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The map label for this gene is pepA

Identifier: 209694119

GI number: 209694119

Start: 581790

End: 583298

Strand: Reverse

Name: pepA

Synonym: VSAL_I0526

Alternate gene names: 209694119

Gene position: 583298-581790 (Counterclockwise)

Preceding gene: 209694122

Following gene: 209694118

Centisome position: 17.54

GC content: 43.61

Gene sequence:

>1509_bases
ATGGAGTTCAGTGTAAAAAGTGGCAGTCCAGAGAAACAACGCAGCGCATGTATCGTTGTCGGTGTTTTTGAACCACGTCG
TTTGTCTCCAATAGCAGAACAGCTTGATAAAATCAGTGACGGTTACATTAGTTCATTACTTCGCCGTGGTGATCTAGAAG
GTAAACCGGGTCAAATGCTGTTATTACATCAAGTACCAAATATTCTTTCTGAGCGTGTTTTATTAGTCGGTTGTGGTAAA
GAGCGTGAACTTGGTGAGCGCCAGTATAAAGATATCATCAAAAAAACCATCAGCACACTAAATGAAACGGGCTCTATGGA
AGCAGTATGTTTCCTTACAGAACTACACGTTAAAGGCCGTGATACGTATTGGAAAGTACGTCAAGCGGTTGAATCAACCA
AAGACAGTTTATACACATTCAATCAATTCAAGAGTAATAAACCTGAGACTCGTCGCCCACTTCGTAAGTTAGTATTTAAT
GTACCAACTCGTAGAGAGCTTAGCTTAGGTGAGAAAGCCATCAATCACGGTCTTTCTATCTCTTCTGGCGTTAAAGCATC
AAAAGATTTAGGCAACATGCCACCAAACGTTGCAAACCCTGCTTATCTTGCTTCTCAAGCACGCCGCCTTGCTGACGACT
TTGAAACCGTAACGACAAAAGTTATTGGCGAAGAAGAAATGAAGAAATTGGGAATGACGTCTTACCTAGCTGTAGGCCAA
GGCTCTCACAATGAATCAATGATGTCGGTAATGGAATACAAAGGCCACCCGAATCCTGATGCAAAACCAATTGTCCTTAT
CGGCAAAGGCCTAACATTTGATTCCGGCGGTATCTCTTTGAAACCTAGCGATAGCATGGATGAGATGAAATACGACATGT
GTGGCGCCGCTTCTGTCTTTGGCGCAATGAAAGCACTTGCGAAGCTAAATCTTCCATTAAATGTTGTTGGTATACTTGCT
GGTTGTGAAAACATGCCAAGCAGTAACTCTTACCGCCCCGGTGATATTTTAACAACCATGTCAGGCCAAACCGTTGAAGT
ATTAAATACCGATGCAGAAGGTCGTTTGGTTCTTTGTGACGCATTAACGTATGTTGAGCGCTACGAACCAGATTGTGTGG
TTGATGTCGCGACGTTAACCGGTGCATGTGTTGTTGCTTTAGGCCACCACATCAACGGTCTGCTTTCTAACCATAATCCA
TTAGCACATGAACTGATTAATGCGTCAGAGCAATCAGGTGATCGTGCATGGCGTTTACCAATGTCCGAAGAATACAACGA
ACAGTTAAATAGCCCGTTCGCTGACATGGCAAATATTGGTGGTAAAGCAGGTGGTACTATTACCGCTGGTTGTTTCCTTG
CTCGTTTTGCTAAGAAATACAACTGGGCTCACATTGATAGTGCTGGTACCGCTTGGGTTTCAGGTGCAAACAAAGGCTCT
ACCGGCCGACCAGTCTCATTGCTTGTCCAATTCTTACTGAATCGTTCAGGTCCAGAAAGCGTAGAGTAA

Upstream 100 bases:

>100_bases
TTAGCCTGCGAAATCGGTACACTAATATTATAGTATCTAACTAGATTTTGCTCATTATCTAACATTTAGTTCTATTTGTC
TTTAGGATGTAGGAGTACGC

Downstream 100 bases:

>100_bases
CCCTCCTCACTTTCATGATATTAAGGGCCGATATTAAGGCCCTTTTTTAATGACTTTATTTCCGTCATTATGTTGTAAAA
TATAAGAGATACTATGAGCC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPNILSERVLLVGCGK
ERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFN
VPTRRELSLGEKAINHGLSISSGVKASKDLGNMPPNVANPAYLASQARRLADDFETVTTKVIGEEEMKKLGMTSYLAVGQ
GSHNESMMSVMEYKGHPNPDAKPIVLIGKGLTFDSGGISLKPSDSMDEMKYDMCGAASVFGAMKALAKLNLPLNVVGILA
GCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERYEPDCVVDVATLTGACVVALGHHINGLLSNHNP
LAHELINASEQSGDRAWRLPMSEEYNEQLNSPFADMANIGGKAGGTITAGCFLARFAKKYNWAHIDSAGTAWVSGANKGS
TGRPVSLLVQFLLNRSGPESVE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPNILSERVLLVGCGK
ERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFN
VPTRRELSLGEKAINHGLSISSGVKASKDLGNMPPNVANPAYLASQARRLADDFETVTTKVIGEEEMKKLGMTSYLAVGQ
GSHNESMMSVMEYKGHPNPDAKPIVLIGKGLTFDSGGISLKPSDSMDEMKYDMCGAASVFGAMKALAKLNLPLNVVGILA
GCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERYEPDCVVDVATLTGACVVALGHHINGLLSNHNP
LAHELINASEQSGDRAWRLPMSEEYNEQLNSPFADMANIGGKAGGTITAGCFLARFAKKYNWAHIDSAGTAWVSGANKGS
TGRPVSLLVQFLLNRSGPESVE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPNILSERVLLVGCGK
ERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFN
VPTRRELSLGEKAINHGLSISSGVKASKDLGNMPPNVANPAYLASQARRLADDFETVTTKVIGEEEMKKLGMTSYLAVGQ
GSHNESMMSVMEYKGHPNPDAKPIVLIGKGLTFDSGGISLKPSDSMDEMKYDMCGAASVFGAMKALAKLNLPLNVVGILA
GCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERYEPDCVVDVATLTGACVVALGHHINGLLSNHNP
LAHELINASEQSGDRAWRLPMSEEYNEQLNSPFADMANIGGKAGGTITAGCFLARFAKKYNWAHIDSAGTAWVSGANKGS
TGRPVSLLVQFLLNRSGPESVE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=333, Percent_Identity=39.9399399399399, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI47155554, Length=319, Percent_Identity=30.7210031347962, Blast_Score=133, Evalue=5e-31,
Organism=Escherichia coli, GI1790710, Length=498, Percent_Identity=78.1124497991968, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=37.5394321766561, Blast_Score=186, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=309, Percent_Identity=33.0097087378641, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17565172, Length=133, Percent_Identity=36.0902255639098, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129969, Length=518, Percent_Identity=28.5714285714286, Blast_Score=193, Evalue=2e-49,
Organism=Drosophila melanogaster, GI21355725, Length=324, Percent_Identity=33.9506172839506, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24661038, Length=324, Percent_Identity=34.2592592592593, Blast_Score=191, Evalue=7e-49,
Organism=Drosophila melanogaster, GI21355645, Length=501, Percent_Identity=28.1437125748503, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662223, Length=501, Percent_Identity=28.1437125748503, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24662227, Length=510, Percent_Identity=27.6470588235294, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI161077148, Length=491, Percent_Identity=27.9022403258656, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI20130057, Length=491, Percent_Identity=27.9022403258656, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI20129963, Length=505, Percent_Identity=29.1089108910891, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI19922386, Length=496, Percent_Identity=28.6290322580645, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI221379063, Length=319, Percent_Identity=30.7210031347962, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI221379062, Length=319, Percent_Identity=30.7210031347962, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21357381, Length=319, Percent_Identity=30.7210031347962, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24646701, Length=230, Percent_Identity=29.1304347826087, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24646703, Length=230, Percent_Identity=29.1304347826087, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21358201, Length=230, Percent_Identity=29.1304347826087, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_ALISL (B6EMT2)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002262047.1
- MEROPS:   M17.003
- GeneID:   6988676
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0526
- HOGENOM:   HBG742580
- OMA:   LGHHISG
- ProtClustDB:   PRK00913
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54606; Mature: 54606

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 281-281 ACT_SITE 355-355

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISSLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEE
LLHQVPNILSERVLLVGCGKERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGR
EHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFNVPTRRELSLGEKAINHGLSI
CHHHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
SSGVKASKDLGNMPPNVANPAYLASQARRLADDFETVTTKVIGEEEMKKLGMTSYLAVGQ
CCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHEEEECC
GSHNESMMSVMEYKGHPNPDAKPIVLIGKGLTFDSGGISLKPSDSMDEMKYDMCGAASVF
CCCHHHHHHHHHHCCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHH
GAMKALAKLNLPLNVVGILAGCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEH
ALTYVERYEPDCVVDVATLTGACVVALGHHINGLLSNHNPLAHELINASEQSGDRAWRLP
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEECC
MSEEYNEQLNSPFADMANIGGKAGGTITAGCFLARFAKKYNWAHIDSAGTAWVSGANKGS
CCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCC
TGRPVSLLVQFLLNRSGPESVE
CCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISSLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEE
LLHQVPNILSERVLLVGCGKERELGERQYKDIIKKTISTLNETGSMEAVCFLTELHVKGR
EHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVESTKDSLYTFNQFKSNKPETRRPLRKLVFNVPTRRELSLGEKAINHGLSI
CHHHHHHHHHHHHHHHHEEHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCC
SSGVKASKDLGNMPPNVANPAYLASQARRLADDFETVTTKVIGEEEMKKLGMTSYLAVGQ
CCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHEEEECC
GSHNESMMSVMEYKGHPNPDAKPIVLIGKGLTFDSGGISLKPSDSMDEMKYDMCGAASVF
CCCHHHHHHHHHHCCCCCCCCCEEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHH
GAMKALAKLNLPLNVVGILAGCENMPSSNSYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEH
ALTYVERYEPDCVVDVATLTGACVVALGHHINGLLSNHNPLAHELINASEQSGDRAWRLP
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEECC
MSEEYNEQLNSPFADMANIGGKAGGTITAGCFLARFAKKYNWAHIDSAGTAWVSGANKGS
CCHHHHHHHCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCC
TGRPVSLLVQFLLNRSGPESVE
CCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA