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The map label for this gene is rkpK [H]

Identifier: 209550563

GI number: 209550563

Start: 3051111

End: 3052436

Strand: Direct

Name: rkpK [H]

Synonym: Rleg2_2987

Alternate gene names: 209550563

Gene position: 3051111-3052436 (Clockwise)

Preceding gene: 209550562

Following gene: 209550565

Centisome position: 67.24

GC content: 60.26

Gene sequence:

>1326_bases
ATGCGCATCACGATGATTGGATCAGGCTATGTCGGCCTCGTTTCAGGCGTTTGCTTTGCGGATTTCGGCCACGACGTCAT
CTGCGTAGACAAGGATCTGAGTAAGATCGAAGCCCTTCGCGAAGGCCGCATTCCGATCTACGAGCCGGGTCTGGAACAAT
TGGTCGCCGAAAATACCAGCACCGGCCGGCTGTCGTTTTCGACGGATGTCGGTGAAAGCGTCCGTAGCGCCGATGTCGTC
TTCATCGCGGTCGGCACGCCATCCCGGCGCGGCGACGGCCACGCGGACCTTTCCTATGTCTACGCCGCTGCGCGCGAGAT
TGCCACTTATGTGGAAGGCTTCACCGTTATCGTCACCAAGTCGACGGTGCCGGTCGGCACCGGCGACGAAGTCGAGCGCA
TCATGCGCGAAACCAATCCTGCGGCGGATGTCGCCGTGGTTTCCAATCCGGAATTCCTGCGCGAAGGTGCGGCGATCGAA
GATTTCAAGCGTCCTGACCGTATCGTTGTCGGGCTGAATGACGACCGGGCGCGCGAAACCATGACCGAGGTCTATCGTCC
GCTTTACCTCAACCAGGCGCCGCTGGTCTTCACCACCCGCCGTACCTCGGAACTGATCAAATATGCGGCCAATGCCTTCC
TCGCGATGAAGATCACCTTCATCAACGAGATCGCCGATCTCTGCGAACGGGTCGACGCAAACGTCCAGGACGTCTCGCGC
GGCATCGGTCTCGACGGCCGAATCGGCGCCAAGTTCCTGCATGCCGGCCCGGGTTACGGCGGCTCGTGCTTCCCCAAGGA
TACGCTTGCTCTTGCCAAGACGGCGCAGGATTACGACGCGCCGATCCGTCTCATCGAGACGACGATCTCGATCAACGACA
ACCGCAAGCGGGCCATGGGACGCAAAGTCATCTCGGCCGTCGGCGGAGACATTCGCGGCAAGAAGATCGCCATTCTCGGC
CTGACCTTCAAGCCGAACACCGACGACATGCGCGACAGCCCGGCGATTGCCGTCATCCAGACCCTGCAGGACGCCGGCGC
CAAGGTGGTCGGCTACGATCCCGAGGGCATGGAGAACGCCCGCAAGGTGATCGAGAACATCGAATATGCGAACGGTCCCT
ATGAAGCGGCCGCCGATGCGGATGCGCTTGTCATCGTCACCGAATGGAATCAGTTCCGCGCACTCGATTTCAATCGCCTG
AAGCAGTCGATGCGCGCCCCGGTCCTGGTCGACTTGCGCAATATTTACCGCAGCGACGAGGTCCGCAAATACGGCTTTAC
CTATACCGGCATCGGCACCAATCTCTATCAGGAATCAAACGCCTGA

Upstream 100 bases:

>100_bases
TCAAGCGATCTTCGATATTGTCTTTTCGCCCAGATTAAGTATGACGGACGCCCATGCTGCGACGCAGCATGATGTCCTAC
TCTAATGATTTGAGGGAATT

Downstream 100 bases:

>100_bases
CAGGTTCTGGTGAACCGGTAATCGTCCTGACGCCGCGGAGCAAATCCCGCGGCGTTTTGGTTTTTAATGCATGTCGCCCG
GAAGTGTGCAGCGGTTCCGG

Product: nucleotide sugar dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MRITMIGSGYVGLVSGVCFADFGHDVICVDKDLSKIEALREGRIPIYEPGLEQLVAENTSTGRLSFSTDVGESVRSADVV
FIAVGTPSRRGDGHADLSYVYAAAREIATYVEGFTVIVTKSTVPVGTGDEVERIMRETNPAADVAVVSNPEFLREGAAIE
DFKRPDRIVVGLNDDRARETMTEVYRPLYLNQAPLVFTTRRTSELIKYAANAFLAMKITFINEIADLCERVDANVQDVSR
GIGLDGRIGAKFLHAGPGYGGSCFPKDTLALAKTAQDYDAPIRLIETTISINDNRKRAMGRKVISAVGGDIRGKKIAILG
LTFKPNTDDMRDSPAIAVIQTLQDAGAKVVGYDPEGMENARKVIENIEYANGPYEAAADADALVIVTEWNQFRALDFNRL
KQSMRAPVLVDLRNIYRSDEVRKYGFTYTGIGTNLYQESNA

Sequences:

>Translated_441_residues
MRITMIGSGYVGLVSGVCFADFGHDVICVDKDLSKIEALREGRIPIYEPGLEQLVAENTSTGRLSFSTDVGESVRSADVV
FIAVGTPSRRGDGHADLSYVYAAAREIATYVEGFTVIVTKSTVPVGTGDEVERIMRETNPAADVAVVSNPEFLREGAAIE
DFKRPDRIVVGLNDDRARETMTEVYRPLYLNQAPLVFTTRRTSELIKYAANAFLAMKITFINEIADLCERVDANVQDVSR
GIGLDGRIGAKFLHAGPGYGGSCFPKDTLALAKTAQDYDAPIRLIETTISINDNRKRAMGRKVISAVGGDIRGKKIAILG
LTFKPNTDDMRDSPAIAVIQTLQDAGAKVVGYDPEGMENARKVIENIEYANGPYEAAADADALVIVTEWNQFRALDFNRL
KQSMRAPVLVDLRNIYRSDEVRKYGFTYTGIGTNLYQESNA
>Mature_441_residues
MRITMIGSGYVGLVSGVCFADFGHDVICVDKDLSKIEALREGRIPIYEPGLEQLVAENTSTGRLSFSTDVGESVRSADVV
FIAVGTPSRRGDGHADLSYVYAAAREIATYVEGFTVIVTKSTVPVGTGDEVERIMRETNPAADVAVVSNPEFLREGAAIE
DFKRPDRIVVGLNDDRARETMTEVYRPLYLNQAPLVFTTRRTSELIKYAANAFLAMKITFINEIADLCERVDANVQDVSR
GIGLDGRIGAKFLHAGPGYGGSCFPKDTLALAKTAQDYDAPIRLIETTISINDNRKRAMGRKVISAVGGDIRGKKIAILG
LTFKPNTDDMRDSPAIAVIQTLQDAGAKVVGYDPEGMENARKVIENIEYANGPYEAAADADALVIVTEWNQFRALDFNRL
KQSMRAPVLVDLRNIYRSDEVRKYGFTYTGIGTNLYQESNA

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=463, Percent_Identity=37.3650107991361, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI296040438, Length=364, Percent_Identity=37.3626373626374, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI296040443, Length=458, Percent_Identity=32.0960698689956, Blast_Score=209, Evalue=4e-54,
Organism=Escherichia coli, GI48994968, Length=434, Percent_Identity=30.184331797235, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=29.8342541436464, Blast_Score=162, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17560350, Length=470, Percent_Identity=37.0212765957447, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI17136908, Length=467, Percent_Identity=37.2591006423983, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48263; Mature: 48263

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRITMIGSGYVGLVSGVCFADFGHDVICVDKDLSKIEALREGRIPIYEPGLEQLVAENTS
CEEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
TGRLSFSTDVGESVRSADVVFIAVGTPSRRGDGHADLSYVYAAAREIATYVEGFTVIVTK
CCEEEECCCCCCHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIMRETNPAADVAVVSNPEFLREGAAIEDFKRPDRIVVGLNDDRARET
CCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHCCCCHHHCCCCCEEEEECCCHHHHHH
MTEVYRPLYLNQAPLVFTTRRTSELIKYAANAFLAMKITFINEIADLCERVDANVQDVSR
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDGRIGAKFLHAGPGYGGSCFPKDTLALAKTAQDYDAPIRLIETTISINDNRKRAMG
CCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHH
RKVISAVGGDIRGKKIAILGLTFKPNTDDMRDSPAIAVIQTLQDAGAKVVGYDPEGMENA
HHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHH
RKVIENIEYANGPYEAAADADALVIVTEWNQFRALDFNRLKQSMRAPVLVDLRNIYRSDE
HHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEECCHHHHHHHHCCCEEEEHHHHHCCCC
VRKYGFTYTGIGTNLYQESNA
HHHCCCEEECCCCCCCCCCCC
>Mature Secondary Structure
MRITMIGSGYVGLVSGVCFADFGHDVICVDKDLSKIEALREGRIPIYEPGLEQLVAENTS
CEEEEEECCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCCCCCHHHHHHCCCC
TGRLSFSTDVGESVRSADVVFIAVGTPSRRGDGHADLSYVYAAAREIATYVEGFTVIVTK
CCEEEECCCCCCHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERIMRETNPAADVAVVSNPEFLREGAAIEDFKRPDRIVVGLNDDRARET
CCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHCCCCHHHCCCCCEEEEECCCHHHHHH
MTEVYRPLYLNQAPLVFTTRRTSELIKYAANAFLAMKITFINEIADLCERVDANVQDVSR
HHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDGRIGAKFLHAGPGYGGSCFPKDTLALAKTAQDYDAPIRLIETTISINDNRKRAMG
CCCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEEEEECCCHHHHHH
RKVISAVGGDIRGKKIAILGLTFKPNTDDMRDSPAIAVIQTLQDAGAKVVGYDPEGMENA
HHHHHHHCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEECCCCCHHHH
RKVIENIEYANGPYEAAADADALVIVTEWNQFRALDFNRLKQSMRAPVLVDLRNIYRSDE
HHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEECCHHHHHHHHCCCEEEEHHHHHCCCC
VRKYGFTYTGIGTNLYQESNA
HHHCCCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]