Click here to switch to the map view.

The map label for this gene is mutM [H]

Identifier: 209693803

GI number: 209693803

Start: 229584

End: 230402

Strand: Reverse

Name: mutM [H]

Synonym: VSAL_I0188

Alternate gene names: 209693803

Gene position: 230402-229584 (Counterclockwise)

Preceding gene: 209693804

Following gene: 209693802

Centisome position: 6.93

GC content: 41.51

Gene sequence:

>819_bases
ATGCCAGAACTACCAGAAGTCGAAACCAGCCGATTAGGAATAACACCACACCTACAAGGTCAAACTATCAAAGCGATCAC
AGTCAGAACAGAAAAGCTGCGCTGGCCGATCCCACAAGAGCTACAAAAACTCGTAGGGCAAAGAATTCAATCCATCCGCC
GGCGTGCTAAATATTTAATGATAGACACCCCAGAAGGCACAGCCATCATTCATTTAGGTATGTCTGGTAGTCTACGTATA
CTCGATGAGGCGATCCCAACAGCAAAACACGATCATGTCGATCTTGTTTTAGATAGCGGTAAATTGCTTCGTTATAACGA
TCCTCGTAAATTTGGTGCTTGGCTATATTCTGAAGTAGGCGTTTCACATGACGTGCTTGCCAAGCTTGGCCCAGAGCCAC
TTACCGATGTATTTAATGTGGAATATCTAGCAGAAAAAGCAAAGAATAAAAAAATCGTCGTAAAACAGTTTATTATGAAC
AACACTATTGTGGTGGGGGTGGGGAATATCTACGCCAGTGAATCCTTATTTATGGCAAAGATAAATCCTAAGGCACCAGT
AGGTACATTGACGTTAGCCCAAATTGAACGATTAGTATCTGACATTAAAAAAGTACTAGAGACGGCTATTAAACAAGGTG
GAACCACCTTAAAAGACTTTAACCAAGTCGATGGTAAACCGGGATATTTTGCACAAGAATTGCAAGTTTACGGACGAGCA
GGAGAGGCGTGCTTAATTTGTCAGTCATTGATCCAAGAACAGAAAATAGGGCAAAGAAATACGTTTTGGTGTGAAAAGTG
CCAACCTATTAATCAGTAA

Upstream 100 bases:

>100_bases
TTTTATAGGAGCGAAGCGGTCTAGTTAGCGCAGCGTATAGTTTCTAGTCTCGTTGCGATCATCTCTGAACGCTAAGGATT
TATTTTTAAAAGGATCAAAA

Downstream 100 bases:

>100_bases
AATAGTGATCAGAATACCAATAGAAAAGAGATATAGATGAGCTTTCAACAAAACTTCAAACAACTCAGTAGAACCATATG
GTTATCTGTTTTTATTGCCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MPELPEVETSRLGITPHLQGQTIKAITVRTEKLRWPIPQELQKLVGQRIQSIRRRAKYLMIDTPEGTAIIHLGMSGSLRI
LDEAIPTAKHDHVDLVLDSGKLLRYNDPRKFGAWLYSEVGVSHDVLAKLGPEPLTDVFNVEYLAEKAKNKKIVVKQFIMN
NTIVVGVGNIYASESLFMAKINPKAPVGTLTLAQIERLVSDIKKVLETAIKQGGTTLKDFNQVDGKPGYFAQELQVYGRA
GEACLICQSLIQEQKIGQRNTFWCEKCQPINQ

Sequences:

>Translated_272_residues
MPELPEVETSRLGITPHLQGQTIKAITVRTEKLRWPIPQELQKLVGQRIQSIRRRAKYLMIDTPEGTAIIHLGMSGSLRI
LDEAIPTAKHDHVDLVLDSGKLLRYNDPRKFGAWLYSEVGVSHDVLAKLGPEPLTDVFNVEYLAEKAKNKKIVVKQFIMN
NTIVVGVGNIYASESLFMAKINPKAPVGTLTLAQIERLVSDIKKVLETAIKQGGTTLKDFNQVDGKPGYFAQELQVYGRA
GEACLICQSLIQEQKIGQRNTFWCEKCQPINQ
>Mature_271_residues
PELPEVETSRLGITPHLQGQTIKAITVRTEKLRWPIPQELQKLVGQRIQSIRRRAKYLMIDTPEGTAIIHLGMSGSLRIL
DEAIPTAKHDHVDLVLDSGKLLRYNDPRKFGAWLYSEVGVSHDVLAKLGPEPLTDVFNVEYLAEKAKNKKIVVKQFIMNN
TIVVGVGNIYASESLFMAKINPKAPVGTLTLAQIERLVSDIKKVLETAIKQGGTTLKDFNQVDGKPGYFAQELQVYGRAG
EACLICQSLIQEQKIGQRNTFWCEKCQPINQ

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=268, Percent_Identity=60.0746268656716, Blast_Score=333, Evalue=5e-93,
Organism=Escherichia coli, GI1786932, Length=274, Percent_Identity=23.3576642335766, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30430; Mature: 30299

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETSRLGITPHLQGQTIKAITVRTEKLRWPIPQELQKLVGQRIQSIRRRAKYLM
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEE
IDTPEGTAIIHLGMSGSLRILDEAIPTAKHDHVDLVLDSGKLLRYNDPRKFGAWLYSEVG
EECCCCCEEEEECCCCCHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHC
VSHDVLAKLGPEPLTDVFNVEYLAEKAKNKKIVVKQFIMNNTIVVGVGNIYASESLFMAK
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCEECCCCEEEEE
INPKAPVGTLTLAQIERLVSDIKKVLETAIKQGGTTLKDFNQVDGKPGYFAQELQVYGRA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHCCC
GEACLICQSLIQEQKIGQRNTFWCEKCQPINQ
CCHHHHHHHHHHHHHCCCCCCEEHHCCCCCCC
>Mature Secondary Structure 
PELPEVETSRLGITPHLQGQTIKAITVRTEKLRWPIPQELQKLVGQRIQSIRRRAKYLM
CCCCCCCCCCCCCCCCCCCCEEEEEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCEEE
IDTPEGTAIIHLGMSGSLRILDEAIPTAKHDHVDLVLDSGKLLRYNDPRKFGAWLYSEVG
EECCCCCEEEEECCCCCHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHC
VSHDVLAKLGPEPLTDVFNVEYLAEKAKNKKIVVKQFIMNNTIVVGVGNIYASESLFMAK
CCHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEEEECCEECCCCEEEEE
INPKAPVGTLTLAQIERLVSDIKKVLETAIKQGGTTLKDFNQVDGKPGYFAQELQVYGRA
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHCCC
GEACLICQSLIQEQKIGQRNTFWCEKCQPINQ
CCHHHHHHHHHHHHHCCCCCCEEHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA