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The map label for this gene is fdh [H]

Identifier: 209549902

GI number: 209549902

Start: 2375692

End: 2376708

Strand: Direct

Name: fdh [H]

Synonym: Rleg2_2318

Alternate gene names: 209549902

Gene position: 2375692-2376708 (Clockwise)

Preceding gene: 209549898

Following gene: 209549903

Centisome position: 52.35

GC content: 65.49

Gene sequence:

>1017_bases
ATGCTCGGCACCGTCCTTCGCGCCCCCGGCGATATCCGCTGCGAGGAAGTCGCGGAACCGAAGATCCAGAAACCCACCGA
CGCGATCATCAAGCTGTCGGCATCCTGTGTCTGCGGCTCCGACCTCTGGCCCTATCGCGGCCTTCAACCGATAAATGCCC
CGCAGCACATGGGCCACGAATATTGCGGTGTCGTCGTTGAGGTCGGCAGCGAGGTCAGGACTGTTCGGCCAGGCCAGTTC
GTCGTCGGCTCGTTCTGCCTCTCCGACAACACCTGCCCGCATTGCCGCTATGGCTTCCAGTCGTCCTGCGAGCATCGCGA
ATTCATGTCGGGCGCGCAGGCGCCCTATGCCCGGATCGCGCTTGCCGACGGCACGCTTGTGGCGACCGACACCATACCCT
CCGACGACCTGATCCCAAGCCTGCTCGCGGCTTCGGATGTTCTCGGCACCGGCTGGTATGCGGCCGACGCCGCGCGGGTC
ACGCCGGGATGCACGGCGGTCGTGGTCGGCGACGGCGCGGTCGGGCTGATGGGCGTGCTCGCGGCCAAGCAGCTTGGCGC
CGGCCGCATCATTGCCATGAGCCGCCACAAGCAGCGCCAGGACCTCGCACTCGAATATGGCGCGACCGATATCGTCACCG
AGCGCGGCGACGAGGGTGTGGCCAGGATCAGGGAATTGACGGGTGGCGTCGGTGCTGACTCGGTGCTGGAATGCGTCGGC
ACTGAGGAGTCGATGATGCAGGCGATCAATGCCTGCCGCCCCGGCGGCTCGATCGGCTATGTCGGCGTTCCCCATGGCGT
CAGTCTCGACGGACAGATGCTGTTCTTCGCACAGAAGAACCTGTTGGGCGGCCCGGCGCCGGTGCGCCGCTTCCTGCCGC
ACCTGATCGATCTCATCCTGTCGCGCAAGATCAACCCCGGAAAGGTCTTCGATCTCGAAGTGCCGCTCGCCGATGTCGCC
CAAGGCTACAAGGCAATGGACGAGCGCTCGGCGATCAAGACGCTGCTGCGGATGTGA

Upstream 100 bases:

>100_bases
ATAAGTCCATGCAAATTGCAGCGGCTAATCCGAGTTATCGAATGGTGCTATCCATCTCCCAAAGAATGAGACGGGCATTC
CGCCCGGACAGGAGATGACC

Downstream 100 bases:

>100_bases
CGTCCGGATTTCGGATCACACCGAGGACCCCAAAACTTAGCCGTCCGAGATTTCGAAATCGACGACGCCGGCATGGCTTG
CCGGCGCGACCCTGGTCGCC

Product: alcohol dehydrogenase zinc-binding domain-containing protein

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MLGTVLRAPGDIRCEEVAEPKIQKPTDAIIKLSASCVCGSDLWPYRGLQPINAPQHMGHEYCGVVVEVGSEVRTVRPGQF
VVGSFCLSDNTCPHCRYGFQSSCEHREFMSGAQAPYARIALADGTLVATDTIPSDDLIPSLLAASDVLGTGWYAADAARV
TPGCTAVVVGDGAVGLMGVLAAKQLGAGRIIAMSRHKQRQDLALEYGATDIVTERGDEGVARIRELTGGVGADSVLECVG
TEESMMQAINACRPGGSIGYVGVPHGVSLDGQMLFFAQKNLLGGPAPVRRFLPHLIDLILSRKINPGKVFDLEVPLADVA
QGYKAMDERSAIKTLLRM

Sequences:

>Translated_338_residues
MLGTVLRAPGDIRCEEVAEPKIQKPTDAIIKLSASCVCGSDLWPYRGLQPINAPQHMGHEYCGVVVEVGSEVRTVRPGQF
VVGSFCLSDNTCPHCRYGFQSSCEHREFMSGAQAPYARIALADGTLVATDTIPSDDLIPSLLAASDVLGTGWYAADAARV
TPGCTAVVVGDGAVGLMGVLAAKQLGAGRIIAMSRHKQRQDLALEYGATDIVTERGDEGVARIRELTGGVGADSVLECVG
TEESMMQAINACRPGGSIGYVGVPHGVSLDGQMLFFAQKNLLGGPAPVRRFLPHLIDLILSRKINPGKVFDLEVPLADVA
QGYKAMDERSAIKTLLRM
>Mature_338_residues
MLGTVLRAPGDIRCEEVAEPKIQKPTDAIIKLSASCVCGSDLWPYRGLQPINAPQHMGHEYCGVVVEVGSEVRTVRPGQF
VVGSFCLSDNTCPHCRYGFQSSCEHREFMSGAQAPYARIALADGTLVATDTIPSDDLIPSLLAASDVLGTGWYAADAARV
TPGCTAVVVGDGAVGLMGVLAAKQLGAGRIIAMSRHKQRQDLALEYGATDIVTERGDEGVARIRELTGGVGADSVLECVG
TEESMMQAINACRPGGSIGYVGVPHGVSLDGQMLFFAQKNLLGGPAPVRRFLPHLIDLILSRKINPGKVFDLEVPLADVA
QGYKAMDERSAIKTLLRM

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71743840, Length=364, Percent_Identity=25.8241758241758, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI262073058, Length=364, Percent_Identity=25.8241758241758, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=26.5027322404372, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=26.6304347826087, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=26.0869565217391, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI156523966, Length=361, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI71565152, Length=357, Percent_Identity=26.3305322128852, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501939, Length=328, Percent_Identity=27.7439024390244, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71565154, Length=364, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786825, Length=383, Percent_Identity=27.4151436031332, Blast_Score=127, Evalue=9e-31,
Organism=Escherichia coli, GI1788073, Length=350, Percent_Identity=28.8571428571429, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788075, Length=355, Percent_Identity=26.4788732394366, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI226510992, Length=321, Percent_Identity=25.2336448598131, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788407, Length=272, Percent_Identity=26.1029411764706, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790045, Length=280, Percent_Identity=26.7857142857143, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082125, Length=348, Percent_Identity=27.0114942528736, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786552, Length=357, Percent_Identity=26.3305322128852, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=311, Percent_Identity=26.0450160771704, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790718, Length=330, Percent_Identity=24.2424242424242, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=346, Percent_Identity=25.7225433526012, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=266, Percent_Identity=26.3157894736842, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=26.4880952380952, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=275, Percent_Identity=30.5454545454545, Blast_Score=100, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319955, Length=276, Percent_Identity=29.7101449275362, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=276, Percent_Identity=29.7101449275362, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=263, Percent_Identity=29.277566539924, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=336, Percent_Identity=25.8928571428571, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319257, Length=275, Percent_Identity=26.9090909090909, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=269, Percent_Identity=27.1375464684015, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323961, Length=288, Percent_Identity=24.6527777777778, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=355, Percent_Identity=26.4788732394366, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137530, Length=267, Percent_Identity=29.9625468164794, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17737897, Length=266, Percent_Identity=28.1954887218045, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 35865; Mature: 35865

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGTVLRAPGDIRCEEVAEPKIQKPTDAIIKLSASCVCGSDLWPYRGLQPINAPQHMGHE
CCCCCCCCCCCCCHHHHCCCCCCCCHHHHHEECCCEEECCCCCCCCCCCCCCCHHHCCHH
YCGVVVEVGSEVRTVRPGQFVVGSFCLSDNTCPHCRYGFQSSCEHREFMSGAQAPYARIA
HHHHHEECCCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEE
LADGTLVATDTIPSDDLIPSLLAASDVLGTGWYAADAARVTPGCTAVVVGDGAVGLMGVL
EECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
AAKQLGAGRIIAMSRHKQRQDLALEYGATDIVTERGDEGVARIRELTGGVGADSVLECVG
HHHHCCCCEEEEEHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHC
TEESMMQAINACRPGGSIGYVGVPHGVSLDGQMLFFAQKNLLGGPAPVRRFLPHLIDLIL
CHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHH
SRKINPGKVFDLEVPLADVAQGYKAMDERSAIKTLLRM
HCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGTVLRAPGDIRCEEVAEPKIQKPTDAIIKLSASCVCGSDLWPYRGLQPINAPQHMGHE
CCCCCCCCCCCCCHHHHCCCCCCCCHHHHHEECCCEEECCCCCCCCCCCCCCCHHHCCHH
YCGVVVEVGSEVRTVRPGQFVVGSFCLSDNTCPHCRYGFQSSCEHREFMSGAQAPYARIA
HHHHHEECCCCCEECCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEE
LADGTLVATDTIPSDDLIPSLLAASDVLGTGWYAADAARVTPGCTAVVVGDGAVGLMGVL
EECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
AAKQLGAGRIIAMSRHKQRQDLALEYGATDIVTERGDEGVARIRELTGGVGADSVLECVG
HHHHCCCCEEEEEHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHC
TEESMMQAINACRPGGSIGYVGVPHGVSLDGQMLFFAQKNLLGGPAPVRRFLPHLIDLIL
CHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEHHCCCCCCHHHHHHHHHHHHHHH
SRKINPGKVFDLEVPLADVAQGYKAMDERSAIKTLLRM
HCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]