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The map label for this gene is hemF [H]

Identifier: 209550365

GI number: 209550365

Start: 2830954

End: 2831865

Strand: Direct

Name: hemF [H]

Synonym: Rleg2_2786

Alternate gene names: 209550365

Gene position: 2830954-2831865 (Clockwise)

Preceding gene: 209550363

Following gene: 209550366

Centisome position: 62.38

GC content: 62.17

Gene sequence:

>912_bases
ATGGAAAGACCGGAACTGCCGATCGGCTTGCCTGAGGACATCGAAGAGAAGAAGGCCGCCGCCCGCAGCTGGTTCGAAGG
ACTGCGCGATACGATCTGCGCCTCCTTTGAAGCCCTCGAAGACGAGTTGGAGGGCCCGCTCTCCGATCAGGAGCCCGGCC
GTTTCGTCGCCAAGGACTGGTCGCGCGAAAACGGCGCCGGCGGCGGTGGCCGCATGTCGATGATGGAAGGCCGGGTCTTC
GAGAAGGTCGGCGTCCACACCTCCACCGTCCATGGCGAATTCTCCCCGGACTTCCGGGCGCAGATACCCGGCGCCAAGGA
CGATCCGCGCTTCTGGGCCTCGGGCATTTCGCTGATCGCCCATCCCGTCAACCCCAACGTCCCCGCCGTGCATATGAACA
CCCGCATGGTGGTCACATCAAGCCGCTGGTTCGGCGGTGGCGCCGACCTGACGCCGGTGCTGTCGCGCCGCCGCACCCAG
GAGGACGAGGACAGCCAGCTCTTCCACAAGGCGATGGAGATCGCCTGCCGCAATCATGCCGTCGCCGATTACGATGCCTA
CAAAGCCTGGTGCGACGACTATTTCTTCCTGAAGCACCGCAACGAGGCCCGCGGCATTGGCGGCATTTTCTATGACTGGC
TGCATTCGAACGAGGATGCCGGCGGCTGGGACGCCGATTTCGCCTTCACTCGCGATGTCGGCCGGGCCTTTTCCATGGTC
TATCCGAAAATCGTCCGATCCAACTTCAATAAGTTGTGGACAGAGGCCGATCGCGACGAACAATTGATCCGCCGAGGCCG
CTACGTCGAATTCAATTTGCTGTATGATCGCGGTACGATCTTCGGCCTGAAGACCGGCGGCAACGTTGAATCCATTCTTT
CGTCCCTGCCCCCTGTCGTCCGCTGGCCATGA

Upstream 100 bases:

>100_bases
CCTCGGCTTGGCGAGATGCGGCGCCACCTGCTAAACGGGGCGGGTAATCGAGAATGAGCGAGTCGCTTCCTATGATGATG
CCGACCGCCGGAGACGCGAC

Downstream 100 bases:

>100_bases
GACTGTGATAACTCGTCGATAAATTCGAGTTGATTGACCTTCACGAAAATTAAGCGCGTCCTAACTTTATATGTATGTGC
GTAACAATCGGAGGAGGATT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MERPELPIGLPEDIEEKKAAARSWFEGLRDTICASFEALEDELEGPLSDQEPGRFVAKDWSRENGAGGGGRMSMMEGRVF
EKVGVHTSTVHGEFSPDFRAQIPGAKDDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTSSRWFGGGADLTPVLSRRRTQ
EDEDSQLFHKAMEIACRNHAVADYDAYKAWCDDYFFLKHRNEARGIGGIFYDWLHSNEDAGGWDADFAFTRDVGRAFSMV
YPKIVRSNFNKLWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVVRWP

Sequences:

>Translated_303_residues
MERPELPIGLPEDIEEKKAAARSWFEGLRDTICASFEALEDELEGPLSDQEPGRFVAKDWSRENGAGGGGRMSMMEGRVF
EKVGVHTSTVHGEFSPDFRAQIPGAKDDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTSSRWFGGGADLTPVLSRRRTQ
EDEDSQLFHKAMEIACRNHAVADYDAYKAWCDDYFFLKHRNEARGIGGIFYDWLHSNEDAGGWDADFAFTRDVGRAFSMV
YPKIVRSNFNKLWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVVRWP
>Mature_303_residues
MERPELPIGLPEDIEEKKAAARSWFEGLRDTICASFEALEDELEGPLSDQEPGRFVAKDWSRENGAGGGGRMSMMEGRVF
EKVGVHTSTVHGEFSPDFRAQIPGAKDDPRFWASGISLIAHPVNPNVPAVHMNTRMVVTSSRWFGGGADLTPVLSRRRTQ
EDEDSQLFHKAMEIACRNHAVADYDAYKAWCDDYFFLKHRNEARGIGGIFYDWLHSNEDAGGWDADFAFTRDVGRAFSMV
YPKIVRSNFNKLWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVVRWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=262, Percent_Identity=41.9847328244275, Blast_Score=184, Evalue=6e-47,
Organism=Escherichia coli, GI1788777, Length=292, Percent_Identity=41.4383561643836, Blast_Score=205, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320249, Length=300, Percent_Identity=39, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17864388, Length=262, Percent_Identity=43.1297709923664, Blast_Score=193, Evalue=2e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34254; Mature: 34254

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPELPIGLPEDIEEKKAAARSWFEGLRDTICASFEALEDELEGPLSDQEPGRFVAKDW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHC
SRENGAGGGGRMSMMEGRVFEKVGVHTSTVHGEFSPDFRAQIPGAKDDPRFWASGISLIA
CCCCCCCCCCCHHHHHCHHHHHHCCCEEEECCCCCCCHHEECCCCCCCHHHHHCCHHHEE
HPVNPNVPAVHMNTRMVVTSSRWFGGGADLTPVLSRRRTQEDEDSQLFHKAMEIACRNHA
ECCCCCCCEEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
VADYDAYKAWCDDYFFLKHRNEARGIGGIFYDWLHSNEDAGGWDADFAFTRDVGRAFSMV
CCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YPKIVRSNFNKLWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVV
HHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEECCEEEEEECCCCHHHHHHHCCCCC
RWP
CCC
>Mature Secondary Structure
MERPELPIGLPEDIEEKKAAARSWFEGLRDTICASFEALEDELEGPLSDQEPGRFVAKDW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHC
SRENGAGGGGRMSMMEGRVFEKVGVHTSTVHGEFSPDFRAQIPGAKDDPRFWASGISLIA
CCCCCCCCCCCHHHHHCHHHHHHCCCEEEECCCCCCCHHEECCCCCCCHHHHHCCHHHEE
HPVNPNVPAVHMNTRMVVTSSRWFGGGADLTPVLSRRRTQEDEDSQLFHKAMEIACRNHA
ECCCCCCCEEEECCEEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
VADYDAYKAWCDDYFFLKHRNEARGIGGIFYDWLHSNEDAGGWDADFAFTRDVGRAFSMV
CCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHH
YPKIVRSNFNKLWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNVESILSSLPPVV
HHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEECCEEEEEECCCCHHHHHHHCCCCC
RWP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA