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The map label for this gene is iscA [H]

Identifier: 209694308

GI number: 209694308

Start: 804048

End: 804371

Strand: Direct

Name: iscA [H]

Synonym: VSAL_I0719

Alternate gene names: 209694308

Gene position: 804048-804371 (Clockwise)

Preceding gene: 209694307

Following gene: 209694309

Centisome position: 24.18

GC content: 39.81

Gene sequence:

>324_bases
ATGGCCATTTCAGTAACCGAAGCAGCAGCAAGCCGTGTTCAAACATTTCTTGAAAACCGAGGAAAAGGCATTGGTCTACG
TTTAGGCGTAAGAACCTCTGGTTGCTCTGGTATGGCGTATATTCTTGAGTTTGTTGATGATCTAAATGAAGAAGACGAAG
TCTTTGAAAAGTTTGGTGTAAAAATCATCATCGATCCAAAAAGTTTAGCTTATATGGATGGCACTGAATTAGACTTTGCC
AAAGAAGGTCTAAATGAAGGCTTCAAGTTCAACAACCCTAACGTAAAAAGTGAATGTGGGTGTGGTGAAAGCTTCAACGT
ATAG

Upstream 100 bases:

>100_bases
CGTTTTGTTTGTAATATAGTAAAGCGCTTTGTTATCTAAGTAGGTCATTATTAGTTAATGACATCCATGACCACAAAACA
AATATAGTAAAGGTTGTAGT

Downstream 100 bases:

>100_bases
AGCATAACGTTAACTATGAATCATTTTGAATTATTTGGGCTACCAAACCAGTTTGAACTGGATGGTGGCCTTCTTTCTGC
TCAGTTCCTTGAATTGCAGA

Product: iron-binding protein IscA (iron-sulfur cluster assembly protein)

Products: NA

Alternate protein names: Iron-sulfur cluster assembly protein [H]

Number of amino acids: Translated: 107; Mature: 106

Protein sequence:

>107_residues
MAISVTEAAASRVQTFLENRGKGIGLRLGVRTSGCSGMAYILEFVDDLNEEDEVFEKFGVKIIIDPKSLAYMDGTELDFA
KEGLNEGFKFNNPNVKSECGCGESFNV

Sequences:

>Translated_107_residues
MAISVTEAAASRVQTFLENRGKGIGLRLGVRTSGCSGMAYILEFVDDLNEEDEVFEKFGVKIIIDPKSLAYMDGTELDFA
KEGLNEGFKFNNPNVKSECGCGESFNV
>Mature_106_residues
AISVTEAAASRVQTFLENRGKGIGLRLGVRTSGCSGMAYILEFVDDLNEEDEVFEKFGVKIIIDPKSLAYMDGTELDFAK
EGLNEGFKFNNPNVKSECGCGESFNV

Specific function: Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that iscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transi

COG id: COG0316

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesB/iscA family [H]

Homologues:

Organism=Homo sapiens, GI52426768, Length=106, Percent_Identity=38.6792452830189, Blast_Score=100, Evalue=3e-22,
Organism=Homo sapiens, GI160420328, Length=96, Percent_Identity=37.5, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788877, Length=107, Percent_Identity=71.9626168224299, Blast_Score=166, Evalue=3e-43,
Organism=Escherichia coli, GI1787974, Length=105, Percent_Identity=41.9047619047619, Blast_Score=106, Evalue=3e-25,
Organism=Escherichia coli, GI1786351, Length=110, Percent_Identity=40.9090909090909, Blast_Score=81, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI25146411, Length=106, Percent_Identity=39.622641509434, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193209025, Length=106, Percent_Identity=39.622641509434, Blast_Score=98, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71998452, Length=106, Percent_Identity=34.9056603773585, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323001, Length=105, Percent_Identity=39.0476190476191, Blast_Score=83, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24642263, Length=106, Percent_Identity=42.4528301886792, Blast_Score=102, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24649697, Length=108, Percent_Identity=32.4074074074074, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000361
- InterPro:   IPR016092
- InterPro:   IPR017870
- InterPro:   IPR011302 [H]

Pfam domain/function: PF01521 Fe-S_biosyn [H]

EC number: NA

Molecular weight: Translated: 11681; Mature: 11550

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS01152 HESB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISVTEAAASRVQTFLENRGKGIGLRLGVRTSGCSGMAYILEFVDDLNEEDEVFEKFGV
CCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
KIIIDPKSLAYMDGTELDFAKEGLNEGFKFNNPNVKSECGCGESFNV
EEEECCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AISVTEAAASRVQTFLENRGKGIGLRLGVRTSGCSGMAYILEFVDDLNEEDEVFEKFGV
CCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
KIIIDPKSLAYMDGTELDFAKEGLNEGFKFNNPNVKSECGCGESFNV
EEEECCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA