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The map label for this gene is pth [H]

Identifier: 209550347

GI number: 209550347

Start: 2813755

End: 2814486

Strand: Direct

Name: pth [H]

Synonym: Rleg2_2768

Alternate gene names: 209550347

Gene position: 2813755-2814486 (Clockwise)

Preceding gene: 209550346

Following gene: 209550348

Centisome position: 62.01

GC content: 61.34

Gene sequence:

>732_bases
ATGCTGATCATCGCGGGTCTCGGCAATCCCGGCGGCAAATACGCCGGCAACCGCCACAATATCGGCTTCATGGCCGTCGA
CGCCATTCATCGGCGCCACAGCTTTTCACCCTGGTCGAAAAAGTTCAGGGCCGAGATTGCCGAAGGCGAGCTCGGCGGCG
AGAAGGTGCTGCTGATCAAGCCGCAGACCTTCATGAATCTCTCCGGCGAGGCCGTCGGCGAAGCGATGCGCTTCTACAAG
CTCCAGCCCGCCGATCTTGTCGCGATCTATGACGAACTCGACCTTCCCGCGGGCAAGGCACGGCTGAAGACCGGCGGCGG
CCATGGCGGCCATAACGGCATCAAGTCACTGGACGCCCATTGCGGCAAGGAGTACCGGCGGCTGCGCCTCGGCATCGGGC
ACCCCGGCATCAAGGAAATGGTGCAGAACCACGTGCTCGGCGATTTCGCCAAGGCTGACAAGGCTTGGCTGGAGCCGCTT
CTCGATACGCTCGCCGACAATGCCGACATGCTGGTGCGAAACGAGGATTCGCAGCTGATGAACAAGATCGCGCTGGCACT
TGGCGGCAAGGCCGAGGAGGAGAAGCCGCGGAAGGACAACAAGACGACCGAAAAGAAGCCGGCCGGCCAGTCGCATATAC
ACCAGGCGCGCAATCACAATCAGCCGAAGGTGCTGACCACCGGCCCGATGGCCGATATTCTGAAGAAGATGTTCGGCAAC
AAAGGGGAATGA

Upstream 100 bases:

>100_bases
TCTCGGAGTGACGCGGCCGGCGGGCTTGCCCTTTCCGCTTGACTTTGCTCTCGTTTCCGGGTGGTGAACGTGGGCAAAAG
TTAAGCGAGGACGACAGGCC

Downstream 100 bases:

>100_bases
GGTCGGTGCCGGATCAGAACCTCGCCATCCGTCCGGCCGTCGCCGGCGATCTTCCTGGGCTGACCACACTCTACCGGCAT
TTGAACCCGGCCGATCCGGT

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLIIAGLGNPGGKYAGNRHNIGFMAVDAIHRRHSFSPWSKKFRAEIAEGELGGEKVLLIKPQTFMNLSGEAVGEAMRFYK
LQPADLVAIYDELDLPAGKARLKTGGGHGGHNGIKSLDAHCGKEYRRLRLGIGHPGIKEMVQNHVLGDFAKADKAWLEPL
LDTLADNADMLVRNEDSQLMNKIALALGGKAEEEKPRKDNKTTEKKPAGQSHIHQARNHNQPKVLTTGPMADILKKMFGN
KGE

Sequences:

>Translated_243_residues
MLIIAGLGNPGGKYAGNRHNIGFMAVDAIHRRHSFSPWSKKFRAEIAEGELGGEKVLLIKPQTFMNLSGEAVGEAMRFYK
LQPADLVAIYDELDLPAGKARLKTGGGHGGHNGIKSLDAHCGKEYRRLRLGIGHPGIKEMVQNHVLGDFAKADKAWLEPL
LDTLADNADMLVRNEDSQLMNKIALALGGKAEEEKPRKDNKTTEKKPAGQSHIHQARNHNQPKVLTTGPMADILKKMFGN
KGE
>Mature_243_residues
MLIIAGLGNPGGKYAGNRHNIGFMAVDAIHRRHSFSPWSKKFRAEIAEGELGGEKVLLIKPQTFMNLSGEAVGEAMRFYK
LQPADLVAIYDELDLPAGKARLKTGGGHGGHNGIKSLDAHCGKEYRRLRLGIGHPGIKEMVQNHVLGDFAKADKAWLEPL
LDTLADNADMLVRNEDSQLMNKIALALGGKAEEEKPRKDNKTTEKKPAGQSHIHQARNHNQPKVLTTGPMADILKKMFGN
KGE

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis [H]

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family [H]

Homologues:

Organism=Homo sapiens, GI50897284, Length=168, Percent_Identity=36.9047619047619, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1787455, Length=185, Percent_Identity=40, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001328
- InterPro:   IPR018171 [H]

Pfam domain/function: PF01195 Pept_tRNA_hydro [H]

EC number: =3.1.1.29 [H]

Molecular weight: Translated: 26598; Mature: 26598

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1 ; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIIAGLGNPGGKYAGNRHNIGFMAVDAIHRRHSFSPWSKKFRAEIAEGELGGEKVLLIK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEC
PQTFMNLSGEAVGEAMRFYKLQPADLVAIYDELDLPAGKARLKTGGGHGGHNGIKSLDAH
CHHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCEECCCCCCCCCHHHHHHHHH
CGKEYRRLRLGIGHPGIKEMVQNHVLGDFAKADKAWLEPLLDTLADNADMLVRNEDSQLM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHH
NKIALALGGKAEEEKPRKDNKTTEKKPAGQSHIHQARNHNQPKVLTTGPMADILKKMFGN
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHCCC
KGE
CCC
>Mature Secondary Structure
MLIIAGLGNPGGKYAGNRHNIGFMAVDAIHRRHSFSPWSKKFRAEIAEGELGGEKVLLIK
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEC
PQTFMNLSGEAVGEAMRFYKLQPADLVAIYDELDLPAGKARLKTGGGHGGHNGIKSLDAH
CHHHHCCCHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCEECCCCCCCCCHHHHHHHHH
CGKEYRRLRLGIGHPGIKEMVQNHVLGDFAKADKAWLEPLLDTLADNADMLVRNEDSQLM
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHH
NKIALALGGKAEEEKPRKDNKTTEKKPAGQSHIHQARNHNQPKVLTTGPMADILKKMFGN
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHCCC
KGE
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA