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The map label for this gene is phoQ [H]

Identifier: 209549868

GI number: 209549868

Start: 2340355

End: 2341725

Strand: Direct

Name: phoQ [H]

Synonym: Rleg2_2284

Alternate gene names: 209549868

Gene position: 2340355-2341725 (Clockwise)

Preceding gene: 209549867

Following gene: 209549869

Centisome position: 51.57

GC content: 66.23

Gene sequence:

>1371_bases
ATGAATGCTCCGTTGTTCAAGCCGAGATCGATCGCCGGCCGGCTGCTGATGTTCTCGGGCATCTTCGTGACACTGGCGCT
CGTTGTGGCCGCGATCGTGCTCTGGCTGGCGCTGAAGACTGTGGTGCGCGAGCAGGTCGATCAGCGTCTCGACACCCAGA
TCGGCGCCCTTGCCGGCGCCGTGACGCGCGACGCGGCGGGAAGGATTGCTCTCTCCGCGCCGCTCGATGCGCCGCCCTTC
GATCGCCCCTCCTCCGGCTGGTACTGGCAGATCGACGATGGAGAGCAGCGCCTGACCTCCCGCTCCCTGATGAACGGCAC
GATCGATGCGCCGCCGCCACGGCAGGATCTGCGCCATATGCTGATGGGCATGCCGACATCCGGCACGGGCGGCGATCGTG
GAAGAGGGCCGCTTTACCTTCGCCAAGCCGTCCGCAGCATTGATGGCGTGGCGCTGACGATCACCGCGACTGCGCCGATG
ATCGCCCTTGTCGGCCCGGCGCTCCGTGCGCTCTTCTGGCTGGTTCCCTGCATGCTGCTGCTGGGGCTTGTGCTGATGGC
GGGCACCCTCTGGCAAATCCGCTTTGGCTTGCGGCCGCTGACATCCATGGCGGCCAATATCGACGCCATCAACCGGGGAG
AACGCGCCCGCCTGCCGGAGGAAGCAAGTGCCGAGCTTGCCCCGCTGTCGTTGAAAACCAATGCACTGCTGGCCGCCAGC
GACGAGCGGCTCGCGGCAACACGCATGCAGTTCGCAAACCTCGCCCATGGCCTGAAGACGCCGGTGGCGAGCCTGCTGCT
GGCGCTCGACGAGCAAAACGATCCCAAGGGCGCATTGCGGGGCCTGGCCGCCCGGATCGACAACAGGATCAAGCACCACC
TCGCCGCCGCCCGCCGGGTGATGGCTTCGTCGAACAATGTTGCCAGCACCGATCTGGCGGCATCGATCGCCGATCTGCAT
CGGGCGATCGGTCAGATCTACGCCGAGCGCAGCATTGCCTTCGACACCGATATCACCGAACGCCTGTGGGTCGCCTGCGA
CGAAAGCGATGTCGAGGAAATGCTCGGAAACCTGATCGACAACGCTTTCAAATGGGCCACCTCACGCGTCACCGTCCGCG
CCCGCCGCGACGGTCCGACCGCCCGGATCACGATCGAAGACGACGGCCCGGGCATCCCTCCTGATCGCCTCGCCGCCGTC
ATGCAGCCCGGCGTCCGGGAAGACGAAACCGTCCCCGGCAACGGCTTCGGCCTGAGTATCGTCAACGAGCTTGCCGGGCT
CTACGGCGGGTCGCTGGTGCTGGAGGCGAACGATGCGGCGGGATTGCGGTGTGTGTTGTGTCTGCCGGTGACGGTGGGGG
TGGCAGGATAG

Upstream 100 bases:

>100_bases
CCATCGAAGTGATCATCGCCCGGCTGCGCAAGAAACTGGGGGGCGACCGCATCGAGACCGTGCGCGGCCGCGGCTATATG
CTGACGGCGGCAGCGGCGCC

Downstream 100 bases:

>100_bases
GGTTCAAGGCATAATCGCCATAGCTCGACATGATGTTCTCTCCCTCAAATCCACGAACAAATCCGTTTCCCCCTGGCAGC
TGCTCTCGCCGAGACGTCTT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MNAPLFKPRSIAGRLLMFSGIFVTLALVVAAIVLWLALKTVVREQVDQRLDTQIGALAGAVTRDAAGRIALSAPLDAPPF
DRPSSGWYWQIDDGEQRLTSRSLMNGTIDAPPPRQDLRHMLMGMPTSGTGGDRGRGPLYLRQAVRSIDGVALTITATAPM
IALVGPALRALFWLVPCMLLLGLVLMAGTLWQIRFGLRPLTSMAANIDAINRGERARLPEEASAELAPLSLKTNALLAAS
DERLAATRMQFANLAHGLKTPVASLLLALDEQNDPKGALRGLAARIDNRIKHHLAAARRVMASSNNVASTDLAASIADLH
RAIGQIYAERSIAFDTDITERLWVACDESDVEEMLGNLIDNAFKWATSRVTVRARRDGPTARITIEDDGPGIPPDRLAAV
MQPGVREDETVPGNGFGLSIVNELAGLYGGSLVLEANDAAGLRCVLCLPVTVGVAG

Sequences:

>Translated_456_residues
MNAPLFKPRSIAGRLLMFSGIFVTLALVVAAIVLWLALKTVVREQVDQRLDTQIGALAGAVTRDAAGRIALSAPLDAPPF
DRPSSGWYWQIDDGEQRLTSRSLMNGTIDAPPPRQDLRHMLMGMPTSGTGGDRGRGPLYLRQAVRSIDGVALTITATAPM
IALVGPALRALFWLVPCMLLLGLVLMAGTLWQIRFGLRPLTSMAANIDAINRGERARLPEEASAELAPLSLKTNALLAAS
DERLAATRMQFANLAHGLKTPVASLLLALDEQNDPKGALRGLAARIDNRIKHHLAAARRVMASSNNVASTDLAASIADLH
RAIGQIYAERSIAFDTDITERLWVACDESDVEEMLGNLIDNAFKWATSRVTVRARRDGPTARITIEDDGPGIPPDRLAAV
MQPGVREDETVPGNGFGLSIVNELAGLYGGSLVLEANDAAGLRCVLCLPVTVGVAG
>Mature_456_residues
MNAPLFKPRSIAGRLLMFSGIFVTLALVVAAIVLWLALKTVVREQVDQRLDTQIGALAGAVTRDAAGRIALSAPLDAPPF
DRPSSGWYWQIDDGEQRLTSRSLMNGTIDAPPPRQDLRHMLMGMPTSGTGGDRGRGPLYLRQAVRSIDGVALTITATAPM
IALVGPALRALFWLVPCMLLLGLVLMAGTLWQIRFGLRPLTSMAANIDAINRGERARLPEEASAELAPLSLKTNALLAAS
DERLAATRMQFANLAHGLKTPVASLLLALDEQNDPKGALRGLAARIDNRIKHHLAAARRVMASSNNVASTDLAASIADLH
RAIGQIYAERSIAFDTDITERLWVACDESDVEEMLGNLIDNAFKWATSRVTVRARRDGPTARITIEDDGPGIPPDRLAAV
MQPGVREDETVPGNGFGLSIVNELAGLYGGSLVLEANDAAGLRCVLCLPVTVGVAG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=273, Percent_Identity=27.8388278388278, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1789808, Length=288, Percent_Identity=26.0416666666667, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=24.6963562753036, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=25.6756756756757, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=305, Percent_Identity=25.9016393442623, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48731; Mature: 48731

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPLFKPRSIAGRLLMFSGIFVTLALVVAAIVLWLALKTVVREQVDQRLDTQIGALAGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTRDAAGRIALSAPLDAPPFDRPSSGWYWQIDDGEQRLTSRSLMNGTIDAPPPRQDLRHM
HHHHCCCCEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHH
LMGMPTSGTGGDRGRGPLYLRQAVRSIDGVALTITATAPMIALVGPALRALFWLVPCMLL
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
LGLVLMAGTLWQIRFGLRPLTSMAANIDAINRGERARLPEEASAELAPLSLKTNALLAAS
HHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCCCCCCCCHHCCCCCCEEEECCEEEEEC
DERLAATRMQFANLAHGLKTPVASLLLALDEQNDPKGALRGLAARIDNRIKHHLAAARRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MASSNNVASTDLAASIADLHRAIGQIYAERSIAFDTDITERLWVACDESDVEEMLGNLID
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHEEECCHHHHHHHHHHHHH
NAFKWATSRVTVRARRDGPTARITIEDDGPGIPPDRLAAVMQPGVREDETVPGNGFGLSI
HHHHHHHHEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
VNELAGLYGGSLVLEANDAAGLRCVLCLPVTVGVAG
HHHHHHHCCCEEEEEECCCCCCEEEEEEEHHHCCCC
>Mature Secondary Structure
MNAPLFKPRSIAGRLLMFSGIFVTLALVVAAIVLWLALKTVVREQVDQRLDTQIGALAGA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTRDAAGRIALSAPLDAPPFDRPSSGWYWQIDDGEQRLTSRSLMNGTIDAPPPRQDLRHM
HHHHCCCCEEEECCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHH
LMGMPTSGTGGDRGRGPLYLRQAVRSIDGVALTITATAPMIALVGPALRALFWLVPCMLL
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
LGLVLMAGTLWQIRFGLRPLTSMAANIDAINRGERARLPEEASAELAPLSLKTNALLAAS
HHHHHHHHHHHHHHHCCCHHHHHHHCCHHHCCCCCCCCCCHHCCCCCCEEEECCEEEEEC
DERLAATRMQFANLAHGLKTPVASLLLALDEQNDPKGALRGLAARIDNRIKHHLAAARRV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
MASSNNVASTDLAASIADLHRAIGQIYAERSIAFDTDITERLWVACDESDVEEMLGNLID
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHHHEEECCHHHHHHHHHHHHH
NAFKWATSRVTVRARRDGPTARITIEDDGPGIPPDRLAAVMQPGVREDETVPGNGFGLSI
HHHHHHHHEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHH
VNELAGLYGGSLVLEANDAAGLRCVLCLPVTVGVAG
HHHHHHHCCCEEEEEECCCCCCEEEEEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA