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The map label for this gene is alr

Identifier: 209693985

GI number: 209693985

Start: 422726

End: 423802

Strand: Direct

Name: alr

Synonym: VSAL_I0383

Alternate gene names: 209693985

Gene position: 422726-423802 (Clockwise)

Preceding gene: 209693984

Following gene: 209693986

Centisome position: 12.71

GC content: 43.36

Gene sequence:

>1077_bases
ATGACAGCCGCTGCTGCACAGATTGATATGTCTGCCTTAGCGCATAATTTGCAAAAAATTAAACAGCAAGCACCAAACAG
CAAACTCCTTGCTGTGGTAAAAGCAAATGGTTATGGCCATGGTTTACTCAATATTGCTAAAGGTGCGCACGGTGTAGATG
CTTTTGGTGTGGCGCGAATTGAAGAGGCTTTACAGCTTCGAGCTGGTGGCATAGTGAAACAAGTTTTATTACTCGAAGGA
TTTTATTCTGCGGGTGATTTACCAATTTTAGTCGCTAATAACATTCAAACGGCAGTGCATTGCAAAGAGCAACTTGAAGC
ATTAGAAAATGCAGATCTTGAAGGCCCTGTTGTTGTTTGGTTGAAAGTCGATTCAGGTATGCATCGCTTAGGTATTCGCC
CTGAAGAATACCAAGAATATGTTGATCGTTTGCATGCGTGTAAAAATGTAGCTCAGCCACTGCGTTATATGAGCCATTTT
GGTTGTGCAGATGAATTAGATAATCCGACGACGAACGAACAAATTGAAACGTTCATGTCATTGACGGATGGATGCCAAGG
GGAACGGTCGCTTGCGGCTTCTGCTGGATTGCTTGCATGGCCAGACAGTCAATTGGATTGGGTTCGTCCCGGTATCATTA
TGTATGGTGTCTCTCCTTTTTCTGAGAAAACGGCTCAAGATTTAGGGTATTTACCTACCATGACTCTCACTTCTCATTTG
ATCGCGGTAAGAGAAGTAAAAGCCGGAGAAAGTGTTGGTTATGGTGCGATGTGGACCAGTGAGCGTGATACTAAAATTGG
GGTTATCGCGATCGGTTACGGCGATGGTTACCCAATTGCAGCACCGAATGGAACGCCAGTATTAGTTAATGGACGCAAAG
TTCCGGTAGCTGGTCGTGTTTCGATGGATATGCTAACGGTTGATTTAGGACCTGATGCAGAAGATAACGTTGGTGATGAA
GCTATTTTGTGGGGACGAGATCTTCCTGCAGAAGAAGTAGCAGAACACATTGGAACTATTGCTTATGAGTTAGTGACTAA
ACTAACATCAAGAGTACAAATGCAATATATTCCTTAA

Upstream 100 bases:

>100_bases
TGGCTCGGTAAGTTTAACCTTCCAAGGGCAATTTTCTCGCTTTGATAATTACGCAGGTCCTGCGTTTGATGATGAATAAT
AAGGCAAAAGTATGAGCTAT

Downstream 100 bases:

>100_bases
TGTATCTTTGACCCATGAGAGTTAATTTGAAACAACTGTTCTTAAGAAGCGCTACTGGTTTAGCGCTTTTTCTTATTTCA
CCTTATGTCTTTTCTGAAAG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTAAAAQIDMSALAHNLQKIKQQAPNSKLLAVVKANGYGHGLLNIAKGAHGVDAFGVARIEEALQLRAGGIVKQVLLLEG
FYSAGDLPILVANNIQTAVHCKEQLEALENADLEGPVVVWLKVDSGMHRLGIRPEEYQEYVDRLHACKNVAQPLRYMSHF
GCADELDNPTTNEQIETFMSLTDGCQGERSLAASAGLLAWPDSQLDWVRPGIIMYGVSPFSEKTAQDLGYLPTMTLTSHL
IAVREVKAGESVGYGAMWTSERDTKIGVIAIGYGDGYPIAAPNGTPVLVNGRKVPVAGRVSMDMLTVDLGPDAEDNVGDE
AILWGRDLPAEEVAEHIGTIAYELVTKLTSRVQMQYIP

Sequences:

