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The map label for this gene is fmt

Identifier: 209554203

GI number: 209554203

Start: 559058

End: 559975

Strand: Reverse

Name: fmt

Synonym: UUR10_0508

Alternate gene names: 209554203

Gene position: 559975-559058 (Counterclockwise)

Preceding gene: 209554285

Following gene: 209554000

Centisome position: 64.04

GC content: 28.21

Gene sequence:

>918_bases
ATGAAATACAATGTAATGTTTTTTGGTACGCCAGAGATTGCTAAAATTGTTTTAGAAACATTATTTAATATGCCTGAAGT
TAATTTGATTGGTGTTGTAAGTCAACCAGATTCTCATTTTGATCGCAAAAAAAATGTTGTTTACTCACCTGTAAAACAAT
TTTGTTTAGATCATGATATTAAATTGTTTCAACCACAAAAAATTAAAGAAATTGAAGAAGAAATTCGTAGCCTTGCACCA
GATATTATTATTACTTGTGCTTTTGGACAATTTATTAACCAGGGAATTATTGATATTCCTAAATACAAAATTGTTAATGT
CCATGCTTCACTTTTGCCAAAATTACGTGGTGGAGCGCCCATTCATTATGCTATTTTAAATGGTGATTTACAAACAGGAA
TTACTTTAATGCATACGATTAAAAAAATGGATGCAGGAAATATTTTGTTTCAAAGATCTTTAGCGATTAATGAGCAAACT
ACAACAAAAATACTAACCTTAGAATTAGCTAATCTTGGCGCATTAATGATCAAAGAGCATTTTTTAGAATTAGTAAAATC
AGATTTAGTTGGAATTCAACAAGATGAAAACGATGTTAGTTTTGCTTATAATATTCAAAAAAACCAAAACATTATTGATT
TTAATAAACCCGCTTTTTTTGTAAATCGTTTTGTTAACGCTATGTATGATAAGCCAATTGCTATTATGGAATATAATGAT
GTCTTAATTAAGGTTCATCAAATCAAAATTACGAATCAAAAATCAACACAAAAACCAGGCACAATTGCAATTTCTAAACA
TCAAATTTTTGTAAGCACGCAAGATTTTAATGTAGAACTATTATTAATTCAACTACCAAATAAAAAACCCCTAGCACCAA
AAGCTTTATTAAATGGCAAAAACCCTTTTAGTAATTAG

Upstream 100 bases:

>100_bases
AAAAACAAAAAAGCAAAACGAAATAATAACTCCAATCCTAAAGGAGTTATTTTATTATTTTTATAGTGTTTTTAATGCTA
TTTAAAAGGAGTTTATTAAA

Downstream 100 bases:

>100_bases
AGTTATTAAATTGTTATAATTTAACAATATTAGCGTAGAAAGGATAGTAAATGAATTTAAAGCATTCAAAAACTTCTTGA
TTTAAAAAACCCTTTCAAAC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKYNVMFFGTPEIAKIVLETLFNMPEVNLIGVVSQPDSHFDRKKNVVYSPVKQFCLDHDIKLFQPQKIKEIEEEIRSLAP
DIIITCAFGQFINQGIIDIPKYKIVNVHASLLPKLRGGAPIHYAILNGDLQTGITLMHTIKKMDAGNILFQRSLAINEQT
TTKILTLELANLGALMIKEHFLELVKSDLVGIQQDENDVSFAYNIQKNQNIIDFNKPAFFVNRFVNAMYDKPIAIMEYND
VLIKVHQIKITNQKSTQKPGTIAISKHQIFVSTQDFNVELLLIQLPNKKPLAPKALLNGKNPFSN

Sequences:

>Translated_305_residues
MKYNVMFFGTPEIAKIVLETLFNMPEVNLIGVVSQPDSHFDRKKNVVYSPVKQFCLDHDIKLFQPQKIKEIEEEIRSLAP
DIIITCAFGQFINQGIIDIPKYKIVNVHASLLPKLRGGAPIHYAILNGDLQTGITLMHTIKKMDAGNILFQRSLAINEQT
TTKILTLELANLGALMIKEHFLELVKSDLVGIQQDENDVSFAYNIQKNQNIIDFNKPAFFVNRFVNAMYDKPIAIMEYND
VLIKVHQIKITNQKSTQKPGTIAISKHQIFVSTQDFNVELLLIQLPNKKPLAPKALLNGKNPFSN
>Mature_305_residues
MKYNVMFFGTPEIAKIVLETLFNMPEVNLIGVVSQPDSHFDRKKNVVYSPVKQFCLDHDIKLFQPQKIKEIEEEIRSLAP
DIIITCAFGQFINQGIIDIPKYKIVNVHASLLPKLRGGAPIHYAILNGDLQTGITLMHTIKKMDAGNILFQRSLAINEQT
TTKILTLELANLGALMIKEHFLELVKSDLVGIQQDENDVSFAYNIQKNQNIIDFNKPAFFVNRFVNAMYDKPIAIMEYND
VLIKVHQIKITNQKSTQKPGTIAISKHQIFVSTQDFNVELLLIQLPNKKPLAPKALLNGKNPFSN

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=221, Percent_Identity=28.9592760180996, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI238814322, Length=209, Percent_Identity=25.8373205741627, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1789683, Length=303, Percent_Identity=29.7029702970297, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI1788589, Length=240, Percent_Identity=25, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45550868, Length=225, Percent_Identity=31.1111111111111, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=31.1111111111111, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_UREU1 (B5ZBV9)

Other databases:

- EMBL:   CP001184
- RefSeq:   YP_002284899.1
- ProteinModelPortal:   B5ZBV9
- SMR:   B5ZBV9
- GeneID:   6983944
- GenomeReviews:   CP001184_GR
- KEGG:   uue:UUR10_0508
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   CLSK2298953
- BioCyc:   UURE95664:UUR10_0508-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34556; Mature: 34556

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNVMFFGTPEIAKIVLETLFNMPEVNLIGVVSQPDSHFDRKKNVVYSPVKQFCLDHDI
CEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHCCCCC
KLFQPQKIKEIEEEIRSLAPDIIITCAFGQFINQGIIDIPKYKIVNVHASLLPKLRGGAP
EECCCHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCC
IHYAILNGDLQTGITLMHTIKKMDAGNILFQRSLAINEQTTTKILTLELANLGALMIKEH
EEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEEEECCCCHHHHHHH
FLELVKSDLVGIQQDENDVSFAYNIQKNQNIIDFNKPAFFVNRFVNAMYDKPIAIMEYND
HHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECC
VLIKVHQIKITNQKSTQKPGTIAISKHQIFVSTQDFNVELLLIQLPNKKPLAPKALLNGK
EEEEEEEEEEECCCCCCCCCEEEEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHCCC
NPFSN
CCCCC
>Mature Secondary Structure
MKYNVMFFGTPEIAKIVLETLFNMPEVNLIGVVSQPDSHFDRKKNVVYSPVKQFCLDHDI
CEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHCCCCHHHHHHHHCCCCC
KLFQPQKIKEIEEEIRSLAPDIIITCAFGQFINQGIIDIPKYKIVNVHASLLPKLRGGAP
EECCCHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCCCCCEEEEEEHHHHHHHHCCCCC
IHYAILNGDLQTGITLMHTIKKMDAGNILFQRSLAINEQTTTKILTLELANLGALMIKEH
EEEEEECCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEEEEEEECCCCHHHHHHH
FLELVKSDLVGIQQDENDVSFAYNIQKNQNIIDFNKPAFFVNRFVNAMYDKPIAIMEYND
HHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECC
VLIKVHQIKITNQKSTQKPGTIAISKHQIFVSTQDFNVELLLIQLPNKKPLAPKALLNGK
EEEEEEEEEEECCCCCCCCCEEEEEEEEEEEEECCCCEEEEEEECCCCCCCCCHHHHCCC
NPFSN
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA