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The map label for this gene is neuC [H]

Identifier: 209693787

GI number: 209693787

Start: 210148

End: 211332

Strand: Reverse

Name: neuC [H]

Synonym: VSAL_I0170

Alternate gene names: 209693787

Gene position: 211332-210148 (Counterclockwise)

Preceding gene: 209693788

Following gene: 209693786

Centisome position: 6.36

GC content: 39.75

Gene sequence:

>1185_bases
ATGAGTCAGCTATTCATGAATAAGAAAGTAGCCGTTTTTACAGGGACAAGAGCAGAGTATGGCCTGCTCTTTTGGCTTTT
AAAAGATATTCAAAATGACCCAGAACTTCAGTTGCAACTTTTGGTTTCTGGCATGCATTTATCTCCAGAATTCGGAGAAA
CCTATAAGCAAATAGAAACCGATGGGTTTGTGATTGATGAAAAAATTGAAATTCTTCTTTCATCCGATTCAGCAGTAGGT
ACAGCCAAAAGTATGGGGTTGGGTGTGTTAGGGTTTGCAGATTCGCTTTCACGATTACAACCTGATGTTCTAGTGATTCT
TGGTGATCGTTTTGAGGCGTTAGCTGCCGCACAAACAGCAATGATCATGCGTATTCCCATTGTTCATTTACATGGTGGTG
AAATCACTGAAGGTGCTTATGATGATGCGATTCGCCATGCAATCACTAAACTTAGTTACTTGCACGGAACATCAACTGAA
GACTATCGCCAACGTGTTATACAATTAGGTGAAGATCCGAGTCGAGTGCAAAATGTTGGTGCTATTGGGTTAGACCATTT
AAAACGTGCGACATTTATGACGGTGGCAGAGTTATCTGAATCATTAGATTTTACTTTAGATAAGCCTTTCTTTTTGGTAA
CCTATCATCCTGTAACCCTCGGTAATGAAGCACCAGAAGAGAGTTTTCAAGCCTTATTAAATGCGTTAGATGAGTACCCA
GATCATCAAGTTATTTTAACGTATCCAAATGCCGATGATGGTGGGCGACGTATAATTCCAATTCTTGAAGAATACGCTCG
TAGCAATCCAACACGAGTATTAGCAATCCCTTCTTTAGGACAGGTTCGTTATCTTAGCTCGGTTATGCATGCAACTGCTG
TTATTGGTAATTCATCAAGCGGAATAATTGAAGTGCCTGCCTTTGATGTTCCGACCGTAAATATAGGTTCAAGACAAAAA
GGGCGTTTAGCCGCTAAGAGTGTTTTGAATGTTGAACCTAATCAACAGTCGATTTCAGACGCGATACAAGTTGCTATAGA
CCGAACTTATAAACTTGCTGATGAAAAGATCCATAATCCATATGGTCAGGGTGATACTAGCGGTAAAGTGATTGAAATGA
TTAAATCGTTGCAATTCACACCAAGCAAAGCGTTTTACGATATAACTATTAACGATGTAGAGTGA

Upstream 100 bases:

>100_bases
ACTCAGTCTGAATATATTGAAGCACACTTGATTAATTTACCTAGCACGCCTGTTGCACTGTAGCTGTAATGAAAGACAAC
AAAGAGGTAATCGGTTTATT

Downstream 100 bases:

>100_bases
GAGAGTCATGACCCTAATTATTGCAGAAGCTGGCGTTAACCATAACGGTGATGAAAATCTGGCCTTTCAACTTGTTGATG
CGGCTTATCACGCAGGTGCA

Product: UDP-N-acetylglucosamine 2-epimerase

Products: UDP-N-acetyl-D-mannosamine [C]

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSQLFMNKKVAVFTGTRAEYGLLFWLLKDIQNDPELQLQLLVSGMHLSPEFGETYKQIETDGFVIDEKIEILLSSDSAVG
TAKSMGLGVLGFADSLSRLQPDVLVILGDRFEALAAAQTAMIMRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTE
DYRQRVIQLGEDPSRVQNVGAIGLDHLKRATFMTVAELSESLDFTLDKPFFLVTYHPVTLGNEAPEESFQALLNALDEYP
DHQVILTYPNADDGGRRIIPILEEYARSNPTRVLAIPSLGQVRYLSSVMHATAVIGNSSSGIIEVPAFDVPTVNIGSRQK
GRLAAKSVLNVEPNQQSISDAIQVAIDRTYKLADEKIHNPYGQGDTSGKVIEMIKSLQFTPSKAFYDITINDVE

Sequences:

>Translated_394_residues
MSQLFMNKKVAVFTGTRAEYGLLFWLLKDIQNDPELQLQLLVSGMHLSPEFGETYKQIETDGFVIDEKIEILLSSDSAVG
TAKSMGLGVLGFADSLSRLQPDVLVILGDRFEALAAAQTAMIMRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTE
DYRQRVIQLGEDPSRVQNVGAIGLDHLKRATFMTVAELSESLDFTLDKPFFLVTYHPVTLGNEAPEESFQALLNALDEYP
DHQVILTYPNADDGGRRIIPILEEYARSNPTRVLAIPSLGQVRYLSSVMHATAVIGNSSSGIIEVPAFDVPTVNIGSRQK
GRLAAKSVLNVEPNQQSISDAIQVAIDRTYKLADEKIHNPYGQGDTSGKVIEMIKSLQFTPSKAFYDITINDVE
>Mature_393_residues
SQLFMNKKVAVFTGTRAEYGLLFWLLKDIQNDPELQLQLLVSGMHLSPEFGETYKQIETDGFVIDEKIEILLSSDSAVGT
AKSMGLGVLGFADSLSRLQPDVLVILGDRFEALAAAQTAMIMRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTED
YRQRVIQLGEDPSRVQNVGAIGLDHLKRATFMTVAELSESLDFTLDKPFFLVTYHPVTLGNEAPEESFQALLNALDEYPD
HQVILTYPNADDGGRRIIPILEEYARSNPTRVLAIPSLGQVRYLSSVMHATAVIGNSSSGIIEVPAFDVPTVNIGSRQKG
RLAAKSVLNVEPNQQSISDAIQVAIDRTYKLADEKIHNPYGQGDTSGKVIEMIKSLQFTPSKAFYDITINDVE

Specific function: May be involved in the synthesis of polysialic acid (PSA) [H]

COG id: COG0381

COG function: function code M; UDP-N-acetylglucosamine 2-epimerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI298566312, Length=377, Percent_Identity=32.0954907161804, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI4885285, Length=377, Percent_Identity=32.0954907161804, Blast_Score=195, Evalue=8e-50,
Organism=Homo sapiens, GI190014632, Length=377, Percent_Identity=32.0954907161804, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI298566325, Length=345, Percent_Identity=31.0144927536232, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI298566315, Length=144, Percent_Identity=36.8055555555556, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020004
- InterPro:   IPR003331 [H]

Pfam domain/function: PF02350 Epimerase_2 [H]

EC number: 5.1.3.14 [C]

Molecular weight: Translated: 43366; Mature: 43235

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLFMNKKVAVFTGTRAEYGLLFWLLKDIQNDPELQLQLLVSGMHLSPEFGETYKQIET
CCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
DGFVIDEKIEILLSSDSAVGTAKSMGLGVLGFADSLSRLQPDVLVILGDRFEALAAAQTA
CCEEEECEEEEEEECCCCCCCHHHCCCEEEEHHHHHHHCCCCEEEEECCCHHHHHHHHHH
MIMRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDYRQRVIQLGEDPSRVQNVG
EEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHCC
AIGLDHLKRATFMTVAELSESLDFTLDKPFFLVTYHPVTLGNEAPEESFQALLNALDEYP
CCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCC
DHQVILTYPNADDGGRRIIPILEEYARSNPTRVLAIPSLGQVRYLSSVMHATAVIGNSSS
CCEEEEECCCCCCCCCEEHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHEECCCCC
GIIEVPAFDVPTVNIGSRQKGRLAAKSVLNVEPNQQSISDAIQVAIDRTYKLADEKIHNP
CEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
YGQGDTSGKVIEMIKSLQFTPSKAFYDITINDVE
CCCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCC
>Mature Secondary Structure 
SQLFMNKKVAVFTGTRAEYGLLFWLLKDIQNDPELQLQLLVSGMHLSPEFGETYKQIET
CCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCC
DGFVIDEKIEILLSSDSAVGTAKSMGLGVLGFADSLSRLQPDVLVILGDRFEALAAAQTA
CCEEEECEEEEEEECCCCCCCHHHCCCEEEEHHHHHHHCCCCEEEEECCCHHHHHHHHHH
MIMRIPIVHLHGGEITEGAYDDAIRHAITKLSYLHGTSTEDYRQRVIQLGEDPSRVQNVG
EEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHCC
AIGLDHLKRATFMTVAELSESLDFTLDKPFFLVTYHPVTLGNEAPEESFQALLNALDEYP
CCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHCC
DHQVILTYPNADDGGRRIIPILEEYARSNPTRVLAIPSLGQVRYLSSVMHATAVIGNSSS
CCEEEEECCCCCCCCCEEHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHEECCCCC
GIIEVPAFDVPTVNIGSRQKGRLAAKSVLNVEPNQQSISDAIQVAIDRTYKLADEKIHNP
CEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
YGQGDTSGKVIEMIKSLQFTPSKAFYDITINDVE
CCCCCCCCHHHHHHHHCCCCCCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: UDP-N-acetylglucosamine [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.63 {UDP-N-acetylglucosamine}} 1 {UDP-N-acetylmannosamine}} 0.5 {UDP-N-acetylmannosamine}} [C]

Substrates: UDP-N-acetyl-D-glucosamine [C]

Specific reaction: UDP-N-acetyl-D-glucosamine --> UDP-N-acetyl-D-mannosamine [C]

General reaction: Epimerization [C]

Inhibitor: PCMB [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1729218 [H]