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The map label for this gene is dht [H]

Identifier: 209550614

GI number: 209550614

Start: 3097293

End: 3098747

Strand: Direct

Name: dht [H]

Synonym: Rleg2_3038

Alternate gene names: 209550614

Gene position: 3097293-3098747 (Clockwise)

Preceding gene: 209550613

Following gene: 209550616

Centisome position: 68.25

GC content: 63.23

Gene sequence:

>1455_bases
ATGAGCACAGTCATCAAAAACGGCACCATCGTCACCGCCGACCTGACCTACAAGGCTGACGTCAAGATCGACGGCGGCAA
GATCGTCGAGATCGGCCCGAACCTCTCGGGCGACGAGACGCTGGACGCCTCCGGCTGTTATGTCATGCCTGGTGGTATCG
ATCCGCACACCCATCTCGAAATGCCCTTCATGGGCACCTATTCCTCCGACGATTTCGAGAGCGGCACGCGGGCGGCCCTT
TCCGGCGGCACCACCATGGTGGTCGATTTCGCCCTGCCCGCCCCCGGCCAGTCGCTGCTCGAAGCGCTGGCCATGTGGGA
TAACAAGTCGACGCGGGCCAATTGCGACTATTCTTTCCACATGGCGGTTACCTGGTGGAGCGAGCAGGTCTTCCAGGAGA
TGGAGACCATCGTCCGCGACAAGGGCATCAACACCTTCAAGCACTTCATGGCCTATAAGGGCGCGCTGATGGTCGACGAC
GACGAGATGTTCGCCTCGTTCCAGCGCTGCGCCGAACTCGGCGCGCTGCCGCTGGTGCACGCCGAAAACGGCGATGTCGT
CGCCTCGATGTCGGCAAAGCTGCTCGCCGAAGGCAACAACGGTCCCGAGGCGCATGCCTATTCCCGCCCTGCCGAGGTAG
AGGGCGAGGCCACCAACCGCGCCATCATGATCGCCGACATGGCCGGCTGCCCGGTCTATATCGTCCATACCTCCTGCGAG
CAGGCGCATGAAGCGATCCGCCGGGCCCGTGCCAAGGGCATGCGTGTCTACGGCGAACCGCTGATCCAGCACCTGACGCT
CGACGAGAGCGAATATTCCAATCCAGACTGGGACCACGCCGCCCGCCGCGTGATGTCACCGCCGTTCCGCAACAAGCAGC
ACCAGGACAGTCTCTGGGCCGGGCTTGCCTCCGGCTCGCTGCAGGTGGTCGCTACCGACCATTGCGCCTTCACCACGGCG
CAGAAGCGTTTCGGCGTCGGTGATTTCACCAAGATCCCGAACGGCACCGGCGGCCTTGAAGACCGCATGCCGATGCTCTG
GACACGCGGCGTCAACACCGGCCGGCTGACGATGAACGAGTTCGTCGCCGTGACCTCGACCAACATCGCCAAGATCCTCA
ACATCTATCCGAAGAAAGGCGCGATCCTCGTCGGCGCCGATGCCGATATCGTCGTCTGGGATCCGAAGCGGTCAAAAACC
ATCTCGTCCAAGAGCCAGCAGTCGGCGATCGACTACAACGTCTTCGAAGGCAAGGAAGTGACCGGCCTGCCGCGCTACAC
GCTGACGCGCGGCGTCGTCGCTATCGAGGAAAGCACCATCAAGACCCAAGAGGGCCATGGTGAATTCGTCCGGCGCGAAC
CGGTGACGGCCGTCAGCAGGGCACTCTCCACCTGGAAGGAGATCACCGCCCCGCGCAAGGTGACGCGCAGCGGCATTCCG
GCGACCGGCGTTTGA

Upstream 100 bases:

>100_bases
TGCCTCAATGGCCTCAATTCATGCGCGGTTGCATCCGCTATCGTCAGTCATTGGATAAACAGCTTGCGCAGGCACCGCGC
AGCGACAGGGAGTTCGGAGA

Downstream 100 bases:

>100_bases
CGATGTTCCATGACCAACCGGCCATCAACCGGAGAACGGCGCCTTCATGTCGATGACCTCATGCCGGCACCAGCGCATCC
AACTCCGGCAGCAGCACGAC

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTVIKNGTIVTADLTYKADVKIDGGKIVEIGPNLSGDETLDASGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAAL
SGGTTMVVDFALPAPGQSLLEALAMWDNKSTRANCDYSFHMAVTWWSEQVFQEMETIVRDKGINTFKHFMAYKGALMVDD
DEMFASFQRCAELGALPLVHAENGDVVASMSAKLLAEGNNGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
QAHEAIRRARAKGMRVYGEPLIQHLTLDESEYSNPDWDHAARRVMSPPFRNKQHQDSLWAGLASGSLQVVATDHCAFTTA
QKRFGVGDFTKIPNGTGGLEDRMPMLWTRGVNTGRLTMNEFVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKT
ISSKSQQSAIDYNVFEGKEVTGLPRYTLTRGVVAIEESTIKTQEGHGEFVRREPVTAVSRALSTWKEITAPRKVTRSGIP
ATGV

Sequences:

>Translated_484_residues
MSTVIKNGTIVTADLTYKADVKIDGGKIVEIGPNLSGDETLDASGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAAL
SGGTTMVVDFALPAPGQSLLEALAMWDNKSTRANCDYSFHMAVTWWSEQVFQEMETIVRDKGINTFKHFMAYKGALMVDD
DEMFASFQRCAELGALPLVHAENGDVVASMSAKLLAEGNNGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
QAHEAIRRARAKGMRVYGEPLIQHLTLDESEYSNPDWDHAARRVMSPPFRNKQHQDSLWAGLASGSLQVVATDHCAFTTA
QKRFGVGDFTKIPNGTGGLEDRMPMLWTRGVNTGRLTMNEFVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKT
ISSKSQQSAIDYNVFEGKEVTGLPRYTLTRGVVAIEESTIKTQEGHGEFVRREPVTAVSRALSTWKEITAPRKVTRSGIP
ATGV
>Mature_483_residues
STVIKNGTIVTADLTYKADVKIDGGKIVEIGPNLSGDETLDASGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAALS
GGTTMVVDFALPAPGQSLLEALAMWDNKSTRANCDYSFHMAVTWWSEQVFQEMETIVRDKGINTFKHFMAYKGALMVDDD
EMFASFQRCAELGALPLVHAENGDVVASMSAKLLAEGNNGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCEQ
AHEAIRRARAKGMRVYGEPLIQHLTLDESEYSNPDWDHAARRVMSPPFRNKQHQDSLWAGLASGSLQVVATDHCAFTTAQ
KRFGVGDFTKIPNGTGGLEDRMPMLWTRGVNTGRLTMNEFVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKTI
SSKSQQSAIDYNVFEGKEVTGLPRYTLTRGVVAIEESTIKTQEGHGEFVRREPVTAVSRALSTWKEITAPRKVTRSGIPA
TGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=460, Percent_Identity=49.3478260869565, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI4503379, Length=479, Percent_Identity=43.4237995824635, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI4503051, Length=455, Percent_Identity=45.2747252747253, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI4503377, Length=456, Percent_Identity=44.2982456140351, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI190194363, Length=455, Percent_Identity=45.4945054945055, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI62422571, Length=455, Percent_Identity=45.2747252747253, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI19923821, Length=481, Percent_Identity=42.8274428274428, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI18105007, Length=447, Percent_Identity=26.6219239373602, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI87082175, Length=461, Percent_Identity=39.6963123644252, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1786722, Length=440, Percent_Identity=27.5, Blast_Score=168, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=46.9979296066253, Blast_Score=444, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71989490, Length=455, Percent_Identity=45.9340659340659, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI86575075, Length=456, Percent_Identity=32.4561403508772, Blast_Score=241, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI193204318, Length=428, Percent_Identity=24.7663551401869, Blast_Score=91, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=403, Percent_Identity=26.7990074441687, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=45.2747252747253, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=44.1501103752759, Blast_Score=406, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=44.2176870748299, Blast_Score=265, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24644289, Length=258, Percent_Identity=44.5736434108527, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24642586, Length=437, Percent_Identity=26.5446224256293, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859883, Length=419, Percent_Identity=22.1957040572792, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52764; Mature: 52633

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVIKNGTIVTADLTYKADVKIDGGKIVEIGPNLSGDETLDASGCYVMPGGIDPHTHLE
CCCEEECCEEEEEEEEEEEEEEECCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAALSGGTTMVVDFALPAPGQSLLEALAMWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCHHEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEE
MAVTWWSEQVFQEMETIVRDKGINTFKHFMAYKGALMVDDDEMFASFQRCAELGALPLVH
EEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCEEEE
AENGDVVASMSAKLLAEGNNGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
CCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCHH
QAHEAIRRARAKGMRVYGEPLIQHLTLDESEYSNPDWDHAARRVMSPPFRNKQHQDSLWA
HHHHHHHHHHHCCCEEECCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
GLASGSLQVVATDHCAFTTAQKRFGVGDFTKIPNGTGGLEDRMPMLWTRGVNTGRLTMNE
HHCCCCEEEEEECCEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEHHH
FVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKTISSKSQQSAIDYNVFEGKEV
EEEEECCCHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCCHHCCCCEEEECCCCC
TGLPRYTLTRGVVAIEESTIKTQEGHGEFVRREPVTAVSRALSTWKEITAPRKVTRSGIP
CCCCCHHHHCCEEEEECCCEECCCCCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCC
ATGV
CCCC
>Mature Secondary Structure 
STVIKNGTIVTADLTYKADVKIDGGKIVEIGPNLSGDETLDASGCYVMPGGIDPHTHLE
CCEEECCEEEEEEEEEEEEEEECCCEEEEECCCCCCCCCCCCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAALSGGTTMVVDFALPAPGQSLLEALAMWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCHHEECCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCEEEE
MAVTWWSEQVFQEMETIVRDKGINTFKHFMAYKGALMVDDDEMFASFQRCAELGALPLVH
EEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHCCCEEEE
AENGDVVASMSAKLLAEGNNGPEAHAYSRPAEVEGEATNRAIMIADMAGCPVYIVHTSCE
CCCCCEEEECCEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCHH
QAHEAIRRARAKGMRVYGEPLIQHLTLDESEYSNPDWDHAARRVMSPPFRNKQHQDSLWA
HHHHHHHHHHHCCCEEECCHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
GLASGSLQVVATDHCAFTTAQKRFGVGDFTKIPNGTGGLEDRMPMLWTRGVNTGRLTMNE
HHCCCCEEEEEECCEEEEHHHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCEEEHHH
FVAVTSTNIAKILNIYPKKGAILVGADADIVVWDPKRSKTISSKSQQSAIDYNVFEGKEV
EEEEECCCHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCCCCCCHHCCCCEEEECCCCC
TGLPRYTLTRGVVAIEESTIKTQEGHGEFVRREPVTAVSRALSTWKEITAPRKVTRSGIP
CCCCCHHHHCCEEEEECCCEECCCCCCCHHHCCHHHHHHHHHHHHHHHCCCHHHHHCCCC
ATGV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]