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The map label for this gene is apt_2 [H]

Identifier: 209554238

GI number: 209554238

Start: 681531

End: 682052

Strand: Reverse

Name: apt_2 [H]

Synonym: UUR10_0558

Alternate gene names: 209554238

Gene position: 682052-681531 (Counterclockwise)

Preceding gene: 209554012

Following gene: 209554201

Centisome position: 78.0

GC content: 29.5

Gene sequence:

>522_bases
ATGATCAATATTGATTATATTAAATCAAAAATTAAGGATGTCCCTGATTTCCCTAAAAAAGGAATTATTTTTAAAGACAT
TACTCCTTTATTTTTAGAACCAAAGGTTATTGAAAAAATTGTTGATGATTTTGCTGAATTTGCTAAATCATTAGATGTTG
ATGTCATAATAGGAGCAGAATCACGCGGTTTTTTATTTGCTGCTCCATTATCAATTAAGTTAAATAAACCATTTGTTTTA
GTACGAAAACCAAATAAATTACCAAATGATGTTTATAGCGCTGAATATACATTAGAGTATGGAAGTTCACGTGTAGAAAT
GCATAAGGATGCATTAAAACCAAACCAACGTGTTTTAATTGTTGATGATTTATTAGCAACTGGAGGAACTGTTGCTGCAA
TTGAAAATCTTGTTCATCAAGCTCAAGCAACTGTGGTTGGTAGTGTTTATTTGATTCGTTTAGGATTTTTAAAAGGCGAA
GAGAAATTAAGTGGAAAAGTTCACGCTTTAATTAATTATTAA

Upstream 100 bases:

>100_bases
CATTAGCTAAGAGTGATAATGCAAATAATGTTTATGATAAATTTGATGAACAAGAAATTGTTAATATCAACAAATTTTAA
AAGGAAGACTTAGAACGTTT

Downstream 100 bases:

>100_bases
TTTTTATAAAAAATTTAATTTACTCTAGAAGTTTAAAAATAATTTCTAGAGTTTTTTATTATAAACATAATTTACACAAA
AATATGTTCCAAAAATTTTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 173; Mature: 173

Protein sequence:

>173_residues
MINIDYIKSKIKDVPDFPKKGIIFKDITPLFLEPKVIEKIVDDFAEFAKSLDVDVIIGAESRGFLFAAPLSIKLNKPFVL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVHQAQATVVGSVYLIRLGFLKGE
EKLSGKVHALINY

Sequences:

>Translated_173_residues
MINIDYIKSKIKDVPDFPKKGIIFKDITPLFLEPKVIEKIVDDFAEFAKSLDVDVIIGAESRGFLFAAPLSIKLNKPFVL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVHQAQATVVGSVYLIRLGFLKGE
EKLSGKVHALINY
>Mature_173_residues
MINIDYIKSKIKDVPDFPKKGIIFKDITPLFLEPKVIEKIVDDFAEFAKSLDVDVIIGAESRGFLFAAPLSIKLNKPFVL
VRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLIVDDLLATGGTVAAIENLVHQAQATVVGSVYLIRLGFLKGE
EKLSGKVHALINY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=42.4242424242424, Blast_Score=137, Evalue=5e-33,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=41.8604651162791, Blast_Score=112, Evalue=2e-25,
Organism=Escherichia coli, GI1786675, Length=161, Percent_Identity=43.4782608695652, Blast_Score=145, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=42.3529411764706, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=40.5882352941176, Blast_Score=118, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=33.9181286549708, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136334, Length=175, Percent_Identity=42.8571428571429, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19243; Mature: 19243

Theoretical pI: Translated: 8.76; Mature: 8.76

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINIDYIKSKIKDVPDFPKKGIIFKDITPLFLEPKVIEKIVDDFAEFAKSLDVDVIIGAE
CCCHHHHHHHHHCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHCCEEEEEECC
SRGFLFAAPLSIKLNKPFVLVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLI
CCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
VDDLLATGGTVAAIENLVHQAQATVVGSVYLIRLGFLKGEEKLSGKVHALINY
EEHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCHHHCCEEEEEEEC
>Mature Secondary Structure
MINIDYIKSKIKDVPDFPKKGIIFKDITPLFLEPKVIEKIVDDFAEFAKSLDVDVIIGAE
CCCHHHHHHHHHCCCCCCCCCEEEECCCCHHCCHHHHHHHHHHHHHHHHHCCEEEEEECC
SRGFLFAAPLSIKLNKPFVLVRKPNKLPNDVYSAEYTLEYGSSRVEMHKDALKPNQRVLI
CCCEEEECCEEEEECCCEEEEECCCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEE
VDDLLATGGTVAAIENLVHQAQATVVGSVYLIRLGFLKGEEKLSGKVHALINY
EEHHHHCCCHHHHHHHHHHHHHHHHHHHEEEEEEHHCCCCHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA