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The map label for this gene is pyc [H]

Identifier: 209551980

GI number: 209551980

Start: 46633

End: 50130

Strand: Reverse

Name: pyc [H]

Synonym: Rleg2_6118

Alternate gene names: 209551980

Gene position: 50130-46633 (Counterclockwise)

Preceding gene: 209551981

Following gene: 209551979

Centisome position: 16.24

GC content: 63.15

Gene sequence:

>3498_bases
TTGCGCGTTGCGCTTCGAACCGTGGATAACGCCGTGATCAGAAAAATCCTTGTTGCCAATCGCTCCGAAATTGCGATTCG
CGTGTTCCGCGCGGCCAACGAGCTTGGAATAAAAACCGTGGCGATCTGGGCGGAGGAGGACAAGCTGGCGCTGCACCGCT
TCAAGGCGGACGAGAGCTACCAGGTCGGCCGCGGCCCGCATCTTTCCAAGGACATGGGCCCGATCGAGAGCTATCTGTCG
ATCGACGAGGTGATCCGCGTCGCCAAGCTCTCGGGCGCCGACGCCATTCACCCGGGTTACGGCCTGCTGTCGGAAAGCCC
GGAATTCGTCGATGCCTGCGACAAGGCCGGCATCATCTTCATCGGCCCGCGGGCCGATACGATGCGCCAGCTCGGCAACA
AGGTTGCGGCGCGCAATCTGGCGATCTCGGTCGGCGTGCCCGTCGTGCCGGCAACCGAACCGTTGCCTGACGATATGGCC
GAAGTGGCGAAGATGGCGAAAGAGATCGGTTATCCCGTCATGCTGAAGGCCTCCTGGGGCGGCGGCGGGCGCGGCATGCG
CGCCATCCGCGACCCGAAGGATCTCGCCCGTGAGGTGACTGAGGCCAAGCGCGAGGCGATGGCGGCCTTCGGCAAGGACG
AGGTCTATCTGGAAAAGCTGGTCGAACGCGCCCGCCACGTCGAAAGCCAGGTTCTCGGCGATACGCACGGCAATGTCGTG
CATCTGTTCGAGCGTGACTGCTCCATCCAGCGCCGCAACCAGAAGGTCGTCGAGCGGGCGCCGGCCCCTTATCTTTCCGA
GGCGCAGCGCCAGGAGCTCGCCGCCTATTCGCTGAAGATCGCAGCGGCGACCAATTATGTCGGCGCCGGCACCGTCGAAT
ATCTGATGGATGCCGATACCGGCAAATTCTACTTCATCGAGGTCAATCCGCGCATCCAGGTCGAGCACACGGTGACCGAA
GTCGTCACCGGCATCGACATCGTCAAGGCGCAGATCCACATTCTCGACGGCGCCGCGATCGGCACGCCGGAATCCGGCGT
TCCCGCTCAGGCCGTTATCCGCCTCAACGGCCATGCGCTGCAGTGCCGCATCACCACCGAGGATCCGGAGCACAACTTCA
TTCCGGATTACGGCCGCATCACCGCCTATCGCTCGGCCTCCGGTTTCGGTATCCGCCTCGACGGCGGCACCTCCTATTCC
GGCGCGATCATCACCCGCTTTTATGATCCGCTGCTCGTCAAGGTCACGGCCTGGGCGCCGAACCCCTCCGAAGCGATTTC
CCGCATGGACCGGGCGCTGCGCGAATTCCGTATTCGCGGCGTCGCCACCAACCTGACCTTCCTCGAAGCGATCATCGGCC
ATCCGAAATTCCGCGACAACAGCTACACCACCCGCTTCATCGACACGACGCCGGAACTCTTCCAGCAGGTCAAGCGCCAG
GACCGGGCGACGAAGCTGCTGACCTATCTCGCCGACGTCACCGTCAACGGTCATCCCGAAGCCAAGGACAGGCCGAGGCC
GCTTGATAACGCCGCCCAGCCGGTGGTGCCCTATGCCAACGGCAATGGCGTCAAGGACGGCACCAAGCAGCTTCTCGACA
CCCTCGGCCCGAAGAAATTCGGCGAATGGATGCGCAACGAAAAGCGCGTGCTTCTGACCGACACGACGATGCGCGACGGT
CACCAGTCGCTGCTCGCCACCCGCATGCGCACCTATGACATCGCCCGCATCGCCGGCACCTATGCGCATGCACTGCCGAA
CCTGCTTTCGCTGGAATGCTGGGGCGGTGCGACCTTCGACGTCTCGATGCGCTTCCTGACCGAAGATCCGTGGGAGCGGC
TGGCGCTGATCCGCGAGGGCGCGCCGAACCTGCTCTTACAGATGCTGCTGCGTGGCGCCAACGGTGTCGGCTACACCAAT
TATCCCGACAATGTCGTCAAATATTTCGTCCGCCAGGCGGCGCGCGGCGGCATCGACCTCTTCCGCGTCTTCGACTGCCT
GAATTGGGTCGAGAACATGCGCGTCTCGATGGATGCCATCGCCGAAGAGAACAAGCTCTGCGAGGCGGCGATCTGCTATA
CCGGCGATATTCTCAATTCGGCCCGCCCGAAATATGACCTGAAATATTATACCGACCTTGCGGTCGAGCTGGAAAAGGCC
GGCGCCCATATCATCGCGCTCAAGGACATGGCGGGCCTGCTCAAGCCTGCGGCGGCGAAGGTTCTGTTCAAGGCGCTGCG
CGAGGCGACCAGCCTGCCGATCCATTTCCACACGCATGACACATCGGGCATTGCAGCGGCAACCGTGCTTGCCGCGGTCG
ACGCCGGCGTCGATGCCGTCGATGCGGCCATGGATGCGCTGTCCGGCAATACGTCGCAGCCCTGTCTCGGCTCGATCGTC
GAGGCGCTGCGCGGTACGGAGCGCGATCCGGGTCTCGATCCGGAATGGATCCGCCGCGTCTCCTTCTATTGGGAAGCGGT
GCGCAACCAATATGCCGCCTTCGAAAGCGATCTGAAGGGGCCGGCATCGGAAGTCTATTTGCATGAAATGCCGGGCGGTC
AGTTCACCAACCTCAAGGAACAGGCCCGCTCGCTGGGTCTGGAGACCCGCTGGCATCGGGTGGCGCAGGCTTATGCCGAC
GCCAACCAGATGTTCGGCGACATCGTCAAGGTGACGCCGTCCTCCAAGGTGGTCGGCGACATGGCGCTGATGATGGTGAG
CCAGGACCTGACGGTCGCCGACGTCGTCAGCCCCGAGCGCGAAGTCTCCTTCCCGGAATCGGTGGTGTCGATGCTGAAGG
GCGATCTCGGCCAGCCGCCGTCGGGATGGCCGGAAGCGCTGCAGAAGAAGGCGCTGAAGGGCGACAAGCCCTACACGGTG
CGTCCCGGCTCGCTGCTGAAGGAAGCCGATCTCGATGCCGAACGCAAGGTCATCGAGACGAAGCTGGAGCGCGAGGTCAG
CGATTTCGAGTTCGCCTCCTATCTGATGTATCCGAAGGTCTTTACCGACTTCGCGCTCGCCTCCGATACTTACGGCCCGG
TTTCGGTGCTGCCGACGCCTGCCTATTTCTACGGGCTTGGGGATGGCGAAGAGCTGTTTGCCGATATCGAACGCGGCAAG
ACGCTTGTCATCGTCAACCAGGCGATGAGCGCCACCGACAGCCAGGGCATGGTGACCATCTTCTTCGAACTCAACGGCCA
GCCGCGCCGTATCAAGGTGCCGGACCGGGCCCATGGGGCGACGGGGGCGGCGGTCCGCCGCAAGGCCGAACCGGGCAATG
CCGTCCATGTCGGTGCGCCGATGCCGGGCGTCATCTCACGCGTCTTCGTCTCTGCAGGCCAAGCCGTCAGCGCCGGCGAC
GTGCTCGTCTCGATCGAGGCGATGAAGATGGAAACGGCGCTGCATGCTGAGAAGGACGGCACTATCGCCGAAGTGCTGGT
CAAAGCCGGAGACCAAATCGACGCAAAGGACCTGCTGATCGTTTACGGCTCCTTATGA

Upstream 100 bases:

>100_bases
CCGCTTCACGGTTTTCTTCACTGGCCAAACGTTTCGGCAAGGCGGAGACGGTGAACCAACAGATGATCGCATTCTGTCAT
GCGCAGGGCAGGAAGAATAA

Downstream 100 bases:

>100_bases
GATTGGCTGTCCTTGAACGAGGGTCTCCTCAAAATGTTCGTCGGACGAGAGAAAGAGGCTCTCGCATCCCCCGTCAGATC
GCGTTCAGTCTGTAGTGCCA

Product: pyruvate carboxylase

Products: NA

Alternate protein names: Pyruvic carboxylase; PYC [H]

Number of amino acids: Translated: 1165; Mature: 1165

Protein sequence:

>1165_residues
MRVALRTVDNAVIRKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLALHRFKADESYQVGRGPHLSKDMGPIESYLS
IDEVIRVAKLSGADAIHPGYGLLSESPEFVDACDKAGIIFIGPRADTMRQLGNKVAARNLAISVGVPVVPATEPLPDDMA
EVAKMAKEIGYPVMLKASWGGGGRGMRAIRDPKDLAREVTEAKREAMAAFGKDEVYLEKLVERARHVESQVLGDTHGNVV
HLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYVGAGTVEYLMDADTGKFYFIEVNPRIQVEHTVTE
VVTGIDIVKAQIHILDGAAIGTPESGVPAQAVIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYS
GAIITRFYDPLLVKVTAWAPNPSEAISRMDRALREFRIRGVATNLTFLEAIIGHPKFRDNSYTTRFIDTTPELFQQVKRQ
DRATKLLTYLADVTVNGHPEAKDRPRPLDNAAQPVVPYANGNGVKDGTKQLLDTLGPKKFGEWMRNEKRVLLTDTTMRDG
HQSLLATRMRTYDIARIAGTYAHALPNLLSLECWGGATFDVSMRFLTEDPWERLALIREGAPNLLLQMLLRGANGVGYTN
YPDNVVKYFVRQAARGGIDLFRVFDCLNWVENMRVSMDAIAEENKLCEAAICYTGDILNSARPKYDLKYYTDLAVELEKA
GAHIIALKDMAGLLKPAAAKVLFKALREATSLPIHFHTHDTSGIAAATVLAAVDAGVDAVDAAMDALSGNTSQPCLGSIV
EALRGTERDPGLDPEWIRRVSFYWEAVRNQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHRVAQAYAD
ANQMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVVSPEREVSFPESVVSMLKGDLGQPPSGWPEALQKKALKGDKPYTV
RPGSLLKEADLDAERKVIETKLEREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTPAYFYGLGDGEELFADIERGK
TLVIVNQAMSATDSQGMVTIFFELNGQPRRIKVPDRAHGATGAAVRRKAEPGNAVHVGAPMPGVISRVFVSAGQAVSAGD
VLVSIEAMKMETALHAEKDGTIAEVLVKAGDQIDAKDLLIVYGSL

Sequences:

>Translated_1165_residues
MRVALRTVDNAVIRKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLALHRFKADESYQVGRGPHLSKDMGPIESYLS
IDEVIRVAKLSGADAIHPGYGLLSESPEFVDACDKAGIIFIGPRADTMRQLGNKVAARNLAISVGVPVVPATEPLPDDMA
EVAKMAKEIGYPVMLKASWGGGGRGMRAIRDPKDLAREVTEAKREAMAAFGKDEVYLEKLVERARHVESQVLGDTHGNVV
HLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYVGAGTVEYLMDADTGKFYFIEVNPRIQVEHTVTE
VVTGIDIVKAQIHILDGAAIGTPESGVPAQAVIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYS
GAIITRFYDPLLVKVTAWAPNPSEAISRMDRALREFRIRGVATNLTFLEAIIGHPKFRDNSYTTRFIDTTPELFQQVKRQ
DRATKLLTYLADVTVNGHPEAKDRPRPLDNAAQPVVPYANGNGVKDGTKQLLDTLGPKKFGEWMRNEKRVLLTDTTMRDG
HQSLLATRMRTYDIARIAGTYAHALPNLLSLECWGGATFDVSMRFLTEDPWERLALIREGAPNLLLQMLLRGANGVGYTN
YPDNVVKYFVRQAARGGIDLFRVFDCLNWVENMRVSMDAIAEENKLCEAAICYTGDILNSARPKYDLKYYTDLAVELEKA
GAHIIALKDMAGLLKPAAAKVLFKALREATSLPIHFHTHDTSGIAAATVLAAVDAGVDAVDAAMDALSGNTSQPCLGSIV
EALRGTERDPGLDPEWIRRVSFYWEAVRNQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHRVAQAYAD
ANQMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVVSPEREVSFPESVVSMLKGDLGQPPSGWPEALQKKALKGDKPYTV
RPGSLLKEADLDAERKVIETKLEREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTPAYFYGLGDGEELFADIERGK
TLVIVNQAMSATDSQGMVTIFFELNGQPRRIKVPDRAHGATGAAVRRKAEPGNAVHVGAPMPGVISRVFVSAGQAVSAGD
VLVSIEAMKMETALHAEKDGTIAEVLVKAGDQIDAKDLLIVYGSL
>Mature_1165_residues
MRVALRTVDNAVIRKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLALHRFKADESYQVGRGPHLSKDMGPIESYLS
IDEVIRVAKLSGADAIHPGYGLLSESPEFVDACDKAGIIFIGPRADTMRQLGNKVAARNLAISVGVPVVPATEPLPDDMA
EVAKMAKEIGYPVMLKASWGGGGRGMRAIRDPKDLAREVTEAKREAMAAFGKDEVYLEKLVERARHVESQVLGDTHGNVV
HLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYVGAGTVEYLMDADTGKFYFIEVNPRIQVEHTVTE
VVTGIDIVKAQIHILDGAAIGTPESGVPAQAVIRLNGHALQCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYS
GAIITRFYDPLLVKVTAWAPNPSEAISRMDRALREFRIRGVATNLTFLEAIIGHPKFRDNSYTTRFIDTTPELFQQVKRQ
DRATKLLTYLADVTVNGHPEAKDRPRPLDNAAQPVVPYANGNGVKDGTKQLLDTLGPKKFGEWMRNEKRVLLTDTTMRDG
HQSLLATRMRTYDIARIAGTYAHALPNLLSLECWGGATFDVSMRFLTEDPWERLALIREGAPNLLLQMLLRGANGVGYTN
YPDNVVKYFVRQAARGGIDLFRVFDCLNWVENMRVSMDAIAEENKLCEAAICYTGDILNSARPKYDLKYYTDLAVELEKA
GAHIIALKDMAGLLKPAAAKVLFKALREATSLPIHFHTHDTSGIAAATVLAAVDAGVDAVDAAMDALSGNTSQPCLGSIV
EALRGTERDPGLDPEWIRRVSFYWEAVRNQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHRVAQAYAD
ANQMFGDIVKVTPSSKVVGDMALMMVSQDLTVADVVSPEREVSFPESVVSMLKGDLGQPPSGWPEALQKKALKGDKPYTV
RPGSLLKEADLDAERKVIETKLEREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTPAYFYGLGDGEELFADIERGK
TLVIVNQAMSATDSQGMVTIFFELNGQPRRIKVPDRAHGATGAAVRRKAEPGNAVHVGAPMPGVISRVFVSAGQAVSAGD
VLVSIEAMKMETALHAEKDGTIAEVLVKAGDQIDAKDLLIVYGSL

Specific function: Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second, leading to oxaloacetate production. Fulfills an anaplerotic functi

COG id: COG1038

COG function: function code C; Pyruvate carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=1162, Percent_Identity=47.3321858864028, Blast_Score=1017, Evalue=0.0,
Organism=Homo sapiens, GI106049295, Length=1162, Percent_Identity=47.3321858864028, Blast_Score=1017, Evalue=0.0,
Organism=Homo sapiens, GI106049292, Length=1162, Percent_Identity=47.3321858864028, Blast_Score=1017, Evalue=0.0,
Organism=Homo sapiens, GI116805327, Length=466, Percent_Identity=42.4892703862661, Blast_Score=380, Evalue=1e-105,
Organism=Homo sapiens, GI189095269, Length=478, Percent_Identity=40.1673640167364, Blast_Score=338, Evalue=1e-92,
Organism=Homo sapiens, GI295821183, Length=464, Percent_Identity=40.5172413793103, Blast_Score=337, Evalue=6e-92,
Organism=Homo sapiens, GI65506442, Length=464, Percent_Identity=40.5172413793103, Blast_Score=337, Evalue=6e-92,
Organism=Homo sapiens, GI38679960, Length=549, Percent_Identity=30.2367941712204, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI38679977, Length=549, Percent_Identity=30.2367941712204, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI38679967, Length=549, Percent_Identity=30.2367941712204, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI38679974, Length=549, Percent_Identity=30.2367941712204, Blast_Score=231, Evalue=3e-60,
Organism=Homo sapiens, GI38679971, Length=549, Percent_Identity=30.2367941712204, Blast_Score=231, Evalue=3e-60,
Organism=Homo sapiens, GI134142062, Length=518, Percent_Identity=30.8880308880309, Blast_Score=226, Evalue=9e-59,
Organism=Escherichia coli, GI1789654, Length=458, Percent_Identity=43.8864628820961, Blast_Score=354, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI17562816, Length=1172, Percent_Identity=48.6348122866894, Blast_Score=1044, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71987519, Length=466, Percent_Identity=43.1330472103004, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17567343, Length=464, Percent_Identity=39.8706896551724, Blast_Score=331, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI71997163, Length=444, Percent_Identity=30.8558558558559, Blast_Score=208, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71997168, Length=444, Percent_Identity=30.8558558558559, Blast_Score=208, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=503, Percent_Identity=30.2186878727634, Blast_Score=207, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319695, Length=1159, Percent_Identity=46.6781708369284, Blast_Score=1014, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6321376, Length=1159, Percent_Identity=47.2821397756687, Blast_Score=1008, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319685, Length=454, Percent_Identity=38.1057268722467, Blast_Score=311, Evalue=6e-85,
Organism=Saccharomyces cerevisiae, GI6324343, Length=522, Percent_Identity=30.8429118773946, Blast_Score=226, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=436, Percent_Identity=32.5688073394495, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24652212, Length=1155, Percent_Identity=47.6190476190476, Blast_Score=1016, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652210, Length=1155, Percent_Identity=47.6190476190476, Blast_Score=1016, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652214, Length=1155, Percent_Identity=47.6190476190476, Blast_Score=1016, Evalue=0.0,
Organism=Drosophila melanogaster, GI19921944, Length=1155, Percent_Identity=47.6190476190476, Blast_Score=1016, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652216, Length=1155, Percent_Identity=47.6190476190476, Blast_Score=1016, Evalue=0.0,
Organism=Drosophila melanogaster, GI281363050, Length=1174, Percent_Identity=47.0187393526405, Blast_Score=1013, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652224, Length=1174, Percent_Identity=47.0187393526405, Blast_Score=1013, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652222, Length=1174, Percent_Identity=47.0187393526405, Blast_Score=1013, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652220, Length=1174, Percent_Identity=47.0187393526405, Blast_Score=1013, Evalue=0.0,
Organism=Drosophila melanogaster, GI24652218, Length=1174, Percent_Identity=47.0187393526405, Blast_Score=1013, Evalue=0.0,
Organism=Drosophila melanogaster, GI24651757, Length=460, Percent_Identity=40.8695652173913, Blast_Score=353, Evalue=5e-97,
Organism=Drosophila melanogaster, GI24651759, Length=422, Percent_Identity=40.0473933649289, Blast_Score=313, Evalue=4e-85,
Organism=Drosophila melanogaster, GI161076407, Length=516, Percent_Identity=29.8449612403101, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586460, Length=516, Percent_Identity=29.8449612403101, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24586458, Length=516, Percent_Identity=29.8449612403101, Blast_Score=211, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161076409, Length=516, Percent_Identity=29.8449612403101, Blast_Score=211, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR000089
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR003379
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR000891
- InterPro:   IPR005930
- InterPro:   IPR011054
- InterPro:   IPR011053 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00364 Biotin_lipoyl; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =6.4.1.1 [H]

Molecular weight: Translated: 127624; Mature: 127624

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC ; PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVALRTVDNAVIRKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLALHRFKADESY
CEEEHHHHHHHHHHHHHHCCCCHHEEHEEHHHHHCCCEEEEEEECCCCHHHHHCCCCCCC
QVGRGPHLSKDMGPIESYLSIDEVIRVAKLSGADAIHPGYGLLSESPEFVDACDKAGIIF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEE
IGPRADTMRQLGNKVAARNLAISVGVPVVPATEPLPDDMAEVAKMAKEIGYPVMLKASWG
ECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
GGGRGMRAIRDPKDLAREVTEAKREAMAAFGKDEVYLEKLVERARHVESQVLGDTHGNVV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
HLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYVGAGTVEYLMDADT
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHEECCC
GKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILDGAAIGTPESGVPAQAVIRLNGHAL
CEEEEEEECCEEEEHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCEEEEEECCEEE
QCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYSGAIITRFYDPLLVKVTAWAP
EEEEECCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCEEHEECCCCEEEEEEECCC
NPSEAISRMDRALREFRIRGVATNLTFLEAIIGHPKFRDNSYTTRFIDTTPELFQQVKRQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHH
DRATKLLTYLADVTVNGHPEAKDRPRPLDNAAQPVVPYANGNGVKDGTKQLLDTLGPKKF
HHHHHHHHHHHHCEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCHHHH
GEWMRNEKRVLLTDTTMRDGHQSLLATRMRTYDIARIAGTYAHALPNLLSLECWGGATFD
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
VSMRFLTEDPWERLALIREGAPNLLLQMLLRGANGVGYTNYPDNVVKYFVRQAARGGIDL
EEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHH
FRVFDCLNWVENMRVSMDAIAEENKLCEAAICYTGDILNSARPKYDLKYYTDLAVELEKA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEHHHHHCCCCCCCEEEHHHHHHHHHHC
GAHIIALKDMAGLLKPAAAKVLFKALREATSLPIHFHTHDTSGIAAATVLAAVDAGVDAV
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCHHH
DAAMDALSGNTSQPCLGSIVEALRGTERDPGLDPEWIRRVSFYWEAVRNQYAAFESDLKG
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PASEVYLHEMPGGQFTNLKEQARSLGLETRWHRVAQAYADANQMFGDIVKVTPSSKVVGD
CHHHEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHH
MALMMVSQDLTVADVVSPEREVSFPESVVSMLKGDLGQPPSGWPEALQKKALKGDKPYTV
HHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEE
RPGSLLKEADLDAERKVIETKLEREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTP
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
AYFYGLGDGEELFADIERGKTLVIVNQAMSATDSQGMVTIFFELNGQPRRIKVPDRAHGA
CEEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCC
TGAAVRRKAEPGNAVHVGAPMPGVISRVFVSAGQAVSAGDVLVSIEAMKMETALHAEKDG
CCHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHCCCCC
TIAEVLVKAGDQIDAKDLLIVYGSL
HHHHHHHHCCCCCCCCCEEEEEECC
>Mature Secondary Structure
MRVALRTVDNAVIRKILVANRSEIAIRVFRAANELGIKTVAIWAEEDKLALHRFKADESY
CEEEHHHHHHHHHHHHHHCCCCHHEEHEEHHHHHCCCEEEEEEECCCCHHHHHCCCCCCC
QVGRGPHLSKDMGPIESYLSIDEVIRVAKLSGADAIHPGYGLLSESPEFVDACDKAGIIF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEE
IGPRADTMRQLGNKVAARNLAISVGVPVVPATEPLPDDMAEVAKMAKEIGYPVMLKASWG
ECCCHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCC
GGGRGMRAIRDPKDLAREVTEAKREAMAAFGKDEVYLEKLVERARHVESQVLGDTHGNVV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEE
HLFERDCSIQRRNQKVVERAPAPYLSEAQRQELAAYSLKIAAATNYVGAGTVEYLMDADT
EEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHEECCC
GKFYFIEVNPRIQVEHTVTEVVTGIDIVKAQIHILDGAAIGTPESGVPAQAVIRLNGHAL
CEEEEEEECCEEEEHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCCCCCEEEEEECCEEE
QCRITTEDPEHNFIPDYGRITAYRSASGFGIRLDGGTSYSGAIITRFYDPLLVKVTAWAP
EEEEECCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCCEEHEECCCCEEEEEEECCC
NPSEAISRMDRALREFRIRGVATNLTFLEAIIGHPKFRDNSYTTRFIDTTPELFQQVKRQ
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHHHHHH
DRATKLLTYLADVTVNGHPEAKDRPRPLDNAAQPVVPYANGNGVKDGTKQLLDTLGPKKF
HHHHHHHHHHHHCEECCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCCHHHH
GEWMRNEKRVLLTDTTMRDGHQSLLATRMRTYDIARIAGTYAHALPNLLSLECWGGATFD
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEE
VSMRFLTEDPWERLALIREGAPNLLLQMLLRGANGVGYTNYPDNVVKYFVRQAARGGIDL
EEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCHHH
FRVFDCLNWVENMRVSMDAIAEENKLCEAAICYTGDILNSARPKYDLKYYTDLAVELEKA
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHEEHHHHHCCCCCCCEEEHHHHHHHHHHC
GAHIIALKDMAGLLKPAAAKVLFKALREATSLPIHFHTHDTSGIAAATVLAAVDAGVDAV
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCHHH
DAAMDALSGNTSQPCLGSIVEALRGTERDPGLDPEWIRRVSFYWEAVRNQYAAFESDLKG
HHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
PASEVYLHEMPGGQFTNLKEQARSLGLETRWHRVAQAYADANQMFGDIVKVTPSSKVVGD
CHHHEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHH
MALMMVSQDLTVADVVSPEREVSFPESVVSMLKGDLGQPPSGWPEALQKKALKGDKPYTV
HHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEE
RPGSLLKEADLDAERKVIETKLEREVSDFEFASYLMYPKVFTDFALASDTYGPVSVLPTP
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
AYFYGLGDGEELFADIERGKTLVIVNQAMSATDSQGMVTIFFELNGQPRRIKVPDRAHGA
CEEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCEEECCCCCCCC
TGAAVRRKAEPGNAVHVGAPMPGVISRVFVSAGQAVSAGDVLVSIEAMKMETALHAEKDG
CCHHHHCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCCCCEEEEEEHHHHHHHHHCCCCC
TIAEVLVKAGDQIDAKDLLIVYGSL
HHHHHHHHCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]