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The map label for this gene is pgi

Identifier: 209693987

GI number: 209693987

Start: 425233

End: 426885

Strand: Direct

Name: pgi

Synonym: VSAL_I0385

Alternate gene names: 209693987

Gene position: 425233-426885 (Clockwise)

Preceding gene: 209693986

Following gene: 209693990

Centisome position: 12.79

GC content: 39.75

Gene sequence:

>1653_bases
ATGTTAAAAAACATCAACCCAACAGAAACTCAAGCTTGGGCAGATTTGACTGCACATTTTGAAACCGCGCAAAACTTCAA
TTTAGCGGATTTGTTTTCTGCTGATGCTCAACGTTTTGATAAATTTTCAACAACGTTTGGCCAAGATATCTTAGTTGATT
TCTCTAAAAATTTAGTGACAGAAGAAACGATGCAAAAGCTATTTTCTTTAGCTGAGCAAACTGAATTATCAGAAGCAATC
AAAGCGATGTTCAGTGGTGAAAAAATCAATAAGACTGAAGATCGTTCAGTGCTTCATACGGCACTTCGTAACCGCAGTAA
TACGCCAGTTATCGTTGATGGCGAAGACGTTATGCCTGCTGTAAATGCAGTGCTAGAAAAAATGAAAGCGTTCACTGAGC
GTTTAATTTCTGGTGAGTGGAAAGGTTACACAGGCAAAGAAATTACGGATATCGTAAACATTGGTATCGGTGGTTCAGAT
CTTGGCCCTTACATGGTGTCAGAAGCATTAGCACCATACAAAACACGCTTAAACATGCACTTTGTTTCAAACGTCGATGG
CACACACATTGTTGAAACATTGAAGCCATTAAATCCAGAAACAACGTTGTTCTTAATCGCATCGAAAACATTCACGACTC
AAGAAACAATGACAAATGCACACAGTGCTCGTGATTGGTTCTTAGCAGAAGCTGGCGATCAAGCACATGTAGCGAAACAC
TTCGCTGCACTTTCAACAAACGCAGAATCAGTGTCTGAGTTTGGTATTGATACCGATAACATGTTTGAGTTCTGGGATTG
GGTTGGCGGTCGTTATTCTTTATGGTCAGCGATTGGTCTTTCAATTGCTTTAGCGGTTGGTTTTGATAATTTTGTTGAGC
TTCTTGAAGGCGCTCACGAAGTGGATAATCATTTCGCAAATACAGAACTTGAAAATAACGTACCAGTAATCTTGGCATTG
ATTGGCCTATGGTATAACAACTTCCATGGTTCTGAATCAGAATCGATTCTGCCATACGATCAATACCTACACCGTTTTGC
TGCGTATTTCCAACAAGGTAATATGGAATCAAACGGTAAATGTGTTGACCGTAATGGCAATCCAGTTGATTACCAAACGG
GTCCAATTATTTGGGGTGAACCAGGTACAAATGGTCAGCATGCGTTCTACCAATTGATTCACCAAGGTACGAAATTGATC
CCATGTGATTTTATTGCTCCTGCAATCAGTCATAACCAAGTGGGCGATCATCATCAAAAACTGATGTCTAACTTCTTTGC
ACAAACAGAAGCATTGGCGTTTGGTAAAAAAGAAGAAACAGTAAGAGCAGAGTTTGCAGCGGCAGGTAAAACTGAAGCAG
AAATGGCAGAGTTGGTGGCATTTAAAGTCTTTGAAGGTAACCGCCCAACTAACTCAATCTTAGTGAAAAAAGTGACACCT
AAAACATTAGGCAACTTGATTGCTATGTACGAACATAAAATCTTCGTACAGGGTGTGATTTGGAATATCTTCAGTTTTGA
CCAATGGGGTGTAGAACTTGGTAAGCAATTGGCTAACCAAATTCTTCCTGAATTGGCTGATGATAAAGCGATTAACTCGC
ATGACAGTTCAACGAATGGCTTAATTAACGCATTTAAAGCGTTTAAAGCATAA

Upstream 100 bases:

>100_bases
TCATAATAGATAAAGCTCATCAAATTTTAGATTCGTATAAACGGGGAGTTCAGAAATTTATTTTTGAACCGACAAGCATA
TTACACGGGATAATTTCACC

Downstream 100 bases:

>100_bases
TTGAATTGCACTCGATAATATGAAAGAGCTGACTTCGGTTGGCTCTTTTTATATGTGCTGATTTTATACAGATAATAAAA
AAGGTTGATGTATTACTACA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MLKNINPTETQAWADLTAHFETAQNFNLADLFSADAQRFDKFSTTFGQDILVDFSKNLVTEETMQKLFSLAEQTELSEAI
KAMFSGEKINKTEDRSVLHTALRNRSNTPVIVDGEDVMPAVNAVLEKMKAFTERLISGEWKGYTGKEITDIVNIGIGGSD
LGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
FAALSTNAESVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFVELLEGAHEVDNHFANTELENNVPVILAL
IGLWYNNFHGSESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKKEETVRAEFAAAGKTEAEMAELVAFKVFEGNRPTNSILVKKVTP
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAINSHDSSTNGLINAFKAFKA

Sequences:

>Translated_550_residues
MLKNINPTETQAWADLTAHFETAQNFNLADLFSADAQRFDKFSTTFGQDILVDFSKNLVTEETMQKLFSLAEQTELSEAI
KAMFSGEKINKTEDRSVLHTALRNRSNTPVIVDGEDVMPAVNAVLEKMKAFTERLISGEWKGYTGKEITDIVNIGIGGSD
LGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
FAALSTNAESVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFVELLEGAHEVDNHFANTELENNVPVILAL
IGLWYNNFHGSESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKKEETVRAEFAAAGKTEAEMAELVAFKVFEGNRPTNSILVKKVTP
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAINSHDSSTNGLINAFKAFKA
>Mature_550_residues
MLKNINPTETQAWADLTAHFETAQNFNLADLFSADAQRFDKFSTTFGQDILVDFSKNLVTEETMQKLFSLAEQTELSEAI
KAMFSGEKINKTEDRSVLHTALRNRSNTPVIVDGEDVMPAVNAVLEKMKAFTERLISGEWKGYTGKEITDIVNIGIGGSD
LGPYMVSEALAPYKTRLNMHFVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
FAALSTNAESVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFVELLEGAHEVDNHFANTELENNVPVILAL
IGLWYNNFHGSESESILPYDQYLHRFAAYFQQGNMESNGKCVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLI
PCDFIAPAISHNQVGDHHQKLMSNFFAQTEALAFGKKEETVRAEFAAAGKTEAEMAELVAFKVFEGNRPTNSILVKKVTP
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAINSHDSSTNGLINAFKAFKA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=532, Percent_Identity=64.2857142857143, Blast_Score=712, Evalue=0.0,
Organism=Homo sapiens, GI296080693, Length=532, Percent_Identity=60.1503759398496, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI1790457, Length=549, Percent_Identity=75.2276867030965, Blast_Score=891, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996708, Length=550, Percent_Identity=61.8181818181818, Blast_Score=703, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71996703, Length=545, Percent_Identity=62.2018348623853, Blast_Score=702, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319673, Length=547, Percent_Identity=58.6837294332724, Blast_Score=645, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651916, Length=543, Percent_Identity=62.6151012891344, Blast_Score=701, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651914, Length=543, Percent_Identity=62.6151012891344, Blast_Score=701, Evalue=0.0,
Organism=Drosophila melanogaster, GI17737445, Length=543, Percent_Identity=62.6151012891344, Blast_Score=701, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_ALISL (B6ELK8)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002261915.1
- GeneID:   6986454
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0385
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 61161; Mature: 61161

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 387-387 ACT_SITE 515-515

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNINPTETQAWADLTAHFETAQNFNLADLFSADAQRFDKFSTTFGQDILVDFSKNLVT
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
EETMQKLFSLAEQTELSEAIKAMFSGEKINKTEDRSVLHTALRNRSNTPVIVDGEDVMPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHH
VNAVLEKMKAFTERLISGEWKGYTGKEITDIVNIGIGGSDLGPYMVSEALAPYKTRLNMH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHEEEE
FVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
EECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHH
FAALSTNAESVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFVELLEGAHE
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VDNHFANTELENNVPVILALIGLWYNNFHGSESESILPYDQYLHRFAAYFQQGNMESNGK
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
CVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNQVGDHHQK
EECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHH
LMSNFFAQTEALAFGKKEETVRAEFAAAGKTEAEMAELVAFKVFEGNRPTNSILVKKVTP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCCCCEEEEECCH
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAINSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
LINAFKAFKA
HHHHHHHHCC
>Mature Secondary Structure
MLKNINPTETQAWADLTAHFETAQNFNLADLFSADAQRFDKFSTTFGQDILVDFSKNLVT
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
EETMQKLFSLAEQTELSEAIKAMFSGEKINKTEDRSVLHTALRNRSNTPVIVDGEDVMPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEECCHHHHHH
VNAVLEKMKAFTERLISGEWKGYTGKEITDIVNIGIGGSDLGPYMVSEALAPYKTRLNMH
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHCHHHHHEEEE
FVSNVDGTHIVETLKPLNPETTLFLIASKTFTTQETMTNAHSARDWFLAEAGDQAHVAKH
EECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHEECCCCHHHHHHH
FAALSTNAESVSEFGIDTDNMFEFWDWVGGRYSLWSAIGLSIALAVGFDNFVELLEGAHE
HHHHCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
VDNHFANTELENNVPVILALIGLWYNNFHGSESESILPYDQYLHRFAAYFQQGNMESNGK
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCE
CVDRNGNPVDYQTGPIIWGEPGTNGQHAFYQLIHQGTKLIPCDFIAPAISHNQVGDHHQK
EECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCHHHHH
LMSNFFAQTEALAFGKKEETVRAEFAAAGKTEAEMAELVAFKVFEGNRPTNSILVKKVTP
HHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHEECCCCCCCCEEEEECCH
KTLGNLIAMYEHKIFVQGVIWNIFSFDQWGVELGKQLANQILPELADDKAINSHDSSTNG
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
LINAFKAFKA
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA