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The map label for this gene is proC [H]

Identifier: 209694135

GI number: 209694135

Start: 596137

End: 596955

Strand: Reverse

Name: proC [H]

Synonym: VSAL_I0542

Alternate gene names: 209694135

Gene position: 596955-596137 (Counterclockwise)

Preceding gene: 209694136

Following gene: 209694134

Centisome position: 17.95

GC content: 43.83

Gene sequence:

>819_bases
ATGGAACATCGTAACATTGCTTTTATTGGTGCGGGAAACATGACTCGTTCAATCATTGCAGGCTTAATTAGCAGTGGTTA
TCCAAAAAAAAATATCACCGCAACAAACCCAAGCACTGACAAACTAAACAATTTAGAGCAATGCTATGGTATTAACATCA
GTACCGATAACCTTGCCGCAGCTCAACAGGCTGACGTTATTGTTCTTGCTGTAAAACCACAAATGATGGAGACCGCAGCA
AAGCCACTCCAATCCGTGGATTACTCTGATAAACTGGTTATTTCGATTGCTGCTGGTATTTCAGCTAAACGCTTAAATGA
AATGTTCGCTGCCGAATTAAATTTGGTTCGAGTCATGCCGAATACGCCAGCATTAGTCGGTAAAGGCATGAGTGGCCTAT
TTGCCGTTGAGCATATTTCCGAACAAGACAAACATTTTGCAAGTGATTTACTTTCAGCCGTGGGGGAAGTCTGCTGGGTT
GAAAAAGAATCTGGTATTAATTCTGTCATTGCAGCAGCAGGAAGCGCACCTGCGTATTTCTTCTTATTTATGGAAGCAAT
GCAGGCCGAAGCCATTAAACAGGGCTTTAGTGAGGATACCGCTCGTCTGTTAGTGCAACAATCCGCACTCGGTGCCGCCG
AAATGGTCATAGCAAATCCTGAAACACCATTATCAACACTGCGTGAACAAGTGACCTCAAAAGGTGGGACTACTGCTGAA
GCACTTCGCACGTTTAATGAACATCATCTGCAAGAGATCGTCGCTAAAGCAATGCAAGCGGCCGTAGCTCGTGCAGAAGA
AATGGAAACGTTGTTTTAA

Upstream 100 bases:

>100_bases
ATGGTACGTATTGGTACTGCTATTTTTGGTGCAAGAAACTATACCAATGAAGTAATAATACACAGTAAGCGACTCTTAAA
AATAAAAAATAGGAATACGA

Downstream 100 bases:

>100_bases
AAACTGCTTTGCTTGAAGCAACTCTGTTTAAAAAACGCTATAAAAAAAACCAATGATTTTTAAGGTTAACTAACTATGAA
TGCAATGAGCTTTTTAATCT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 272; Mature: 272

Protein sequence:

>272_residues
MEHRNIAFIGAGNMTRSIIAGLISSGYPKKNITATNPSTDKLNNLEQCYGINISTDNLAAAQQADVIVLAVKPQMMETAA
KPLQSVDYSDKLVISIAAGISAKRLNEMFAAELNLVRVMPNTPALVGKGMSGLFAVEHISEQDKHFASDLLSAVGEVCWV
EKESGINSVIAAAGSAPAYFFLFMEAMQAEAIKQGFSEDTARLLVQQSALGAAEMVIANPETPLSTLREQVTSKGGTTAE
ALRTFNEHHLQEIVAKAMQAAVARAEEMETLF

Sequences:

>Translated_272_residues
MEHRNIAFIGAGNMTRSIIAGLISSGYPKKNITATNPSTDKLNNLEQCYGINISTDNLAAAQQADVIVLAVKPQMMETAA
KPLQSVDYSDKLVISIAAGISAKRLNEMFAAELNLVRVMPNTPALVGKGMSGLFAVEHISEQDKHFASDLLSAVGEVCWV
EKESGINSVIAAAGSAPAYFFLFMEAMQAEAIKQGFSEDTARLLVQQSALGAAEMVIANPETPLSTLREQVTSKGGTTAE
ALRTFNEHHLQEIVAKAMQAAVARAEEMETLF
>Mature_272_residues
MEHRNIAFIGAGNMTRSIIAGLISSGYPKKNITATNPSTDKLNNLEQCYGINISTDNLAAAQQADVIVLAVKPQMMETAA
KPLQSVDYSDKLVISIAAGISAKRLNEMFAAELNLVRVMPNTPALVGKGMSGLFAVEHISEQDKHFASDLLSAVGEVCWV
EKESGINSVIAAAGSAPAYFFLFMEAMQAEAIKQGFSEDTARLLVQQSALGAAEMVIANPETPLSTLREQVTSKGGTTAE
ALRTFNEHHLQEIVAKAMQAAVARAEEMETLF

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=28.1954887218045, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI24797097, Length=274, Percent_Identity=28.4671532846715, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI24797095, Length=274, Percent_Identity=28.4671532846715, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI21361454, Length=273, Percent_Identity=27.1062271062271, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786585, Length=267, Percent_Identity=35.9550561797753, Blast_Score=155, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=33.2075471698113, Blast_Score=132, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=31.7689530685921, Blast_Score=116, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=285, Percent_Identity=26.3157894736842, Blast_Score=92, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=32.8358208955224, Blast_Score=135, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24648116, Length=274, Percent_Identity=30.2919708029197, Blast_Score=121, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24647700, Length=170, Percent_Identity=32.9411764705882, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29119; Mature: 29119

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHRNIAFIGAGNMTRSIIAGLISSGYPKKNITATNPSTDKLNNLEQCYGINISTDNLAA
CCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCHHH
AQQADVIVLAVKPQMMETAAKPLQSVDYSDKLVISIAAGISAKRLNEMFAAELNLVRVMP
HHHCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEECC
NTPALVGKGMSGLFAVEHISEQDKHFASDLLSAVGEVCWVEKESGINSVIAAAGSAPAYF
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHH
FLFMEAMQAEAIKQGFSEDTARLLVQQSALGAAEMVIANPETPLSTLREQVTSKGGTTAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHCCCCHHH
ALRTFNEHHLQEIVAKAMQAAVARAEEMETLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEHRNIAFIGAGNMTRSIIAGLISSGYPKKNITATNPSTDKLNNLEQCYGINISTDNLAA
CCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHCCCCCCCCHHH
AQQADVIVLAVKPQMMETAAKPLQSVDYSDKLVISIAAGISAKRLNEMFAAELNLVRVMP
HHHCCEEEEEECHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEECC
NTPALVGKGMSGLFAVEHISEQDKHFASDLLSAVGEVCWVEKESGINSVIAAAGSAPAYF
CCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCHHHH
FLFMEAMQAEAIKQGFSEDTARLLVQQSALGAAEMVIANPETPLSTLREQVTSKGGTTAE
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHCCCCHHH
ALRTFNEHHLQEIVAKAMQAAVARAEEMETLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8982386 [H]