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The map label for this gene is adk [H]

Identifier: 209552151

GI number: 209552151

Start: 257342

End: 257920

Strand: Reverse

Name: adk [H]

Synonym: Rleg2_6306

Alternate gene names: 209552151

Gene position: 257920-257342 (Counterclockwise)

Preceding gene: 209552152

Following gene: 209552150

Centisome position: 83.54

GC content: 57.69

Gene sequence:

>579_bases
ATGCGTTTGGTAATGCTCGGCCCGCCCGGAGCGGGAAAAGGAACGCAGGCCAGGAAGCTGTCGGCCCATTTCAACGTTCC
TCAGCTTTCCACTGGCGATATGCTTCGTGCGGCGGTCAGCAGCGGTTCGCCTGTAGGGTTGGCCGCCAAAAGCGTAATCG
ACTCAGGCGGACTTGTCGGTGATAAGATTGTGATCGATTGTGTGCAGGAACGGCTCTCGCATGATGATGCACGCCGCGGC
TTTATCCTTGACGGCTTTCCGAGAACGGTCGCGCAGGCGAAATCGCTGGATTCAATGCTCGGGCCGGGTAAGCGCAGCTT
GTCGACCGTGATTGAACTACTCGTCGACGAGGAATTGCTTGCTCAGCGGATCGAGCGCCGTGCGGGCGAAGCCATTGCCA
ACGGCGAAACTCCCCGTTCGGATGACAACATCGAAACGATGCGCAAAAGGCTTGCAGCCTATCGGGAAAGTACCGAGGTC
CTTTCGAATTTCTACTACAACCAGGGCCGTCTGGTCCGGATCGACGGAATGCGCGACGTGGACCAGGTCACCGCAGACAT
ATTCGAGGCATTGTCATGA

Upstream 100 bases:

>100_bases
ACCTCCGTCCCTTTGATCAACATGTGGTGCCATATCGAGAGCCGCGAACCGCGCGCTTGAACAAGCACGCTCAAAAAACT
ATCACGCCTTGGAGATTCGA

Downstream 100 bases:

>100_bases
CTTTTCGAGAGGACGCGGACCAAAGCATTCGCCTTCGGCTATGGCGCGGAGTGGTGCTCGAGGATTGGTTGGATTACAAC
GGTCACATGACCGAGCATCG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRLVMLGPPGAGKGTQARKLSAHFNVPQLSTGDMLRAAVSSGSPVGLAAKSVIDSGGLVGDKIVIDCVQERLSHDDARRG
FILDGFPRTVAQAKSLDSMLGPGKRSLSTVIELLVDEELLAQRIERRAGEAIANGETPRSDDNIETMRKRLAAYRESTEV
LSNFYYNQGRLVRIDGMRDVDQVTADIFEALS

Sequences:

>Translated_192_residues
MRLVMLGPPGAGKGTQARKLSAHFNVPQLSTGDMLRAAVSSGSPVGLAAKSVIDSGGLVGDKIVIDCVQERLSHDDARRG
FILDGFPRTVAQAKSLDSMLGPGKRSLSTVIELLVDEELLAQRIERRAGEAIANGETPRSDDNIETMRKRLAAYRESTEV
LSNFYYNQGRLVRIDGMRDVDQVTADIFEALS
>Mature_192_residues
MRLVMLGPPGAGKGTQARKLSAHFNVPQLSTGDMLRAAVSSGSPVGLAAKSVIDSGGLVGDKIVIDCVQERLSHDDARRG
FILDGFPRTVAQAKSLDSMLGPGKRSLSTVIELLVDEELLAQRIERRAGEAIANGETPRSDDNIETMRKRLAAYRESTEV
LSNFYYNQGRLVRIDGMRDVDQVTADIFEALS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=213, Percent_Identity=39.906103286385, Blast_Score=143, Evalue=9e-35,
Organism=Homo sapiens, GI4502013, Length=213, Percent_Identity=39.906103286385, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI4502011, Length=193, Percent_Identity=33.6787564766839, Blast_Score=104, Evalue=6e-23,
Organism=Homo sapiens, GI19923437, Length=197, Percent_Identity=32.994923857868, Blast_Score=101, Evalue=4e-22,
Organism=Homo sapiens, GI28144897, Length=189, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144899, Length=189, Percent_Identity=30.1587301587302, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI310110345, Length=219, Percent_Identity=28.310502283105, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI53832003, Length=219, Percent_Identity=28.310502283105, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI8051579, Length=219, Percent_Identity=28.310502283105, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI53832001, Length=219, Percent_Identity=28.310502283105, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI7706497, Length=194, Percent_Identity=27.8350515463918, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=41.0138248847926, Blast_Score=147, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17552384, Length=209, Percent_Identity=38.755980861244, Blast_Score=140, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=36.7567567567568, Blast_Score=120, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17533833, Length=186, Percent_Identity=29.5698924731183, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=191, Percent_Identity=27.2251308900524, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=215, Percent_Identity=24.1860465116279, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320432, Length=217, Percent_Identity=41.0138248847926, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321018, Length=197, Percent_Identity=35.0253807106599, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322828, Length=193, Percent_Identity=31.0880829015544, Blast_Score=93, Evalue=2e-20,
Organism=Drosophila melanogaster, GI22026816, Length=209, Percent_Identity=40.6698564593301, Blast_Score=153, Evalue=8e-38,
Organism=Drosophila melanogaster, GI17647141, Length=190, Percent_Identity=31.5789473684211, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24663208, Length=190, Percent_Identity=31.5789473684211, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=29.4416243654822, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=29.4416243654822, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=26.8817204301075, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=26.8817204301075, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20801; Mature: 20801

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVMLGPPGAGKGTQARKLSAHFNVPQLSTGDMLRAAVSSGSPVGLAAKSVIDSGGLVG
CEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCH
DKIVIDCVQERLSHDDARRGFILDGFPRTVAQAKSLDSMLGPGKRSLSTVIELLVDEELL
HHHHHHHHHHHHCCCHHHCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQRIERRAGEAIANGETPRSDDNIETMRKRLAAYRESTEVLSNFYYNQGRLVRIDGMRDV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
DQVTADIFEALS
HHHHHHHHHHCC
>Mature Secondary Structure
MRLVMLGPPGAGKGTQARKLSAHFNVPQLSTGDMLRAAVSSGSPVGLAAKSVIDSGGLVG
CEEEEECCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCH
DKIVIDCVQERLSHDDARRGFILDGFPRTVAQAKSLDSMLGPGKRSLSTVIELLVDEELL
HHHHHHHHHHHHCCCHHHCCCEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQRIERRAGEAIANGETPRSDDNIETMRKRLAAYRESTEVLSNFYYNQGRLVRIDGMRDV
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCH
DQVTADIFEALS
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA