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The map label for this gene is hmuU [H]

Identifier: 209550596

GI number: 209550596

Start: 3080107

End: 3081219

Strand: Direct

Name: hmuU [H]

Synonym: Rleg2_3020

Alternate gene names: 209550596

Gene position: 3080107-3081219 (Clockwise)

Preceding gene: 209550595

Following gene: 209550597

Centisome position: 67.87

GC content: 66.85

Gene sequence:

>1113_bases
ATGGTCCTGCCGCAAGCCATGATGGAGCGAAGGCGACCATTCTCGTTGGTGGAGATCAGCGCAAACCGGCAGACGGGCGA
CAGAACGCGGCTCGCCTTGCTGGTCATTGCGGTGCTCGTCGTCGGCTCGGTCTTCTCGATGCTGTTTTCGGTGACGACAG
GCGCCTCGGATGCCTCGATCCTCGACGTTATCGGCAACATGGCCGGTTCCGGGACGGCGCTCAGCACGCGCGACCGGATC
ATCATCTTCGACATCCGCCTGCCGAGAGCGATCCTCGGCTTCCTGATCGGCGCCTCACTGGCCGTTTCCGGCACGGTGAT
GCAGGGCCTGTTCCGCAATCCGCTGGCCGATCCCGGCCTCGTCGGCGTCTCCTCCGGTGCAAGTCTCGGTGCGGTTATCA
TGATCGTGCTCGGCGGCAGCCTTGCAGCGCCGCTTCAGGCGCTTCTCGGCATCTATGCCCTGCCGGCGGCCGCCTTTGGC
GGCGGTCTCGTCACGACGCTGCTGCTCTACAGGATCGCCACCCGTCACGGCCAGACCTCGGTGGCGACGATGCTGCTGGC
CGGCATCGCGCTCGGCGCCCTCACGCTCGCCCTGACCGGCCTGCTGATCTACATGGCCAACGACCAGCAGCTGCGCGACC
TGACATTCTGGAGCATGGGCTCGCTGGCCGGCGCCACATGGACGAAGATCGCCGCCGCCGCCCCGATCATTCTGCTGTCC
TTCACCGCCCTTCCCTTCATGGCGCGTGGCCTCAATGCCATCACGCTCGGCGAGGCCGCCGCCTTTCATATGGGCGTGCC
GGTGCAGCGGCTGAAGAATGTCGCTGTCGTCGGCGTCGCCGCGGCAACCGGTGCGTCCGTCGCCGCCAGCGGCGGCATCG
GTTTCGTCGGCATCGTCGTGCCGCATATCCTGCGTATGGCCATCGGTCCGGACCATCGTTTCCTGCTGCCGGCCGCAGCT
CTTCTCGGCGGCTCGCTCCTGATTTTCGCCGATGTCCTGGCGCGCACCCTGGTCGCCCCGGCCGAGCTGCCGATCGGCAT
CATCACCGCAGCGGTCGGCGGACCGTTCTTCCTGTGGATTCTGCTGAGGCAGCGTTCGCGCCTTGCCCTGTGA

Upstream 100 bases:

>100_bases
AGGCGATCATCCGCATGGACGGCATCTACCTGCTTGGCTTCGGCCCCCGGACCGCAGCTGCCGCGCGTGAGCTCAACGCG
GCGATCTACGGGGGCTGATC

Downstream 100 bases:

>100_bases
GTGCTGTCGTGAGTGACGAGATGATCGAAGTGTCCGGCCTCTCCGTGCGCCTTTCCGGCAAATCAATCATCAGCGACGTC
GCCTTCACGGCAAAGGCCGG

Product: transporter permease

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MVLPQAMMERRRPFSLVEISANRQTGDRTRLALLVIAVLVVGSVFSMLFSVTTGASDASILDVIGNMAGSGTALSTRDRI
IIFDIRLPRAILGFLIGASLAVSGTVMQGLFRNPLADPGLVGVSSGASLGAVIMIVLGGSLAAPLQALLGIYALPAAAFG
GGLVTTLLLYRIATRHGQTSVATMLLAGIALGALTLALTGLLIYMANDQQLRDLTFWSMGSLAGATWTKIAAAAPIILLS
FTALPFMARGLNAITLGEAAAFHMGVPVQRLKNVAVVGVAAATGASVAASGGIGFVGIVVPHILRMAIGPDHRFLLPAAA
LLGGSLLIFADVLARTLVAPAELPIGIITAAVGGPFFLWILLRQRSRLAL

Sequences:

>Translated_370_residues
MVLPQAMMERRRPFSLVEISANRQTGDRTRLALLVIAVLVVGSVFSMLFSVTTGASDASILDVIGNMAGSGTALSTRDRI
IIFDIRLPRAILGFLIGASLAVSGTVMQGLFRNPLADPGLVGVSSGASLGAVIMIVLGGSLAAPLQALLGIYALPAAAFG
GGLVTTLLLYRIATRHGQTSVATMLLAGIALGALTLALTGLLIYMANDQQLRDLTFWSMGSLAGATWTKIAAAAPIILLS
FTALPFMARGLNAITLGEAAAFHMGVPVQRLKNVAVVGVAAATGASVAASGGIGFVGIVVPHILRMAIGPDHRFLLPAAA
LLGGSLLIFADVLARTLVAPAELPIGIITAAVGGPFFLWILLRQRSRLAL
>Mature_370_residues
MVLPQAMMERRRPFSLVEISANRQTGDRTRLALLVIAVLVVGSVFSMLFSVTTGASDASILDVIGNMAGSGTALSTRDRI
IIFDIRLPRAILGFLIGASLAVSGTVMQGLFRNPLADPGLVGVSSGASLGAVIMIVLGGSLAAPLQALLGIYALPAAAFG
GGLVTTLLLYRIATRHGQTSVATMLLAGIALGALTLALTGLLIYMANDQQLRDLTFWSMGSLAGATWTKIAAAAPIILLS
FTALPFMARGLNAITLGEAAAFHMGVPVQRLKNVAVVGVAAATGASVAASGGIGFVGIVVPHILRMAIGPDHRFLLPAAA
LLGGSLLIFADVLARTLVAPAELPIGIITAAVGGPFFLWILLRQRSRLAL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=296, Percent_Identity=43.2432432432432, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1790740, Length=289, Percent_Identity=38.4083044982699, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1790741, Length=291, Percent_Identity=34.7079037800687, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1786805, Length=300, Percent_Identity=36.3333333333333, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786804, Length=339, Percent_Identity=32.4483775811209, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1786347, Length=286, Percent_Identity=32.5174825174825, Blast_Score=108, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 38048; Mature: 38048

Theoretical pI: Translated: 11.87; Mature: 11.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLPQAMMERRRPFSLVEISANRQTGDRTRLALLVIAVLVVGSVFSMLFSVTTGASDASI
CCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LDVIGNMAGSGTALSTRDRIIIFDIRLPRAILGFLIGASLAVSGTVMQGLFRNPLADPGL
HHHHHCCCCCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VGVSSGASLGAVIMIVLGGSLAAPLQALLGIYALPAAAFGGGLVTTLLLYRIATRHGQTS
EECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHH
VATMLLAGIALGALTLALTGLLIYMANDQQLRDLTFWSMGSLAGATWTKIAAAAPIILLS
HHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
FTALPFMARGLNAITLGEAAAFHMGVPVQRLKNVAVVGVAAATGASVAASGGIGFVGIVV
HHHHHHHHCCCCEEEECCHHHHHCCCCHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHH
PHILRMAIGPDHRFLLPAAALLGGSLLIFADVLARTLVAPAELPIGIITAAVGGPFFLWI
HHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHH
LLRQRSRLAL
HHHHHHHCCC
>Mature Secondary Structure
MVLPQAMMERRRPFSLVEISANRQTGDRTRLALLVIAVLVVGSVFSMLFSVTTGASDASI
CCCCHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LDVIGNMAGSGTALSTRDRIIIFDIRLPRAILGFLIGASLAVSGTVMQGLFRNPLADPGL
HHHHHCCCCCCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
VGVSSGASLGAVIMIVLGGSLAAPLQALLGIYALPAAAFGGGLVTTLLLYRIATRHGQTS
EECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHH
VATMLLAGIALGALTLALTGLLIYMANDQQLRDLTFWSMGSLAGATWTKIAAAAPIILLS
HHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
FTALPFMARGLNAITLGEAAAFHMGVPVQRLKNVAVVGVAAATGASVAASGGIGFVGIVV
HHHHHHHHCCCCEEEECCHHHHHCCCCHHHHCCCCEEEEEHHCCCCCCCCCCCHHHHHHH
PHILRMAIGPDHRFLLPAAALLGGSLLIFADVLARTLVAPAELPIGIITAAVGGPFFLWI
HHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHHHHH
LLRQRSRLAL
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]