>Translated_358_residues
MTAAAAQIDMSALAHNLQKIKQQAPNSKLLAVVKANGYGHGLLNIAKGAHGVDAFGVARIEEALQLRAGGIVKQVLLLEG
FYSAGDLPILVANNIQTAVHCKEQLEALENADLEGPVVVWLKVDSGMHRLGIRPEEYQEYVDRLHACKNVAQPLRYMSHF
GCADELDNPTTNEQIETFMSLTDGCQGERSLAASAGLLAWPDSQLDWVRPGIIMYGVSPFSEKTAQDLGYLPTMTLTSHL
IAVREVKAGESVGYGAMWTSERDTKIGVIAIGYGDGYPIAAPNGTPVLVNGRKVPVAGRVSMDMLTVDLGPDAEDNVGDE
AILWGRDLPAEEVAEHIGTIAYELVTKLTSRVQMQYIP
>Mature_357_residues
TAAAAQIDMSALAHNLQKIKQQAPNSKLLAVVKANGYGHGLLNIAKGAHGVDAFGVARIEEALQLRAGGIVKQVLLLEGF
YSAGDLPILVANNIQTAVHCKEQLEALENADLEGPVVVWLKVDSGMHRLGIRPEEYQEYVDRLHACKNVAQPLRYMSHFG
CADELDNPTTNEQIETFMSLTDGCQGERSLAASAGLLAWPDSQLDWVRPGIIMYGVSPFSEKTAQDLGYLPTMTLTSHLI
AVREVKAGESVGYGAMWTSERDTKIGVIAIGYGDGYPIAAPNGTPVLVNGRKVPVAGRVSMDMLTVDLGPDAEDNVGDEA
ILWGRDLPAEEVAEHIGTIAYELVTKLTSRVQMQYIP

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=358, Percent_Identity=59.7765363128492, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1787439, Length=348, Percent_Identity=41.9540229885057, Blast_Score=274, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_ALISL (B6ELK6)

Other databases:

- EMBL:   FM178379
- RefSeq:   YP_002261913.1
- GeneID:   6988412
- GenomeReviews:   FM178379_GR
- KEGG:   vsa:VSAL_I0383
- HOGENOM:   HBG712172
- OMA:   EGTPVWV
- ProtClustDB:   PRK00053
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38619; Mature: 38487

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 34-34 ACT_SITE 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAAAQIDMSALAHNLQKIKQQAPNSKLLAVVKANGYGHGLLNIAKGAHGVDAFGVARI
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHCCCCCCCHHHHHHH
EEALQLRAGGIVKQVLLLEGFYSAGDLPILVANNIQTAVHCKEQLEALENADLEGPVVVW
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEE
LKVDSGMHRLGIRPEEYQEYVDRLHACKNVAQPLRYMSHFGCADELDNPTTNEQIETFMS
EEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHH
LTDGCQGERSLAASAGLLAWPDSQLDWVRPGIIMYGVSPFSEKTAQDLGYLPTMTLTSHL
HHCCCCCCHHHHHCCCEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHH
IAVREVKAGESVGYGAMWTSERDTKIGVIAIGYGDGYPIAAPNGTPVLVNGRKVPVAGRV
HHHHHHCCCCCCCCCEEECCCCCCEEEEEEEECCCCCCEECCCCCEEEECCEECCEECCC
SMDMLTVDLGPDAEDNVGDEAILWGRDLPAEEVAEHIGTIAYELVTKLTSRVQMQYIP
EEEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECC
>Mature Secondary Structure 
TAAAAQIDMSALAHNLQKIKQQAPNSKLLAVVKANGYGHGLLNIAKGAHGVDAFGVARI
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHCCCCCCCHHHHHHH
EEALQLRAGGIVKQVLLLEGFYSAGDLPILVANNIQTAVHCKEQLEALENADLEGPVVVW
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEE
LKVDSGMHRLGIRPEEYQEYVDRLHACKNVAQPLRYMSHFGCADELDNPTTNEQIETFMS
EEECCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHH
LTDGCQGERSLAASAGLLAWPDSQLDWVRPGIIMYGVSPFSEKTAQDLGYLPTMTLTSHL
HHCCCCCCHHHHHCCCEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHH
IAVREVKAGESVGYGAMWTSERDTKIGVIAIGYGDGYPIAAPNGTPVLVNGRKVPVAGRV
HHHHHHCCCCCCCCCEEECCCCCCEEEEEEEECCCCCCEECCCCCEEEECCEECCEECCC
SMDMLTVDLGPDAEDNVGDEAILWGRDLPAEEVAEHIGTIAYELVTKLTSRVQMQYIP
EEEEEEEECCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA