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The map label for this gene is macA [H]

Identifier: 209550620

GI number: 209550620

Start: 3103618

End: 3104808

Strand: Direct

Name: macA [H]

Synonym: Rleg2_3044

Alternate gene names: 209550620

Gene position: 3103618-3104808 (Clockwise)

Preceding gene: 209550619

Following gene: 209550621

Centisome position: 68.39

GC content: 63.39

Gene sequence:

>1191_bases
ATGGCACGCAAGCCGATTGAAATTCTAGGCGCCGCTACCCTTTTTGCAGCGGCTCTCGCTGCATCCACGGCATTTTCGCA
GGAAAAGCCGGTCGAAAAACCGCAGCAGAATCTGCCGGCGATCGTCGTCACCAAGGCTGTGAATCGCACGCTTGTCGACC
GTGTCATCGGCACGGGAACGATCAAGCCCGTTGAAGAAGTTTATATTCAACCGCAGGTCGAAGGCCTGTCAATCCGTACG
CTGAAAGCCGATGTCGGCGACAAGGTTCAGGCGGAAAGCACCTTGGCGACGCTCAACGACGACGCGCTGGTGCTGGAGAA
GAGCCAGATGATGGCGACGAAGGCCAAGGGTGAGGCAAGCCTCGCCCAGCTGCGCGCCCAGCTCATCGAGGCGCAAGCCA
ATGCCGAACAGGCAAGACAGCAGCAGGCCCGCGCCCAGGAAATGGTCAAGAAGGGTACGGTTTCCACCGCTCAGGTCGAG
CAGGCCGACGCGACGGCCGCCGCCGCCAATGCCCGCGTCGTCTCAGCCGAACAGGCGATCGAGGTAGCCGAGGCCGATCT
CAAAGTCTTCGACAGCCAGATCGCCGATGCGGATCTGAAGCTGGCACGCACCGATGTGAAGACGCCGGTGGCCGGCACGG
TCGCGGCGAAGAACGCCAAGGTCGGCGCCATTGCCGCCGGCAACGGCGATCCGCTGTTCACCCTCATTCGCGATGGTGAT
GTCGAGCTTGTCGCTGAGGTCGCCGAAAGCGACATCGTCAGGGTCGCGGCCGGCCAGAAGGCGGCGATTTCGCTGTCCGG
CAGCCGCGAGAAGCTGTCCGGCGCCGTGCGCCTGGTGTCGCCGACCGTCGATCCCACCACCCGCCTCGGTCTCGTCCACA
TCTCCATCGACGACGACAGCAAGGCGCGCTCCGGCATGTATGGCAGCGCCGAGATTATCGTTCGCGAGACGGAGGGCGTA
TCGCTTCCGCTGACCGCCGTGCTCACCGGCAATGAAGGCTCGTCGGCCCGCAAGGTCGAAGATGGCGTGGTGAAATTCGC
CAAGGTCGAGACCGGCATCCAGGACGGTGCCTATGTCGAGATCGTCGATGGATTGAAGAGCGGCGACGAGGTCGTGGCCA
AGGCGGGCGCTTATGTCCGTGACGGCGACCACATCACGCCGGTGCGTGAACAGCCCCCGGCTTCCAACTAA

Upstream 100 bases:

>100_bases
GGATACCCCTGAGAATGCAGGAAAGGCAGTGGCCTGGTCGCGAGCTGAGTGGCAGACGCGCGAGTTCGGCTAAGCTTGTT
ACAAGATTGGACGAAGACGC

Downstream 100 bases:

>100_bases
AGAGACCATCCGATGAATTTTTCAGCCTGGTCCATTCGAAATCCGATCGCGCCGCTGCTGGCCTTCTGCCTGTTGATATT
CATCGGCATGCAGTCCTTCA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MARKPIEILGAATLFAAALAASTAFSQEKPVEKPQQNLPAIVVTKAVNRTLVDRVIGTGTIKPVEEVYIQPQVEGLSIRT
LKADVGDKVQAESTLATLNDDALVLEKSQMMATKAKGEASLAQLRAQLIEAQANAEQARQQQARAQEMVKKGTVSTAQVE
QADATAAAANARVVSAEQAIEVAEADLKVFDSQIADADLKLARTDVKTPVAGTVAAKNAKVGAIAAGNGDPLFTLIRDGD
VELVAEVAESDIVRVAAGQKAAISLSGSREKLSGAVRLVSPTVDPTTRLGLVHISIDDDSKARSGMYGSAEIIVRETEGV
SLPLTAVLTGNEGSSARKVEDGVVKFAKVETGIQDGAYVEIVDGLKSGDEVVAKAGAYVRDGDHITPVREQPPASN

Sequences:

>Translated_396_residues
MARKPIEILGAATLFAAALAASTAFSQEKPVEKPQQNLPAIVVTKAVNRTLVDRVIGTGTIKPVEEVYIQPQVEGLSIRT
LKADVGDKVQAESTLATLNDDALVLEKSQMMATKAKGEASLAQLRAQLIEAQANAEQARQQQARAQEMVKKGTVSTAQVE
QADATAAAANARVVSAEQAIEVAEADLKVFDSQIADADLKLARTDVKTPVAGTVAAKNAKVGAIAAGNGDPLFTLIRDGD
VELVAEVAESDIVRVAAGQKAAISLSGSREKLSGAVRLVSPTVDPTTRLGLVHISIDDDSKARSGMYGSAEIIVRETEGV
SLPLTAVLTGNEGSSARKVEDGVVKFAKVETGIQDGAYVEIVDGLKSGDEVVAKAGAYVRDGDHITPVREQPPASN
>Mature_395_residues
ARKPIEILGAATLFAAALAASTAFSQEKPVEKPQQNLPAIVVTKAVNRTLVDRVIGTGTIKPVEEVYIQPQVEGLSIRTL
KADVGDKVQAESTLATLNDDALVLEKSQMMATKAKGEASLAQLRAQLIEAQANAEQARQQQARAQEMVKKGTVSTAQVEQ
ADATAAAANARVVSAEQAIEVAEADLKVFDSQIADADLKLARTDVKTPVAGTVAAKNAKVGAIAAGNGDPLFTLIRDGDV
ELVAEVAESDIVRVAAGQKAAISLSGSREKLSGAVRLVSPTVDPTTRLGLVHISIDDDSKARSGMYGSAEIIVRETEGVS
LPLTAVLTGNEGSSARKVEDGVVKFAKVETGIQDGAYVEIVDGLKSGDEVVAKAGAYVRDGDHITPVREQPPASN

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=335, Percent_Identity=27.4626865671642, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI87082036, Length=346, Percent_Identity=28.0346820809249, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 41290; Mature: 41159

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARKPIEILGAATLFAAALAASTAFSQEKPVEKPQQNLPAIVVTKAVNRTLVDRVIGTGT
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHCCCC
IKPVEEVYIQPQVEGLSIRTLKADVGDKVQAESTLATLNDDALVLEKSQMMATKAKGEAS
CCCHHHEEECCCCCCEEEEEEECCCCCCCCCCHHHEECCCCEEEEEHHHHHHHHCCCHHH
LAQLRAQLIEAQANAEQARQQQARAQEMVKKGTVSTAQVEQADATAAAANARVVSAEQAI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEHHHHH
EVAEADLKVFDSQIADADLKLARTDVKTPVAGTVAAKNAKVGAIAAGNGDPLFTLIRDGD
HHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCCEEEECCCCEEEEEECCCCEEEEEEECCC
VELVAEVAESDIVRVAAGQKAAISLSGSREKLSGAVRLVSPTVDPTTRLGLVHISIDDDS
HHHHHHHHHCCEEEEECCCEEEEEECCCHHHHCCEEEEECCCCCCCCEEEEEEEEECCCC
KARSGMYGSAEIIVRETEGVSLPLTAVLTGNEGSSARKVEDGVVKFAKVETGIQDGAYVE
CHHCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
IVDGLKSGDEVVAKAGAYVRDGDHITPVREQPPASN
EECCCCCCHHHHHHCCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARKPIEILGAATLFAAALAASTAFSQEKPVEKPQQNLPAIVVTKAVNRTLVDRVIGTGT
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCEEEEEHHHHHHHHHHHHCCCC
IKPVEEVYIQPQVEGLSIRTLKADVGDKVQAESTLATLNDDALVLEKSQMMATKAKGEAS
CCCHHHEEECCCCCCEEEEEEECCCCCCCCCCHHHEECCCCEEEEEHHHHHHHHCCCHHH
LAQLRAQLIEAQANAEQARQQQARAQEMVKKGTVSTAQVEQADATAAAANARVVSAEQAI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEHHHHH
EVAEADLKVFDSQIADADLKLARTDVKTPVAGTVAAKNAKVGAIAAGNGDPLFTLIRDGD
HHHHHHHHHHHHHHCCCCCEEEHHCCCCCCCCEEEECCCCEEEEEECCCCEEEEEEECCC
VELVAEVAESDIVRVAAGQKAAISLSGSREKLSGAVRLVSPTVDPTTRLGLVHISIDDDS
HHHHHHHHHCCEEEEECCCEEEEEECCCHHHHCCEEEEECCCCCCCCEEEEEEEEECCCC
KARSGMYGSAEIIVRETEGVSLPLTAVLTGNEGSSARKVEDGVVKFAKVETGIQDGAYVE
CHHCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCEEE
IVDGLKSGDEVVAKAGAYVRDGDHITPVREQPPASN
EECCCCCCHHHHHHCCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]