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The map label for this gene is prs [H]

Identifier: 209550342

GI number: 209550342

Start: 2806590

End: 2807522

Strand: Direct

Name: prs [H]

Synonym: Rleg2_2763

Alternate gene names: 209550342

Gene position: 2806590-2807522 (Clockwise)

Preceding gene: 209550341

Following gene: 209550344

Centisome position: 61.85

GC content: 61.63

Gene sequence:

>933_bases
ATGAAGGTTTTCGCAGGCAATTCGAACCGGCAACTCGCCGAAGCGATCTGCACCTATCTCAACGTTCCCTTGGGGAGAGC
CAGTGTTCGAAGGTTTGCCGATCAGGAAATCTTCGTGGAAATCCAGGAAAATGTGCGCGGCGAGGACGTTTTCCTCGTGC
AGCCCACCGCCTTCCCTGCCAACGACCACCTGATGGAACTGCTGATCATGATCGACGCGATGCGTCGTTCTTCAGCCCGT
CGCATCACGGCCGTGCTTCCCTATTTCGGCTATGCGCGTCAGGACCGTCGCGCCTCAGGCCGCACACCGATCTCCGCCAA
GCTGGTCGCAAACCTCATTACCGAAGCCGGCGCCGACCGCGTCATGACGCTCGATCTCCATGCCGGGCAGATCCAGGGCT
TCTTCGATATACCCACAGACAATCTCTTCGCCCTGCCCGTGCTGACGCGCGACATCAAGAGCCATTACGACCTCAGCAAC
GTCATGGTCGTCTCGCCGGATGTCGGCGGCGTGGTGCGTGCCCGCGCGCTTGCCAAGCGGCTGGACTGTCTTCTGGCCAT
CGTCGACAAGCGTCGCGATCGGCCGGGTGAATCCGAAGTGATGAACATCATCGGCGACATTGACGGCAAGGACTGCCTGC
TGATCGACGACATCGTCGATTCCGGCGGCACGCTCTGCAACGCCGCCGACGCGATGCTGGCCAAGGGCGCAGCCAGCGTC
ACCGCCTATATCACCCACGGCGTCCTATCCGGCGGCGCGGTCACCCGCGTCACCTCCTCCAAGCTTCGCGAACTCGTCAT
CACGGATTCGATCCAGCCGACCACGGCGGTGCTCTCGGCACATAATATCCGCATCGTGACGACGGCGCCGCTGATCGGCG
AAGCCATCAGCCGAACGGCCCAGGAAGAGTCCGTCTCCAGCCTCTTCGATTAA

Upstream 100 bases:

>100_bases
AACTTTTTGCAAATATCAAAGCCTGTGGCGCCTTTGCCCTTGCATTCACGGGGAAGCTGGCTAAAAAGCGCGGCTATCAG
CGCATAACAGGCGGACCAAA

Downstream 100 bases:

>100_bases
AAAGAGCCGGCATTCGACCGGTTCTTGCATCAGATGGGCACAAATCAGTAGAAAATTGTCGCCCTAAGAGATCGCCGTCC
ACCCCTCATCCGGCTGCCGC

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MKVFAGNSNRQLAEAICTYLNVPLGRASVRRFADQEIFVEIQENVRGEDVFLVQPTAFPANDHLMELLIMIDAMRRSSAR
RITAVLPYFGYARQDRRASGRTPISAKLVANLITEAGADRVMTLDLHAGQIQGFFDIPTDNLFALPVLTRDIKSHYDLSN
VMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNIIGDIDGKDCLLIDDIVDSGGTLCNAADAMLAKGAASV
TAYITHGVLSGGAVTRVTSSKLRELVITDSIQPTTAVLSAHNIRIVTTAPLIGEAISRTAQEESVSSLFD

Sequences:

>Translated_310_residues
MKVFAGNSNRQLAEAICTYLNVPLGRASVRRFADQEIFVEIQENVRGEDVFLVQPTAFPANDHLMELLIMIDAMRRSSAR
RITAVLPYFGYARQDRRASGRTPISAKLVANLITEAGADRVMTLDLHAGQIQGFFDIPTDNLFALPVLTRDIKSHYDLSN
VMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNIIGDIDGKDCLLIDDIVDSGGTLCNAADAMLAKGAASV
TAYITHGVLSGGAVTRVTSSKLRELVITDSIQPTTAVLSAHNIRIVTTAPLIGEAISRTAQEESVSSLFD
>Mature_310_residues
MKVFAGNSNRQLAEAICTYLNVPLGRASVRRFADQEIFVEIQENVRGEDVFLVQPTAFPANDHLMELLIMIDAMRRSSAR
RITAVLPYFGYARQDRRASGRTPISAKLVANLITEAGADRVMTLDLHAGQIQGFFDIPTDNLFALPVLTRDIKSHYDLSN
VMVVSPDVGGVVRARALAKRLDCLLAIVDKRRDRPGESEVMNIIGDIDGKDCLLIDDIVDSGGTLCNAADAMLAKGAASV
TAYITHGVLSGGAVTRVTSSKLRELVITDSIQPTTAVLSAHNIRIVTTAPLIGEAISRTAQEESVSSLFD

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=310, Percent_Identity=44.1935483870968, Blast_Score=285, Evalue=5e-77,
Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=43.5483870967742, Blast_Score=281, Evalue=5e-76,
Organism=Homo sapiens, GI4506129, Length=308, Percent_Identity=43.1818181818182, Blast_Score=280, Evalue=9e-76,
Organism=Homo sapiens, GI84875539, Length=311, Percent_Identity=42.7652733118971, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI4506133, Length=342, Percent_Identity=33.0409356725146, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI194018537, Length=342, Percent_Identity=31.5789473684211, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI310128524, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310115209, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310118259, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI310119946, Length=144, Percent_Identity=31.9444444444444, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787458, Length=312, Percent_Identity=53.2051282051282, Blast_Score=338, Evalue=3e-94,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=45.1612903225806, Blast_Score=285, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=45.1612903225806, Blast_Score=284, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=45.1612903225806, Blast_Score=283, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17554704, Length=308, Percent_Identity=45.1298701298701, Blast_Score=282, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17570245, Length=337, Percent_Identity=32.0474777448071, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320946, Length=312, Percent_Identity=45.5128205128205, Blast_Score=268, Evalue=8e-73,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=44.8717948717949, Blast_Score=262, Evalue=4e-71,
Organism=Saccharomyces cerevisiae, GI6321776, Length=310, Percent_Identity=41.9354838709677, Blast_Score=254, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6322667, Length=196, Percent_Identity=41.3265306122449, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324511, Length=86, Percent_Identity=45.3488372093023, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=44.1935483870968, Blast_Score=274, Evalue=5e-74,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=41.1411411411411, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI281362873, Length=351, Percent_Identity=31.3390313390313, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651454, Length=351, Percent_Identity=31.3390313390313, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651458, Length=351, Percent_Identity=31.3390313390313, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651456, Length=351, Percent_Identity=31.3390313390313, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24651462, Length=370, Percent_Identity=30.5405405405405, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24651464, Length=370, Percent_Identity=30.5405405405405, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI45552010, Length=370, Percent_Identity=30.5405405405405, Blast_Score=168, Evalue=4e-42,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33566; Mature: 33566

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFAGNSNRQLAEAICTYLNVPLGRASVRRFADQEIFVEIQENVRGEDVFLVQPTAFPA
CEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHEEHHCCCCCEEEEECCCCCCC
NDHLMELLIMIDAMRRSSARRITAVLPYFGYARQDRRASGRTPISAKLVANLITEAGADR
HHHHHHHHHHHHHHHHHCHHHHEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VMTLDLHAGQIQGFFDIPTDNLFALPVLTRDIKSHYDLSNVMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
LDCLLAIVDKRRDRPGESEVMNIIGDIDGKDCLLIDDIVDSGGTLCNAADAMLAKGAASV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEHHHCCCCCCHHHHHHHHHCCHHHH
TAYITHGVLSGGAVTRVTSSKLRELVITDSIQPTTAVLSAHNIRIVTTAPLIGEAISRTA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHH
QEESVSSLFD
HHHHHHHHCC
>Mature Secondary Structure
MKVFAGNSNRQLAEAICTYLNVPLGRASVRRFADQEIFVEIQENVRGEDVFLVQPTAFPA
CEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHEEHHCCCCCEEEEECCCCCCC
NDHLMELLIMIDAMRRSSARRITAVLPYFGYARQDRRASGRTPISAKLVANLITEAGADR
HHHHHHHHHHHHHHHHHCHHHHEEHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
VMTLDLHAGQIQGFFDIPTDNLFALPVLTRDIKSHYDLSNVMVVSPDVGGVVRARALAKR
EEEEEECCCCCCEEEECCCCCEEEHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
LDCLLAIVDKRRDRPGESEVMNIIGDIDGKDCLLIDDIVDSGGTLCNAADAMLAKGAASV
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEHHHCCCCCCHHHHHHHHHCCHHHH
TAYITHGVLSGGAVTRVTSSKLRELVITDSIQPTTAVLSAHNIRIVTTAPLIGEAISRTA
HHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCHHHHHHHHHH
QEESVSSLFD
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]