
HHCCCCCCC
>Mature Secondary Structure 
TKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKTSHLWKPLLHEVATGSLDEGVD
EEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCHHCCCH
AISYRAHAKNHSFDFQMGSLCDIDREKKQIKLAVIKDEHGEVIVPVRHIDYDFLILAIGS
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEEEECCEEEEEEEECC
TSNDFNTPGVRDNCIFLDSPEQANRFRTEMNNQFLKLHSHPTQKTVDIAIVGAGATGVEL
CCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEECCCCCCEE
SAELHNAVKELRSYGFGDLDSSKLNVSLVEAGERILPALPPRISASAHSELTKLGVNVRT
HHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHCCCCCCCCCCHHHHHHHHHCCCEEE
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTT
EEEEEECCCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCHHCC
RDDCIFVIGDLASCQQADGSFVPPRAQSAHQMASHAFKNIVAKMTDREMKPYVYKDHGSL
CCCEEEEEECCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCE
VSLSNFSTVGSLMGNLTKGSMMIEGRIARIVYISLYRMHQVALHGVFKTALIVLVGRINR
EEECCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPNLKLH
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]