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The map label for this gene is guaD [H]

Identifier: 209550448

GI number: 209550448

Start: 2920974

End: 2922281

Strand: Direct

Name: guaD [H]

Synonym: Rleg2_2870

Alternate gene names: 209550448

Gene position: 2920974-2922281 (Clockwise)

Preceding gene: 209550447

Following gene: 209550449

Centisome position: 64.37

GC content: 61.54

Gene sequence:

>1308_bases
ATGACGACGACACTCCTGCGCGGCCGCCTGCTTTCTTTTCGTCGCGCGCCGCTGAGCCTGACCGACAGCCAGAGCTATCT
CTACGAGGAAGATGGCGGCCTGCTGATCGAAGACGGGCTGATCGCGGCGGCCGGCGCCTATGCCGACGTCAAGGCAAAGG
CAGCCGCTGATGTGGTCGAGATCGACCATCGCCCGCATCTGATCCTGCCCGGCTTCATCGACATGCATTTGCATTTTCCG
CAGATGCAGGTGATCGCCTCCTATGCCGCCAATCTGCTCGAATGGCTGAACACCTATACCTTTCCCGAGGAATGCCGTTT
CGTCGAAAGCGCGCATGCTGAAAGGATCGCCACCCATTTCTACGACGAACTGATCCGCCACGGCACGACGACGGCAGTCG
CCTATTGCTCCGTGCACAAGACTTCGGCCGACGCCTTCTTCGCCGAGGCGATGAAGCGCAACATGCGCATGGTCGGCGGC
AAGGTGATGATGGACCGCAACGCCCCGCAGGGCCTGCTCGACACGCCGGAGATCGGCTATGACGAGACCCGCCAGGTAAT
ATCGGACTGGCACGGCAAGGGCCGCAACCATGTCGCCATCACCCCGCGTTTCGCCATCACCTCGACGCCGGCGCAGATGG
AAGCAACCTCAGCCCTTGCCCGCGAATTTCCCGACCTGCACATCCAGACGCATCTTTCGGAAAACCACGACGAGATCAAA
TTCACCTGCGAACTCTATCCTGATGCGATCGACTATACCGACATCTACGCCCGCTATGGCCTGCTCGGACCGAAAAGCCT
CTTCGGCCACGCCATCCACCTGTCGGAGCGCGAAGCCGATGTGATGAGCGAGACGGGCGCCGTCGCCGTCCATTGCCCGA
CCTCGAACCTCTTCCTCGGCTCCGGCCTGTTTCCGTTGAAGGCATTGGCGCGGCGCGAAAAGCCGGTCCGCATCGGTGTC
GCCACCGATATCGGCGGCGGTTCCAGCTATTCGATGCTGAGGACGATGGACGAGGCCTACAAGATCCAGCAGCTGCTCGG
CGAACGATTGAACCCGCTGGAAAGCTATTACCTGATGACGCGCGGCAATGCCGAGGCGCTGTCGCTGGCCGACCGGATCG
GCACACTGGAACCCGGCACCGAGGCCGATCTCGTCGTCCTCGACGCGGCGGCAACCCCGGCCATGGCGCTGAAGATGGAA
GCGGTGAAGACGCTGCCCGAAGAACTCTTCCTGCTGCAGACGATGGGCGATGACAGGGCAATCGCCGAAACCTATGTGGC
GGGTGTAGACTTGAAAAAGAACCTTTAG

Upstream 100 bases:

>100_bases
GCAGCCATGCGATGCCGCCCGGCAACATCACCGATATCACGCCGGACGAACGCAAGCTGCTCGTCGCCTGGTTTGAAAGC
GCAGTCGAAGGCCAAAAACA

Downstream 100 bases:

>100_bases
CGAACTTGCAAAAATCCGCCGATCTTCCCATAGTTCTCCGAGAAGATCGCCTATGGACCTGACCGTTTCACTGCCCGATG
AGCTGGCGAGCTACATCAAG

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTTTLLRGRLLSFRRAPLSLTDSQSYLYEEDGGLLIEDGLIAAAGAYADVKAKAAADVVEIDHRPHLILPGFIDMHLHFP
QMQVIASYAANLLEWLNTYTFPEECRFVESAHAERIATHFYDELIRHGTTTAVAYCSVHKTSADAFFAEAMKRNMRMVGG
KVMMDRNAPQGLLDTPEIGYDETRQVISDWHGKGRNHVAITPRFAITSTPAQMEATSALAREFPDLHIQTHLSENHDEIK
FTCELYPDAIDYTDIYARYGLLGPKSLFGHAIHLSEREADVMSETGAVAVHCPTSNLFLGSGLFPLKALARREKPVRIGV
ATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESYYLMTRGNAEALSLADRIGTLEPGTEADLVVLDAAATPAMALKME
AVKTLPEELFLLQTMGDDRAIAETYVAGVDLKKNL

Sequences:

>Translated_435_residues
MTTTLLRGRLLSFRRAPLSLTDSQSYLYEEDGGLLIEDGLIAAAGAYADVKAKAAADVVEIDHRPHLILPGFIDMHLHFP
QMQVIASYAANLLEWLNTYTFPEECRFVESAHAERIATHFYDELIRHGTTTAVAYCSVHKTSADAFFAEAMKRNMRMVGG
KVMMDRNAPQGLLDTPEIGYDETRQVISDWHGKGRNHVAITPRFAITSTPAQMEATSALAREFPDLHIQTHLSENHDEIK
FTCELYPDAIDYTDIYARYGLLGPKSLFGHAIHLSEREADVMSETGAVAVHCPTSNLFLGSGLFPLKALARREKPVRIGV
ATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESYYLMTRGNAEALSLADRIGTLEPGTEADLVVLDAAATPAMALKME
AVKTLPEELFLLQTMGDDRAIAETYVAGVDLKKNL
>Mature_434_residues
TTTLLRGRLLSFRRAPLSLTDSQSYLYEEDGGLLIEDGLIAAAGAYADVKAKAAADVVEIDHRPHLILPGFIDMHLHFPQ
MQVIASYAANLLEWLNTYTFPEECRFVESAHAERIATHFYDELIRHGTTTAVAYCSVHKTSADAFFAEAMKRNMRMVGGK
VMMDRNAPQGLLDTPEIGYDETRQVISDWHGKGRNHVAITPRFAITSTPAQMEATSALAREFPDLHIQTHLSENHDEIKF
TCELYPDAIDYTDIYARYGLLGPKSLFGHAIHLSEREADVMSETGAVAVHCPTSNLFLGSGLFPLKALARREKPVRIGVA
TDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESYYLMTRGNAEALSLADRIGTLEPGTEADLVVLDAAATPAMALKMEA
VKTLPEELFLLQTMGDDRAIAETYVAGVDLKKNL

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=389, Percent_Identity=34.1902313624679, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1789249, Length=399, Percent_Identity=47.1177944862155, Blast_Score=390, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6319963, Length=346, Percent_Identity=32.0809248554913, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24643849, Length=443, Percent_Identity=30.9255079006772, Blast_Score=186, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48042; Mature: 47911

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTLLRGRLLSFRRAPLSLTDSQSYLYEEDGGLLIEDGLIAAAGAYADVKAKAAADVVE
CCCHHHHHHHHHHHCCCCEEECCCCEEEECCCCEEEECCCEEECCCHHHHHHHHHHHHHE
IDHRPHLILPGFIDMHLHFPQMQVIASYAANLLEWLNTYTFPEECRFVESAHAERIATHF
ECCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YDELIRHGTTTAVAYCSVHKTSADAFFAEAMKRNMRMVGGKVMMDRNAPQGLLDTPEIGY
HHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCH
DETRQVISDWHGKGRNHVAITPRFAITSTPAQMEATSALAREFPDLHIQTHLSENHDEIK
HHHHHHHHHHCCCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEE
FTCELYPDAIDYTDIYARYGLLGPKSLFGHAIHLSEREADVMSETGAVAVHCPTSNLFLG
EEEEECCCCCCHHHHHHHHCCCCCHHHHHHEEECCCHHHHHHHCCCCEEEECCCCCEEEC
SGLFPLKALARREKPVRIGVATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESYYLMT
CCCHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEE
RGNAEALSLADRIGTLEPGTEADLVVLDAAATPAMALKMEAVKTLPEELFLLQTMGDDRA
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHH
IAETYVAGVDLKKNL
HHHHHHHCCCHHCCC
>Mature Secondary Structure 
TTTLLRGRLLSFRRAPLSLTDSQSYLYEEDGGLLIEDGLIAAAGAYADVKAKAAADVVE
CCHHHHHHHHHHHCCCCEEECCCCEEEECCCCEEEECCCEEECCCHHHHHHHHHHHHHE
IDHRPHLILPGFIDMHLHFPQMQVIASYAANLLEWLNTYTFPEECRFVESAHAERIATHF
ECCCCCEEECCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
YDELIRHGTTTAVAYCSVHKTSADAFFAEAMKRNMRMVGGKVMMDRNAPQGLLDTPEIGY
HHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCH
DETRQVISDWHGKGRNHVAITPRFAITSTPAQMEATSALAREFPDLHIQTHLSENHDEIK
HHHHHHHHHHCCCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEE
FTCELYPDAIDYTDIYARYGLLGPKSLFGHAIHLSEREADVMSETGAVAVHCPTSNLFLG
EEEEECCCCCCHHHHHHHHCCCCCHHHHHHEEECCCHHHHHHHCCCCEEEECCCCCEEEC
SGLFPLKALARREKPVRIGVATDIGGGSSYSMLRTMDEAYKIQQLLGERLNPLESYYLMT
CCCHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHEEEEE
RGNAEALSLADRIGTLEPGTEADLVVLDAAATPAMALKMEAVKTLPEELFLLQTMGDDRA
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCCCCHH
IAETYVAGVDLKKNL
HHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]